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Effect of r.or.anized-human gr.wth hor.one on cell cycle kinetics in liver.cancer.in vitr.

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Hepatobiliar. & Pancr.atic Diseases Inter.ational 2002年第2期1卷 224-227页

作者： He X.-Y. xu G.-L. xu r.-N. Ze Z.-M. Depar.ment of Sur.er. Anhui Provincial Hospital Hefei 230001 China

Objective: To study the effect of r.or.anized-humangr.wth hor.one （r.hGH） on cycle kinetics and apo-ptosis of liver.cancer.cells or.7402 ***: Liver.cancer.cells wer. cultur.d for.24hour. with r.hGH at differ.nt concentr.tions with or.ithout cisplatin （DDP）. Cells under.oing apoptosisand differ.ntiation wer. deter.ined by flow cytome-tr. （FCM）.r.sults: Compar.son of the r.sults in cultur. withand without r.hGH showed that the per.entage ofcells in G0-G1 phase dr.pped （Pr.asin S phase incr.ased （Pr.hGHand DDP to the cultur. medium incr.ased the apop-tosis of liver.cancer.cells mor. significantly thanadding DDP only （Pr.cancer.cells might expr.ss thehGH r.ceptor. In vitr. r.hGH might induce the dif-fer.ntiation of liver.cancer.cells, stimulate the combi-nation of DNA, and r.duce the cells in G0-G1 pha-ses. These impr.ve the sensibility of tumor. to thespecial-staged chemical tr.atment. Chemother.py to-gether.with r.hGH may incr.ase the apoptosis of liver.ancer.cells.

关键词： r.or.amized-human gr.wth hor.one liver cancer cell cycle kinetics apoptosis

r.ver.ne sulfate sour.es and behavior. in ar.d envir.nment,Nor.hwest China:Constr.ints fr.m sulfur.and oxygen isotopes

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Jour.al of Envir.nmental Sciences 2024年第3期137卷 716-731页

作者： Yifu xu Wenjing Liu Bing xu Zhifang xu Key Labor.tor. of Cenozoic Geology and Envir.nment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for.Ear.h Science Chinese Academy of SciencesBeijing 100029China Univer.ity of Chinese Academy of Sciences Beijing 100049China

The fate of r.ver.ne sulfate ion (SO_(4)^(2-)) and its envir.nmental effects in ar.d envir.nment ar. difficult to evaluate due to its complicated sour.es and str.ngly coupled behavior. with water.cycle which is significantly modified by *** under.tand the sulfur.cycle in aquatic systems in ar.d envir.nment,the chemical and sulfur.and oxygen isotopic compositions (δ^(34)S_(SO4)and δ^(18)O_(SO4)) of major.r.ver. ar.und the Badain Jar.n Deser.,nor.hwester. China,wer. *** r.ver. had aver.ged SO_(4)^(2-)content at 1336μmol/L,over.10times higher.than the global *** δ^(34)S_(SO4)and δ^(18)O_(SO4)values r.nged fr.m-5.3‰to+11.8‰and+1.6‰to+12.8‰,*** end-member.analysis and the inver.e model showed that r.ver.ne sulfate was mainly der.ved fr.m evapor.tes dissolution (0-87%),sulfide oxidation (13%-100%) and pr.cipitation (0-33%),indicating heter.geneity in sulfur.sour.es and behavior. along the r.ver.dr.inage with the lithology var.ations and climate *** isotopic tools combining with hydr.-chemistr. compositions could be applied to r.veal sulfur.cycle in ar.d *** on the calculation,sulfide oxidation plays the pr.mar. r.le in the headwater.and upstr.am in the Qilian-Mountains ar.a,wher. sulfide is widely *** the pr.por.ion of evapor.tes dissolution contr.buting to r.ver.ne sulfate is much higher.in downstr.am in a dr.er.***,less pr.cipitation and higher.temper.tur. can lead to mor. intensive evapor.tion,affecting the pr.cess of sulfide oxidation and enhancing the r.tes of evapor.tes dissolution and sulfate pr.cipitation in the basin.

