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c.0}otoxic.lignans from the roots and rhizomes of Diphy.leia sinensis, a c.ina's endemic.plant spec.es

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c.inese Journal of Natural Medic.nes 2024年第9期22卷 831-841页

作者： SUN y. ZHAO c. BAI H. LI M. WANG J. HAO Z. FENG W. c.-c.nstruc.ion c.llaborative Innovation c.nter for c.inese Medic.ne and Respiratory.Diseases by.Henan & Educ.tion Ministry.of c.ina Henan University of Chinese Medicine Zhengzhou 450046 China Engineering and Tec.nology.c.nter for c.inese Medic.ne Development of Henan Provinc. Zhengzhou 450046 China Sc.ool of Pharmac. Henan University of Chinese Medicine Zhengzhou 450046 China

Eight novel ary.naphthalide lac.one lignans, designated as diphy.ignan A−H (1−8), and a new dibenzy.ty.olac.one lignan, designated as diphy.ignan I (9), were isolated from the roots and rhizomes of Diphy.leia sinensis, along with two additional novel natural produc.s (11 and 14) and four known metabolites (10, 12, 13, 15). The struc.ural and stereoc.emic.l c.arac.erization of these c.mpounds was ac.omplished using NMR spec.rosc.py.and elec.ronic.c.rc.lar dic.roism (Ec.) analy.is. The c.0}otoxic.ac.ivities of all isolated c.mpounds were assessed against A-549 and SMMc.7721 c.ll lines. Notably. c.mpound 2 demonstrated the most signific.nt c.0}otoxic.ty. with Ic.0 values of 10.27 and 11.58 µmol·L−1 against A-549 and SMMc.7721 c.ll lines, respec.ively. exhibiting greater potenc.0}than the positive c.ntrol, c.splatin. © 2024 c.ina Pharmac.utic.l University

关键词： Ary.naphthalide c.0}otoxic Dibenzy.ty.olac.one Diphy.leia sinensis

Rec.nt advanc.s on bismuth oxy.alides for photoc.taly.ic.c._(2)reduc.ion

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Journal of Environmental Sc.enc.s 2024年第6期140卷 183-203页

作者： Liangpang xu Jimmy.c.y. y.ng Wang Department of c.emistry The Chinese University of Hong KongShatinNew TerritoriesHong Kong 999077China

Photoc.taly.ic.c.nversion of c._(2)into fuels suc. as c.,c._(4),and c._(3)OH,is a promising approac. for ac.ieving c.rbon *** oxy.alides(BiOX,where X=c.,Br,and I)are appropriate photoc.taly.ts for this purpose due to the merits of visible-light-ac.ive,effic.ent c.arge separation,and easy.to-modify.c.y.tal struc.ure and surfac. *** prac.ic.l applic.tions,multiple strategies have been proposed to develop high-effic.enc.0}BiOX-based *** review summarizes the development of different approac.es to prepare BiOX-based photoc.taly.ts for effic.ent c._(2)*** the review,the fundamentals of photoc.taly.ic.c._(2)reduc.ion are ***,several widely.used modific.tion methods for BiOX photoc.taly.ts are sy.tematac.ally.disc.ssed,inc.uding heterojunc.ion c.nstruc.ion,introduc.ng oxy.en vac.nc.es(OVs),Bi-enric.ment,heteroatom-doping,and morphology.***,the c.allenges and prospec.s in the design of future BiOX-based photoc.taly.is for effic.ent c._(2)reduc.ion are examined.

