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附着点炎在脊柱关节炎患者中的表现及其对生物制剂治疗的反应

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临床内科杂志 2024年第6期41卷 384-389页

作者：申悦罗丽平苗婕妤赵旭马伶俐徐胜前安徽医科大学第一附属医院风湿免疫科合肥230022

目的分析附着点炎在脊柱关节炎(SpA)患者中的发生情况及其对生物制剂治疗的反应。方法收集560例SpA患者[强直性脊柱炎(AS)组446例、放射学阴性中轴型SpA(nr-axSpaA)组79例和外周型SpA(pSpA)组35例]的临床资料;根据有无附着点炎将其分为... 详细信息

目的分析附着点炎在脊柱关节炎(SpA)患者中的发生情况及其对生物制剂治疗的反应。方法收集560例SpA患者[强直性脊柱炎(AS)组446例、放射学阴性中轴型SpA(nr-axSpaA)组79例和外周型SpA(pSpA)组35例]的临床资料;根据有无附着点炎将其分为无附着点炎组(290例)与附着点炎组(270例);将有至少6个月的完整随访资料的194例患者根据治疗方式不同分为非生物制剂组(32例)及生物制剂组(162例),分别对其临床资料进行分组比较。结果最常发生附着点炎的5个部位是第5腰椎棘突、右髂后上嵴、左髂后上嵴、左跟腱和右跟腱。附着点炎组患者临床医师整体评分(PGA)、红细胞沉降率(ESR)、C反应蛋白(CRP)水平、Bath AS活动性评分(BASDAI)、基于CRP计算的AS活动性评分(ASDAScrp)及外周关节炎患者比例均高于无附着点炎组;胸廓扩张度、腰椎活动度、Bath AS功能指数(BASFI)及关节功能Ⅰ~Ⅱ级患者比例均低于无附着点炎组(P0分患者比例均更低;与非生物制剂组同期比较,生物制剂组患者治疗前胸廓扩张度均更低,治疗后CRP、ASDAScrp均更低(P<0.05)。多因素logistic回归分析结果显示,ASDAScrp升高、合并外周关节炎为SpA患者发生附着点炎的危险因素,ESR升高、使用生物制剂为其保护因素(P<0.05)。结论SpA患者合并附着点炎提示疾病活动。ASDAScrp和合并外周关节炎为SpA发生附着点炎的危险因素,而使用生物制剂可以减少附着点炎的发生。

关键词：附着点炎脊柱关节炎生物制剂治疗

类风湿关节炎患者CYP3A4、2C9和2D6基因多态性与艾瑞昔布胃肠道不良反应的相关性研究

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中国医院药学杂志 2024年第8期44卷 890-894页

作者：马学婧杨春兰俞海霞於坤夏梓橦陈亮徐胜前夏泉安徽医科大学第一附属医院药剂科安徽合肥230032 合肥市第一人民医院药学部安徽合肥230001 安徽医科大学药学院安徽合肥230022 安徽医科大学第一附属医院风湿免疫科安徽合肥230022

目的:探讨代谢酶CYP3A4、2C9和2D6基因多态性与类风湿关节炎(rheumatoid arthritis,RA)患者使用艾瑞昔布期间胃肠道不良反应的相关性。方法:前瞻性收集服用艾瑞昔布的RA患者,记录服药期间的胃肠道反应,采用Mass ARRAY芯片系统检测患者CY... 详细信息

