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New approach to eliminate structural redundancy in case resource pools using α mutual information

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Journal of Systems Engineering and Electronics 2013年第4期24卷 625-633页

作者： man xu Haiyan Yu Jiang Shen Department of Industrial Engineering Nankai University College of management and Economics Tianjin University

Structural redundancy elimination in case resource pools （CRP） is critical for avoiding performance bottlenecks and maintaining robust decision capabilities in cloud computing services. For these purposes, this paper proposes a novel approach to ensure redundancy elimination of a reasoning system in CRP. By using α entropy and mutual information, functional measures to eliminate redundancy of a system are developed with respect to a set of outputs. These measures help to distinguish both the optimal feature and the relations among the nodes in reasoning networks from the redundant ones with the elimination criterion. Based on the optimal feature and its harmonic weight, a model for knowledge reasoning in CRP （CRPKR） is built to complete the task of query matching, and the missing values are estimated with Bayesian networks. Moreover, the robustness of decisions is verified through parameter analyses. This approach is validated by the simulation with benchmark data sets using cloud SQL. Compared with several state-of-the-art techniques, the results show that the proposed approach has a good performance and boosts the robustness of decisions.

关键词： case resource pool (CRP) knowledge reasoning redundancy elimination α mutual information robust decision.

Recombinant *** LLO/OVA Induces Murine BMDCs Maturation via TLR4 and NOD1 Receptor and Promotes Specific Cytotoxic T Cell Immunity

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Biomedical and Environmental Sciences 2010年第5期23卷 350-356页

作者： man xu MING-SHEN DAI Department of Pathology Molecular Medicine and Cancer Research Centre Chongqing Medical University Chongqing 400016 China Centre for Molecular Oncology Institute of Cancer Queen Mary 's School of Medicine and Dentistry London EC1M 6BQ UK

Objective To explore the immune stimulation effect of recombinant *** LLO/OVA on mice bone marrow-derived dendritic cells （BMDCs） and T lymphocytes in *** After BMDCs stimulated by *** LLO/OVA,their Toll-like receptor （TLR） and nucleotide-binding oligomerization domain （NOD） receptor signalling pathway were examined by superarray hybridization;and the priming effect of the vaccine activated BMDCs on CD4＋T and CD8＋T was determined by [3H]thymidine uptake and ELISA,the tumor cytotoxic effect of activated CD8＋T cells was determined by cytotoxic *** After BMDCs were activated by *** LLO/OVA via TLR4,NOD1 receptor and NF-κB signalling pathway,the expression of their surface molecules including MHC class Ⅰ,MHC class Ⅱ,CD40,CD80 and CD86 significantly up-regulated;the secretion of IL-12 and IFN-？ increased *** mature BMDCs stimulated the allergic CD4＋T and CD8＋T cells proliferation and their IL-2 and IFN-γ secretion,and the activated CD8＋T cells effectively killed B16-OVA melanoma cells and RMA-S/OVA lymphoma cells in *** *** LLO/OVA is effective in inducing BMDCs maturation via activating TLR4 and NOD1 receptor signalling pathway and promoting specific anti-tumor T cell immunity in vitro.

关键词： Bone marrow-derived dendritic cells BMDCs Recombinant Escherichia coli Toll-like receptor (TLR) Nucleotide-binding oligomerization domain (NOD) CD8+T cells

Relationship between high dietary fat intake and Parkinson’s disease risk: a meta-analysis

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Neural Regeneration Research 2019年第12期14卷 2156-2163页

作者： Yan Qu Xi Chen man-man xu Qiang Sun Department of Physiology School of Basic Medicine Qingdao University Qingdao Shandong Province China Intensive Care Unit The Affiliated Hospital of Qingdao University Qingdao Shandong Province China

