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EZH2-dependent myelination following sciatic nerve injury

Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li Mu xi xu Tianyi Huang Ying Wang Siyuan xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

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A high-entropy spinel ceramic oxide as the cathode for proton-conducting solid oxide fuel cells

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Journal of Advanced Ceramics 2022年第5期11卷 794-804页

作者： Yangsen xu xi xu Lei BI School of Resource Environment and Safety Engineering University of South ChinaHengyang 421001China Department of Materials Imperial College London SW72BPUK

A high-entropy ceramic oxide is used as the cathode for the first time for proton-conducting solid oxide fuel cells(H-SOFCs).The Fe_(0.6)Mn_(0.6)Co_(0.6)Ni_(0.6)Cr_(0.6)O_(4)(FMCNC)high-entropy spinel oxide has been successfully prepared,and the in situ chemical stability test demonstrates that the FMCNC material has good stability against CO_(2).The first-principles calculation indicates that the high-entropy structure enhances the properties of the FMCNC material that surpasses their individual components,leading to lower O_(2)adsorption energy for FMCNC than that for the individual *** HSOFC using the FMCNC cathode reaches an encouraging peak power density(PPD)of 1052 mW·cm^(-2)at 700℃,which is higher than those of the H-SOFCs reported *** comparison was made between the high-entropy FMCNC cathode and the traditional Mn_(1.6)Cu_(1.4)O_(4)(MCO)spinel cathode without the high-entropy structure,revealing that the formation of the high-entropy material allows the enhanced protonation ability as well as the movement of the O p-band center closer to the Fermi level,thus improving the cathode catalytic *** a result,the high-entropy FMCNC has a much-decreased polarization resistance of 0.057Ω·cm^(2)at 700℃,which is half of that for the traditional MCO spinel cathode without the high-entropy *** excellent performance of the FMCNC cell indicates that the high-entropy design makes a new life for the spinel oxide as the cathode for HSOFCs,offering a novel and promising route for the development of high-performance materials for H-SOFCs.

关键词： proton-conducting oxides high-entropy oxides cathode solid oxide fuel cells(SOFCs)

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Prospects for the application of transcranial magnetic stimulation in diabetic neuropathy

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Neural Regeneration Research 2021年第5期16卷 955-962页

作者： xi xu Dong-Sheng xu Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghaiChina School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina

Encouraging results have been reported for the use of transcranial magnetic stimulationbased nerve stimulation in studies of the mechanisms of neurological regulation,nerve injury repair,and nerve ***,to date,there are only a few reviews on the use of transcranial magnetic stimulation for diabetic *** with diabetic neuropathy vary in disease progression and show neuropathy in the early stage of the disease with mild symptoms,making it difficult to screen and *** the later stage of the disease,irreversible neurological damage occurs,resulting in treatment *** this review,we summarize the current state of diabetic neuropathy research and the prospects for the application of transcranial magnetic stimulation in diabetic *** review significant studies on the beneficial effects of transcranial magnetic stimulation in diabetic neuropathy treatment,based on the outcomes of its use to treat neurodegeneration,pain,blood flow change,autonomic nervous disorders,vascular endothelial injury,and ***,the studies suggest that transcranial magnetic stimulation can produce excitatory/inhibitory stimulation of the cerebral cortex or local areas,promote the remodeling of the nervous system,and that it has good application prospects for the localization of the injury,neuroprotection,and the promotion of nerve ***,transcranial magnetic stimulation is useful for the screening and early treatment of diabetic *** magnetic stimulation can also alleviate pain symptoms by changing the cortical threshold and inhibiting the conduction of sensory information in the thalamo-spinal pathway,and therefore it has therapeutic potential for the treatment of pain and pain-related depressive symptoms in patients with diabetic ***,based on the effect of transcranial magnetic stimulation on local blood flow and its ability to change heart rate and urine protein conten

关键词： autonomic neuropathy central nervous system depression inflammation oxidative stress pain peripheral nerve plasticity recovery regeneration vascular

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Mass Spectrometric Fragmentation of 1-(Benzyloxycarbonyl)amino-2-alkyl/cycloalkyl Thioacetates:a Thioester Pyrolysis-type Rearrangement under Electron Impact Ionization

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Chinese Chemical Letters 2006年第8期17卷 1069-1072页

作者： Shu xu Jia xi xu Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education College of Chemistry and Molecular Engineering Peking University Beijing 100871

The mass spectrometric fragmentation of 1-（benzyloxycarbonyl）amino-2-alkyl/cycloalkyl thioacetates has been studied with the aid of mass-analysed ion kinetic energy spectrometry under electron impact ionization. All compounds show a tendency to eliminate a ketene, thioacetic acid, and benzyl carbamate molecule, or an acetyl and benzyloxy radicals. A thioester pyrolysis-type rearrangement under electron impact ionizations was observed.

