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Chinese Science Bulletin 2011年第9期56卷 906-911页

作者： SHAO PengRui DENG shaozhi CHEN Jun xu NingSheng State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Materials and TechnologySchool of Physics and Engineering Sun Yat-sen University Guangzhou 510275 China

真空 microelectronic 来源的数组用含铜的氧化物(CuO ) 在玻璃底层上被制作 nanowire emitters。电子来源的数组拥有 microdiode 结构，它能有效地导致域排放并且在三极管类型设备操作控制射出的电子的交货到阳极。为没有使用催化剂并... 详细信息

真空 microelectronic 来源的数组用含铜的氧化物(CuO ) 在玻璃底层上被制作 nanowire emitters。电子来源的数组拥有 microdiode 结构，它能有效地导致域排放并且在三极管类型设备操作控制射出的电子的交货到阳极。为没有使用催化剂并且在象 400 潩?敦摥慢正瀠牡浡瑥牥甠楳杮琠敨猠瑡汥楬整猭湥敳?潎浲污穩摥?晩敦敲据?敖敧慴楴湯?摮硥?一样低的温度，精确在一个数组在 microcavities 的中心种 CuO nanowires 的一种技术???湡?扯敳癲摥琠浥数慲畴敲?潦?桴?数楲摯ㄠ?有????污?敳獡湯?瘠来瑥瑡潩?硥牥獴愠洠'?瑳潲杮牥映牯楣杮漠??慭?桴湡漠??業?愠摮琠畨?慨???獢慴瑮慩?晥敦瑣漠?桴?楤牵慮?整灭牥瑡牵?慲杮??剔?癯牥?楨慮?楓湧晩捩湡?潰楳楴敶映敥'N捡獫漠??慭?湡?桴?呄?耶喌嚊?牡慥?景?楨慮眠瑩?桴?

关键词：真空微电子器件场发射性能纳米线氧化铜催化剂阵列排放玻璃

Enhanced Performance of a Monolayer MoS_2/WSe_2 Heterojunction as a Photoelectrochemical Cathode

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Nano-Micro Letters 2018年第4期10卷 52-60页

作者： Jingwei Xiao Yu Zhang Huanjun Chen Ningsheng xu shaozhi Deng State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information Technology Sun Yat-sen University

Transition-metal dichalcogenide(TMD) semiconductors have attracted interest as photoelectrochemical(PEC) electrodes due to their novel band-gap structures,optoelectronic properties, and photocatalytic ***, the photo-harvesting efficiency still requires improvement. In this study, A TMD stacked heterojunction structure was adopted to further enhance the performance of the PEC cathode. A P-type WSe_2 and an N-type Mo S_2 monolayer were stacked layer-by-layer to build a ultrathin vertical heterojunction using a micro-fabrication *** situ measurement was employed to characterize the intrinsic PEC performance on a single-sheet *** from its built-in electric field and type II band alignment, the MoS_2/WSe_2 bilayer heterojunction exhibited exceptional photocatalytic activity and a high incident photo-to-current conversion efficiency(IPCE). Comparing with the monolayer WSe_2 cathode, the PEC current and the IPCE of the bilayer heterojunction increased by a factor of 5.6 and enhanced 50%, respectively. The intriguing performance renders the MoS_2/WSe_2 heterojunction attractive for application in high-performance PEC water splitting.

关键词： MoS2/WSe2 Monolayer Bilayer Heterojunction Photoelectrochemical cathode

Optimization study on the rehydration process of lyophilized human platelets

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Chinese Science Bulletin 2011年第4期56卷 455-460页

作者： FAN JuLi xu XianGuo ZHANG shaozhi xu MengJie ZHU FaMing CHEN GuangMing Department of Man-machine and Environment Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China Institute of Refrigeration and Cryogenics Zhejiang University Hangzhou 310027 China Blood Center of Zhejiang Province Hangzhou 310006 China Key Laboratory of Blood Safety Research Ministry of Health Hangzhou 310006 China