OBJECTIVE: To assess whether dietary fat intake influences Parkinson’s disease risk. DATA SOURCES: We systematically surveyed the Embase and PubMed databases, reviewing manuscripts published prior to October 2018. The following terms were used:(“Paralysis agitans” OR “Parkinson disease” OR “Parkinson” OR “Parkinson’s” OR “Parkinson’s disease”) AND (“fat” OR “dietary fat” OR “dietary fat intake”). DATA SELECTION: Included studies were those with both dietary fat intake and Parkinson’s disease risk as exposure factors. The Newcastle-Ottawa Scale was adapted to investigate the quality of included studies. Stata V12.0 software was used for statistical analysis. OUTCOME MEASURES: The primary outcomes included the relationship between high total energy intake, high total fat intake, and Parkinson’s disease risk. The secondary outcomes included the relationship between different kinds of fatty acids and Parkinson’s disease risk. RESULTS: Nine articles met the inclusion criteria and were incorporated into this meta-analysis. Four studies scored 7 and the other five studies scored 9 on the Newcastle-Ottawa Scale, meaning that all studies were of high quality. Meta-analysis results showed that high total energy intake was associated with an increased risk of Parkinson’s disease (P = 0.000, odds ratio (OR)= 1.49, 95% confidence interval (CI): 1.26–1.75);in contrast, high total fat intake was not associated with Parkinson’s disease risk (P = 0.123, OR = 1.07, 95% CI: 0.91–1.25). Subgroup analysis revealed that polyunsaturated fatty acid intake (P = 0.010, OR = 1.03, 95% CI: 0.88–1.20) reduced the risk of Parkinson’s disease, while arachidonic acid (P = 0.026, OR = 1.15, 95% CI: 0.97–1.37) and cholesterol (P = 0.002, OR = 1.09, 95% CI: 0.92–1.29) both increased the risk of Parkinson’s disease. Subgroup analysis also demonstrated that, although the results were not significant, consumption of n-3 polyunsaturated fatty acids (P = 0.071, OR = 0.88, 95% CI: 0.73–1.05),α-linolenic ac

关键词： nerve regeneration dietary fat Parkinson's disease risk meta-analysis total energy intake polyunsaturated fatty acids arachidonic acid cholesterol α-linolenic acid linoleic acid n-3/n-6 polyunsaturated fatty acid intake ratio monounsaturated fatty acids neural regeneration

Adenocarcinoma of esophagogastric junction:controversial classification,surgical management,and clinicopathology

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Chinese Journal of Cancer Research 2014年第3期26卷 226-230页

作者： Lei Huang A-man xu Department of Gastrointestinal Surgery the Fourth Affiliated Hospital of Anhui Medical University Department of Gastrointestinal Surgery the First Affiliated Hospital of Anhui Medical University

In recent years the world is witnessing an increasing incidence of adenocarcinoma of esophagogastric junction （AEG）, which originates from epithelial tissue of esophagogastric junction （EGJ）, and mainly derives from Barrett＇s esophagus. It＇s now gaining more and more attention due to the controversial etiology, classification and treatment.

关键词： Adenocarcinoma of esophagogastric junction AEG node than TNM NAC

A Convenient Synthesis of Antibacterial Linezolid from (S)-Glyceraldehyde Acetonide

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Chinese Chemical Letters 2006年第3期17卷 302-304页

作者： Guang Yu xu Yi ZHOU man Cai xu College of Chemistry and Chemical Engineering Hunan Normal University Changsha 410081

A convenient synthesis of oxazolidinone antibacterial linezolid from readily available L-ascorbic acid is described. The key steps include reductive amination of arylamine and （S）-glyceraldehyde acetonide in the pre... 详细信息

关键词： Linezolid antibacterial synthesis ascorbic acid.

Recombinant *** LLO/OVA Vaccination Effectively Inhibits Murine Melanoma Metastasis to Lung by CD8^+T Cells Immunity

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Chinese Journal of Cancer Research 2009年第1期21卷 44-49页

作者： man xu Ming-shen Dai Can Mi Department of Pathology Molecular Medicine ＆ Cancer Research Centre Chongqing Medical University Chongqing 400016 China Centre for Molecular Oncology Institute of Cancer Queen Mary＇s School of Medicine and Dentistry London EC1M 6BQ UK

Objective： To construct recombinant *** LLO/OVA and investigate its tumor metastatic inhibition effect in B16 OVA melanoma challenged mice. Methods： Recombinant *** LLO/OVA was constructed and the expression of listeriolysin O （LLO） and ovalbumin （OVA） of the vaccine was determined by coomassie brilliant blue staining and western blotting, After 3 subcutaneous injections of *** LLO/OVA, the percentages of CD3^＋CD4^＋T, CD4^＋CD25^＋T, CD3^CD8^＋T and OVA257-264 SIINFEKL specific CD8^＋T cells were determined by flow cytomytry, and the tumor metastatic inhibition effect in B16 OVA melanoma challenged mice was observed. Results： Recombinant *** LLO/OVA was successfully constructed, and the expression of LLO and OVA of the vaccine was confirmed. After 3 subcutaneous injections of *** LLO/OVA and *** OVA in mice, the percentages of CD3^＋CD4^＋T, CD4^＋CD25^＋T and CD3^＋CD8^＋T cells were equivalent in the two groups of mice. However, there were significantly more OVA257-264 SIINFEKL specific CD8^＋T cells in *** LLO/OVA vaccinated mice than that in *** OVA vaccinated mice. The prophylactic *** LLO/OVA vaccination effectively prevented the tumor metastasis to lungs in B16 OVA melanoma challenged mice. Depletion of CD8^＋T cells significantly impaired the tumor inhibition effect of the vaccine in B16 OVA challenged mice. The therapeutic vaccination of *** LLO/OVA significantly prevented melanoma metastasis to lungs in B I6 OVA challenged mice too. Conclusion： Recombinant *** LLO/OVA vaccination is highly effective in inhibiting murine malignant melanoma metastasis by promoting CD8^＋T cell immunity.

