检索结果-南通市图书馆

Single-Nucleus RNA Sequencing Reveals Cardiac Macrophage Landscape in Hypoplastic Left Heart Syndrome

Congenital Heart Disease 2024年第2期19卷 233-246页

作者： Xiaozhuo xu Yilin Huang xu Han First Clinical Medical College Affiliated Hospital of Nanjing University of Chinese MedicineNanjing210008China Department of Geriatrics Affiliated Hospital of Nanjing University of Chinese MedicineNanjing210029China

Background:Hypoplastic left heart syndrome(HLHS)is one of the most challenging congenital heart diseases in clinical *** cardiac tissues,resident macrophages fulfill critical functions in maintaining a stable cardiac state and have strong regenerative capacity and organ ***,the molecular mechanisms of macro-phages in HLHS remained ***:Single-nucleus RNA sequencing(snRNA-seq)data of HLHS and healthy control(donors)samples obtained from the Gene Expression Omnibus(GEO)database were normalized and clustered using the Seurat ***“FindMarkers”function was used to screen differentially expressed genes(DEGs)between the HLHS and donor groups and to analyze the functional enrichment of the set of genes of ***,cell-cell communication,pseudotime,and single-cell regulatory network inference and cluster-ing(SCENIC)analyses were used to study the mechanisms of macrophages in ***:Based on the snRNA-seq data of HLHS and donors,we identified a total of 9 cell clusters,among which the proportion of macrophages was significantly less in the HLHS group than in the control *** of macrophage subpopulations(Macrophages 1,2,and 3)showed that Macrophages 1 was mainly involved in nervous system development,angiogenesis,and apoptotic *** addition,analysis of communication between Macro-phages 1 and cardiomyocytes revealed that ligand-acceptor pairs such as GAS6/AXL,IL6,IGF1,THY1,and L1CAM were present only in the donor ***,pesudotime and SCENIC analyses demonstrated that FOXO3 and ELF2 played a critical role for Macrophages 1 to maintain cardiac function in patients with ***:Our study improved the current understanding of the molecular mechanisms of macrophage devel-opment in HLHS,showing that manipulating the regulatory role of macrophages in the heart can be a novel treat-ment for HLHS.

关键词： Hypoplastic left heart syndrome single-nucleus RNA sequencing macrophage cellular subpopulation transcription factor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Global Tangentially Analytical Solutions of the 3D Axially Symmetric Prandtl Equations

引用

Chinese Annals of Mathematics,Series B 2024年第4期45卷 573-596页

作者： Xinghong PAN Chaojiang xu School of Mathematics and Key Laboratory of MIIT Nanjing University of Aeronautics and Astronautics Laboratoire de Mathématiques Rapha?l Salem UMR 6085 CNRSUniversité de Rouen Normandie

In this paper,the authors will prove the global existence of solutions to the three dimensional axially symmetric Prandtl boundary layer equations with small initial data,which lies in H1Sobolev space with respect to the normal variable and is analytical with respect to the tangential *** main novelty of this paper relies on careful constructions of a tangentially weighted analytic energy functional and a specially designed good unknown for the reformulated *** result extends that of Paicu-Zhang in[Paicu,*** Zhang,P.,Global existence and the decay of solutions to the Prandtl system with small analytic data,***.,241（1）,2021,403–446].from the two dimensional case to the three dimensional axially symmetric case,but the method used here is a direct energy estimates rather than Fourier analysis techniques applied there.

关键词： Axially symmetric Global existence Prandtl equations Tangentially analytical solutions

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The Essential 2-rank for Classical Groups

引用

Acta Mathematica Sinica,English Series 2024年第9期40卷 2169-2186页

作者： Jian Bei AN Yong xu Department of Mathematics University of AucklandAucklandNew Zealand School of Mathematics and Statistics He’nan University of Science and TechnologyLuoyang 471023P.R.China

Let G be a symplectic or orthogonal group defined over a finite field with odd characteristic and let D≤G be a Sylow *** this paper,we classify the essential 2-subgroups and determine the essential 2-rank of the Frobenius category FD(G).Together with the results of An–Dietrich and Cao–An–Zeng,this completes the work of essential subgroups and essential ranks of classical groups.