Long-term preservation of human platelets will greatly reduce the risk of their shortage. Lyophilization has been proved feasible for this purpose. For the recovery of lyophilized platelets,rehydration is an important process. In this paper,the rehydration proc-esses for 1 mL and 2 mL samples were studied. The effects of prehydration duration(15,30,60,90,120 and 150 min) in 37°C water vapor and the concentration of rehydration solution(25%,50%,75%,100% platelet-poor plasma) on the recovery rate,MPV(mean platelet volume) and PDW(platelet distribution width) were investigated. The mass changes during the prehydration process were weighed. The optimized rehydration conditions are as follows:(1) for 1 mL sample,the prehydration duration was 15 min and for 2 mL sample the prehydration duration was 90 min;(2) the rehydration solution was 75% platelet-poor plasma. Under optimized conditions,the morphology of the rehydrated platelets kept normal and their ultrastructures kept intact,their aggregation capacity to thrombin(1 U/mL) was 82.8% of the fresh ones. These results will be helpful for designing the freeze-drying protocols for human platelets.

关键词：复水过程冷冻干燥优化条件血小板补液盐长期保存分布宽度质量变化

Room-temperature strong coupling between dipolar plasmon resonance in single gold nanorod and two-dimensional excitons in monolayer WSe_2

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Chinese Physics B 2018年第9期27卷 144-150页

作者： Jinxiu Wen Hao Wang Huanjun Chen shaozhi Deng Ningsheng xu State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and TechnologySun Yat-sen UniversityGuangzhou 510275China School of Electronics and Information Technology Sun Yat-sen UniversityGuangzhou 510006China School of Physics Sun Yat-sen UniversityGuangzhou 510275China School of Applied Physics and Materials Wuyi UniversityJiangmen 529020China

All-solid-state strong coupling systems with large vacuum Rabi splitting energy have great potential applications in future quantum information technologies, such as quantum manipulations, quantum information storage and processing,and ultrafast optical switches. Monolayer transition metal dichalcogenides（TMDs） have recently been explored as excellent candidates for the observation of solid-state strong coupling phenomena. In this work, from both experimental and theoretical aspects, we explored the strong coupling effect by integrating an individual plasmonic gold nanorod into the monolayer tungsten diselenide（WSe2）. Evident anti-crossing behavior was observed from the coupled energy diagram at room temperature; a Rabi splitting energy of 98 meV was extracted.

关键词： Au nanorod-WSe2 heterostructures strong coupling all-solid-state system room temperature

Numerical simulation and experimental research on heat transfer and flow resistance characteristics of asymmetric plate heat exchangers

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Frontiers in Energy 2020年第2期14卷 267-282页

作者： shaozhi ZHANG Xiao NIU Yang LI Guangming CHEN Xiangguo xu Key Laboratory of Refrigeration and Cryogenic Technology of Zhejiang Province Institute of Refrigeration and CryogenicsZhejiang UniversityHangzhou 310027China

The asymmetric plate heat exchanger(APHE)has the possibility of achieving balanced pressure drops on both hot and cold sides for situations with unbalanced flow,which may in turn enhance the heat *** this paper,the single-phase water flow and heat transfer of an APHE consisted of two types of plates are numerically(400≤Re≤12000)and experimentally(400≤Re≤3400)*** numerical model is verified by the experimental *** are conducted to study the effects of,an asymmetric index proposed to describe the geometry of *** correlations of the Nusselt number and friction factor in the APHEs are determined by taking and working fluids into *** is found that an optimal exists where the pressure drops are balanced and the heat transfer area reaches the *** comparison between heat transfer and flow characteristics of the APHEs and the conventional plate heat exchanger(CPHE)is made under various flow rate ratios of the hot side and the cold side and different allowable pressure *** situations under which APHE may perform better are identified based on a comprehensive index.