关键词： Electron impact ionization mass spectrometry rearrangement thioacetate.

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Design and construction of three-dimensional graphene/conducting polymer for supercapacitors

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Chinese Chemical Letters 2016年第8期27卷 1437-1444,1471页

作者： Meng Wang Yu-xi xu School of Nuclear Science and Technology University of South China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan University

Three-dimensional graphene/conducting polymer（3DGCP） composites have received significant attention in recent years due to their unique structures and promising applications in energy *** the structural diversity of graphene and π-functional conducting polymers via rich chemical routes,a number of 3DGCP composites with novel structures and attractive performance have been ***,the hierarchical porosity,the interactions between graphene and conducting polymers as well as the their synergetic effects within 3DGCP composites can be well combined and elaborated by various synthetic methods,which made 3DGCP composites show unique electrochemical properties and significantly improved performance in energy storage fields compared to other graphenebased *** this short review,we present recent advances in 3DGCP composites in developing effective strategies to prepare 3DGCP composites and exploring them as a unique platform for supercapacitors with unprecedented *** challenges and future opportunities are also discussed for promotion of further study.

关键词： Three-dimensional graphene Conducting polymer Composite Synthetic method Supercapacitor

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What is the relationship between ecosystem services and urbanization? A case study of the mountainous areas in Southwest China

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Journal of Mountain Science 2019年第12期16卷 2867-2881页

作者： PENG Li WANG xu-xi Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China College of Land and Resource China West Normal UniversityNanchong 637009China Institute of Jialing River Basin China West Normal UniversityNanchong 637009China

China is undergoing a rapid urbanization process,and urbanization will have a direct impact on regional ecosystems and affect regional ecosystem *** the mountainous counties in Southwestern China as the research object,this study reveals the spatial clustering characteristics of four typical ecosystem services(food production,soil conservation,water yield and carbon sequestration)as well as the trade-offs and synergies among ecosystem services in different urbanized *** the same time,piecewise linear regression is used to determine the threshold of the influence of urbanization on ecosystem *** results indicate that:1)There are spatial autocorrelations among the four typical ecosystem services;with strong clustering characteristics,the positive correlation types are"clustered"locally;and with significant spatial heterogeneity,the negative correlation types are scattered and mainly appear in the highly urbanized area.2)There are also remarkable differences in the relationship among various ecosystem services in different urbanized areas,and in particular,there are marked trade-offs between food production and carbon sequestration in the moderately urbanized area and the highly urbanized ***,there are synergies between them in the lowly urbanized area.3)With an increase in the compounded night light index(CNLI),water yield,carbon sequestration,food production and overall ecosystem services values present an increasing-decreasing trend,the soil conservation function value shows a decreasing-increasing *** response of water yield,carbon sequestration,food production,and overall ecosystem services to the compounded night light index(CNLI)has a threshold of 1.2642,1.4833,1.3388,1.5146 and 1.2237,*** on the detected relationships between urbanization and ecosystem services,this study provides a theoretical reference for the selection of urbanization development models in key ecological functional areas.

关键词： Ecosystem services Urbanization Spatial clustering pattern Trade-offs/synergies Southwestern China

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Effects of temperature distribution and level on heat transfer on a rotating free disk

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航空动力学报 2011年第6期26卷 1310-1320页

作者： ZHAO xi xu Guo-qiang LUO xiang National Key Laboratory of Science and Technology on Aero-Engine Aero-thermodynamics School of Jet Propulsion Beijing University of Aeronautics and Astronautics Beijing 100191 China

In gas turbine engines,with the existence of the intense forced convection and significant buoyancy effects,temperature distribution and level on turbine or compressor disks affect the heat transfer characteristics *** this paper,numerical simulations were performed to analyze these influences for a free disk,with the laminar and turbulent flow *** influences of temperature distribution on the heat transfer were observed by using incompressible cooling air,and temperature profiles of nth order monomial and polynomial were assumed on the *** analysis revealed that the heat transfer for two flow states on the free disk is determined by the exponent n of the monomial profile when specifying the rotating Reynolds number;for an arbitrary polynomial profile,the local Nusselt number can be deduced from results of monomial *** study the effects of temperature level on heat transfer singly,monomial profiles were used and the local Nusselt number of compressible and incompressible cooling air were *** both for two flow states,the following conclusions could be drawn: the relative difference of local Nusselt number is mainly controlled by nondimensional local temperature difference,and almost independent of the monomial's coefficient C,exponent n and the rotating Reynolds ***,a correction method for heat transfer of the free disk is presented and verified computationally,with which the local Nusselt number,obtained with a uniform and low temperature profile,can be revised by arbitrary distribution and high temperature magnitude.

