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Effect of treatment course of comprehensive intervention with Traditional Chinese Medicine on mortality of acquired immunodeficiency syndrome patients treated with combined antiretroviral therapy

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Journal of Traditional Chinese Medicine 2016年第4期36卷 411-417页

作者： Guo Huijun Wang Jian Li Zhengwei Jiang Ziqiang xu Qianlei xu liran Department of Acquired Immune Deficiency Syndrome AIDS Treatment and Research Center the First Affiliated Hospital of Henan University of Traditional Chinese Medicine Traditional Chinese Medicine Center for Acquired Immune Deficiency Syndrome Prevention and Treatment China Academy of Traditional Chinese Medicine

OBJECTIVE:To investigate the effect of a treatment course of comprehensive intervention with Traditional Chinese Medicine(TCM) on the mortality of patients with acquired immunodeficiency syndrome(AIDS) treated with combined antiretroviral therapy(c ART).METHODS:AIDS patients who had taken c ART in a national TCM human immunodeficiency virus treatment trial program(NTCMTP) before 2009 were enrolled in this study and followed for 36 months from November 2009.Patients enrolled in the NTCMTP in 2004 were taken as the first group,those enrolled in 2006 as the second group,and those enrolled in 2009 as the third group.Cumulative survival rates were calculated by the life table method.Survival curves for subgroups were compared by the log-rank test.Hazard ratios were calculated with a Cox proportional hazards model.RESULTS:A total of 1443 AIDS patients were followed for 3 years(4198 person-years).During this period,91(6.3%) patients died and 13(0.9%) were lost to follow-up.The total mortality rate was 2.17/100 person-years.The mortality rate of patients enrolled in the NTCMTP in 2004 was 1.49/100 person-years,which was lower than that of patients enrolled in 2006(2.23/100 person-years) and 2009(3.48/100 person-years).After adjusting for other factors,a shorter time of treatment with TCM,male sex,older age,lower CD4 + T-cell counts,and long-term treatment with c ART were risk factors of mortality.CONCLUSION:Long-term treatment with TCM decreased the mortality risk of AIDS patients.Factors such as being male,older age,CD4+ T-cell counts,and time of treatment with TCM and c ART were correlated with mortality.

关键词： Acquired immunodeficiency syndrome Antiretroviral therapy highly active Mortality Medicine Chinese traditional Retrospective cohort study

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Differences in acquired immune deficiency syndrome treatment and evaluation strategies between Chinese and Western Medicine

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Journal of Traditional Chinese Medicine 2015年第6期35卷 718-722页

作者： Liu Zhibin Li Xia Yang Jiping xu liran Guo Huijun Department of the Acquired Immune Deficiency Syndrome Treatment and Research Center the First Affiliated Hospital of Henan University of Traditional Chinese Medicine Department of Cellular Immunology Lab Key Laboratory of Viral Diseases Prevention and Treatment of Traditional Chinese Medicine of Henan Province Department of Neurology Baoji City Chinese Medicine Hospital

Complementary and alternative medicine, including Chinese medicine(CM), has been used to treat acquired immune deficiency syndrome(AIDS) for almost 30 years. We aimed to compare the main differences between AIDS treatment and evaluation strategies between CM and Western Medicine(WM), and analyze advantages and disadvantages.The characteristics of integrative medicine(IM),based on CM and WM, include a patient-centered mode of medicine based on evidence. IM focuses on complex intervention and management with systemic and individual treatment. The evaluation indexes of IM might consist of objective indicators and subjective indexes. IM might be a more valuable method for treating AIDS in the future instead of WM or CM alone.

关键词： Acquired immunodeficiency syn-drome HIV Complementary therapies Medicine,Chinese Traditional Integrative medicine

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Asymptomatic stage of human immunodeficiency virus infection is the optimal timing for its management with Traditional Chinese Medicine

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Journal of Traditional Chinese Medicine 2015年第2期35卷 244-248页

作者： Chen Xiumin Yuan Qingting Liu Zhibin Yang Jiping xu liran Guo Huijun Department of Acquired Immune Deficiency Syndrome Treatment and Research Center the First Affiliated Hospital of Henan University of Traditional Chinese Medicine Department of Academic Degrees & Graduate Education Henan University of Traditional Chinese Medicine Department of Cellular and Molecular Immunology Lab Key Laboratory of Viral Diseases Prevention and Treatment of Traditional Chinese Medicine of Henan Province