关键词： plate heat exchanger asymmetric simulation correlation heat transfer enhancement

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东非鲁武马盆地气藏分布规律及主控因素

世界石油工业 2024年第2期31卷 23-32页

作者：孙辉王红平丁梁波左国平许小勇鲁银涛刘少治庞旭吴佳男中国石油集团杭州地质研究所有限公司浙江杭州310023

深水是全球油气来源的重要组成部分,快速寻找深水油气富集区可以大幅促进油气勘探开发进程。通过分析和解剖东非鲁武马盆地已发现气藏的分布特征,总结气藏类型及分布规律,进一步探讨气藏分布的主控因素。研究认为,鲁武马盆地古新世—渐... 详细信息

深水是全球油气来源的重要组成部分,快速寻找深水油气富集区可以大幅促进油气勘探开发进程。通过分析和解剖东非鲁武马盆地已发现气藏的分布特征,总结气藏类型及分布规律,进一步探讨气藏分布的主控因素。研究认为,鲁武马盆地古新世—渐新世主力含气层系的沉积类型与气藏类型具有一定的相关性,发育构造–断层气藏、岩性–构造气藏以及岩性气藏这3种主要气藏类型。气藏平面局部聚集、垂向多层叠置,表现出前渊缓坡汇聚、中–中高孔隙度浊积砂富集、高位体系域封盖的特征。控制盆地油气的富集有5个主要因素:①独特的三角洲改造型盆地的两期裂谷烃源岩为盆地提供了充足的油气来源;②充足的物源、窄陡的陆架边缘地貌以及底流作用,促成了厚层、粗粒、洁净的深水沉积储层的发育;③多期海侵形成的区域盖层及重力流沉积的细粒组成,构成了多个独立气藏的有效盖层;④东非沿海盆地陆上抬升作用间接促进大气田圈闭的形成;⑤断层的性质、活动期次等对天然气的输导发挥了重要作用。

关键词：深水沉积气藏类型气藏分布规律控制因素东非鲁武马盆地非洲

KRAS mutation-induced EndMT of brain arteriovenous malformation is mediated through the TGF-β/BMP-SMAD4 pathway

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Stroke & Vascular Neurology 2023年第3期8卷 197-206,I0006-I0027页

作者： Hongyuan xu Ran Huo Hao Li Yuming Jiao Jiancong Weng Jie Wang Zihan Yan Junze Zhang shaozhi Zhao Qiheng He Yingfan Sun Shuo Wang Yong Cao Department of Neurosurgery Beijing Tiantan HospitalCapital medical universityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Beijing Neurosurgical Institute Capital Medical UniversityBeijingChina

Objective Somatic KRAS mutations have been identified in the majority of brain arteriovenous malformations(bAVMs),and subsequent in vivo experiments have confirmed that KRAS mutation in endothelial cells(ECs)causes AVMs in mouse and zebrafish *** previous study demonstrated that the KRASG12D mutant independently induced the endothelial-mesenchymal transition(EndMT),which was reversed by treatment with the lipid-lowering drug ***,the underlying mechanisms of action were *** We used human umbilical vein ECs(HUVECs)overexpressing the KRASG12D mutant for Western blotting,quantitative real-time PCR,and immunofluorescence and wound healing assays to evaluate the EndMT and determine the activation of downstream *** of SMAD4 by RNA interference was performed to explore the role of SMAD4 in regulating the *** ECs expressing the KRASG12D mutant were obtained to verify the SMAD4 ***,we performed a coimmunoprecipitation assay to probe the mechanism by which lovastatin affects *** HUVECs infected with KRASG12D adenovirus underwent the *** growth factor beta(TGF-β)and bone morphogenetic protein(BMP)signalling pathways were activated in the KRASG12D-mutant HUVECs and ECs in bAVM *** down SMAD4 expression in both KRASG12D-mutant HUVECs and ECs in bAVM tissues inhibited the *** attenuated the EndMT by downregulating p-SMAD2/3,p-SMAD1/5 and acetylated SMAD4 expression in KRASG12D-mutant *** Our findings suggest that the KRASG12D mutant induces the EndMT by activating the ERK-TGF-β/BMP-SMAD4 signalling pathway and that lovastatin inhibits the EndMT by suppressing TGF-β/BMP pathway activation and SMAD4 acetylation.