目的:探讨代谢酶CYP3A4、2C9和2D6基因多态性与类风湿关节炎(rheumatoid arthritis,RA)患者使用艾瑞昔布期间胃肠道不良反应的相关性。方法:前瞻性收集服用艾瑞昔布的RA患者,记录服药期间的胃肠道反应,采用Mass ARRAY芯片系统检测患者CYP3A4(rs2242480、rs2246709、rs3735451、rs4646437、rs4646440),CYP2C9(rs1934967、rs2253635、rs2475376、rs4918766、rs9325473、rs9332098),CYP2D6(rs1080983)位点的基因型,SPSS 26.0软件统计分析CYP450不同基因型与艾瑞昔布治疗后胃肠道不良反应的相关性。结果:纳入安徽医科大学第一附属医院风湿免疫科2020年2月—2021年2月收治的服用艾瑞昔布的88例RA患者,发生胃肠道反应15例,基因型分布符合Hardy-Weinberg平衡检测。CYP3A4rs4646437 GG型、rs4646440 GG型、rs2242480 CC型、rs3735451 TT型;CYP2C9rs4918766GG、rs2253635CC型胃肠道反应发生率更高。结论:CYP3A4、CYP2C9部分基因型与RA患者服用艾瑞昔布的胃肠道不良反应发生具有一定的相关性。

关键词：艾瑞昔布基因多态性胃肠道不良反应相关性

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阿达木单抗注射液联合风湿骨痛胶囊治疗肾虚督寒型强直性脊柱炎患者的效果观察

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中国医药 2024年第7期19卷 1066-1070页

作者：申悦纵何香王健雄储依然赵旭马伶俐徐胜前安徽医科大学第一附属医院风湿免疫科合肥230022

目的观察阿达木单抗注射液联合风湿骨痛胶囊治疗肾虚督寒型强直性脊柱炎(AS)患者的临床效果。方法选取2021年5月至2023年4月于安徽医科大学第一附属医院风湿免疫科确诊的AS患者77例。所有患者随机分为对照组(39例)和观察组(38例)。对照... 详细信息

目的观察阿达木单抗注射液联合风湿骨痛胶囊治疗肾虚督寒型强直性脊柱炎(AS)患者的临床效果。方法选取2021年5月至2023年4月于安徽医科大学第一附属医院风湿免疫科确诊的AS患者77例。所有患者随机分为对照组(39例)和观察组(38例)。对照组给予阿达木单抗联合艾瑞昔布治疗,观察组给予阿达木单抗联合风湿骨痛胶囊治疗。比较2组患者的治疗前资料,治疗前后实验室检查结果、疾病活动指标、临床达标率以及安全性指标。结果2组患者治疗前各指标比较差异均无统计学意义(均P>0.05)。治疗6个月后,对照组临床医师整体评估(PGA)评分、BathAS疾病活动性指数(BASDAI)、AS疾病活动性积分(ASDAScrp)、红细胞沉降率(ESR)和C反应蛋白(CRP)均低于治疗前;观察组BASDAI、ESR和CRP均低于治疗前,临床达标率高于治疗前,差异均有统计学意义(均P<0.05)。治疗12个月后,对照组指地距、PGA评分、BASDAI、ASDAScrp、ESR和CRP均低于治疗前,胸廓扩张度和临床达标率均高于治疗前;观察组指地距、PGA评分、BASDAI、ASDAScrp、ESR和CRP均低于治疗前,腰椎活动度和临床达标率均高于治疗前,差异均有统计学意义(均P<0.05)。治疗12个月后,观察组胃肠道不适发生率低于对照组[0(0/22)比16.7%(4/24)],差异有统计学意义(χ^(2)=4.016,P=0.045)。结论肾虚督寒型AS患者采用阿达木单抗注射液联合风湿骨痛胶囊治疗,与阿达木单抗注射液联合艾瑞昔布治疗效果相当,可为AS的治疗提供新的选择。

关键词：强直性脊柱炎阿达木单抗风湿骨痛胶囊临床疗效

肌骨超声在类风湿关节炎和痛风性关节炎患者有症状关节病变诊断中的作用比较

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安徽医科大学学报 2024年第5期59卷 880-884页

作者：王佩瑶徐胜前何丹青岑阳秦杨阳李军邵丽萍黄猛安徽医科大学第一附属医院超声科合肥230022 安徽医科大学第一附属医院风湿免疫科合肥230022 安徽医科大学第一附属医院东城院区(肥东县人民医院)超声科合肥231600

