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Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment

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Chinese Chemical Letters 2024年第4期35卷 414-419页

作者： Peide Zhu Yangjia Liu Yaoyao Tang Siqi Zhu Xinyang Liu Lei Yin quan Liu Zhiqiang Yu quan xu Dixian Luo Juncheng Wang State Key Laboratory of Heavy Oil Processing China University of Petroleum-BeijingBeijing 102249China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer ResearchAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523058China Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen 518052China Institute of Stomatology First Medical CenterChinese PLA General HospitalBeijing 100853China

Liposomes are one of the significant classes of antitumor nanomaterials and the most successful nanomedicine drugs in clinical translation. However, it is difficult to accurately reveal liposome delivery modes and drug release rates at different p H values to assess the biodistribution and drug delivery pathways in vivo. Here, we established a strategy to integrate Bi-doped carbon quantum dots(CQDs)with liposomes to produce fluorescence visualization and therapeutic effects, namely lipo/Bi-doped ***/Bi-doped CQDs show good water solubility and physicochemical properties, which can be used for in vitro labeling of colon cancer(CT26) cells and in vivo imaging localization tracking tumors for monitoring. Simultaneously, thanks to the excellent p H sensitivity and ion doping characteristic of Bi-doped CQDs, lipo/Bi-doped CQDs can be used to reveal the drug release rate of liposomes at different p H values and exhibit potential effects in vivo antitumor therapy.

关键词： Bi-doped CQDs Lipo/Bi-doped CQDs pH sensitivity In vitro/in vivo imaging Diagnosis and treatment integration

Fabrication of highly effective electrodes for iron chromium redox flow battery

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Nano Research 2024年第5期17卷 3988-3996页

作者： Yingchun Niu Chao Guo Yinping Liu Guangfu Wu Tianhang Zhou Fangang Qu Ziji Yang Ali Heydari Chunming xu quan xu State Key Laboratory of Heavy Oil Processing China University of Petroleum(Beijing)Beijing 102249China

Iron-chromium redox flow batteries(ICRFBs)have emerged as promising energy storage devices due to their safety,environmental protection,and reliable *** carbon cloth(CC),often used in ICRFBs as the electrode,provides a suitable platform for electrochemical processes owing to its high surface area and interconnected porous ***,the CC electrodes have issues,such as,insufficient electron transfer performance,which limits their industrial ***,we employed silicic acid etching to carve dense nano-porous structures on the surface of CC electrodes based on the favorable design of ICRFBs and the fundamental principles of electrode polarization *** a result,we developed a multifunctional carbon cloth electrode with abundant vacancies,notably enhancing the performance of the *** fabricated electrode showcased a wealth of defect sites and superior electronic transport properties,offering an extensive and effective reaction area for rapidly flowing *** an electrode compression ratio of 40%and the highest current density in ICRFBs so far(140 mA·cm^(-2)),the battery achieved the average energy efficiency of 81.3%,11.24%enhancement over the previously published ***,throughout 100 charge-discharge cycles,the average energy efficiency degradation was negligible(~0.04%),which has the potential to become the most promising candidate for large-scale and long-term electrochemical energy storage applications.

关键词： iron chromium redox flow battery electron carbon cloth defect site density functional theory(DFT)calculation

Asymmetric frequency multiplexing topological devices based on a floating edge band

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Photonics Research 2024年第6期12卷 1201-1212页

作者： JIAJUN MA CHUNMEI OUYANG YUTING YANG DONGYANG WANG HONGYI LI LI NIU YI LIU quan xu YANFENG LI ZHEN TIAN JIAGUANG HAN WEILI ZHANG Center for Terahertz Waves and College of Precision Instrument and Optoelectronics Engineering and Key Laboratory of Optoelectronics Information and TechnologyTianjin UniversityTianjin 300072China School of Materials Science and Physics China University of Mining and TechnologyXuzhou 221116China Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK Guangxi Key Laboratory of Optoelectronic Information Processing School of Optoelectronic EngineeringGuilin University of Electronic TechnologyGuilin 541004China School of Electrical and Computer Engineering Oklahoma State UniversityStillwaterOklahoma 74078USA