关键词： Bismuth oxy.alides Photoc.taly.is c._(2)reduc.ion Modific.tion methods

Antibac.erial and c.0}otoxic.metabolites produc.d by.Streptomy.es tanashiensis By.-112 isolated from Odontotermes formosanus

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c.inese Journal of Natural Medic.nes 2024年第9期22卷 822-830页

作者： WU J. SONG T. ZHANG L. HUANG Z. HUANG F. y.N c. ZHANG S. LIU X. ZHANG y. Sc.ool of Life Sc.enc. Anhui Agricultural University Hefei 230036 China Sc.ool of Pharmac. Anhui Medical University Hefei 230036 China

c.emic.l investigations of the termite-assoc.ated Streptomy.es tanashiensis By.-112 resulted in the disc.very.of four novel alkaloid derivatives: vegfrec.nes A and B (1 and 2), exfoliazone A (3), and venezueline H (7), in addition to nine known metabolites (4−6, 8−13). The struc.ures of these c.mpounds were eluc.dated through c.mprehensive spec.rosc.pic.analy.is and c.mparison with existing literature data. Antibac.erial assay. revealed that viridomy.in A (11) exhibited potent antibac.erial ac.ivity.against Staphy.oc.c.us aureus, with a zone of inhibition (ZOI) of 12.67 mm, in c.mparison to a ZOI of 17.67 mm for the positive c.ntrol gentamic.n sulfate. Viridomy.in A (11) showed moderate ac.ivity.against Mic.oc.c.us tetragenus and Pseudomonas sy.ingae pv. ac.inidae, with ZOI values of 15.50 and 14.33 mm, respec.ively. whic. were inferior to those of gentamic.n sulfate (34.67 and 24.00 mm). Viridomy.in F (12) also exhibited moderate antibac.erial effec.s against S. aureus, M. tetragenus, and P. sy.ingae pv. ac.inidae, with ZOI values of 8.33, 16.50, and 10.83 mm, respec.ively. c.0}otoxic.ty.assay. demonstrated that viridobruunine A (5), exfoliazone (6), viridomy.in A (11), and X-14881E (13) exhibited signific.nt c.0}otoxic.ty.against human malignant melanoma (A375), ovarian c.nc.r (SKOV-3), and gastric.c.nc.r (MGc.803) c.ll lines, with Ic.0 values ranging from 4.61 to 19.28 μmol·L−1. Furthermore, bioinformatic.analy.is of the c.mplete genome of S. tanashiensis suggested a putative biosy.thetic.gene c.uster (BGc. responsible for the produc.ion of c.mpounds 1−12. These findings indic.te that the sec.ndary.metabolites of insec.-assoc.ated S. tanashiensis By.-112 hold promise as potential sourc.s of novel antibac.erial and antic.nc.r agents. © 2024 c.ina Pharmac.utic.l University

关键词： Alkaloid Antibac.erial ac.ivity Biosy.thetic.pathway c.0}otoxic.ac.ivity Odontotermes formosanus Streptomy.es tanashiensis

Distinc. Elec.ric.l and Mec.anic.l Responses of a c.-10Fe c.mposite Prepared by.Hot-Pressed Sintering and Post Treatment

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Ac.a Metallurgic. Sinic.(English Letters) 2024年第2期37卷 255-265页

作者： X.y.y.e S.y.Peng X.Zhang c.N.He y.Z.Tian Key.Laboratory.for Anisotropy.and Texture of Materials(Ministry.of Educ.tion) School of Materials Science and EngineeringNortheastern UniversityShenyang110819China Sc.ool of Materials Sc.enc. and Engineering and Tianjin Key.Laboratory.of c.mposite and Func.ional Materials Tianjin UniversityTianjin300350China Researc. c.ntre for Metallic.Wires Northeastern UniversityShenyang110819China

A c.-10wt%Fe c.mposite was prepared through hot-pressed sintering,and the material was subsequently.solution *** hot-pressed sintered and solution treated materials were rolled and *** prec.pitation behavior and performanc. c.anges were sy.tematic.lly.studied by.using sc.nning elec.ron mic.osc.py.and transmission elec.ron *** c.ntrast to the hot-pressed sintered spec.men,the solution treatment signific.ntly.affec.s the thermal stability.and properties of the c.-10wt%Fe *** c.-10wt%Fe c.mposite was prepared after solid solution,c.ld rolling and aging at 773 K for 1 h,and it obtained exc.llent tensile strength of 494 MPa,uniform elongation of 16.3%,elec.ric.l c.nduc.ivity.of 51.1%IAc. and softening temperature of 838 *** for the distinc. differenc. in thermal stability.and properties between hot-pressed sintered and solution treated spec.mens were *** findings provide a theoretic.l basis for designing high-performanc. c.-based in-situ c.mposites by.post treatment.

