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Isolated traumatic orbital floor fracture: An analysis of the National Trauma Data Bank

世界耳鼻咽喉头颈外科杂志英文版 2024年第3期10卷 187-192页

作者： De Ravin Emma xu katherine Fritz Christian S. Parhar Harman Rajasekaran Karthik Department of Otorhinolaryngology Head and Neck Surgery University of Pennsylvania Philadelphia Pennsylvania USA Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA Leonard Davis Institute of Health Economics University of Pennsylvania Philadelphia Pennsylvania USA

Objectives: To date, no study provides a comprehensive analysis of traumatic orbital floor fractures across the United States. We aimed to characterize patient demographics, injury-related variables, and operative management in this ***: The National Trauma Data Bank was queried for open or closed orbital floor fractures from 2008 to 2016. Clinical data were ***: Overall, 148,592 orbital floor fractures were identified, with 142,577 (95.9%) closed- and 6158 (4.1%) open-type fractures. A total of 106,243 (71.5%) patients were male and the median patient age was 41 years. The majority of patients (79.2%) had abbreviated injury scale scores of ≤2, indicating minor/moderate injury. Fracture mechanism of injury (MOI) differed by gender, with the most frequent being unarmed fights in men (34.3%) and falls in women (14.0%). There were 29,600 patients (19.9%) with isolated orbital floor (I-OF) fractures. The MOI most strongly associated with operative intervention of with I-OF fractures were penetrating injuries caused by a firearm (odds ratio [OR]: 2.91; 95%confidence interval [CI]: 1.62–5.20) and cuttings/piercings (OR: 2.17; 95%CI: 1.29–3.65).Conclusion: This large epidemiological study reveals that orbital floor fractures tend to present with minor or moderate injuries and are more likely to require operative intervention in setting of firearm or cut/pierce injuries.

关键词： epidemiology National Trauma Data Bank orbital fracture risk factors trauma

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A comprehensive review and characterization of nasopharyngeal carcinoma clinical trials

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第2期9卷 174-182页

作者： katherine xu Emma De Ravin Neeraj Suresh Robert M.Brody Karthik Rajasekaran Department of Otorhinolaryngology-Head&Neck Surgery University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Perelman School of Medicine at the University of Pennsylvania PhiladelphiaPennsylvaniaUSA Leonard Davis Institute of Health Economics University of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:Although standard of care for primary nasopharyngeal carcinoma(NPC)is chemoradiotherapy,there remains no consensus on management of recurrent or metastatic *** characterized recent clinical trials on NPC to assess trends in NPC treatment and establish promising areas for future *** Design:Retrospective database ***:*** ***:Retrospective review of all NPC trials from November 1999 to June *** each study,the following variables were extracted:study characteristics,intervention,outcome measures,and inclusion *** searches via PubMed and Google scholar determined trial publication ***:A total of 448 clinical trials were identified:72(16%)observational and 376(84%)interventional,of which there were 30(8%)Phase I,183(49%)Phase II,86 Phase III(23%),and 5(1%)Phase IV ***-four percent of trials included only primary NPC while 111(25%)exclusively studied recurrent *** most common interventions were cisplatin(n=64)and intensity modulated radiation therapy(n=54);there were 38 trials involving PD-1 monoclonal ***-four studies examined quality of life measures,including xerostomia and *** the completed studies,53.2%have published *** patient accrual was the most common reason for premature study ***:Novel immunotherapies have been increasingly incorporated into NPC studies in recent years,however,chemotherapy and radiation,despite their numerous side effects,are still widely used due to their clinical *** trials are warranted to determine the optimal therapeutic regimens to decrease relapse rates and side effects.

关键词： chemoradiotherapy clinical trial immunotherapy nasopharyngeal carcinoma nasopharyngeal neoplasms

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The Or Gene Enhances Carotenoid Accumulation and Stability During Post-Harvest Storage of Potato Tubers

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Molecular Plant 2012年第2期5卷 339-352页

作者： Li Li Yong Yang Qiang xu katherine Owsiany Ralf Welsch Chureeporn Chitchumroonchokchai Shan Lu Joyce Van Eck Xiu-Xin Deng Mark Failla Theodore W. Thannhauser Robert W. Holley Center for Agriculture and Health USDA-ARS Cornell University Ithaca NY 14853 USA Department of Plant Breeding and Genetics Cornell University Ithaca NY 14853 USA Key Laboratory of Horticultural Plant Biology （Ministry of Education） Huazhong Agricultural University Wuhan Hubei China Faculty of Biology University of Freiburg Freiburg Germany Department of Human Nutrition Ohio State University Columbus OH 43210 USA State Kay Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Nanjing 210093 China Boyce Thompson Institute for Plant Research Cornell University Ithaca NY 14853 USA