Topological photonics provides a platform for robust energy transport regardless of sharp corners and ***,the frequency multiplexing topological devices have attracted much attention due to the ability to separate optical signals by wavelength and hence the potential application in optical communication *** frequency multiplexing topological devices are generally based on the slow light ***,the resulting static local spatial mode or finely tuned flat band has zero-group velocity,making it difficult for both experimental excitation and channel ***,we propose and experimentally demonstrate an alternative prototype of asymmetric frequency multiplexing devices including a topological rainbow and frequency router based on floating topological edge mode(instead of localized ones);hence the multiple wavelength channels can be collectively excited with a point source and efficiently routed to separate output *** channel separation in our design is achieved by gradually tuning the band gap truncation on a topological edge band over a wide range of frequencies.A crucial feature lies in that the topological edge band is detached from bulk states and floating within the upper and lower photonic band *** interestingly,due to the sandwiched morphology of the edge band,the top and bottom band gaps will each truncate into transport channels that support topological propagation towards opposite directions,and the asymmetrical transportation is realized for the frequency multiplexing topological devices.

关键词： tuning floating hence

On-chip terahertz orbital angular momentum demultiplexer

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Photonics Research 2024年第5期12卷 1044-1054页

作者： XIAOHAN JIANG WANYING LIU quan xu YUANHAO LANG YIKAI FU FAN HUANG HAITAO DAI YANFENG LI xuEQIAN ZHANG JIANQIANG GU JIAGUANG HAN WEILI ZHANG Center for Terahertz Waves College of Precision Instrument and Optoelectronics Engineeringand Key Laboratory of Optoelectronics Information and Technology(Ministry of Education)Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology School of ScienceTianjin UniversityTianjin 300072China Guangxi Key Laboratory of Optoelectronic Information Processing School of Optoelectronic EngineeringGuilin University of Electronic TechnologyGuilin 541004China School of Electrical and Computer Engineering Oklahoma State UniversityStillwaterOklahoma 74078USA

The terahertz regime is widely recognized as a fundamental domain with significant potential to address the demands of next-generation wireless *** parallel,mode division multiplexing based on orbital angular momentum(OAM)shows promise in enhancing bandwidth utilization,thereby expanding the overall communication channel *** this study,we present both theoretical and experimental demonstrations of an on-chip terahertz OAM *** device effectively couples and steers seven incident terahertz vortex beams into distinct high-quality focusing surface plasmonic beams,and the focusing directions can be arbitrarily *** proposed design strategy integrates space-to-chip mode conversion,OAM recognition,and on-chip routing in a compact space with subwavelength thickness,exhibiting versatility and superior performance.

关键词： demultiplexer momentum angular

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籼粳杂种不育的遗传分析和候选基因鉴定

中国农业科学 2024年第8期57卷 1417-1429页

作者：许娜唐颖徐正进孙健徐铨沈阳农业大学水稻研究所

【目的】籼粳亚种间杂交F1的育性问题严重阻碍了亚种间杂种优势的利用，探究籼粳杂种不育的遗传机理，挖掘新的籼粳杂种不育调控基因，为促进籼粳杂种结实率遗传改良提供理论依据。【方法】粳稻品种Sasanishiki和籼稻品种Habataki杂交... 详细信息