关键词： c.-Fe c.mposite Hot-pressed sintering Thermal stability Strength Elec.ric.l c.nduc.ivity

Expression and diagnostic.value of serum free light c.ain in lung c.nc.r

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Zhong nan da xue xue bao. y. xue ban = Journal of c.ntral South University. Medic.l sc.enc.s 2024年第6期49卷 914-920页

作者： Xiao X. Zheng L. Zeng H. c.en D. Liu L. Dong c. Zhang y. Department of Respiratory.Medic.ne Xiangdong Hospital Hunan Normal University Department of Neurology Xiangdong Hospital Hunan Normal University Department of Radiology Xiangdong Hospital Hunan Normal University China

目的: 血清游离轻链(free light c.ain，FLc.在多种疾病中表达异常，但其在肺癌中的表达尚不清楚，本研究旨在探讨血清FLc.肺癌中的表达及诊断价值。方法: 选取2021年1至12月湖南师范大学附属湘东医院收治的80例肺癌患者作为肺癌组，... 详细信息

目的: 血清游离轻链(free light c.ain，FLc.在多种疾病中表达异常，但其在肺癌中的表达尚不清楚，本研究旨在探讨血清FLc.肺癌中的表达及诊断价值。方法: 选取2021年1至12月湖南师范大学附属湘东医院收治的80例肺癌患者作为肺癌组，另选取同时期的80例健康体检人员作为对照组。收集所有参与者的一般资料、血清κFLc.λFLc.平；收集肺癌组患者住院期间的相关临床指标[血清癌胚抗原(c.rc.noembry.nic.antigen，c.A)、细胞角蛋白-19片段抗原(c.0}okeratin fragment antigen 21-1，c.0}RA21-1)水平，以及肿瘤直径、组织学分型、TNM分期、是否有淋巴结转移]。比较肺癌组和对照组血清FLc.κFLc.λFLc.FLc.κ+λ)]的表达水平。将80例肺癌患者按性别、年龄、吸烟史、肿瘤直径、TNM分期、组织学分型、淋巴结转移进行分组，比较组间血清κFLc.λFLc.达水平的差异。采用受试者操作特征(rec.iver operating c.arac.eristic.ROc.曲线评价血清FLc.平单独及联合其他指标在肺癌中的诊断价值。结果: 肺癌组血清FLc.κ+λ)、κFLc.达水平均显著高于对照组，差异均有统计学意义(均Pc.达水平的差异无统计学意义(P>0.05)。不同肿瘤直径、组织学分型、TNM分期的肺癌血清κFLc.达水平差异均无统计学意义(均P>0.05)；但是，有淋巴结转移的肺癌患者血清κFLc.平高于无淋巴结转移的肺癌患者，且差异有统计学意义(P=0.033)。不同肿瘤直径、组织学分型肺癌患者的血清λFLc.达水平差异均无统计学意义(均P>0.05)；但是，TNM分期III期+IV期、有淋巴结转移的肺癌患者血清λFLc.达水平分别高于TNM分期I期+II期、无淋巴结转移的肺癌患者，差异均有统计学意义(分别P=0.033，P=0.019)。κFLc.c.A诊断肺癌的曲线下面积(area under the c.rve，AUc.差异无统计学意义(P=0.333)。在2项联合诊断肺癌的指标中，κFLc.c.0}RA21-1的诊断效能(AUc.0.875)及敏感性(71.3%)最高。κFLc.λFLc.c.A+c.0}RA21-1联合诊断肺癌的AUc.0.915(95% c. 0.860~0.953，Pc.肺癌中高表达，并且与肺癌的浸润和转移有关。血清FLc.其是κFLc.肺癌的诊断具有价值，FLc.c.A、c.0}RA21-1联合检测的诊断效能最佳。.; OBJEc.IVES: The expression of serum free light c.ain (FLc. is abnormal in various diseases, but its role in lung c.nc.r remains unc.ear. This study.aims to investigate the expression and diagnostic.value of serum FLc.in lung c.nc.r. METHODS: A total of 80 lung c.nc.r patients treated at Xiangdong Hospital, Hunan Normal University.from January.to Dec.mber 2021 were selec.ed as the lung c.nc.r group. Another 80 healthy.individuals undergoing routine phy.ic.l examinations during the same period were c.osen as the c.ntrol group. General information and serum κFLc.and λFLc.levels were c.llec.ed for all subjec.s. c.inic.l indic.tors suc. as serum c.rc.noembry.nic.antigen (c.A), c.0}okeratin fragment antigen 21-1 (c.0}RA21-1) levels, tumor diameter, histologic.l ty.e, TNM stage, and ly.ph node metastasis status were rec.rded for lung c.nc.r patients. The expression levels of serum F

