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Aggregate 2024年第1期5卷 130-147页

作者： Yuwei Liu Shuting xu Qingyang Lyu Yi Huang weiping Wang State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Laboratory of Molecular Engineering and Nanomedicine Dr.Li Dak-Sum Research CentreThe University of Hong KongHong KongChina

Nowadays,cancer has become the leading cause of death worldwide,driving the need for effective therapeutics to improve patient prognosis.Photodynamic therapy(PDT)has been widely applied as an antitumor modality,owing to its minimal invasiveness,localized tumor damage,and high safety profile.However,its efficacy is limited by poor stability of photosensitizers,inadequate tumor accumulation,and a complex tumor microenvironment.To overcome these challenges,extensive endeavors have been made to explore the co-assembly of the widely used photosensitizer chlorin e6(Ce6)with various functional small molecules to enhance pharmacodynamic activity.This review provides a comprehensive overview of current studies on Ce6-based nanoparticles for effective PDT and precise delivery of functional molecules.The self-assembly mechanism will be discussed in detail,with a focus on potential strategies for combinational therapy with PDT.

关键词： cancer treatment carrier-free chlorin e6(Ce6) light nanomedicine photodynamic therapy(PDT) selfassembly

Fibroblast growth factor 21 inhibits ferroptosis following spinal cord injury by regulating heme oxygenase-1

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Neural Regeneration Research 2024年第7期19卷 1568-1574页

作者： Qi Gu weiping Sha Qun Huang Jin Wang Yi Zhu Tianli xu Zhenhua xu Qiancheng Zhu Jianfei Ge Shoujin Tian Xiaolong Lin Department of Orthopaedic Surgery Zhangjiagang Hospital Affiliated to Soochow UniversitySuzhouJiangsu ProvinceChina Orthopedics Laboratory The First People’s Hospital of Zhangjiagang CitySuzhouJiangsu ProvinceChina Department of Anesthesiology Zhangjiagang Hospital Affiliated to Soochow UniversitySuzhouJiangsu ProvinceChina

Interfering with the ferroptosis pathway is a new strategy for the treatment of spinal cord injury.Fibroblast growth factor 21 can inhibit ferro ptosis and promote neurofunctional recovery,while heme oxygenase-1 is a regulator of iron and reactive oxygen species homeostasis.The relationship between heme oxygenase-1and ferroptosis remains controve rsial.In this study,we used a spinal co rd injury rat model to show that the levels of fibroblast growth factor 21 in spinal co rd tissue decreased after spinal cord injury.In addition,there was a significant aggravation of ferroptosis and a rapid increase in heme oxygenase-1 expression after spinal cord injury.Furthe r,heme oxygenase-1 aggravated fe rroptosis after spinal cord injury,while fibroblast growth factor 21 inhibited fe rroptosis by downregulating heme oxygenase-1.Thus,the activation of fibroblast growth factor 21 may provide a potential treatment for spinal co rd injury.These findings could provide a new potential mechanistic explanation for fibroblast growth factor 21 in the treatment of spinal cord injury.

关键词： ferroptosis fibroblast growth factor 21 functional recovery heme oxygenase-1 lipid peroxidation neuron reactive oxygen species spinal cord injury

Multistep continuous flow synthesis of Erlotinib

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Chinese Chemical Letters 2024年第4期35卷 371-375页

作者： Hui Jin Qin Cai Peiwen Liu Yan Chen Derong Wang weiping Zhu Yufang xu xuhong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

Erlotinib is an orally administered, highly effective, specific epidermal growth factor receptor tyrosine kinase inhibitor, used to treat non-small cell lung cancer and pancreatic cancer. The traditional synthetic methods for Erlotinib exhibit long reaction time and safety concern. Herein, we describe a novel five-step route for the synthesis of Erlotinib in flow. These five steps comprise etherification, nitration, reduction,addition and cyclization reactions. All steps were optimized and converted to continuous flow process,which drastically reduces the reaction time and considerably improves the process safety as well as the total yield. Enabled by five continuous flow units, Erlotinib is efficiently afforded with an E-factor of 38,an overall yield of 83%, and a total residence time of 25.1 min. Majority steps in this process have been optimized for quantitative conversion, which offers the possibility of telescoping the entire process.