目的应用肌骨超声(MSUS)比较类风湿关节炎(RA)和痛风性关节炎(GA)有症状关节病变的超声征象。方法回顾性分析85例RA住院患者和同期55例GA住院患者,比较两组一般资料、病变关节情况及超声征象的差异。结果两组性别、年龄段、病变关节情... 详细信息

目的应用肌骨超声(MSUS)比较类风湿关节炎(RA)和痛风性关节炎(GA)有症状关节病变的超声征象。方法回顾性分析85例RA住院患者和同期55例GA住院患者,比较两组一般资料、病变关节情况及超声征象的差异。结果两组性别、年龄段、病变关节情况比较差异均有统计学意义(均P<0.05);膝关节病变检出率均最高;RA组滑膜炎灵敏度高、半月板损伤特异度高、骨侵蚀诊断效能高,GA组点状强回声、双轨征、痛风石3项联合超声征象诊断效能高于任一项单独诊断且灵敏度和特异度也较高;RA组病程与骨侵蚀呈正相关(P<0.05),GA组病程与痛风石呈正相关(P<0.05)。结论RA与GA的超声征象具有一定差异,MSUS在二者诊断及鉴别诊断上具有较好价值。

关键词：肌骨超声类风湿关节炎痛风性关节炎关节病变诊断

肌少症与女性类风湿性关节炎病人病情及继发骨质疏松的相关性研究

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蚌埠医学院学报 2024年第1期49卷 72-76,80页

作者：张梅徐胜前纵何香王健雄储依然张璟蔡静玉常玲安徽医科大学第一附属医院安徽省公共卫生临床中心肾内风湿科安徽合肥230000 安徽医科大学第一附属医院风湿免疫科安徽合肥230000

目的:探讨肌少症对女性类风湿关节炎(RA)病人病情以及继发骨质疏松(OP)的影响。方法:选取239例RA病人,其中女187例,男52例。通过生物电阻抗分析法测定病人四肢以及躯干的骨骼肌质量,计算骨骼肌质量指数(SMI)。采用GE Lunar Prodigy双能... 详细信息

目的:探讨肌少症对女性类风湿关节炎(RA)病人病情以及继发骨质疏松(OP)的影响。方法:选取239例RA病人,其中女187例,男52例。通过生物电阻抗分析法测定病人四肢以及躯干的骨骼肌质量,计算骨骼肌质量指数(SMI)。采用GE Lunar Prodigy双能X线骨密度仪,测量病人不同部位的骨密度(BMD)。对187例女性RA病人进行疾病相关指标如双手X线、Sharp评分检测,并根据是否存在肌少症,将女性RA病人分为肌少症组和无肌少症组,比较2组OP发生率、疾病活动性以及关节功能相关指标,分析女性RA病人发生OP的影响因素。结果:女性RA病人总OP发生率明显高于男性RA病人(P<0.01)。与无肌少症的女性RA病人相比,合并肌少症的女性RA病人病程更长,体质量指数更低,关节结构损害更严重(P<0.05~P<0.01)。女性RA病人SMI与病程、年龄、健康评估问卷(HAQ)评分、X线分期、Sharp评分均呈负相关关系(r=-0.155、-0.196、-2.040、-0.244、-0.365,P<0.05~P<0.01),与股骨颈-BMD、L_(1)-BMD、L_(2)-BMD、L_(3)-BMD、L_(4)-BMD、L_(1~4)-BMD均呈明显正相关关系(r=0.422、0.410、0.380、0.423、0.434、0.437,P<0.01)。多元回归分析结果显示,SMI值是女性RA病人发生OP的保护因素(P<0.01),年龄是女性RA病人发生OP的危险因素(P<0.01);病程、HAQ评分是女性RA病人DAS28的影响因素(P<0.05和P<0.01)。结论:女性RA病人更容易合并OP,肌少症是OP的危险因素,且与女性RA病人的关节结构损伤密切相关。

关键词：类风湿关节炎骨质疏松肌少症

Covalent triazine frameworks modified by ultrafine Pt nanoparticles for efficient photocatalytic hydrogen production