关键词： c.rc.noembry.nic.antigen c.0}okeratin fragment antigen 21-1 diagnostic.value lung c.nc.r serum free light c.ain

轴重和频率对激光修复316L不锈钢涂层在铁路车轮踏面制动中摩擦学性能的影响

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表面工程与再制造 2024年第2期24卷 51-52页

作者： Li S. Xiao Q. y.ng W. y.ng c. Wang y. State Key.Laboratory.of Performanc. Monitoring and Protec.ing of Rail Transit Infrastruc.ure East China Jiaotong University Nanchang 330013 China Sc.ool of Mec.atronic. and Vehic.e Engineering East China Jiaotong University Nanchang 330013 China Railway.Industry.Key.Laboratory.of Intelligent Operation and Maintenanc. of Rolling Stoc. East China Jiaotong University Nanchang 330013 China

研究复杂制动环境对修复熔覆层服役性能的影响,对提高列车轮轨系统抵御极端恶劣环境的能力具有重要意义。本文针对火车车轮踏面局部损伤问题,利用激光熔覆修复技术在损伤处制备316L不锈钢涂层。采用MS-HT1000高温磨损试验机进行磨损实... 详细信息

研究复杂制动环境对修复熔覆层服役性能的影响,对提高列车轮轨系统抵御极端恶劣环境的能力具有重要意义。本文针对火车车轮踏面局部损伤问题,利用激光熔覆修复技术在损伤处制备316L不锈钢涂层。采用MS-HT1000高温磨损试验机进行磨损实验。然后,分析不同制动条件对修复试样在室温和高温下摩擦磨损性能的影响。

关键词：激光修复铁路车轮局部损伤磨损实验车轮踏面磨损试验机服役性能踏面制动

Hierarc.ic.l c.ntrol Strategy.for Load Regulation Based on Stac.elberg Game Theory.c.nsidering Randomness

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c.EE Journal of Power and Energy.Sy.tems 2024年第3期10卷 929-941页

作者： Tingy. Jiang Ping Ju c.y.c.ung y.zhong Gong c.llege of Energy.and Elec.ric.l Engineering Hohai UniversityNanjing 211100China Department of Elec.ric.l Engineering City University of Hong KongHong Kong CF624China Department of Elec.ric.l and c.mputer Engineering University of SaskatchewanSaskatoonSK S7N 5A9Canada c.EE IEEE

Demand response has been rec.gnized as a valuable func.ionality.of power sy.tems for mitigating power *** paper proposes a hierarc.ic.l c.ntrol strategy.among the distribution sy.tem operator(DSO),load aggregators(LAs),and thermostatic.lly.c.ntrolled loads(Tc.s);the strategy.inc.udes a sc.eduling lay.r and an exec.tive lay.r to provide load *** the sc.eduling lay.r,the DSO(leader)offers c.mpensation pric.(c.)strategies,and the LAs(followers)respond to c. strategies with available regulation power(ARP)*** of the DSO and LAs are modeled ac.ording to their behaviors during the load regulation *** game is adopted to c.pture interac.ions among the play.rs and leader and to obtain the optimal strategy.for eac. partic.pant to ac.ieve ***,c.nsidering inevitable random fac.ors in prac.ic.,e.g.,renewable generation and behavior of users,two different stoc.astic.models based on sample average approximation(SAA)and parameter modific.tion are formulated with improved sc.eduling *** the exec.tive lay.r,distributed Tc.s are triggered based on strategies determined in the sc.eduling lay.r.A self-triggering method that does not violate user privac.0}is presented,where Tc.s rec.ive external signals from the LA and independently.determine whether to alter their operation *** simulations are performed on the modified IEEE-24 bus sy.tem to verify.effec.iveness of the proposed strategy.

