检索结果-南通市图书馆

Roles of combined femoral and acetabular anteversion in pathological changes of hip dysplasia and hip reconstructive surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2024年第5期15卷 390-399页

作者： Can Liu zheng xu Jian-Fa Zeng Zhen-Qi Song Yu-Yin Xie Zhong-Wen Tang Jie Wen Sheng Xiao Department of Anatomy Hunan Normal University School of MedicineChangsha 410003Hunan ProvinceChina Department of Pediatric Orthopedics Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina

Combined femoral and acetabular anteversion is the sum of femoral and acetabular anteversion,representing their morphological relationship in the axial *** with the increasing understanding of hip dysplasia in recent years,numerous scholars have confirmed the role of combined femoral and acetabular anteversion in the pathological changes of hip *** present,the reconstructive surgery for hip dysplasia includes total hip replacement and redirectional hip preservation *** an important surgery index,combined femoral and acetabular anteversion have a crucial role in these ***,we discuss the role of combined femoral and acetabular anteversion in pathological changes of hip dysplasia,total hip replacement,and redirectional hip preservation surgery.

关键词： Combined anteversion Femoral anteversion Acetabular anteversion Hip dysplasia Hip preservation surgery Total hip replacement

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

元代织金锦的分类考据及不同品种的交流融合

丝绸 2024年第7期61卷 133-140页

作者：茅惠伟徐铮浙江纺织服装职业技术学院文化研究院宁波315211 中国美术学院手工艺术学院杭州310024 中国丝绸博物馆陈列保管部杭州310002

织金锦是元代最具特色的织物,元时期流行的织金锦包括西来的纳石失和中国传统的金段子。文章以中西交流为背景,首先采用分类考据的方式,爬梳各类史料汇编,将纳石失和金段子进一步细化分析,认为“素纳石失”也许是织造过程中使用金纬较少... 详细信息

织金锦是元代最具特色的织物,元时期流行的织金锦包括西来的纳石失和中国传统的金段子。文章以中西交流为背景,首先采用分类考据的方式,爬梳各类史料汇编,将纳石失和金段子进一步细化分析,认为“素纳石失”也许是织造过程中使用金纬较少,且面料更适合夏季的纳石失,也可能是没有起花的织金锦。而“草金段子”大概率是来自民间作坊,品级相对较低的金段子。其次通过实物分析,从织造工艺的角度切入,发现随着纳石失而来的特结锦结构与中国传统的地络类插金组织结构产生了融合,使得传统金段子的织造技术发生了改变。最后以一件元代织金袍服作为典型案例分析,展示东西文化的融合,认为织金锦是文明互鉴的重要物证。

关键词：纳石失金段子特结锦地络类组织分类考据交流融合

维普期刊数据库博看期刊

在线全文

学校读者我要写书评

暂无评论

超低场磁共振膝关节正交接收线圈设计

电工技术学报 2024年第7期39卷 1923-1931页

作者：万裁何为沈晟徐征重庆大学电气工程学院重庆400044 麻省总医院Athinoula A.Martinos生物医学成像中心美国马萨诸塞州02114

射频接收线圈是磁共振成像(MRI)系统中的关键部件,用于检测变化的磁场,其性能直接影响图像的质量。超低场MRI射频接收线圈工作在较低频率,其阻抗特性不同于传统临床MRI射频接收线圈。理论上正交接收线圈比单通道线圈的信噪比(SNR)可以提... 详细信息

射频接收线圈是磁共振成像(MRI)系统中的关键部件,用于检测变化的磁场,其性能直接影响图像的质量。超低场MRI射频接收线圈工作在较低频率,其阻抗特性不同于传统临床MRI射频接收线圈。理论上正交接收线圈比单通道线圈的信噪比(SNR)可以提高41%。而与阵列线圈相比,正交接收线圈可以用更低的成本与设计复杂度达到很好的成像效果。因此该文研究了一种用于超低场MRI(50.4 mT)系统的膝关节正交接收线圈,它由鞍形线圈和亥姆霍兹线圈组成。首先,确定了线圈的支撑结构及尺寸,并通过计算单匝接收线圈的效率及磁场的不均匀性来确定鞍形以及亥姆霍兹线圈的最优尺寸。然后,实测了线圈交流电阻,来评估线圈不同匝数的SNR,发现匝数增多会使得交流电阻显著增加,从而使SNR随着线圈匝数增加先增加后减少。最后,得到了两线圈的最佳匝数,并制作了正交接收线圈,从CuSO_(4)·5H_(2)O体膜以及体内膝关节成像来评估正交接收线圈的性能。在体膜和体内膝关节成像中,正交接收线圈与单通道线圈相比,图像SNR分别最大程度地提升了约33.5%和30.9%。