关键词： Frobenius category conjugation families essential 2-rank symplectic groups orthogonal groups

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamic Development Characteristics and Driving Factors of High Quality Development Level in China’s Five Major Urban Agglomerations

引用

Chinese Geographical Science 2024年第5期34卷 777-790页

作者： ZOU Weiyong xu Lingli School of Economics Guangdong Ocean UniversityZhanjiang 524088China School of Economics Shanghai UniversityShanghai 200444China

High-quality development is the primary task of comprehensively building a socialist,modern country,as well as the primary task of building urban agglomerations in *** on the five development concepts,this paper used the entropy method to measure the High Quality Development Index(HQDI)of the five major urban *** results showed that the HQDI of the five major urban agglomerations shows a fluctuating upward ***,using the Dagum Gini coefficient to explore the sources of HQDI development differences in urban agglomerations,we found that the main source of HQDI differences in urban agglomerations was inter-regional differences,while intra-regional differences were not ***,kernel density estimation was used to test the dynamic evolution trend of HQDI within urban *** was a polarisation phenomenon in the HQDI of urban agglomerations,such as the Pearl River Delta urban agglomeration and the Chengdu-Chongqing urban *** overall,the degree of imbalance had ***,using geographic detectors to examine the driving factors of HQDI in urban agglomerations,we found that the main driving forces for improving HQDI in urban agglomerations were economic growth,artificial intelligence technology and fiscal *** the interaction factors had greater explanatory power for the spatial differentiation of HQDI,which can be divided into two types:two-factor improvement and non-linear *** study is conducive to improving and enriching the theoretical system for evaluating the high quality development of urban agglomerations,and provides policy references for promoting the high quality development of urban agglomerations.

关键词： urban agglomeration High Quality Development Index(HQDI) spatio-temporal evolution driving factors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quantitative assessment of the breast cancer marker HER2 using a gold nanoparticle-based lateral flow immunoassay

引用

Nano Research 2024年第6期17卷 5452-5460页

作者： Liya Ye Xinxin xu Aihua Qu Liqiang Liu Chuanlai xu Hua Kuang International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and TechnologyJiangnan UniversityWuxi 214122China

Human epidermal growth factor receptor 2(HER2)is an important biomarker for detection and treatment of breast *** this study,we developed monoclonal antibodies against the extracellular domain(ECD)of HER2 and established a rapid and accurate lateral flow immunoassay(LFIA)for use in community medical *** gene sequence of human HER2-ECD was obtained from the National Center for Biotechnology Information(NCBI)to construct the expression ***2-ECD protein expressed in HEK293F cells was used to immunize BALB/c *** monoclonal antibodies were produced in mouse ascites and isolated by hybridoma cell *** were analyzed for purity by SDS-PAGE(sodium dodecyl sulphate-polyacrylamide gel-electrophoresis)and affinity was assessed by enzyme-linked immunosorbent assay(ELISA)while subtypes were detected using the commercial *** HER2-ECD test strip was prepared based on the sandwich method and evaluated using a portable detection *** affinity of the paired antibodies,4D8 and 8D9,both reached 1×108 L/*** antibodies specifically recognized the HER2-ECD protein in *** limit of detection(LOD)of the gold nanoparticle(AuNP)-based LFIA was 1.7 ng/mL with a detection range of 1.7-400 ng/mL,and the performance of the HER2-ECD strip correlated well with that of a Siemens chemiluminescent immunoassay(CLIA)*** conclusion,the paired antibodies were successfully prepared with high affinity and *** AuNP-based LFIA of HER2-ECD provides a fast and accurate method to detect the concentration of HER2-ECD in serum samples for clinical use in community medical institutions,and could contribute to determining the progress of the disease or the effectiveness of treatment.

