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Aggregation-induced emission biomaterials for anti-pathogen medical applications:detecting,imaging and killing

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Regenerative Biomaterials 2023年第1期10卷 1003-1020页

作者： Zicong Zhang Ziwei Deng Lixun Zhu Jialin Zeng xu min cai Zijie Qiu Zheng Zhao Ben Zhong Tang Clinical Translational Research Center of Aggregation-Induced Emission The Second Affiliated HospitalSchool of MedicineSchool of Science and EngineeringShenzhen Key Laboratory of Functional Aggregate MaterialsThe Chinese University of Hong KongShenzhenGuangdong 518172China Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Rescources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China HKUST-Shenzhen Research Institute South Area Hi-Tech ParkNanshanShenzhenGuangdong Province 518057China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Microbial pathogens,including bacteria,fungi and viruses,greatly threaten the global public *** pathogen infections,early diagnosis and precise treatment are essential to cut the mortality *** emergence of aggregation‐induced emission(AIE)biomaterials provides an effective and promising tool for the theranostics of pathogen *** this review,the recent advances about AIE biomaterials for anti-pathogen theranostics are *** the excellent sensitivity and photostability,AIE biomaterials have been widely applied for precise diagnosis of ***,different types of anti-pathogen methods based on AIE biomaterials will be presented in detail,including chemotherapy and ***,the existing deficiencies and future development of AIE biomaterials for anti-pathogen applications will be discussed.

关键词： aggregation-induced emission fluorescence imaging pathogen differentiation pathogen inactivation

Chromene-based Bio AIEgens:'in-water' synthesis,regiostructure-dependent fluorescence and ER-specific imaging

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National Science Review 2023年第11期10卷 118-127页

作者： xu-min cai Yuting Lin Jianyu Zhang Ying Li Zhenguo Tang xuedan Zhang Ying Jia Wenjin Wang Shenlin Huang Parvej Alam Zheng Zhao Ben Zhong Tang Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry University School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen) Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and Technology Clinical Translational Research Center of Aggregation-Induced Emission School of MedicineThe Second Affiliated HospitalSchool of Science and EngineeringThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)

Exploration of artificial aggregation-induced emission luminogens(AIEgens) has garnered extensive interest in the past two decades. In particular, AIEgens possessing natural characteristics(BioAIEgens) have received more attention recently due to the advantages of biocompatibility, sustainability and ***, the extremely limited number of BioAIEgens extracted from natural sources have retarded their development. Herein, a new class of Bio AIEgens based on the natural scaffold of chromene have been facilely synthesized via green reactions in a water system. These compounds show regiostructure-,polymorphism-and substituent-dependent fluorescence, which clearly illustrates the close relationship between the macroscopic properties and hierarchical structure of aggregates. Due to the superior biocompatibility of the natural scaffold, chromene-based BioAIEgens can specifically target the endoplasmic reticulum(ER) via the introduction of tosyl amide. This work has provided a new chromene scaffold for functional BioAIEgens on the basis of green and sustainable ’in-water’ synthesis, applicable regiostructure-dependent fluorescence, and effective ER-specific imaging.

关键词： chromene BioAIE ‘in-water’ chemistry regiostructure dependence ER-specific imaging

Effect of operating conditions on the performance of riser reactor for oxidative coupling of methane Author links open overlay panel

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Particuology 2024年第8期91卷 235-248页

作者： min cai Shuangzhu Kong Mengxi Liu Chunxi Lu State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China

Oxidative coupling of methane(OCM)is characterized by high temperature and strong heat released.A riser reactor is designed for the OCM process to improve gas-solid contacting and heat *** work illustrates the effect of hydrodynamic conditions and feed gas composition on the performance of an OCM riser *** findings suggest that oxidative reactions predominantly occur within the acceleration zone and developed flow ***,at the low superficial gas velocity accompanied by a high solid circulating rate,the C_(2)yield initially increases in the acceleration zone,followed by a decrease in the developed flow zone and deceleration *** optimal operating conditions are a specific region corresponding to the solids holdup ranges from 0.015 to ***,the C_(2)yield can be elevated using an appropriate feed mixture.