Acquired immune deficiency syndrome(AIDS) is a worldwide public health problem and an incurable disease.The roles of Traditional Chinese Medicine(TCM) on AIDS had been recognized and accepted by more and more people.Being a relatively long period,to initiate combination antiretroviral therapy(cART) for the asymptomatic human immunodeficiency virus(HIV) infection patient is not consensus.According to TCM theory,not only the imbalance of Yin and Yang but also the disharmony of internal body function and external natural environment had occurred in the body of the patient,the imbalance and the disharmony should be adjusted by the means of the treatment based on the patters identified among the symptoms in terms of TCM.We aimed to analyze the feature of patients with asymptomatic infection,and compare the advantages and disadvantages of the usage of cART for asymptomatic infection,explored the possible mechanism underlying TCM treatment of the asymptomatic infection,by reviewing the TCM treatment progress on asymptomatic HIV infection.

关键词：人类免疫缺陷病毒病毒感染中医药症状中医治疗管理公共卫生问题逆转录病毒

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Comment on the intervention of Traditional Chinese Medicine on survival rates of patients living with human immunodeficiency virus and acquired immune deficiency syndrome

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Journal of Traditional Chinese Medicine 2016年第3期36卷 409-410页

作者： Li Qiang Liu Zhibin Yang Jiping Guo Huijun xu liran Department of Acquired Immune Deficiency Syndrome Treatment and Research Center the First Affiliated Hospital of Henan University of Traditional Chinese Medicine

Despite many differences between Traditional Chinese Medicine(TCM) and conventional medicine,the use of TCM in the treatment of human immunodeficiency virus and acquired immune deficiency syndrome(HIV/AIDS) is increasingly recognized and accepted by patients. Recent research findings on the benefits of Chinese herbal medicine on long-term survival in patients with HIV/AIDS are encouraging and hopeful, but inconclusive. More research is needed.

关键词：艾滋病病毒感染者人类免疫缺陷病毒中医药综合征患者生存率传统医学中草药

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Prevalence trend and risk factors for anemia among patients with human immunodeficiency virus infection receiving antiretroviral therapy in rural China

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Journal of Traditional Chinese Medicine 2019年第1期39卷 111-117页

作者： Jin Yantao Liu Sa Yuan Jun Meng Xiangle Guo Huijun xu liran xu Qianlei Department of Acquired Immune Deficiency Syndrome Treatment and Research Center The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 45000China Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhou 510006China Department of Acquired Immune Deficiency Syndrome Treatment and Research Center The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 45000China

OBJECTIVE: To estimate the prevalence trend and risk factors for anemia in patients with human immunodeficiency virus(HIV) infection receiving antiretroviral therapy(ART) in rural China.METHODS: We conducted cross-sectional studies among the same population in 2010, 2012, and2014, based on data from standard medical record registers. Factors associated with anemia were evaluated using a logistic regression model.RESULTS: The number of patients with HIV infec-tion included in each cross-sectional study was1456 in 2010, 1531 in 2012, and 1567 in 2014, and the prevalence of anemia was 44.3%, 34.7%, and27.6%, respectively. The prevalence of anemia was lower in female patients in 2010 [odds ratio(OR)0.68; 95% confidence interval(CI) 0.55-0.85]; however, there was no difference by sex in 2012(OR0.90; 95% CI 0.72-1.11) and 2014(OR 1.05; 95% CI0.84-1.32). Patients with a higher level of education had a lower risk of anemia in 2014(OR 0.72; 95% CI0.56-0.92), but there was no difference in 2010(OR1.00; 95% CI 0.79-1.25) and 2012(OR 0.99; 95% CI0.79-1.24). Patients who had received a longer duration of ART had a higher risk of anemia in 2014(OR1.74; 95% CI 1.15-2.64), but there was no difference in 2010 and 2012(P > 0.05). Patients receiving Traditional Chinese Medicine(TCM) therapy had a lower risk of anemia.CONCLUSION: The prevalence of anemia among patients with HIV infection receiving ART decreased between 2010 and 2014 in Henan Province but was still higher than the prevalence in the general population of China. TCM therapy can potentially decrease the risk of anemia among patients with HIV infection.