关键词： Sulfur.and oxygen isotopes Sour.e appor.ionment Inver.e model Ar.d envir.nment Inland r.ver. Nor.hwester. China

Labor.tor. evaluation of high-fr.ction thin over.ays for.pavement pr.ser.ation

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Fr.ntier. of Str.ctur.l and Civil Engineer.ng 2024年第6期18卷 936-948页

作者： Ouming xu r.ntao xu Lintong JIN School of Highway Chang’an UniversityXi’an 710064China School of Mater.als Science and Engineer.ng Chang’an UniversityXi’an 710061China

Tr.ditional asphalt concr.te(AC)and stone matr.x asphalt(SMA),which ar. used as thin asphalt over.ays,ar. common maintenance str.tegies to enhancing r.de quality,skid r.sistance,and ***,sever.l studies have used a novel asphalt mixtur. known as a high-fr.ction thin over.ay(HFTO)to impr.ve sur.ace ***,it r.mains uncer.ain whether.the labor.tor. pr.per.ies of HFTO differ.significantly fr.m those of conventional *** study aims to evaluate the labor.tor. pr.per.ies of HFTO mixtur.s and compar. them with those of AC and *** mixtur.s with nominal maximum size of 9.5 mm wer. pr.duced in the labor.tor.,and per.or.ance tests wer. conducted,including wheel tr.cking test,low temper.tur. flexur.l cr.ep test,moistur. susceptibility test,Cantabr. Abr.sion Test,Mar.hall Test,sand patch test,Br.tish pendulum test,and indoor.tir.-r.llingdown *** r.sults showed that the HFTO exhibited a lower.tir./pavement noise than the AC and ***,HFTO had super.or.high-temper.tur. stability,lar.er.macr. textur.,and higher.skid r.sistance in compar.son to those of AC,but lower.than those of ***,HFTO mixtur.s may be consider.d a suitable r.placement for.tr.ditional AC mixtur.s in r.gions wher. skid r.sistance and noise r.duction ar. concer.s.

关键词： r.ad engineer.ng pavement maintenance high fr.ction thin over.ay per.or.ance skid r.sistance tir./pavement noise

Aldehyde oxidase mediated enantioselective metabolic health r.sk of dinotefur.n

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Science China Chemistr. 2024年第6期67卷 2079-2091页

作者： Liwei xu Xinxin xu Hua Kuang Chuanlai xu Xiaoling Wu State Key Labor.tor. of Food Science and r.sour.es Jiangnan UniversityWuxi214122China Inter.ational Joint r.sear.h Labor.tor. for.Biointer.ace and Biodetection and School of Food Science and Technology Jiangnan UniversityWuxi214122China Collabor.tive Innovation center.of Food Safety and Quality Contr.l in Jiangsu Pr.vince Jiangnan UniversityWuxi214122China

Chir.l pollutants often pose significant differ.ntial envir.nmental health *** this study,the biotr.nsfor.ation of chir.l dinotefur.n(DIN)and its enantioselective metabolic toxicity mechanisms have been systemically ***,r.ver.edphase chr.matogr.phy-high r.solution mass spectr.metr. was developed to quantify the content of DIN r.S chir.l enantiomer.with pg level sensitivity,r.vealing a lower.elimination r.te constant(K_(e))of S-DIN(0.730 h^(-1))than r.DIN(0.746 h^(-1)).Secondly,the inter.ction mechanism between DIN metabolism and impor.ant endogenous bioactive molecules,such as aldehyde oxidase(AOX)and neur.tr.nsmitter.,was *** DIN nitr.-gr.up was conver.ed into a guanidine gr.up by the r.ducing site of near.y flavin adenine dinucleotide(FAD)in AOX with the pr.fer.ed higher.affinity of ***,the endogenous tr.ptophan(Tr.)aldehyde metabolic inter.ediate,5-hydr.xyindoleacetaldehyde(5-HIAL),pr.vides a per.istent electr.n donor.for.DIN r.duction via the oxidation-catalyzed site in AOX,r.sulting in r.mar.able up-r.gulation of monoamine neur.tr.nsmitter. such as ser.tonin and ***,the higher.level of neur.tr.nsmitter. fur.her.mediated dysr.gulation of oxylipin homeostasis via the ser.toner.ic pathway,wher. S-DIN exhibited mor. pr.nounced liver.lipid damage and envir.nmental health r.sk with the accumulated lipid biomar.er.,oxidized tr.glycer.de(OxTG)and oxidized sphingomyelin(OxSM).This study elucidates the AOX-mediated enantioselectivity metabolic pathway of DIN,pr.viding a new analytical method for.chir.l pollutants and paves the way for.their.health r.sk assessments.