Provitamin A carotenoids in staple crops are not very stable during storage and their loss compromises nutritional quality. To elucidate the fundamental mechanisms underlying carotenoid accumulation and stability, we investigated transgenic potato tubers that expressed the cauliflower Orange （Or） gene. We found that the Or transgene not only promoted retention of 13-carotene level, but also continuously stimulated its accumulation during 5 months of cold storage. In contrast, no increased levels of carotenoids were observed in the tubers of vector-only controls or a yellow- flesh variety during the same period of storage. The increased carotenoid accumulation was found to be associated with the formation of lipoprotein-carotenoid sequestering structures, as well as with the enhanced abundance of phytoene synthase, a key enzyme in the carotenoid biosynthetic pathway. Furthermore, the provitamin A carotenoids stored were shown to be stable during simulated digestion and accessible for uptake by human intestinal absorptive cells. Proteomic analysis identified three major functional groups of proteins （i.e. heat shock proteins, glutathione-S-transferases, and carbohydrate metabolic proteins） that are potentially important in the Or-regulated carotenoid accumulation. Our results show that regulation of carotenoid sequestration capacity is an important mechanism by which carotenoid stability is regulated. Our findings suggest that induction of a proper sink structure formation in staple crops may provide the crops with a unique ability to promote and/or stabilize provitamin A accumulation during plant growth and post-harvest storage.

关键词： Carotenoids chromoplasts Or gene potato provitamin A loss staple crops post-harvest storage.

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Chinese Journal of Plastic and Reconstructive Surgery 2022年第4期4卷 171-177页

作者： Youbai Chen Tianqi Li Yujian xu Jiahua Xing Weiqian Jiang Xiangye Yin Haizhong Zhang Meredith August katherine P.Klein Tong Zhang Department of Plastic and Reconstructive Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Oral and Maxillofacial Surgery Massachusetts General HospitalBeijing 100853China Department of Stomatology The First Medical CenterChinese PLA General HospitalBostonMA 02114USA Harvard School of Dental Medicine BostonMA 02115USA

Background:Although oral health-related quality of life(OHRQoL)in orthodontic patients has been assessed in the past,to date,no study has compared the OHRQoL between two *** aimed to compare the OHRQoL between Chinese and American orthodontic ***:We conducted a two-center questionnaire-based cross-sectional study among patients who underwent orthodontic treatments at the Chinese PLA General Hospital(PLAGH)in Beijing,China and Massachusetts General Hospital(MGH)in Boston,Massachusetts,United *** variables included the participating center,patients’age,sex,Angle’s classification of malocclusion,evaluation stage,and appliances *** primary outcome was patients’OHRQoL assessed with the Oral Health Impact Profile-14(OHIP-14).Descriptive statistics,stratification,and univariate and multivariate analyses were ***:The average age was lower for PLAGH patients than for MGH patients(21.1±7.9 vs.33.1±14.6 years,P<0.001).The most common type of malocclusion was Angle’s Class III malocclusion at PLAGH(39%)and Class I malocclusion at MGH(59.5%).Clear aligners were used in 34.1%and 2.7%of the patients at MGH and PLAGH,***-14 scores were lower for PLAGH patients than for MGH patients(18.4±4.7 vs.22.3±7.4,P<0.001),particularly in functional limitation,psychological discomfort/disability,and *** regression analysis demonstrated that participating center,age,Class I malocclusion,and the use of clear aligners were significantly associated with overall OHIP-14 *** regression analysis demonstrated that patients at PLAGH were associated with lower OHIP-14 scores(coefficient:-3;95%CI:-5,-1.3;P=0.001),and age was positively associated with OHIP-14 scores(coefficient:0.1;95%CI:0.004,0.13;P=0.038).Conclusion:Chinese orthodontic patients had lower OHIP-14 scores,indicating a higher OHRQoL than American *** addition to the younger age,this difference may be attributed to the different ethical

关键词： Oral Health Impact Profile Orthodontic treatment Quality of life Chinese PLA General Hospital Massachusetts General Hospital

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New Reagents for （CF2）n Transfer and the Construction of Fluoroalkyl-Containing Rings

New Reagents for （CF2）n Transfer and the Construction of F...

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中国化学会全国第十一届有机合成化学学术研讨会

作者： Peter Kaplan Bo Chen Siqi Yu Long xu katherine McGarry David A.Vicic Department of Chemistry Lehigh UniversityBethlehemPA 18015 USA

The preparation of a new series of dinuclear zinc reagents is reported（eqs 1 and 2）.Unlikeα,ω-difunctionalized perfluoroalkyl di-Grignard reagents,which have a half-life of only two hours at -50℃in THF,we observed that 87% of the dizinc reagents remained in acetonitrile solution after 300 h at room *** demonstrate that the reagents can be used to prepare novel fluoroorganics containing either perfluoroalkyl ring systems or perfluoroalkyl linked arenes under relatively mild conditions（eqs 3 and 4）.We also show that these zinc reagents can be used to transmetalate nickel to form monocuclear *** reaction conditions are needed for different chain lengths because in some instances the perfluoroalkylations are competitive with unusual dicuprate *** also present results demonstrating that perfluoroalkyl-based metallacycles are exceptionally effective at stabilizing high valent metal complexes.