关键词： Anemia HIV Acquired Immunodeficiency Syndrome Medicine,Chinese traditional Antiretroviral therapy

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Effectiveness of Xielikang capsules in treating HIV-related diarrhea by increasing the plasma concentration of interleukin-17

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Journal of Traditional Chinese Medicine 2017年第5期37卷 616-620页

作者： Zhang Xiaowei Guo Huijun Li Zhen xu liran Zhang Aiping Ji Aiying Department of Clinical Research Center of Acquired Immune Deficiency Syndrome Acquired Immune Deficiency Syndrome The First Affiliated Hospital of Henan University of Traditional Chinese Medicine Zhengzhou 450000 China Department of Obstetrics and Gynecology Zhengzhou Hospital of Traditional Chinese Medicine Zhengzhou 450000 China Department of Digestion The First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou 450000 China

OBJECTIVE: To evaluate the efficacy of Xielikang capsules(XLKC) in the treatment of HIV-related diarrhea(HRD) and its effect on the plasma concentration of interleukin-17(IL-17).METHODS: This was a randomized, open-label, pos-itively-controlled clinical trial. Sixty-seven HRD patients were randomly assigned to two groups: one group was treated with XLKC(n = 35), the other with diosmectite(Smecta~?, n = 32). All patients were treated for 4 weeks. The HRD symptom scores were evaluated in each patient based on the frequency of diarrhea, and the quality and shape of the stool according to the Chinese Medicine Clinical Treatment of AIDS Program. The plasma concentration of IL-17 before and after treatment was measured with ELISA.RESULTS: Compared with the Smecta~? group, the XLKC group had a significantly reduced frequency of diarrhea and HRD symptom score regarding the quality and shape of stools(P < 0.05). The IL-17 concentration in the peripheral blood of the XLKC group was significantly increased after treatment,while the IL-17 concentration in the Smecta~? group significantly decreased after treatment.CONCLUSION: XLKC improves the symptoms of patients with HRD, and increases the plasma concentration of IL-17.

关键词： HIV 获得的免疫不全症候群腹泻 Interleukin-17 Xielikang 囊

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Prevalence of liver injury among patients with acquired immunodeficiency syndrome treated with highly active antiretroviral therapy in China

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Journal of Traditional Chinese Medicine 2019年第2期39卷 275-280页

作者： Yuan Jun xu Qianlei Chen Xiumin Meng Pengfei Li Qingya xu liran Meng Xiangle Jin Yantao Guo Huijun Department of AIDS Treatment and Research Center the First Affiliated Hospital of Henan University of Traditional Chinese Medicine

OBJECTIVE: To estimate the prevalence of liver injury among patients with acquired immunodeficiency syndrome(AIDS) who received highly active antiretroviral therapy(HAART) in rural Henan Province in China, and to explore whether Traditional Chinese Medicine(TCM) treatment based on HAART would increase this risk.METHODS: This was a retrospective cross-sectional study. We collected medical information on patients with AIDS from two treatment databases in2014. Criteria established by the AIDS Clinical Trials Group in 1996 were used for grading liver injury,classified based on the limit of normal(ULN) for alanine transaminase and aspartate aminotransferase:grade 1(1.25-2.5 × ULN); grade 2(2.6-5 × ULN);grade 3(5.1-10 × ULN); and grade 4(> 10 × ULN).Factors associated with liver injury were evaluated using a logistic regression model.RESULTS: A total 6953 patients with AIDS(3324 male and 3629 female patients) were enrolled into this study. The prevalence of liver injury was 22.0%(18.0% grade 1, 3.1% grade 2, 0.9% grade 3). In multivariate analysis, patients aged 34-45 years were more likely to have liver injury than patients in other age groups [adjusted odds ratio(AOR), 1.39; 95%CI, 1.01-1.91)]. Other factors associated with liver injury included male sex(AOR, 1.64; 95% CI,1.46-1.85), HIV infection via blood(AOR, 1.47; 95%CI, 1.19-1.82), hepatitis B virus antibody positive(AOR, 1.07; 95% CI, 0.85-1.36), and hepatitis C virus(HCV) antibody positive(AOR, 2.76; 95% CI,2.28-3.34).CONCLUSION: The prevalence of liver injury was relatively high among HAART-experienced patients. Several factors associated with liver injury included male sex, age 35-45 years old, HIV infection through blood, and concurrent HCV infection. TCM had no relationship with liver injury in patients receiving HAART.