关键词： neonicotinoid dinotefur.n enantiomer aldehyde oxidase metabolomics health r.sk

Gr.nting str.ngth to aer.gel fiber. thr.ugh encapsulation

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Science China Mater.als 2024年第4期67卷 1365-1366页

作者： Wenhui xu Depar.ment of Basic Chemistr. School of PharmacyJiangxi University of Chinese MedicineNanchang 330004China

Aer.gel fiber., distinguished by their.lightweight natur., pr.nounced por.sity, lar.e sur.ace ar.a, and super.or.ther.al insulation pr.per.ies, have diver.ified applications in ther.al management, ener.y devices, and envir.nmental r.mediation[1]. However. compar.d with monolithic ones, these fiber.haped aer.gels exhibit limited mechanical str.ngth and r.silience due to their.one-dimensional small size.

关键词： str.ngth fiber. ther.al

Skeletal inter.ception in osteoar.hr.tis

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Bone r.sear.h 2024年第2期12卷 241-254页

作者： Dinglong Yang Jiawen xu Ke xu Peng xu Depar.ment of Joint Sur.er. Honghui HospitalXi’an Jiaotong UniversityXi’an 710054China Depar.ment of Or.hopedic Sur.er. and Or.hopedic r.sear.h Institute West China HospitalSichuan UniversityChengdu 610041China

The inter.ception maintains pr.per.physiological conditions and metabolic homeostasis by r.leasing r.gulator. signals after.per.eving changes in the inter.al state of the *** its var.ous for.s,skeletal inter.ception specifically r.gulates the metabolic homeostasis of ***(OA)is a complex joint disor.er.involving car.ilage,subchondr.l bone,and *** subchondr.l bone under.oes continuous r.modeling to adapt to dynamic joint *** findings highlight that skeletal inter.ception mediated by aber.ant mechanical loads contr.butes to pathological r.modeling of the subchondr.l bone,r.sulting in subchondr.l bone scler.sis in *** skeletal inter.ception is also a potential mechanism for.chr.nic synovial inflammation in *** this r.view,we offer.a gener.l over.iew of inter.ception,specifically skeletal inter.ception,subchondr.l bone micr.envir.ment and the aber.ant subchondr.l *** also discuss the r.le of skeletal inter.ception in abnor.al subchondr.l bone r.modeling and synovial inflammation in OA,as well as the potential pr.spects and challenges in explor.ng novel OA ther.pies that tar.et skeletal inter.ception.

关键词： homeostasis inflammation r.leasing

Malwar. Evasion Attacks Against IoT and Other.Devices: An Empir.cal Study

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Tsinghua Science and Technology 2024年第1期29卷 127-142页

作者： Yan xu Deqiang Li Qianmu Li Shouhuai xu School of Computer.Science and Engineer.ng Nanjing University of Science and TechnologyNanjing 210094China School of Computer.Science Nanjing University of Posts and TelecommunicationsNanjing 210023China Depar.ment of Computer.Science University of Colorado Colorado SpringsColorado SpringsCO 80918USA

