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Comparative analysis of the short and medium-term efficacy of the Da Vinci robot versus laparoscopic total mesangectomy for rectal cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1681-1690页

作者： Wei-Ge Gao Wen Shi xu-Chen gong Zhi-Wen Li Yiminjiang Tuoheti Department of Anorectal Surgery People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Anus and Intestine Surgery Cancer Hospital of Chinese Academy of Medical SciencesBeijing 100084China

BACKGROUND The Da Vinci robot-assisted surgery technique has been widely used in laparo-scopic mesangectomy for rectal ***,the short-term efficacy of these procedures compared to traditional laparoscopic surgery remains *** purpose of this study was to compare and analyze the short-and medium-term efficacy of Da Vinci robot and laparoscopic surgery in total mesangectomy(TME)for rectal cancer,so as to provide guidance and reference for clinical *** To investigate the safety and long-term efficacy of robotic and laparoscopic total mesorectal resection for the treatment of rectal *** The clinicopathologic data of 240 patients who underwent TME for rectal cancer in the Anorectal Department of People’s Hospital of Xinjiang Uygur Autonomous Region from August 2018 to March 2023 were retrospectively *** them,112 patients underwent laparoscopic TME(L-TME)group,and 128 patients underwent robotic TME(R-TME)*** intraoperative,postoperative,and follow-up conditions of the two groups were *** The conversion rate of the L-TME group was greater than that of the R-TME group(5.4%vs 0.8%,χ^(2)=4.417,P=0.036).The complication rate of the L-TME group was greater than that of the R-TME group(32.1%vs 17.2%,χ^(2)=7.290,P=0.007).The percentage of positive annular margins in the L-TME group was greater than that in the R-TME group(7.1%vs 1.6%,χ^(2)=4.658,P=0.031).The 3-year disease-free survival(DFS)rate and overall survival(OS)rate of the L-TME group were lower than those of the R-TME group(74.1%vs 85.2%,χ^(2)=4.962,P=0.026;81.3%vs 91.4%,χ^(2)=5.494,P=0.019);in patients with American Joint Committee on Cancer stage Ⅲ DFS rate and OS rate in the L-TME group were significantly lower than those in the R-TME group(52.5%vs 76.1%,χ^(2)=5.799,P=0.016;65.0%vs 84.8%,χ^(2)=4.787,P=0.029).CONCLUSION Compared with the L-TME group,the R-TME group had a better tumor prognosis and was more favorable for patients with rectal cancer

关键词： Rectal tumor Robots Laparoscopy Total mesangectomy Survival prognosis Retrospective analysis

Optimization of boron-containing acceptors towards high-efficiency TADF emitters: sky-blue OLEDs with external quantum efficiency of 32.6%

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Science China Materials 2024年

作者： xu gong Wei Yang He Zhang Weimin Ning Shaolong gong Xiang Gao Chuluo Yang Department of Chemistry Renmin Hospital of Wuhan University Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University Shenzhen Key Laboratory of New Information Display and Storage Materials College of Materials Science and Engineering Shenzhen University Department of Pharmacy Renmin Hospital of Wuhan University

Two new thermally activated delayed fluorescence（TADF） molecules, 13-（2,12-di-tert-butyl-5,9-dioxa-13bboranaphtho[3,2,1-de]anthracen-7-yl）-5,5-dimethyl-5,13-dihydrobenzo[4,5]thieno[3,2-c]acridine（BOBT） and 13-(4-（dimesitylboranyl）-3,5-dimethylphenyl)-5,5-dimethyl-5,13-dihydrobenzo[4,5]thieno[3,2-c]acridine（BPBT）, are constructed via connecting the 5,5-dimethyl-5,13-dihydrobenzo[4,5]thieno[3,2-c]acridine（BTDMAC） donor（D） with triarylboron or oxygen-bridged cyclized boron acceptors（A）, respectively. In comparison with the photoluminescence quantum yield（PLQY） of 84% for BPBT, BOBT shows a higher PLQY of100%, due to the multi-resonance effect of the boron-oxygen skeleton. In addition, the D-A-type molecular structural characteristic endows the boron-containing BOBT emitter with a fast reverse intersystem crossing rate on the order of 10～6s-1. The sky-blue organic light-emitting diode（OLED）employing the BOBT emitter achieves state-of-the-art device performances with a high external quantum efficiency of 32.6%.