【目的】籼粳亚种间杂交F1的育性问题严重阻碍了亚种间杂种优势的利用，探究籼粳杂种不育的遗传机理，挖掘新的籼粳杂种不育调控基因，为促进籼粳杂种结实率遗传改良提供理论依据。【方法】粳稻品种Sasanishiki和籼稻品种Habataki杂交后，采用单粒传法自交10代，获得包含95个株系的稳定遗传重组自交系（RIL），基于Illumina平台，对双亲和RIL进行高通量测序，在全基因组水平分析RIL中Habataki血缘的分布与比例，进而鉴定偏分离区域作为潜在的籼粳杂种不育位点。同时，剖析“全球3000份水稻核心种质资源重测序计划”中典型籼粳稻基因组变异数据，对群体水平进一步验证并趋近目标育性基因区域。最终通过序列比对锁定籼粳杂种不育候选基因。应用CRISPR基因编辑技术进行定点基因敲除，对目标基因进行功能验证。【结果】Habataki和Sasanishiki的杂交F1在穗数、每穗粒数和千粒重上体现出明显的杂种优势，但其结实率显著降低，I2-KI镜检发现F1花粉育性显著降低。RIL的全基因组高通量测序在第1、3、5、6、7和12染色体上检测到明显的偏分离，即该区域的基因型趋向于籼稻Habataki。通过序列比对，进一步确定已知育性基因Sc、S5和HSA1为第3、6和12染色体上偏分离区域的目标基因。应用CRISPR基因编辑技术敲除Habataki中Sc-Haba-3的多拷贝，成功改善了其与Sasanishiki杂交F1的花粉育性和结实率，说明该基因可独立行使功能。同时，在第1染色体的偏分离区域发现Habataki和Sasanishiki之间存在复杂的结构性变异，Sasanishiki基因组中一段24.7 kb包含4个预测基因的片段在Habataki中被一段64.8 kb包含10个预测基因的片段取代，此结构性变异可能参与籼粳杂种育性的调控。【结论】检测到多个籼粳杂种不育相关位点，应用CRISPR基因编辑技术敲除Habataki中Sc的多拷贝成功改善其杂种F1育性，确定其为水稻亚种间育性改良的目标基因。同时锁定了第1染色体Sd区域的目标基因。

关键词：水稻籼粳杂种不育高通量测序基因编辑 Sd候选基因

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中小企业国际规则新发展与中国因应

国际经济合作 2024年第1期 22-33,86页

作者：徐泉刘小琳西南政法大学对外开放法治建设研究中心西南政法大学国际法学院

以CPTPP、USMCA、RCEP为代表的区域贸易协定均对中小企业问题进行相应规制,其条款设计集中体现了中小企业国际规则的主要特点和发展趋势。虽然中小企业国际规则存在诸多不足,并面临立法技术困境,但中小企业议题作为国际经贸谈判重要的... 详细信息

以CPTPP、USMCA、RCEP为代表的区域贸易协定均对中小企业问题进行相应规制,其条款设计集中体现了中小企业国际规则的主要特点和发展趋势。虽然中小企业国际规则存在诸多不足,并面临立法技术困境,但中小企业议题作为国际经贸谈判重要的横向议题之一,仍然具有较大的发展潜力,并对中国中小企业管理体制产生了一定影响。中国中小企业规则体系的缺陷严重制约中小企业长远发展,应在准确研判中小企业国际规则及其发展趋势的基础上,深化国内相关体系改革,为中小企业发展提供良好的制度支撑。同时,中国应积极参与本轮国际经贸规则的重构进程,适时通过自由贸易谈判促进中小企业国内规则的国际化,实现中国对全球经济治理体系的规则供给,推动中小企业国际规则的进一步完善。

关键词：中小企业国际经贸规则规则治理 CPTPP USMCA RCEP

CPTPP与DEPA框架下数字产品非歧视待遇规则及中国应因

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中国流通经济 2024年第8期38卷 115-126页

作者：徐泉吴若惜西南政法大学国际法学院重庆市401120

数字产品非歧视待遇在CPTPP与DEPA中均有规定,是我国加入CPTPP与DEPA必须面对的规则。适用该规则要注意数字产品原产地、同类数字产品以及歧视性待遇的认定问题。鉴于目前国际社会尚未对数字产品的性质达成共识,可暂时参考WTO中货物或... 详细信息

数字产品非歧视待遇在CPTPP与DEPA中均有规定,是我国加入CPTPP与DEPA必须面对的规则。适用该规则要注意数字产品原产地、同类数字产品以及歧视性待遇的认定问题。鉴于目前国际社会尚未对数字产品的性质达成共识,可暂时参考WTO中货物或者服务关于以上问题的认定标准。在其适用问题上,有关国家的实践如征收数字服务税、限制网络接入与使用、限制国外数字产品购买可能会与该规则的规定相悖。数字产品非歧视待遇在自由贸易协定、数字贸易协定以及WTO电子商务谈判中均有涉及,以美国、日本等为首的发达国家对该规则持积极肯定态度,不仅在其签署的自贸协定中纳入该规则,同时也积极倡导将该规则纳入WTO电子商务中。与此同时不少发展中国家如智利、秘鲁等在其签订的自贸协定或者数字贸易协定中也纳入了该规则。但是在我国目前签订的自贸协定中均没有涉及该规则,而且我国在WTO电子商务的提案中对该规则也持谨慎态度,主要原因在于我国数字产品与美国、日本、韩国等发达国家的数字产品相比竞争力较弱,接受该规则可能会进一步削弱我国数字产品的竞争力。我国积极申请加入CPTPP与DEPA,必须接受该规则对我国带来的机遇与挑战。该规则对我国的挑战主要表现为美式数字产品定义冲击我国数字贸易、负面清单模式扩大数字产品非歧视待遇适用范围、我国现行数字产品监管规定与其相冲突。为保护我国数字产品的发展,可通过援引政府补贴例外发展数字产品、利用负面清单限缩数字产品非歧视待遇适用范围、修改数字文化产品监管规定予以应对。