关键词： Oxidative coupling of methane Riser Hydrodynamics Solids holdup

Automatic Requirement Dependency Extraction Based on Integrated Active Learning Strategies

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Machine Intelligence Research 2024年第5期21卷 993-1010页

作者： Hui Guan Guorong cai Hang xu Department of Computer Science and Technology Shenyang University of Chemical TechnologyShenyang110142China Key Laboratory of Industrial Intelligence Technology on Chemical Process Shenyang110142China

Since requirement dependency extraction is a cognitively challenging and error-prone task,this paper proposes an automatic requirement dependency extraction method based on integrated active learning *** this paper,the coefficient of variation method was used to determine the corresponding weight of the impact factors from three different angles:uncertainty probability,text similarity difference degree and active learning variant prediction divergence *** combining the three factors with the proposed calculation formula to measure the information value of dependency pairs,the top K dependency pairs with the highest comprehensive evaluation value are selected as the optimal *** the optimal samples are continuously added into the initial training set,the performance of the active learning model using different dependency features for requirement dependency extraction is rapidly ***,compared with other active learning strategies,a higher evaluation measure of requirement dependency extraction can be achieved by using the same number of ***,the proposed method using the PV-DM dependency feature improves the weight-F1 by 2.71%,the weight-recall by 2.45%,and the weight-precision by 2.64%in comparison with other strategies,saving approximately 46%of the labelled data compared with the machine learning approach.

关键词： Requirement dependency dependency extraction dependency features integrated active learning strategies coefficient of variation

Hydrodynamics and OCM reaction performance in a bubbling fluidized bed reactor and a riser reactor

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Particuology 2024年第3期86卷 188-204页

作者： min cai Shuangzhu Kong Sheng Chen Mengxi Liu Chunxi Lu State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China China Special Equipment Inspection and Research Institute Beijing102249China

The reasonable reactor design is of great importance for increasing the C_(2) yield(C2H4 and C2H6)of the oxidative coupling of methane(OCM),and the OCM reactor should remove the heat released in reactions quickly and efficiently and minimize the consecutive reaction of ethylene to carbon *** fluidized bed reactor is characterized by excellent heat transfer,superior mass transport,and large handling capacity,while fewer studies focused on large-scale fluidized bed reactors for the OCM ***,large cold-model experiments and computational fluid dynamics simulations were conducted to investigate hydrodynamics and the OCM reaction performance in a large-scale bubbling fluidized bed(BFB)and a large-scale *** the BFB reactor,consecutive reactions of ethylene are acute because of the strong gas back-mixing,high solids holdup,and non-uniform solids *** the consecutive reactions of ethylene are negligible due to the plug flow structure and low solids holdup in the riser ***,both reactors can achieve isothermal operation for the OCM *** C_(2) selectivity of 45.4% and C_(2) yield of 21.1% are obtained in the riser reactor,increasing by 20.3% and 5.8% individually than that in the BFB *** study provides useful information and reference to the OCM reactor designandcommercialization.

关键词： Oxidative coupling of methane Bubbling fluidized bed reactor Riser reactor Hydrodynamics Isothermal operation

Cu-Based Materials for Enhanced C_(2+) Product Selectivity in Photo-/Electro-Catalytic CO_(2) Reduction: Challenges and Prospects

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Nano-Micro Letters 2024年第4期16卷 25-66页

作者： Baker Rhimi min Zhou Zaoxue Yan Xiaoyan cai Zhifeng Jiang Institute for Energy Research School of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiang 212013People’s Republic of China School of Materials Science and Physics China University of Mining and TechnologyXuzhou 221116People’s Republic of China

Carbon dioxide conversion into valuable products using photocatalysis and electrocatalysis is an effective approach to mitigate global environmental issues and the energy shortages. Among the materials utilized for catalytic reduction of CO_(2), Cu-based materials are highly advantageous owing to their widespread availability, cost-effectiveness, and environmental sustainability. Furthermore, Cu-based materials demonstrate interesting abilities in the adsorption and activation of carbon dioxide, allowing the formation of C_(2+) compounds through C–C coupling process. Herein, the basic principles of photocatalytic CO_(2) reduction reactions(PCO_(2)RR) and electrocatalytic CO_(2) reduction reaction(ECO_(2)RR) and the pathways for the generation C_(2+) products are introduced. This review categorizes Cu-based materials into different groups including Cu metal, Cu oxides, Cu alloys, and Cu SACs, Cu heterojunctions based on their catalytic applications. The relationship between the Cu surfaces and their efficiency in both PCO_(2)RR and ECO_(2)RR is emphasized. Through a review of recent studies on PCO_(2)RR and ECO_(2)RR using Cu-based catalysts, the focus is on understanding the underlying reasons for the enhanced selectivity toward C_(2+) products. Finally, the opportunities and challenges associated with Cu-based materials in the CO_(2) catalytic reduction applications are presented, along with research directions that can guide for the design of highly active and selective Cu-based materials for CO_(2) reduction processes in the future.