关键词： human epidermal growth factor receptor 2 breast cancer monoclonal antibody quantitative lateral flow immunoassay

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

From charge storage mechanism to performance:A strategy toward boosted lithium/sodium storage through heterostructure optimization

引用

Journal of Energy Chemistry 2024年第1期88卷 112-124,I0003页

作者： Xiaoke Zhang Guangfa Deng Mianying Huang Zhaohui xu Jianlin Huang xuan xu Zhiguang xu Maochan Li Lei Hu Xiaoming Lin Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006GuangdongChina Anhui Laboratory of Functional Coordinated Complexes for Materials Chemistry and Application School of Chemical and Environmental EngineeringAnhui Polytechnic UniversityWuhu 241000AnhuiChina National Engineering Research Center for Carbohydrate Synthesis Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of EducationJiangxi Normal UniversityNanchang 330022JiangxiChina

Solving the problems of low electrical conductivity and poor cycling durability in transition metal oxidesbased anode materials for lithium-ion batteries(LIBs)and sodium-ion batteries(SIBs)has already turned into an urgent *** this paper,we successfully synthesized Co_(2)VO_(4)/Co compounds with Co-VMOF(metal-organic framework)as a sacrificial template and investigated their electrochemical mechanism in order to improve the electrochemical properties of LIBs and *** optimized heaping configuration and the existence of metallic Co catalyzed the formation of radical ions,thereby facilitating higher conductivity,shortening Li+and Na+transport paths,and providing more active ***_(2)VO_(4)/Co constructed with 2-methylimidazole as a ligand showed a discharge capacity of 1605.1 mA h g^(-1)after 300 cycles at 0.1 A g^(-1)in LIB and 677.2 mA h g^(-1)in *** functional theory(DFT)calculation emphasizes the crucial role of Co_(2)VO_(4)/Co in enhancing electrode conductivity,decreasing the migratory energy barrier,and thereby strengthening electrochemical *** heterostructure building technique may pave the way for the development of high-performance LIBs and ***,the problem of the low first-loop coulombic efficiency faced by transition metal oxides is improved.

关键词： Metal-organic framework Heterostructure Lithium-ion batteries Sodium-ion batteries DFT calculation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A gold-based multiplex immunochromatographic sensor for detecting paclitaxel

引用

Nano Research 2024年第7期17卷 6420-6429页

作者： Xiaoqian Jiang Aihua Qu Xinxin xu Hua Kuang Liqiang Liu Chuanlai xu State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and TechnologyJiangnan UniversityWuxi 214122China

Paclitaxel(PTX),methotrexate(MTX),and 5-fluorouracil(5-FU)are commonly-used small molecule anti-tumor drugs for breast ***,drug resistance occurs with long-term treatment or excessive use,and the high concentrations of PTX,MTX,and 5-FU in patients may lead to side effects with dose-limiting toxicities,such as myelosuppression,hepatotoxicity,and peripheral ***,concentration monitoring of PTX,MTX,and 5-FU in clinical treatment is very *** prepared highly sensitive and specific monoclonal antibodies using several haptens,and established a multiple paper-based sensor utilizing optical signals of gold nanoparticles,which simultaneously detected PTX,MTX,and 5-FU in human plasma or urine with 10 min.A portable scanner for quantitative detection in plasma and urine samples was used,and the calculated limit of detection(cLOD)values were 0.002 and 0.142μg/mL for PTX,0.187 and 0.976 ng/mL for MTX,and 0.057 and 0.128μg/mL for 5-FU,*** the recovery test,the recovery rates and the coefficient of variation were 85.84%–108.81%and 1.23%–8.80%,respectively,indicating the reliability and accuracy of the multiple gold immunochromatographic strip(GIS).In addition,for the determination of collected clinical plasma samples,the correlation between the test data of the multiple GIS and liquid chromatography–tandem mass spectrometry(LC–MS/MS)was ***,the developed multiple GIS could be applied to the rapid detection of PTX,MTX,and 5-FU in different clinical samples.