关键词：磁共振成像超低场膝关节成像正交接收线圈

同方期刊数据库

在线全文

学校读者我要写书评

暂无评论

中心城区排水泵站与城市公共空间融合设计

中国给水排水 2024年第12期40卷 73-77页

作者：徐文征上海市政工程设计研究总院<集团>有限公司上海200092

为保障城市排水安全,上海中心城区排水标准拟提高至5年一遇,需新增雨水泵站流量487 m^(3)/s,由于用地紧张,应充分挖掘土地综合效益。以黄浦区浙江中路泵站为例,探索排水泵站结合城市更新、与公共空间融合的建设方案。浙江中路泵站规模为... 详细信息

为保障城市排水安全,上海中心城区排水标准拟提高至5年一遇,需新增雨水泵站流量487 m^(3)/s,由于用地紧张,应充分挖掘土地综合效益。以黄浦区浙江中路泵站为例,探索排水泵站结合城市更新、与公共空间融合的建设方案。浙江中路泵站规模为26 m^(3)/s,用地面积约为2922 m^(2),结合街坊内西侧拟建环卫设施停车场统筹建设。街坊总体采用竖向空间的叠合生长策略进行设计,地面一层为泵站以及环卫设施停车场,地面二层为公共空间,泵站用地面积较常规泵站减少30%~40%,地面二层释放公共空间约1040 m^(2);泵站除臭采用洗涤+离子法+化学滤料吸附工艺,执行上海市《恶臭(异味)污染物排放标准》(DB 31/1025—2016);泵站设置独立的出入口,满足运维管理的安全需要。

关键词：排水泵站中心城区城市更新公共空间融合建设

Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第3期9卷 1199-1208页

作者： Xinyi Yang xu zheng Yuqi Zhu Xiaying Zhao Jun Liu Jiangna xun Songhua Yuan Jun Chen Hanyu Pan Jinlong Yang Jing Wang Zhimin Liang Xiaoting Shen Yue Liang Qinru Lin Huitong Liang Min Li Fei Peng Daru Lu Jianqing xu Hongzhou Lu Shibo Jiang Ping Zhao Huanzhang Zhu State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology Ministry of EducationInstitute of GeneticsSchool of Life SciencesYiwu Research InstituteFudan UniversityShanghaiChina Department of Microbiology Faculty of Naval MedicineNaval Medical UniversityShanghai 200433China Scientific Research Center Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Department of Infectious Diseases and Immunology Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Changzheng Hospital Naval Medical UniversityShanghaiChina Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) Shanghai Institute of Infectious Disease and BiosecuritySchool of Basic Medical SciencesFudan UniversityShanghaiChina Department of Infectious Diseases and Nursing Research Institution National Clinical Research Center for Infectious DiseasesThe Third People’s Hospital of ShenzhenShenzhenGuangdongChina