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Efficacy and safety of targeted therapy plus immunotherapy combined with hepatic artery infusion chemotherapy (FOLFOX) for unresectable hepatocarcinoma

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World Journal of Gastroenterology 2024年第17期30卷 2321-2331页

作者： Zhi-Peng Lin Xiao-Long Hu Du Chen Da-Bei Huang xu-gong Zou Hai Zhong Sheng-Xiang xu Yuan Chen Xiao-Qun Li Jian Zhang Department of Interventional Medicine Zhongshan People’s HospitalZhongshan 528400Guangdong ProvinceChina

BACKGROUND The advent of cutting-edge systemic therapies has driven advances in the treatment of hepatocellular carcinoma(HCC),and therapeutic strategies with multiple modes of delivery have been shown to be more efficacious than ***,the mechanisms underlying this innovative treatment modality have not been *** To evaluate the clinical efficacy of targeted therapy plus immunotherapy combined with hepatic arterial infusion chemotherapy(HAIC)of FOLFOX in patients with unresectable *** We enrolled 53 patients with unresectable HCC who received a combination of targeted therapy,immunotherapy,and HAIC of FOLFOX between December 2020 and June 2021 and assessed the efficacy and safety of the treatment *** The objective response rate was 60.4%(32/53),complete response was 24.5%(13/53),partial response was 35.9%(19/53),and stable disease was 39.6%(21/53).The median duration of response and median progression-free survival were 9.1 and 13.9 months,*** surgical conversion rate was 34.0%(18/53),and 1-year overall survival was 83.0%without critical complicating diseases or adverse events(AEs).CONCLUSION The regimen of HAIC of FOLFOX,targeted therapy,and immunotherapy was curative for patients with unresectable HCC,with no serious AEs and a high rate of surgical conversion.

关键词： Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Targeted therapy Immunotherapy Adverse events

Integrating AnyLogic Simulation in Emergency Evacuation Management for Enhanced Security

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Journal of Electronic Research and Application 2024年第3期8卷 213-220页

作者： Lina Liu Songyan Liu xu gong School of China People’s Police University Langfang 065000Hebei ProvinceChina

This study introduces an innovative approach by integrating AnyLogic simulation into emergency evacuation strategies to enhance security *** research focuses on leveraging advanced computational models to simulate and optimize evacuation scenarios in various settings,including public venues,residential areas,and urban *** integrating real-world data and behavioral models,the simulation accurately represents human movements,decision-making processes,and traffic flow dynamics during evacuation *** study evaluates the effectiveness of various evacuation strategies,including route planning,crowd behavior,and emergency response coordination,using a scenario-driven approach within the AnyLogic simulation ***,this research contributes to the establishment of optimized emergency response protocols by systematically evaluating and refining evacuation *** research frameworks mentioned in the research imply the efficient use of the AnyLogic simulation model to be used in different sectors and fields to enhance the strategies for saving lives and implementing an efficient evacuation management system.

关键词： AnyLogic simulation model Evacuation management Security system simulation model

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我国《法律适用法》立法补缺规则的实践省思

当代法学 2024年第1期38卷 147-160页

作者：徐伟功中南财经政法大学法学院

《法律适用法》第2条第2款采取最密切联系原则克服立法的滞后性和不周延性。截至2023年8月31日,我国法院审理涉及第2条第2款涉外民商事案件近300件,其主要分布在东南沿海发达地区。第2条第2款主要适用于法律没有规定或法律规定不周延两... 详细信息

《法律适用法》第2条第2款采取最密切联系原则克服立法的滞后性和不周延性。截至2023年8月31日,我国法院审理涉及第2条第2款涉外民商事案件近300件,其主要分布在东南沿海发达地区。第2条第2款主要适用于法律没有规定或法律规定不周延两种情况,其运用过程中存在无推理、与其他条款混用及错误适用等问题。为了进一步提高第2条第2款司法实践运用水平,立法上应规定意思自治原则进行补充、实践上应明确其适用的具体范围、司法上应采取综合分析方法。

关键词：法律适用法最密切联系原则自由裁量权

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高雷诺数下覆羽控制直翼型流动分离的位置影响实验

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Acta Mechanica Sinica 2024年第4期40卷 125-135页

作者：巩绪安马兴宇姜楠 Department of Mechanics School of Mechanical EngineeringTianjin UniversityTianjin300354China National Key Laboratory of Aerodynamic Noise Control China Aerodynamics Research and Development CenterSichuan621000China National Key Laboratory of Science and Technology on Aerodynamic Design and Research School of AeronauticsNorthwestern Polytechnical UniversityXi’an710072China State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong UniversityChengdu610031China

本文在二维机翼上安装了仿生的覆羽结构,在5.0×105的雷诺数下研究它们控制前缘流动分离的效果.覆羽是指覆盖在鸟类翅膀上的多排短而柔软的带有锯齿状尖端的羽毛.它们覆盖在长而硬的飞羽边缘,使鸟的翅膀保持流线型.当流动分离发生时,这... 详细信息

本文在二维机翼上安装了仿生的覆羽结构,在5.0×105的雷诺数下研究它们控制前缘流动分离的效果.覆羽是指覆盖在鸟类翅膀上的多排短而柔软的带有锯齿状尖端的羽毛.它们覆盖在长而硬的飞羽边缘,使鸟的翅膀保持流线型.当流动分离发生时,这些柔性锯齿形的人工覆羽在来流的激励下能够自适应地变形和颤振.在风洞实验中,本文使用高时间分辨率的粒子图像测速仪(PIV)来测量机翼上表面的速度场,并使用热线风速仪来测量尾流中的高频湍流脉动.安装在20%弦长处的人工覆羽在前缘分离流的激励下会自适应地大幅翻转.安装在80%弦长处的覆羽则会被尾缘卷起的脱落涡向上抬起,并在准平衡状态下轻微摆动.这两类人工覆羽均能够有效地控制流动分离,并减小尾流的湍流脉动强度.