关键词： Fluoroalkylation Fluorine Copper Zinc

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2014美国连锁企业500强

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创业邦 2014年第8期 72-73页

作者： katherine Duncan Tracy Stapp Herold Yelena xu

儿童教育、食品、健身、老年人护理和数码产品连锁店在过去一年中格外火热。2013年,美国经济呈现复苏趋势,但增长略有缓慢。国际连锁协会（IFA）曾预计2013年度连锁店数量增幅将达1.4%（而此数字在2012年为1.5%,是2008年以来的首次增长... 详细信息

儿童教育、食品、健身、老年人护理和数码产品连锁店在过去一年中格外火热。2013年,美国经济呈现复苏趋势,但增长略有缓慢。国际连锁协会（IFA）曾预计2013年度连锁店数量增幅将达1.4%（而此数字在2012年为1.5%,是2008年以来的首次增长）。在过去一年,美国连锁行业多了1.1万个新建店铺,贡献了15万个工作岗位,在新建企业数量及就业增长率两方面均领先于其他行业。事实上,连锁领域的岗位数量占美国新增岗位的10%左右。

关键词：连锁行业老年人护理就业增长率儿童教育国际连锁工作岗位连锁品牌家庭护理连锁业连锁商业

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High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis

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World Journal of Gastroenterology 2015年第18期21卷 5513-5523页

作者： Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong xu Alexandros D Polydorides Li-Yan xue katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy Institute for Technology Assessment Massachusetts General Hospital Harvard Medical School Boston MA 02114 United States Gastrointestinal Unit Massa- chusetts General Hospital Department of Endoscopy Cancer Institute and Hospital Chinese Academy of Medical Sciences Department of Endoscopy The First Hospital of Jilin University Department of Pathology The Mount Sinai Medical Center Icahn School of Medicine Department of Pathology Cancer Institute and Hospital Chinese Academy of Medical Sciences Department of Bioengineering Rice University Baylor Global Initiatives and the Baylor Global Innovation Center Baylor College of Medicine

AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in ***:A decision analytic Markov model of ESCC was *** model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in *** 50-year-old individuals were followed until age 80 or *** compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an *** parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer *** states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and *** ESCC incidence transition rates were generated for the average-risk and high-risk *** in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price ***:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY *** endoscopic screening was weakly *** the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per *** both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per ***-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s i

关键词： Cost-effectiveness analysis Diagnostic imaging Endoscopy Esophageal squamous cell cancer Simulation disease model

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On the Tragedy of Miss Brill in katherine Mansfield's On the Tragedy of Miss Brill in katherine Mansfield's Miss Brill From the Perspective of Contrast

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校园英语 2016年第7期 254-255页

作者： xu Xiaojuan College of Foreign Studies Liaoning University

Miss Brill is a well-known short story of the English writer katherine Mansfield who is adept in the description of one’s interior monologue and analyzing the mental world of human *** contrasts between Miss Brill’s recalls of her past and the present world,between her good mood from the very beginning to the very end and bad mood in the end,and between the aging Miss Brill and the young lovers,this paper shows the loneliness,disillusionment and tragedy of Miss Brill.

关键词： Miss Brill Contrast Loneliness Tragedy Disillusionment

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Song of Herself: An Analysis of Southern Women's Consciousness in“The Jilting of Granny Weatherall”

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校园英语 2015年第2期 247-248页

作者： TANG xu Hengyang Normal University

"The Jilting of Granny Weatherall" is a short story by katherine Anne Porter representing her views of southern women’s self-consciousness in the male-dominated *** the one hand, Granny Weatherall stands for a typical southern woman who cherishes the conventional values in southern partriarchal *** the other, the sense of selfhood obtained from suffering many mishaps in her lifetime, in return, however, strengthens the subjective consciousness constructed through the stream-of-consciousness narrative technique, thus drawing an intimate portrait of a strong, independent woman.

关键词： sense of selfhood conventional southern values stream of consciousness

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论曼斯菲尔德叙事风格的形成

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上海师范大学学报（哲学社会科学版） 2006年第1期35卷 96-100页

作者：徐晗上海师范大学人文与传播学院上海200234

作为英国短篇小说领域的创新者之一,曼斯菲尔德的短篇小说呈现出与传统短篇小说极不相同的叙事风格,经其革新后的英国短篇小说面目一新,自此开始广受世人瞩目。但曼斯菲尔德短篇小说叙事风格的形成绝非一日之功,而是经过漫长的求索求变... 详细信息

作为英国短篇小说领域的创新者之一,曼斯菲尔德的短篇小说呈现出与传统短篇小说极不相同的叙事风格,经其革新后的英国短篇小说面目一新,自此开始广受世人瞩目。但曼斯菲尔德短篇小说叙事风格的形成绝非一日之功,而是经过漫长的求索求变过程。本文将其创作分为前期、转型期、后期三个创作阶段,撷取三个阶段中代表不同风格的三篇作品进行比较,以探知曼斯菲尔德的求变过程和最终风格的形成。

关键词：短篇小说创作叙事风格变化曼斯菲尔德

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