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes multi-organ damage,which includes hepatic dysfunction,as observed in over 50%of COVID-19 *** I converting enzyme(peptidyl-dipeptidase A)2(ACE2)is the primary receptor for SARS-CoV-2 entry into host cells,and studies have shown the presence of intracellular virus particles in human hepatocytes that express ACE2,but at extremely low ***,we asked if hepatocytes might express receptors other than ACE2 capable of promoting the entry of SARS-CoV-2 into *** address this question,we performed a genome-wide CRISPR-Cas9 activation library screening and found that Asialoglycoprotein receptor 1(ASGR1)promoted SARS-CoV-2 pseudovirus infection of HeLa *** Huh-7 cells,simultaneous knockout of ACE2 and ASGR1 prevented SARS-CoV-2 pseudovirus *** the immortalized THLE-2 hepatocyte cell line and primary hepatic parenchymal cells,both of which barely expressed ACE2,SARSCoV-2 pseudovirus could successfully establish an ***,after treatment with ASGR1 antibody or siRNA targeting ASGR1,the infection rate significantly dropped,suggesting that SARS-CoV-2 pseudovirus infects hepatic parenchymal cells mainly through an ASGR1-dependent *** confirmed that ASGR1 could interact with Spike protein,which depends on receptor binding domain(RBD)and N-terminal domain(NTD).Finally,we also used Immunohistochemistry and electron microscopy to verify that SARS-CoV-2 could infect primary hepatic parenchymal *** inhibiting ASGR1 in primary hepatic parenchymal cells by siRNA,the infection efficiency of the live virus decreased ***,these findings indicate that ASGR1 is a candidate receptor for SARS-CoV-2 that promotes infection of hepatic parenchymal cells.

关键词： ACE2 infection glycoprotein

胸腰椎融合术患者术后胃肠功能障碍的危险因素分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华医学杂志 2024年第3期104卷 186-191页

作者：郑旭顾小萍王琛南京医科大学附属苏州医院麻醉科苏州215008 南京鼓楼医院麻醉科南京210008 南京医科大学附属苏州科技城医院麻醉科苏州215153

目的分析胸腰椎融合术患者发生术后胃肠功能障碍(POGD)的危险因素。方法回顾性分析南京鼓楼医院2021年1至12月434例接受胸腰椎融合术患者的临床资料。根据POGD发生情况分为POGD组(n=70)和非POGD组(n=364)。比较两组患者的临床资料,采用... 详细信息

目的分析胸腰椎融合术患者发生术后胃肠功能障碍(POGD)的危险因素。方法回顾性分析南京鼓楼医院2021年1至12月434例接受胸腰椎融合术患者的临床资料。根据POGD发生情况分为POGD组(n=70)和非POGD组(n=364)。比较两组患者的临床资料,采用二元logistic回归分析患者发生POGD的危险因素。结果POGD组男23例,女47例,年龄(60±6)岁;非POGD组男133例,女231例,年龄(62±7)岁。两组患者手术时长、出血量、术中椎管减压、术中低血压、术后24 h白细胞计数、术后24 h C反应蛋白、术后住院时间差异均有统计学意义(均P<0.05)。二元logistic回归分析显示,术中进行椎管减压(OR=2.368,95%CI:1.365~4.106,P=0.002)、出血量≥10.9 ml/kg(OR=2.115,95%CI:1.166~3.835,P=0.014)、术后24 h白细胞计数≥15.2×10^(9)/L(OR=3.580,95%CI:1.773~7.226,P<0.001)、术中低血压(OR=2.019,95%CI:1.080~3.773,P=0.028)是胸腰椎融合术后患者发生POGD的危险因素;使用地塞米松是保护因素(OR=0.408,95%CI:0.218~0.762,P=0.005)。结论胸腰椎融合术中进行椎管减压、出血量≥10.9 ml/kg、术后24 h白细胞计数≥15.2×10^(9)/L、术中低血压是患者发生POGD的危险因素,使用地塞米松是保护因素。

关键词：脊柱融合术术后胃肠功能障碍危险因素

预测抓握力和振动传递的手-臂系统生物动力学模型

在线全文

学校读者我要写书评

暂无评论

声学学报 2024年第2期49卷 194-201页

作者：王遵铭邱毅郑旭刘迟浙江大学能源工程学院杭州310027

针对手-臂的振动问题,提出了一种手-臂混合模型来计算不同抓握力下叉车方向盘传递给手-臂的振动。该模型由肩膀、上臂、前臂和手组成,通过具有刚度和阻尼的关节连接。手部模型包含手掌和五个手指,每个手指的远端、近端和掌指端通过旋转... 详细信息