关键词： Acquired immunodeficiency syndrome Chemical and drug induced liver injury Prevalence Antiretroviral therapy,highly active Medicine,Chinese traditional

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艾滋病功能性治愈治疗策略研究进展

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中国艾滋病性病 2024年第4期30卷 424-430页

作者：张烨煊刘真岳静宇齐聪聪周雪倩徐立然河南中医药大学郑州450046 河南中医药大学第一附属医院郑州450000 河南省病毒性疾病中医药防治重点实验室郑州450000 豫药全产业链研发河南省协同创新中心郑州450046

自cART应用以来,艾滋病患者的疾病进展和病死率得到了极大缓解。由于HIV储存库的隐匿性和潜伏性的特点,在治疗中彻底清除病毒、实现根除性治愈具有很大障碍,使HIV/AIDS患者获得功能性治愈便成为近年来HIV相关治疗研究的主要目标。本文... 详细信息

自cART应用以来,艾滋病患者的疾病进展和病死率得到了极大缓解。由于HIV储存库的隐匿性和潜伏性的特点,在治疗中彻底清除病毒、实现根除性治愈具有很大障碍,使HIV/AIDS患者获得功能性治愈便成为近年来HIV相关治疗研究的主要目标。本文从治疗新思路、单一治疗策略、联合治疗策略等方面对近年来功能性治愈研究进展做出相关阐述,为功能性治愈可行方案寻求思路。

关键词： 1型艾滋病病毒功能性治愈治疗策略潜伏储存库

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“种子-土壤”说与胃癌的发生、发展

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中医学报 2024年第5期39卷 948-952页

作者：孙圣雨徐立然侯思伟河南中医药大学河南郑州450046 河南中医药大学第一附属医院河南郑州450000 河南省病毒性疾病中医药防治重点实验室河南郑州450000

“种子-土壤”说的核心观点为癌症发生具有三个要素:基因、环境和癌,可分别形象地认识为种子、土壤和癌肿(毒草)。在中医理论中,就有“土爰稼穑”的概念,并且脾胃在中医理论体系当中就以“土”性居后天之本的重要位置。同时,近年的研究... 详细信息

“种子-土壤”说的核心观点为癌症发生具有三个要素:基因、环境和癌,可分别形象地认识为种子、土壤和癌肿(毒草)。在中医理论中,就有“土爰稼穑”的概念,并且脾胃在中医理论体系当中就以“土”性居后天之本的重要位置。同时,近年的研究表明,中医体质与人体致病、治疗与预后密切相关。中医辨证论治可通过对“土壤”偏性及偏颇体质的整体调整,杜绝“种子”的生长发育,从本质上干预胃癌的发生。将中医辨证论治与“种子-土壤”说原理相结合,通过改变“土壤”环境,以辨证论治为法,以扶正祛邪为治则,以阴阳平衡为目标,可达到纠正“土壤”偏性、祛除病理产物的效果。

关键词： “种子-土壤”说胃癌胃府中医体质

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基于五行学说探讨从肝防治COVID-19

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中国中医药现代远程教育 2024年第4期22卷 76-78页

作者：杨瑞涵马秀霞徐立然河南中医药大学研究生院河南郑州450046 河南中医药大学第一附属医院艾研中心河南郑州450000 河南省病毒性疾病中医药防治重点实验室河南郑州450008

新型冠状病毒肺炎(COVID-19)肆虐至今,中医药对其的防控与治疗发挥了不可替代的作用。作者基于中医五行学说,从中西医不同角度出发,探讨肝与肺两脏之间的生理联系、病理影响。尤其强调COVID-19与肝脏的功能、机体免疫以及人体正气之间... 详细信息

新型冠状病毒肺炎(COVID-19)肆虐至今,中医药对其的防控与治疗发挥了不可替代的作用。作者基于中医五行学说,从中西医不同角度出发,探讨肝与肺两脏之间的生理联系、病理影响。尤其强调COVID-19与肝脏的功能、机体免疫以及人体正气之间的关系,以期从中西医不同角度探讨从肝防治COVID-19的科学内涵,为中医药防治COVID-19提供理论依据与科研思路。

关键词：疫病新型冠状病毒肺炎中医五行肝

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