关键词：数字产品非歧视待遇例外规定负面清单

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金属有机框架衍生的C-Bi/CC电极制备及其在铁铬液流电池中的电化学性能

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储能科学与技术 2024年第2期13卷 381-389页

作者：周洋韩培玉牛迎春徐春明徐泉中国石油大学(北京) 北京102249

电极是铁铬液流电池的重要组成部分,是电解液中活性组分发生电化学反应的场所。理想的电极材料应具备高电导率、大比表面积、高电化学活性、低成本等特性,而目前的电极材料往往不能兼顾。金属有机框架(MOF)兼具高导电性、高催化性能的优... 详细信息

电极是铁铬液流电池的重要组成部分,是电解液中活性组分发生电化学反应的场所。理想的电极材料应具备高电导率、大比表面积、高电化学活性、低成本等特性,而目前的电极材料往往不能兼顾。金属有机框架(MOF)兼具高导电性、高催化性能的优点,能够为电化学反应提供更多的活性位点,因此被广泛应用在电极材料中。此项工作通过水热法制备了以碳布负载Bi-MOF为前驱体(Bi-MOF/CC)的铋基碳布(CC)电极(C-Bi/CC)。通过探究金属盐的添加量与电极性能的耦合关系,提升了电极的性能,结果显示,使用90 mg金属盐的电极样品极化电阻仅1.069Ω,相较于原始碳布降低了8.5%、Cr3+还原过电位为0.25 V,使用普通碳布作为正极,改性过的电极作为铁铬液流电池负极进行电池循环性能测试,在电流密度为80 mA/cm2时能量效率达89.7%,库仑效率达97.2%,电压效率达92.3%;在电流密度为140 mA/cm2时能量效率达到83.8%,库仑效率达98.1%,电压效率达85.5%。

关键词：铁铬液流电池电极材料电化学性能能量效率

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基于MARS的岩石抗拉强度预测模型

长江科学院院报 2024年第2期41卷 135-141页

作者：徐国权王鑫瑀东华理工大学地球科学学院南昌330000 河北钢铁集团矿业有限公司河北唐山063000

将无损检测技术与机器学习相结合,通过建立预测模型来快速确定岩石抗拉强度已经成为热门研究方向之一。为了建立预测模型,提出一种基于多元自适应回归样条(MARS)的数据驱动建模技术,用于岩石抗拉强度预测。共收集了80组试验数据,包括施... 详细信息

将无损检测技术与机器学习相结合,通过建立预测模型来快速确定岩石抗拉强度已经成为热门研究方向之一。为了建立预测模型,提出一种基于多元自适应回归样条(MARS)的数据驱动建模技术,用于岩石抗拉强度预测。共收集了80组试验数据,包括施密特回弹数、干密度、点荷载强度指数以及巴西抗拉强度。所有数据被随机分为2个部分,其中70%的数据用于训练模型,剩余30%的数据用于测试模型性能。同时开发了人工神经网络、支持向量机和决策树3种数据驱动模型。选择了4种常用的模型性能评价指标,分别为均方根误差、平均绝对误差、相关系数和决定系数,以此来对所开发模型的预测性能进行比较。结果表明:所开发的智能模型均能够提供较高的预测精度,其中MARS模型性能优于其他3种模型,支持向量机和人工神经网络模型次之,决策树模型相对较差。值得一提的是,MARS模型能够通过方差分析来评估每个变量的相对重要性。研究成果有助于快速确定岩石抗拉强度。

关键词：岩石力学抗拉强度多元自适应回归样条(MARS) 机器学习预测模型

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