关键词： Recombinant E.coli Tumor immunity Cytotoxic T cells Metastasis

Morphology and Mechanical Properties of Immiscible Polyethylene/Polyamide12 Blends Prepared by High Shear Processing

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Chinese Journal of Polymer Science 2017年第9期35卷 1132-1142页

作者： wen-jin yu shu-man xu li zhang 傅强 College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China

In this work, completely immiscible polyethylene/polyamidel2 （PE/PA12） blends were prepared by high shear extruder. The morphology and mechanical properties of the blends were investigated as a function of rotation speed. It was found that the high shear processing is an effective method to improve the dispersion of the PAl2 phase in PE matrix when PA 12 contents are 5 wt% and 10 wt%, and the dispersed phase particle size is reduced with the increase of rotation speed from 100 r/min to 500 r/min. However, with further increase of PAl2 content to 20 wt%, high shear processing has no effect on the phase morphology of the blends. Accordingly, a largely increased elongation at break and impact strength are observed for PE/PAl2/95/5 and PE/PA12/90/10 blends obtained at high rotation speeds but no effect on the property of PE/PAI2/80/20. Annealing experiment demonstrated that the obtained phase morphology is not stable thus compatibilizer should be introduced in the future work. This work could provide a guideline for the application of high shear processing in the preparation of polymer blends with huge polarity difference.

关键词： Immiscible polyethylene/polyamidel2 (PE/PA12) blends High shear processing Phase morphology

Alkylene-functionality in bridged and fused nitrogen-rich poly-cyclic energetic materials:Synthesis,structural diversity and energetic properties

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Defence Technology（防务技术） 2024年第5期35卷 18-46页

作者： man xu Nanxi Xiang Ping Yin Qi Lai Siping Pang School of Materials Science&Engineering Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China

From the standpoint of chemical structures,the organic backbones of energetic materials can be classified into aromatic rings,nonaromatic rings,and open *** the category of aromatic energetic compounds exhibits several advantages in the regulation of energetic properties,the nonaromatic heterocycles,assembling nitramino explosophores with simple alkyl bridges,still have prevailed in benchmark *** methylene bridge plays a pivotal role in the constructions of the classic nonaromatic heterocycle-based energetic compounds,e.g.,hexahydro-1,3,5-trinitro-1,3,5-triazine(RDX)and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine(HMX),whereas ethylene bridge is the core moiety of state-of-the-art explosive 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane(CL-20).In this context,it is of great interest to employ simple and practical bridges to assemble aromatic and nonaromatic nitrogen-rich heterocycles,thereby expanding the structural diversity of energetic materials,e.g.,bridged and fused nitrogen-rich ***,alkyl-bridged poly-heterocycles highlight the potential for the open chain type of energetic *** this review,the development of alkyl bridges in linking nitrogen-rich heterocycles is presented,and the perspective of the newly constructed energetic backbones is summarized for the future design of advanced energetic materials.

关键词： Energetic materials Alkyl bridge strategy Nitrogen-rich azoles Fused heterocycles Azoles

Multiple-Stimuli Responsive and Tunable Luminescent Suprarnolecular Assembly by Oligo（p-phenylvinylene） and Surfactant

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Chinese Journal of Chemistry 2018年第6期36卷 526-530页

作者： xu-man Chen Yong Chen Yu Liu College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 China Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Nankai University Tianjin 300071 China

Achieving multicolor photoluminescence under multiple stimuli response based on a single fluorescent compound remains a great challenge. Herein, we report a novel multicolor fluorescent supramolecular assembly, which was constructed from surfactant sodium dodecyl sulfate （SLS） and fluorescent compound 1 bearing a rigid symmetrical acceptor-donor-acceptor structure. The luminescence property of 1/SLS assembly showed the multiple stimuli response towards temperature, cyclodextrin complexation and UV light irradiation, exhibiting the tunable emission wavelengths from 490 nm to 590 nm and the multicolor photoluminescence including cyan, green, yellow and orange. Furthermore, this assembly could be used in light writing owing to the fast fluorescence change within 15 s. These results could provide a convenient and useful method for fabricating smart tunable photoluminescent materials.

关键词： tunable photoluminescence supramolecular assembly multiple stimuli response oligo(p-phenylvinylene) surfactant