针对手-臂的振动问题,提出了一种手-臂混合模型来计算不同抓握力下叉车方向盘传递给手-臂的振动。该模型由肩膀、上臂、前臂和手组成,通过具有刚度和阻尼的关节连接。手部模型包含手掌和五个手指,每个手指的远端、近端和掌指端通过旋转关节相互连接,在手指关节上施加力矩来模拟抓握手柄时的主动肌肉力。通过调整模型材料参数以匹配手和手臂在抓握手柄时的接触压力和振动。将标定后的模型应用于某叉车方向盘对手臂系统振动传递率进行预测,结果表明所建立的考虑抓握力和手与手柄接触条件的模型能够预测车辆驾驶员手臂系统的振动传递。

关键词：手-臂生物动力学模型振动传递率接触压力抓握力

仰卧人体在三轴单向全身振动激励下的振动传递特性

在线全文

学校读者我要写书评

暂无评论

声学学报 2024年第2期49卷 202-208页

作者：陈晨旭邱毅刘迟郑旭浙江大学能源工程学院杭州310027

研究了人体仰卧姿态下,振动的幅值大小和输入方向对人体头部和胸部振动传递率的影响。分别采用频率范围为0.5~20 Hz,振动幅值为0.2~0.8 m/s^(2)r.m.s.的纵向、横向和垂直单轴随机振动激励,测量了12名男性被试者自振源至头部和胸部的振... 详细信息

研究了人体仰卧姿态下,振动的幅值大小和输入方向对人体头部和胸部振动传递率的影响。分别采用频率范围为0.5~20 Hz,振动幅值为0.2~0.8 m/s^(2)r.m.s.的纵向、横向和垂直单轴随机振动激励,测量了12名男性被试者自振源至头部和胸部的振动传递特性。结果表明,人体头部和胸部振动传递率的共振频率在纵向方向上大约为4 Hz,在横向方向上大约为2.4 Hz,而在垂直方向上头部和胸部传递率的共振频率并不相同。在纵向激励下,仰卧人体各部位振动传递率随振幅变化而表现出的非线性特征最为明显。

关键词：仰卧人体全身振动传递率非线性

Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2024年第1期14卷 100-114页

作者： Sze Wan Hung Massimiliano Gaetani Yiran Li Zhouyurong Tan xu zheng Ruizhe Zhang Yang Ding Gene Chi Wai Man Tao Zhang Yi Song Yao Wang Jacqueline Pui Wah Chung Tak Hang Chan Roman A.Zubarev Chi Chiu Wang Department of Obstetrics&Gynaecology The Chinese University of Hong KongHong KongChina Division of Physiological Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Chemical Proteomics Core Facility Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Unit of Chemical Proteomics Science for Life Laboratory(SciLifeLab)StockholmSE 17177Sweden Center for Reproductive Medicine Henan Key Laboratory of Reproduction and GeneticsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450003China Department of Chemistry McGill UniversityMontrealH3A2K6Canada Department of Pharmacological&Technological Chemistry I.M.Sechenov First Moscow State Medical UniversityMoscow119146Russia Reproduction and Development Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChina School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong KongChina

Endometriosis is a common chronic gynecological disease with endometrial cell implantation outside the *** is a major pathophysiology in *** previous studies have demonstrated that the prodrug of epigallocatechin gallate(ProEGCG)exhibits superior anti-endometriotic and anti-angiogenic effects compared to epigallocatechin gallate(EGCG).However,their direct binding targets and underlying mechanisms for the differential effects remain *** this study,we demonstrated that oral ProEGCG can be effective in preventing and treating ***,1D and 2D Proteome Integral Solubility Alteration assay-based chemical proteomics identified metadherin(MTDH)and PX domain containing serine/threonine kinase-like(PXK)as novel binding targets of EGCG and ProEGCG,*** simulation and BioLayer interferometry were used to confirm their binding *** results showed that MTDH-EGCG inhibited protein kinase B(Akt)-mediated angiogenesis,while PXK-ProEGCG inhibited epidermal growth factor(EGF)-mediated angiogenesis via the EGF/hypoxia-inducible factor(HIF-1a)/vascular endothelial growth factor(VEGF)*** vitro and in vivo knockdown assays and microvascular network imaging further confirmed the involvement of these signaling ***,our study demonstrated that ProEGCG has superior therapeutic effects than EGCG by targeting distinct signal transduction pathways and may act as a novel antiangiogenic therapy for endometriosis.

关键词： Molecular targets ProEGCG EGCG Angiogenesis Treatment Endometriosis