关键词： paclitaxel methotrexate 5-fluorouracil immunochromatographic assay plasma urine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transverse mode-coupling instability with longitudinal impedance

引用

Nuclear Science and Techniques 2024年第6期35卷 40-53页

作者： Hai-Sheng xu Chun-Tao Lin Na Wang Jing-Ye xu Yuan Zhang Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Institute of Advanced Science Facilities Shenzhen 518107GuangdongChina

Transverse mode-coupling instability(TMCI)is a dangerous transverse single-bunch instability that can lead to severe par-ticle *** mechanism of TMCI can be explained by the coupling of transverse coherent oscillation modes owing to the transverse short-range wakefield(i.e.,the transverse broadband impedance).Recent studies on future circular colliders,e.g.,FCC-ee,showed that the threshold of TMCI decreased significantly when both longitudinal and transverse impedances were *** performed computations for the circular electron-positron collider(CEPC)and observed a similar *** studies on the influence of longitudinal impedance on the TMCI threshold were *** concluded that the imaginary part of the longitudinal impedance,which caused a reduction in the incoherent synchrotron tune,was the primary reason for the reduction in the TMCI ***,the real part of the longitudinal impedance assists in increasing the TMCI threshold.

关键词： Transverse mode-coupling instability Longitudinal impedance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research on key technologies of UAV cluster cooperative system for Internet of Things applications

引用

Journal of Control and Decision 2024年第1期11卷 26-35页

作者： xu Jing Xi’an International University Xi’anPeople’s Republic of China

The combat tasks faced by UAVs are becoming more and more *** single UAVs are limited by the constraints of platform load capacity,lightweight load,and insufficient lowpower equipment,so it is difficult to complete complex tasks *** at typical UAV collaborative confrontation application scenarios,this paper constructs a multi-agentoriented cluster collaborative intelligent system architecture and establishes a swarm-oriented intelligent UAV cluster collaborative control ***,this paper forms a simulation environment for UAV cluster collaborative confrontation and completes the design and implementation of the UAV cluster collaborative confrontation system based on swarm *** addition,this paper analyses the key technologies of the UAV cluster collaborative system with the support of the Internet of Things technology and verifies the performance of the system after constructing the corresponding *** experimental results show that the system constructed in this paper is effective.

关键词： Internet of Things UAV cluster collaborative control key technology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Knowledge-enhanced Two-stage Generative Framework for Medical Dialogue Information Extraction

引用

Machine Intelligence Research 2024年第1期21卷 153-168页

作者： Zefa Hu Ziyi Ni Jing Shi Shuang xu Bo xu School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Institute of Automation Chinese Academy of SciencesBeijing 100190China

This paper focuses on term-status pair extraction from medical dialogues(MD-TSPE),which is essential in diagnosis dia-logue systems and the automatic scribe of electronic medical records(EMRs).In the past few years,works on MD-TSPE have attracted increasing research attention,especially after the remarkable progress made by generative ***,these generative methods output a whole sequence consisting of term-status pairs in one stage and ignore integrating prior knowledge,which demands a deeper un-derstanding to model the relationship between terms and infer the status of each *** paper presents a knowledge-enhanced two-stage generative framework(KTGF)to address the above *** task-specific prompts,we employ a single model to com-plete the MD-TSPE through two phases in a unified generative form:We generate all terms the first and then generate the status of each generated *** this way,the relationship between terms can be learned more effectively from the sequence containing only terms in the first phase,and our designed knowledge-enhanced prompt in the second phase can leverage the category and status candidates of the generated term for status ***,our proposed special status"not mentioned"makes more terms available and en-riches the training data in the second phase,which is critical in the low-resource *** experiments on the Chunyu and CMDD datasets show that the proposed method achieves superior results compared to the state-of-the-art models in the full training and low-re-sourcesettings.

关键词： Medical dialogue understanding information extraction text generation knowledge-enhanced prompt low-resource setting dataaugmentation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：