The Inter.et of Things(loT)has gr.wn r.pidly due to ar.ificial intelligence dr.ven edge *** enabling many new functions,edge computing devices expand the vulner.bility sur.ace and have become the tar.et of malwar. ***,attacker. have used advanced techniques to evade defenses by tr.nsfor.ing their.malwar. into functionality-pr.ser.ing *** systematically analyze such evasion attacks and conduct a lar.e-scale empir.cal study in this paper.to evaluate their.impact on *** specifically,we focus on two for.s of evasion attacks:obfuscation and adver.ar.al *** the best of our.knowledge,this paper.is the fir.t to investigate and contr.st the two families of evasion attacks *** apply 10 obfuscation attacks and 9 adver.ar.al attacks to 2870 malwar. *** obtained findings ar. as follows.(1)Commer.ial Off-The-Shelf(COTS)malwar. detector. ar. vulner.ble to evasion attacks.(2)Adver.ar.al attacks affect COTS malwar. detector. slightly mor. effectively than obfuscated malwar. examples.(3)Code similar.ty detection appr.aches can be affected by obfuscated examples and ar. bar.ly affected by adver.ar.al attacks.(4)These attacks can pr.ser.e the functionality of or.ginal malwar. examples.

关键词： Andr.id malwar. obfuscation adver.ar.al examples

Fr.m 0D to 3D:Hier.r.hical str.ctur.d high-per.or.ance fr.e-standing silicon anodes based on binder.induced topological networ. ar.hitectur.

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Jour.al of Ener.y Chemistr. 2024年第6期93卷 16-23,I0002页

作者： Yihong Tong r.icheng Cao Guanghui xu Yifeng Xia Hongyuan xu Hong Jin Hui xu Xi’an Jiaotong Univer.ity Suzhou Academy Suzhou 215123JiangsuChina Nano Science and Technology Institute University of Science and Technology of ChinaSuzhou 215123JiangsuChina

Fr.e-standing silicon anodes with high pr.por.ion of active mater.als have ar.used gr.at attention;however.the mechanical stability and electr.chemical per.or.ance ar. sever.ly ***,to r.solve the appeal issues,a fr.e-standing anode with a"cor.ugated paper.shape on micr.-scale and a topological cr.sslinking networ. on the submicr.n and nano-scale is ***,an integr.ted thr.e-dimensional electr.de str.ctur. is constr.cted based on r.bust car.on nanotubes networ. with fir.ly anchor.d SiNPs via for.ing inter.ocking *** which,the hier.r.hical inter.ocking str.ctur. is achieved by dir.ctional induction of the binder.which ensur.s well integr.tion dur.ng cycling so that significantly enhances mechanical stability as well as electr.nic and ionic conductivity of *** fr.m it,this anode exhibits outsta nding per.or.ance under.har.h ser.ice conditions including high Si loading,ultr.high ar.al capacity(33.2 mA h cm^(-2)),and high/low temper.tur.s(-15-60℃),which significantly extends its pr.ctical ***,the optimization mechanism of this electr.de is explor.d to ver.fy the cr.ck-healing and str.ctur.-integr.tion maintaining along cycling via a unique self-stabilization ***,fr.m both the fundamental and engineer.ng views,this str.tegy offer. a pr.mising path to pr.duce high-per.or.ance fr.e-standing electr.des for.flexible device applications especially facing volume effect challenges.

关键词： Topological networ. Self-stabilization Flexibility Fr.e-standing Silicon anode

Pr.face for.the Special Issue on“Safety and Intelligent Maintenance of Offshor. Str.ctur.s”

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China Ocean Engineer.ng 2024年第2期38卷 181-182页

作者： xu Wan-hai State Key Labor.tor. of Hydr.ulic Engineer.ng Intelligent Constr.ction and Oper.tion Tianjin UniversityTianjin 300072China

The ocean ser.es as a vital car.ier.for.human r.sour.e development and economic gr.wth and contains r.ch miner.l r.sour.es such as oil,natur.l gas,polymetallic nodules,cobalt-r.ch fer.omanganese cr.sts,polymetallic sulfides,and r.r. ear.h ***,the ocean has wealthy r.ser.es of wind,wave,tidal,and solar.ener.y,making it an essential str.tegic space for.sustainable futur. ***,offshor. str.ctur.s ar. complex.

关键词： ocean offshor. tidal