关键词： Erlotinib Continuous flow synthesis Microchannel flow reactor Process optimization Continuous nitration Continuous hydrogenation

Histone demethylase Kdm5c regulates osteogenesis and bone formation via PI3K/Akt/HIF1α and Wnt/β-catenin signaling pathways

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Genes & Diseases 2024年第1期11卷 64-66页

作者： Ying Li Lingli Ding Yage Zhang Bingyu Zhou Gene Chi Wai Man Min Wang Jinglan Li Yamei Liu weiping Lin Haibin Wang Sien Lin Liangliang xu Key Laboratory of Orthopaedics&Traumatology Lingnan Medical Research CenterThe First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou University of Chinese MedicineGuangzhouGuangdong 510000China Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong SAR 999077China Departments of Diagnostics of Traditional Chinese Medicine Guangzhou University of Chinese MedicineGuangzhouGuangdong 510000China Orthopaedic Research Lab Affiliated Hospital of Guangdong Medical UniversityGuangdong Medical UniversityZhanjiangGuangdong 524001China

Fractures have an extraordinarily negative impact on individuals'quality of life and functional status.Nonunion or disability of fracture is a major health issue with important clinical,social,and economic implications.1 Mesenchymal stem cells(MSCs)play an indispensable role in the initiation of the fracture repair process including the formation of a callus which is replaced by new bone.The use of MSCs in the treatment of fractures is very attractive as they can reduce the time of healing and occurrence of nonunion.

关键词： PI3K/Akt HIF1α healing

Micro/nano flow chemistry by Beyond Limits Manufacturing

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Chinese Chemical Letters 2024年第5期35卷 3-12页

作者： Peiwen Liu Fang Zhao Jing Zhang Yunpeng Bai Jinxing Ye Bo Bao Xinggui Zhou Li Zhang Changlu Zhou Xinhai Yu Peng Zuo Jianye Xia Lian Cen Yangyang Yang Guoyue Shi Lin xu weiping Zhu Yufang xu xuhong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering Shanghai Collaborative Innovation Center for BiomanufacturingEast China University of Science and TechnologyShanghai 200237China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of ChemistrySchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China

In September 2018,we proposed the cutting-edge concept of“Beyond Limits Manufacturing”(BLM).BLM technology is based on the three-dimensional inner engraving or precise outer engraving of ultra-fast laser,to invent micro/nano scale flow chips or devices,which makes it possible for the microform,integration,economy,safety,high efficiency,green and intelligence of research,development and manufacturing process,so as to realize transformational manufacturing in the era of Industry 4.0.In this paper,we reviewed the representative results we made in the field of micro/nano flow chemistry during the implementation of the BLM major project(December 2019 to August 2023),and discussed its application prospects in micro/nano flow chemistry.

关键词： Beyond Limits Manufacturing Flow chemistry Pharmaceutical manufacturing Microreactor

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知识创生理论下企业教师的隐性知识显化机制

高等工程教育研究 2024年第3期 140-145页

作者：徐梅焕石伟平华东师范大学职业教育与成人教育研究所

促进企业教师隐性的职业经验向显性的教学内容转化是解决企业教师教学困境的关键点。研究基于对9位企业教师深度访谈的资料,识别了企业教师知识转化的行为和过程,从技师社会化、教师社会化、表征化、联结化、内隐化五个方面构建了企业... 详细信息

促进企业教师隐性的职业经验向显性的教学内容转化是解决企业教师教学困境的关键点。研究基于对9位企业教师深度访谈的资料,识别了企业教师知识转化的行为和过程,从技师社会化、教师社会化、表征化、联结化、内隐化五个方面构建了企业教师隐性知识显化的螺旋模型。根据研究结果,持续的技师社会化、建立企业教师与其他教师学习共同体、调动企业教师主体意识对促进企业教师隐性知识显化、实现专业成长具有现实意义。

关键词：企业教师职业经验隐性知识显性知识知识创生理论

Integration method of TINs and Grids for multi-resolution surface modeling

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Geo-Spatial Information Science 2013年第1期16卷 61-68页

作者： Xie XIAO xu weiping Zhu QING Zhang YETING Du ZHIQIANG State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan University129 Luoyu RoadWuhan 430079China b Faculty of Geosciences and Environmental Engineering of Southwest Jiaotong University Chengdu 610031China

Highly detailed surface models and their real-time applications are increasingly popular in architecture,construction and other design and engineering fields.However,new and related problems have emerged concerning the efficient management of the resulting large datasets and the seamless integration of heterogeneous data.Moreover,the increasingly common requirements of local high-fidelity modeling combined with large-scale landscapes lead to difficulty in the seamless multi-resolution representation of hybrid triangulated irregular networks(TINs)and Grids.This paper presents a hybrid data structure with high-efficiency and a related organizational method for the seamless integration of multi-resolution models.This approach is characterized by(1)a self-adaptive algorithm for feature-preserving surface partitioning,(2)an efficient hybrid index structure for combined Grid and TIN surfaces,and(3)a view-dependent scheduling strategy with access to Grids of necessary resolution,giving priority to the dynamic loading of TINs.Experiments using typical real design datasets of highway constructions are able to achieve accuracy-preserved and real-time availability of results that prove the validity and efficiency of this approach.