关键词： Photocatalytic CO_(2)reduction Cu-based materials Electrocatalytic CO_(2)reduction

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Nanomedicine targeting ferroptosis to overcome anticancer therapeutic resistance

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Science China(Life Sciences) 2024年第1期67卷 19-40页

作者： Jing cai Xiaoding xu Phei Er Saw Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineMedical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Nanhai Translational Innovation Center of Precision Immunology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityFoshan 528200China

A potential reason for the failure of tumor therapies is treatment *** to chemotherapy,radiotherapy,and immunotherapy continues to be a major obstacle in clinic,resulting in tumor recurrence and *** major mechanisms of therapy resistance are inhibitions of cell deaths,like apoptosis and necrosis,through drug inactivation and excretion,repair of DNA damage,tumor heterogeneity,or changes in tumor microenvironment,*** studies have shown that ferroptosis play a major role in therapies resistance by inducing phospholipid peroxidation and iron-dependent cell *** ferroptosis inducers in combination with clinical treatment techniques have been used to enhance the effect in tumor ***,versatile ferroptosis nanoinducers exhibit an extensive range of functions in reversing therapy resistance,including directly triggering ferroptosis and feedback ***,we provide a detailed description of the design,mechanism,and therapeutic application of ferroptosis-mediated synergistic tumor *** also discuss the prospect and challenge of nanomedicine in tumor therapy resistance by regulating ferroptosis and combination therapy.

关键词： ferroptosis cancer therapy therapy resistance nanoinducers

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Strong anisotropy of thermal transport in the monolayer of a new puckered phase of PdSe

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Frontiers of physics 2024年第3期19卷 143-151页

作者： Zheng Shu Huifang xu Hejin Yan Yongqing cai Joint Key Laboratory of the ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoTaipaMacao 999078China

We examine the electronic and transport properties of a new phase PdSe monolayer with a puckered structure calculated by first-principles and Boltzmann transport *** spin−orbit coupling is found to play a negligible effect on the electronic properties of PdSe *** lattice thermal conductivity of PdSe monolayer exhibits remarkable anisotropic characteristic due to anisotropic phonon group velocity along different directions and its intrinsic structure *** compromised electronic mobility despite a relatively low thermal conduction results in a moderate ZT value but significantly anisotropic thermoelectric performance in single-layer *** present work suggests that the remarkable thermal transport anisotropy of PdSe monolayer can be used for thermal management,and enhance the scope of possibilities for heat flow manipulation in PdSe based *** sizeable puckered cages and wiggling lattice implies it an ideal platform for ionic and molecular engineering for thermoelectronic applications.

关键词： 2D materials first-principles calculations phonon

Tailoring sulfur-doped and nitrogen-defective carbon nitride nanosheets for efficient photo-controlled radical polymerizations

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Science China Chemistry 2024年第7期67卷 2325-2334页

作者： xue Li Meng Kai xu Yuan Huang Tao cai Key Laboratory of Biomedical Polymers of ministry of Education College of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China Wuhan University Shenzhen Research Institute Shenzhen 518057China

Despite the challenges that remain,the synergistic adjustment of various microstructures and photochemical parameters of graphitic carbon nitride(g-C_(3)N_(4))in photocatalytic reactions holds promises for improving catalytic efficiency and reducing energy ***,sulfur-doped and nitrogen-defective g-C_(3)N_(4)(n-SC_(3)N_(x))nanosheets were designed and elaborately *** resultant n-SC_(3)N_(x)possessed a precisely defined 2D layer structure with extensive porosity and incremental specific surface *** photoinduced electron transfer-reversible addition-fragmentation chain transfer(PET-RAFT)polymerization of vinyl monomers with low dispersity,excellent temporal control and high chain-end fidelity was achieved under mild blue light irradiation in a nondegassed *** to their ultrathin nanostructures with nitrogen defects and sulfur dopants,n-SC_(3)N_(x)was capable of catalyzing RAFT polymerization in aqueous solutions at significantly accelerated rates,which were nearly 8 times faster compared to bulk g-C_(3)N_(4).The ease of separation and efficient reusability in subsequent polymerizations was enabled by the heterogeneous nature of n-SC_(3)N_(x).The appeal of this approach was illustrated by the fact that utilizing a reusable and metal-free photocatalyst in aqueous environments allowed for the synthesis of polymers with molecular weight up to 300 kg mol^(-1) and a dispersity of 1.32.

关键词： graphitic carbon nitride nitrogen defects sulfur dopants PET-RAFT polymerization recyclability

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