关键词： KRAS SMAD4 inhibited

Somatic GJA4 mutation in intracranial extra-axial cavernous hemangiomas

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Stroke & Vascular Neurology 2023年第6期8卷 453-462,I0003-I0037页

作者： Ran Huo Yingxi Yang Hongyuan xu shaozhi Zhao Dong Song Jiancong Weng Ruochen Ma Yingfan Sun Jie Wang Yuming Jiao Junze Zhang Qiheng He Ruolei Wu Shuo Wang Ji-Zong Zhao Junting Zhang Jiguang Wang Yong Cao Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyHong KongChina Division of Life Science Center for Systems Biology and Human Health and State Key Laboratory of Molecular NeuroscienceThe Hong Kong University of Science and TechnologyHong KongChina Department of Neurosurgery China-Japan Friendship HospitalBeijingChina School of Medical Technology Beijing Institute of TechnologyBeijingChina Hong Kong Center for Neurodegenerative Diseases InnoHKHong Kong SARChina Beijing Neurosurgical Institute Capital Medical UniversityBeijingChina

Objective Extra-axial cavernous hemangiomas(ECHs)are sporadic and rare intracranial occupational lesions that usually occur within the cavernous *** aetiology of ECHs remains *** Whole-exome sequencing was performed on ECH lesions from 12 patients(discovery cohort)and droplet digital polymerase-chain reaction(ddPCR)was used to confirm the identified mutation in 46 additional cases(validation cohort).Laser capture microdissection(LCM)was carried out to capture and characterise subgroups of tissue *** and functional investigations were carried out in human umbilical vein endothelial cells and a newly established mouse *** We detected somatic GJA4 mutation(c.121G>T,p.G41C)in 5/12 patients with ECH in the discovery cohort and confirmed the finding in the validation cohort(16/46).LCM followed by ddPCR revealed that the mutation was enriched in lesional *** vitro experiments in endothelial cells demonstrated that the GJA4 mutation activated SGK-1 signalling that in turn upregulated key genes involved in cell hyperproliferation and the loss of arterial *** with wild-type littermates,mice overexpressing the GJA4 mutation developed ECH-like pathological morphological characteristics(dilated venous lumen and elevated vascular density)in the retinal superficial vascular plexus at the postnatal 3 weeks,which were reversed by an SGK1 inhibitor,*** We identified a somatic GJA4 mutation that presents in over one-third of ECH lesions and proposed that ECHs are vascular malformations due to GJA4-induced activation of the SGK1 signalling pathway in brain endothelial cells.

关键词： intracranial superficial hemangioma

Graphene Decorated with Noble Metal Nanorods and Its Surface-Enhanced Raman Scattering Activity

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Graphene Decorated with Noble Metal Nanorods and Its Surface...

中国真空学会2014学术年会

作者： Lei Zhang Huanjun Chen shaozhi Deng Ningsheng xu State Key Lab of Optoelectronic Materials and Technologies Guangdong Province Key Lab of Display Material and TechnologySchool of Physics and EngineeringSun Yat-sen University

Surface-enhanced Raman scattering(SERS)is an important spectroscopic technique for the struc-tural analysis of low-concentration *** this work,we fabricate a composite substrate that is applied for SERS *** combines single layer graphene(SLG)with gold nanorods synthesized by seeded growth *** the composite substrate,gold nanorods covered by single layer graphene provide substantive hot spots for the SRES detection of molecules to be analyzed and graphene can also improve Raman scattering signal when taking the chemical mechanism into *** experiment results are shown in Figure 1.

关键词： surface-enhanced Raman scattering gold nanorod graphene plasmon

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广东省科技竞争力的动态演变研究

科技管理研究 2010年第21期30卷 28-30,17页

作者：郑少智许洋暨南大学经济学院广东广州510632

通过构建科技竞争力综合评价指标体系,运用熵值法,选择1995年、2000年、2005年和2008年四个时间断面,对广东省科技竞争力的地位及动态演变过程进行了归纳总结,结果发现广东省科技竞争力逐步提高且科技竞争力各要素的发展趋向均衡,并在... 详细信息

通过构建科技竞争力综合评价指标体系,运用熵值法,选择1995年、2000年、2005年和2008年四个时间断面,对广东省科技竞争力的地位及动态演变过程进行了归纳总结,结果发现广东省科技竞争力逐步提高且科技竞争力各要素的发展趋向均衡,并在此基础上提出了相应的政策建议。

关键词：科技竞争力熵值法指标体系动态演变