关键词： surface modeling TIN Grid LoDs high fidelity

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基于悬臂梁模型的管道矫直理论及有限元分析

海洋工程 2024年第3期42卷 145-155页

作者：许卫平徐爱进王创祎徐佳璐袁林交通运输部上海打捞局上海200090 天津大学水利工程智能建设与运维全国重点实验室天津300350

海底管道的卷管铺设过程涉及多次正向和反向弯曲,并会产生较大的塑性变形。在铺设入水前,管道必须进行矫直处理,因此如何准确预测矫直过程中管道的力学响应以及如何对矫直器进行合理的设置具有重要意义。针对中国首艘卷管式铺管船“深... 详细信息

海底管道的卷管铺设过程涉及多次正向和反向弯曲,并会产生较大的塑性变形。在铺设入水前,管道必须进行矫直处理,因此如何准确预测矫直过程中管道的力学响应以及如何对矫直器进行合理的设置具有重要意义。针对中国首艘卷管式铺管船“深达号”的矫直装置设计与典型工况,建立了一种基于悬臂梁的力学理论模型。该模型综合考虑了铺设过程中退卷和矫直的加载历程、管道材料的弹塑性特性以及校准器和上、下矫直器的相对位置关系。模型能实现对反弯半径及矫直器姿态等关键参数的计算。建立有限元分析模型,对理论模型进行验证并对管道矫直过程进行数值分析。结果表明理论模型可以准确预测管道矫直所需反弯半径、矫直器侧向行程以及倾角等参数。在管道矫直过程中,上矫直器处的作用载荷远大于下矫直器处。所提出的矫直理论模型可适用于不同尺寸管道的矫直分析,矫直后残余曲率满足DNV规范要求,预期可为“深达号”的实际矫直工艺设计提供指导。

关键词：卷管铺设管道矫直塑性变形悬臂梁海底管道有限元仿真

康莱特注射液联合化疗对晚期非小细胞肺癌患者生活质量及骨髓抑制的影响

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中国基层医药 2024年第3期31卷 361-365页

作者：应卫平钟国美王胜杨旭浙江金华广福肿瘤医院呼吸内科金华321000

目的观察康莱特注射液联合化疗对晚期非小细胞肺癌患者生存质量及骨髓抑制的影响。方法回顾性分析浙江金华广福肿瘤医院2018年8月至2022年2月收治的非小细胞肺癌患者60例的临床资料,按照治疗方法不同分为试验组和对照组各30例。两组分... 详细信息

目的观察康莱特注射液联合化疗对晚期非小细胞肺癌患者生存质量及骨髓抑制的影响。方法回顾性分析浙江金华广福肿瘤医院2018年8月至2022年2月收治的非小细胞肺癌患者60例的临床资料,按照治疗方法不同分为试验组和对照组各30例。两组分别采用康莱特注射液联合吉西他滨及顺铂化疗方案、吉西他滨及顺铂化疗方案。采取功能状态评分表(KPS)评分评价患者生存质量,比较两组治疗前后KPS评分变化情况、骨髓抑制等不良反应发生率、临床治疗效果等。结果治疗后,试验组疾病控制率[86.67%(26/30)]、客观缓解率[60.00%(18/30)]均显著高于对照组的60.00%(18/30)、30.00%(9/30)(χ^(2)=4.18、4.31,均P<0.05)。治疗前两组患者KPS评分分别为(70.68±3.75)分和(70.29±5.11)分(t=0.34,P=0.790),治疗后试验组患者KPS评分[(67.02±5.87)分]高于对照组的(62.37±3.59)分(t=-5.29,P<0.05)。试验组不良反应发生率[40.00%(12/30)]高于对照组的36.67%(11/30),差异无统计学意义(χ^(2)=0.07,P=0.790);试验组骨髓抑制发生率[56.67%(17/30)]显著低于对照组的86.67%(26/30)(χ^(2)=6.90,P=0.030)。结论康莱特注射液联合化疗相比于单纯化疗,能够缓解晚期非小细胞肺癌患者的症状,改善患者预后。

关键词：癌,非小细胞肺抗肿瘤联合化疗方案生活质量药物相关性副作用和不良反应预后康莱特注射液

核心素养下初中科学教学中的项目式学习应用探究

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成才之路 2024年第9期 125-128页

作者：徐卫平浙江省杭州市余杭区良渚第一中学浙江杭州311113

项目式学习作为一种指向问题解决能力的学习方式,利用真实情境培育学生学科核心素养,让学生通过学习任务层层递进,形成认知模型,提升学科理解能力,实现“知识、能力、素养”协调发展。文章基于文献的梳理和教学经验的总结,从项目准备、... 详细信息

项目式学习作为一种指向问题解决能力的学习方式,利用真实情境培育学生学科核心素养,让学生通过学习任务层层递进,形成认知模型,提升学科理解能力,实现“知识、能力、素养”协调发展。文章基于文献的梳理和教学经验的总结,从项目准备、项目优化及项目实施三个维度对核心素养下的初中科学项目式学习应用进行探究,以更好地发挥项目式学习作用,提高学生合作能力,增强学生提出问题和解决问题能力,帮助学生通过科学探究建立严谨的科学知识体系,实现全面发展。

关键词：初中科学核心素养项目式学习教学情境任务驱动