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Nano Research 2024年第6期17卷 4908-4915页

作者： xu Han xueying Ge Wen-Wen He Wangwang Shen Tao Zhou Jian-Sen Wang Rong-Lin Zhong Abdullah MAl-Enizi Ayman Nafady shengqian Ma School of Chemistry and Life Science Advanced Institute of Materials ScienceChangchun University of TechnologyChangchun 130012China Laboratory of Theoretical and Computational Chemistry Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun 130021China Department of Chemistry University of North Texas1508 W.Mulberry St.DentonTX 76201USA Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia

Pt nanoparticles(PtNPs)as active species have always been considered as one of the best semiconductor materials for photocatalytic hydrogen *** this study,a Schottky heterojunction has been successfully constructed by evenly loading ultrafine PtNPs onto a triazine-based covalent organic frameworks(COFs).This strategy maintained the high activity of these ultra-small PtNPs while maximizing the utilization of the Pt active *** fabricated PtNPs@covalent triazine-based framework-1(CTF-1)composite accomplished a significantly high rate of hydrogen evolution(20.0 mmol·g^(−1)·h^(−1),apparent quantum efficiency(AQE)=7.6%,atλ=450 nm)with 0.40 wt.%Pt loading,giving rise to a 44-fold-increase in the efficiency of the photocatalytic hydrogen production compared to the pristine *** calculations revealed that the strong electron transfer(Q(Pt)=−0.726 qe,in the analysis of Bader charge,Q(Pt)is the charge quantity transferred from Pt cluster to CTF-1,and qe is the unit of charge transfer quantity)between PtNPs and CTF-1 triggers a strong interaction,which makes PtNPs being firmly attached to the structure of CTF-1,thereby enabling high stability and excellent hydrogen production ***,the hydrogen binding free energy(ΔGH*)of PtNPs@CTF-1 is much lower than that of the unmodified CTF-1,leading to a much lower intermediate state and hence a significant improvement in photocatalytic *** overall findings of this work provide a new platform to incorporate metallic NPs into COFs for the design and fabrication of highly efficient photocatalysts.

关键词： Pt nanoparticles covalent triazine-based framework-1(CTF-1) photocatalysts hydrogen evolution reaction

Efficacy and safety of Xinfeng capsule in patients with rheumatoid arthritis:a multi-center parallel-group double-blind randomized controlled trial

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Journal of Traditional Chinese Medicine 2015年第5期35卷 487-498页

作者： Liu Jian Wang Yuan Huang Chuanbing xu Jianhua Li Zhijun xu Liang He Liyun Sun Yue Wang Yali xu shengqian Zhao Ping Mao Tongjun Tan Bin Zhu Fubing Zhang Pingheng Fang Li Department of Rheumatism Immunity The First Affiliated HospitalAnhui University of Chinese Medicine Department of Rheumatism Immunity The First Affiliated Hospital of Anhui Medical University Department of Rheumatism Immunity The First Affiliated Hospital of Bengbu Medical College Department of Rheumatism Immunity The First Affiliated Hospital of Wannan Medical College The Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences

OBJECTIVE:To evaluate the efficacy and safety of Xinfeng capsule in patients suffering rheumatoid arthritis(RA).METHODS:A multi-center parallel-group designed,double-blind,randomized,controlled trial was *** 304 RA patients were assigned to two groups:one group was administered Xinfeng capsule(XFC) plus the placebo of leflunomide and the other given leflunomide(LEF) plus the placebo of XFC for twelve *** clinical and laboratory parameters were compared at baseline and fourth,eighth,and twelfth ***:After twelve-week treatment,patients in two groups all showed some trend of effectiveness when compared in terms of American Rheumatism Association(ACR) recommended 20%,50%,70%improvement criteria,but it was *** validity in ameliorate modified disease activity score(DAS28) and laboratory indexes as erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor(RF) were also found no *** score of health assessment questionnaire(HAQ),self-rating anxiety scale(SAS),self-rating depression scale(SDS) and quality of life questionnaire with rheumatoid arthritis(RAQOL)both lower than the first week and the changes showed no ***,the score of SDS dropped more in XFC group than in the other.A total of 147 adverse reaction cases were reported,which shows no difference between the two *** most common adverse reactions were hepatic impairment,anemia,leukocytopenia,epigastric discomfort and ***:XFC demonstrated better improvement in the scores of SDS and compared with those of LEF group.