关键词： thermal boundary condition temperature boundary condition rotating disk free disk heat transfer

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Volume expansion rates of seismic landslides and influencing factors: A case study of the 2008 Wenchuan earthquake

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Journal of Mountain Science 2019年第8期16卷 1731-1742页

作者： MA Si-yuan xu Chong xu xi-wei Key Laboratory of Active Tectonics and Volcano Institute of GeologyChina Earthquake AdministrationBeijing 100029China Institute of Crustal Dynamics China Earthquake AdministrationBeijing 100085China

When a big landside occurs, source material can change into loose deposit during its runout, causing the increase of the total landslide volume to some extent. Such changes can influence the quantification of seismic landslides. The objective of this paper was to study the volume expansion rate of landslides based on the data of 1417 co-seismic landslides triggered by the 2008 Wenchuan, China Mw 7.9 earthquake. We also analyzed the correlations between this rate and landslide geometric parameters(volume, height(H), length-width ratio(L/W), length-height ratio(L/H)), and environmental factors(peak ground acceleration(PGA), lithology, slope angle and aspect). The results show that the total source volume of the 1417 landslides is 1248 million m3, while the total volume of the deposit is 1501 million m3, which means the total volume expanding rate(Et) is 20.3% with the average volume expansion rate(Ea) 22.6%. The analysis indicates that volume expansion rate generally decreases with the increasing volume and height of landslides, while becoming larger with increasing L/H and L/W. Besides, the volume expansion rate is closely related to the landslide type and the volume scale of landslides. This study analyses volume change of co-seismic landslides deeply, permitting to help the correct quantification of the source volume and deposit volume of seismic landslide and a useful reference for the correct quantification of landslide volume.

关键词： Landslide volume Volume expansion rate Wenchuan earthquake Influencing factors

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A Mathematical Approach to the Property of One-dimensional Steady Solution of Reverse Smolder Waves

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Acta Mathematicae Applicatae Sinica 2017年第1期33卷 201-206页

作者： Qiu-shu LI Lan-xi xu Department of Mathematics Beijing University of Chemical Technology Beijing 100029 China

The mathematical property of one-dimensional steady solution for reverse smolder waves in the context of a model that permits both fuel-rich and fuel-lean has been studied using the method of analysis. Based on the equations and the boundary conditions some asymptotic properties of the solution at infinity are proved. It is shown that the value of oxygen or the mass of fuel （corresponding to the fuel-rich case and the fuel-lean case, respectively） tends to zero, and the temperature approaches to a fixed value. This is confirmed by other authors using large activation energy asymptotic methods.

关键词： reverse smolder wave steady solution Fuel-rich Fuel-lean

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1984–2023年苏州高新区景观格局演变及景观生态风险评估

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园林 2025年第1期42卷 93-100页

作者：徐曦钱静印玉琴南京工业大学建筑学院

以苏州高新区为研究对象，通过解译Landsat系列遥感影像建立研究区土地利用数据，分析1984–2023年研究区景观格局演变过程，并构建50 m×50 m的风险小区，利用景观格局指数法对其景观生态风险进行评估。结果表明：近40年间苏州高新区... 详细信息

以苏州高新区为研究对象，通过解译Landsat系列遥感影像建立研究区土地利用数据，分析1984–2023年研究区景观格局演变过程，并构建50 m×50 m的风险小区，利用景观格局指数法对其景观生态风险进行评估。结果表明：近40年间苏州高新区景观格局发生了显著变化，主要表现为耕地向建设用地的转变和建设用地自东南向西北、从伴山到临湖的阶梯扩张，而水网格局和水域面积保持稳定，禁开禁采之后城市山林面积也在稳定恢复提高。在这一过程中，研究区平均景观生态风险值呈现出“提升—下降—回升”的趋势，不同时期景观格局的异质性使得景观生态风险分布差异明显，较大影响区域高值区景观生态风险的因素在这一过程中也发生转变，自发城镇化发展阶段高值区主导因素为景观脆弱度，快速城镇化发展阶段主导因素为景观破碎化，区域优化及高质量发展阶段主导因素为景观优势度。了解苏州高新区生态变化过程，识别提取长期处于高值风险的生态薄弱区，并基于研究结果提出区域发展建议，以期推动苏州高新区可持续发展，并为理解快速城市化进程中生态环境变化提供实证依据。

关键词：苏州高新区土地利用景观格局演变生态风险评估时空变化

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