关键词：流动分离风洞实验分离流湍流脉动高时间分辨率热线风速仪高雷诺数锯齿形

基因工程菌药物递送系统在精准医疗中的研究进展

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生命科学 2024年第4期36卷 419-432页

作者：巩旭杨昀北京航空航天大学生物与医学工程学院北京100191

人体体表与体内存在大量共生微生物,微生物菌群与人类疾病发生、发展密切相关。随着合成生物学的发展,利用基因工程菌药物递送系统助力微生物-宿主互作机制探索以及疾病治疗成为研究热点。基因工程菌是基因工程改造后具有高效生产目标... 详细信息

人体体表与体内存在大量共生微生物,微生物菌群与人类疾病发生、发展密切相关。随着合成生物学的发展,利用基因工程菌药物递送系统助力微生物-宿主互作机制探索以及疾病治疗成为研究热点。基因工程菌是基因工程改造后具有高效生产目标产物能力的微生物。通过理性设计治疗靶点和药物递送基因回路,构建的基因工程菌可实现肠道或肿瘤等部位的精准靶向给药。本文对基因工程菌药物递送的三个关键特征,即药物分子、药物释放方式以及智能响应体系进行了综述,讨论了其在临床应用中需要应对的挑战,并展望了基因工程活体药物的发展前景。

关键词：基因工程菌药物递送药物分子释放方式智能响应

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Numerical Analysis of Explosion Characteristics of Vent Gas From 18650 LiFePO_(4) Batteries With Different States of Charge

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电化学（中英文） 2024年第8期30卷 28-35页

作者： Shi-Lin Wang xu gong Li-Na Liu Yi-Tong Li Chen-Yu Zhang Le-Jun xu xu-Ning Feng Huai-Bin Wang China People's Police University Langfang 065000China State Key Laboratory of Automotive Safety and Energy Tsinghua University Beijing 100084China

The combustion and explosion characteristics of lithium-ion battery vent gas is a key factor in determining the fire hazard of lithium-ion *** the combustion and explosion hazards of lithium-ion batteries vent gas can provide guidance for rescue and protection in explosion accidents in energy storage stations and new energy vehicles,thereby promoting the application and development of lithium-ion *** on this understanding and combined with previous research on gas production from lithium-ion batteries,this article conducted a study on the combustion and explosion risks of vent gas from thermal runaway of 18650 LFP batteries with different states of charge(SOCs).The explosion limit of mixed gases affected by carbon dioxide inert gas is calculated through the“elimination”method,and the Chemkin-Pro software is used to numerically simulate the laminar flame speed and adiabatic flame temperature of the battery vent *** the concentration of free radicals and sensitivity coefficients of major elementary reactions in the system are analyzed to comprehensively evaluate the combustion explosion hazard of battery vent *** study found that the 100%SOC battery has the lowest explosion limit of the vent *** inhibitory elementary reaction sensitivity coefficient in the reaction system is lower and the concentration of free radicals is ***,it has the maximum laminar flame speed and adiabatic flame *** combustion and explosion hazard of battery vent gas increases with the increase of SOC,and the risk of explosion is the greatest and most harmful when SOC reaches 100%.However,the related hazards decrease to varying degrees with overcharging of the *** article provides a feasible method for analyzing the combustion mechanism of vent gas from lithium-ion batteries,revealing the impact of SOC on the hazardousness of battery vent *** provides references for the safety of storage and transportation of lithium

关键词： Combustion and explosion characteristics Explosion limit Laminar flame speed Adiabatic flame temperature Sensitivity analysis

一类微生物连续发酵过程的GMA系统及其参数辨识

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兰州理工大学学报 2024年第4期50卷 153-158页

作者：赵雅芝徐恭贤渤海大学数学科学学院辽宁锦州121013

研究了一类微生物连续发酵过程的数学建模与参数辨识问题.提出了微生物连续发酵过程的GMA系统数学模型,并论述了该系统的数学性质.以状态变量的稳态实验数据与计算数据的误差平方和最小为性能指标构建了参数辨识模型.基于等价对数变换和... 详细信息

研究了一类微生物连续发酵过程的数学建模与参数辨识问题.提出了微生物连续发酵过程的GMA系统数学模型,并论述了该系统的数学性质.以状态变量的稳态实验数据与计算数据的误差平方和最小为性能指标构建了参数辨识模型.基于等价对数变换和SQP算法提出了一种参数辨识模型的求解方法,通过计算获得了最优参数值.与已有文献误差结果相比,取得了更小的浓度误差值.

关键词：连续发酵 GMA系统 1,3-丙二醇参数辨识

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