关键词：类风湿关节炎对照试验多中心患者随机胶囊新风平行

Riverine sulfate sources and behaviors in arid environment,Northwest China:Constraints from sulfur and oxygen isotopes

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Journal of Environmental Sciences 2024年第3期137卷 716-731页

作者： Yifu xu Wenjing Liu Bing xu Zhifang xu Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

The fate of riverine sulfate ion (SO_(4)^(2-)) and its environmental effects in arid environment are difficult to evaluate due to its complicated sources and strongly coupled behaviors with water cycle which is significantly modified by *** understand the sulfur cycle in aquatic systems in arid environment,the chemical and sulfur and oxygen isotopic compositions (δ^(34)S_(SO4)and δ^(18)O_(SO4)) of major rivers around the Badain Jaran Desert,northwestern China,were *** rivers had averaged SO_(4)^(2-)content at 1336μmol/L,over 10times higher than the global *** δ^(34)S_(SO4)and δ^(18)O_(SO4)values ranged from-5.3‰to+11.8‰and+1.6‰to+12.8‰,*** end-member analysis and the inverse model showed that riverine sulfate was mainly derived from evaporites dissolution (0-87%),sulfide oxidation (13%-100%) and precipitation (0-33%),indicating heterogeneity in sulfur sources and behaviors along the river drainage with the lithology variations and climate *** isotopic tools combining with hydro-chemistry compositions could be applied to reveal sulfur cycle in arid *** on the calculation,sulfide oxidation plays the primary role in the headwater and upstream in the Qilian-Mountains area,where sulfide is widely *** the proportion of evaporites dissolution contributing to riverine sulfate is much higher in downstream in a drier ***,less precipitation and higher temperature can lead to more intensive evaporation,affecting the process of sulfide oxidation and enhancing the rates of evaporites dissolution and sulfate precipitation in the basin.

关键词： Sulfur and oxygen isotopes Source apportionment Inverse model Arid environment Inland rivers Northwestern China

Laboratory evaluation of high-friction thin overlays for pavement preservation

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Frontiers of Structural and Civil Engineering 2024年第6期18卷 936-948页

作者： Ouming xu Rentao xu Lintong JIN School of Highway Chang’an UniversityXi’an 710064China School of Materials Science and Engineering Chang’an UniversityXi’an 710061China

Traditional asphalt concrete(AC)and stone matrix asphalt(SMA),which are used as thin asphalt overlays,are common maintenance strategies to enhancing ride quality,skid resistance,and ***,several studies have used a novel asphalt mixture known as a high-friction thin overlay(HFTO)to improve surface ***,it remains uncertain whether the laboratory properties of HFTO differ significantly from those of conventional *** study aims to evaluate the laboratory properties of HFTO mixtures and compare them with those of AC and *** mixtures with nominal maximum size of 9.5 mm were produced in the laboratory,and performance tests were conducted,including wheel tracking test,low temperature flexural creep test,moisture susceptibility test,Cantabro Abrasion Test,Marshall Test,sand patch test,British pendulum test,and indoor tire-rollingdown *** results showed that the HFTO exhibited a lower tire/pavement noise than the AC and ***,HFTO had superior high-temperature stability,larger macro texture,and higher skid resistance in comparison to those of AC,but lower than those of ***,HFTO mixtures may be considered a suitable replacement for traditional AC mixtures in regions where skid resistance and noise reduction are concerns.

关键词： road engineering pavement maintenance high friction thin overlay performance skid resistance tire/pavement noise