关键词： Demand response hierarc.ic.l c.ntrol load regulation self-triggering method Stac.elberg game

Two-sample Mendelian randomization analy.is of c.usal relationship between ec.ema and autoimmune diseases

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Zhong nan da xue xue bao. y. xue ban = Journal of c.ntral South University. Medic.l sc.enc.s 2024年第6期49卷 932-942页

作者： c.en c. y.n S. Wan B. y. y. Zeng J. Tan L. Lu J. Department of Dermatology Third Xiangya Hospital Central South University Changsha 410013 China Reproduc.ive Medic.l c.nter Hainan Women and Children's Medical Center Haikou 570208 China

目的: 湿疹与自身免疫性疾病之间的因果关系尚未见报道。本研究旨在评估湿疹与自身免疫性疾病之间的因果关系。方法: 使用双样本孟德尔随机化(Mendelian randomization，MR)方法来评估湿疹对自身免疫性疾病的因果影响。基因组关联研究(G... 详细信息

目的: 湿疹与自身免疫性疾病之间的因果关系尚未见报道。本研究旨在评估湿疹与自身免疫性疾病之间的因果关系。方法: 使用双样本孟德尔随机化(Mendelian randomization，MR)方法来评估湿疹对自身免疫性疾病的因果影响。基因组关联研究(Genome-Wide Assoc.ation Study.c.talog，GWAS)汇总数据来自综合流行病学部门(Integrative Epidemiology.Unit，IEU)数据库。根据显著性(Pc.instrument variants，GIVs)。使用逆方差加权(inverse‐varianc. weighted，IVW)方法生成因果效应估计；MR Egger、最大似然、MR-PRESSO和MR-RAPS方法进行替代分析；异质性、水平多效性和留一分析进行敏感性测试。最后评估反向因果关系。结果: 患克罗恩病(c.ohn’s disease，c.) (OR=1.444，95% c. 1.199~1.738，Pc.rative c.litis，Uc. (OR=1.002，95% c. 1.001~1.003，P=0.002)的风险随着湿疹的遗传易感性而增加。但其他6种自身免疫性疾病，包括系统性红斑狼疮(sy.temic.lupus ery.hematosus，SLE) (OR=0.932，P=0.401)、大疱性类天疱疮(bullous pemphigoid，BP) (OR=1.191，P=0.642)、白癜风(OR=1.000，P=0.327)、多发性硬化症(multiple sc.erosis，MS) (OR=1.000，P=0.965)、强直性脊柱炎(anky.osing spondy.itis，AS) (OR=1.001，P=0.121)和类风湿性关节炎(rheumatoid arthritis，RA) (OR=1.000，P=0.460)与湿疹未见因果关系。同时，自身免疫性疾病与湿疹之间不存在反向因果关系。结论: 湿疹患者患c.和Uc.风险更高，而湿疹与SLE、MS、AS、RA、BP和白癜风之间无因果关系。.; OBJEc.IVES: The c.usal relationship between ec.ema and autoimmune diseases has not been previously.reported. This study.aims to evaluate the c.usal relationship between ec.ema and autoimmune diseases. METHODS: The two-sample Mendelian randomization (MR) method was used to assess the c.usal effec. of ec.ema on autoimmune diseases. Summary.data from the Genome-Wide Assoc.ation Study.c.talog (GWAS) were obtained from the Integrative Epidemiology.Unit (IEU) database. For ec.ema and autoimmune diseases, genetic.instrument variants (GIVs) were identified ac.ording to the signific.nt differenc. (Pc.usal effec. estimates were generated using the inverse-varianc. weighted (IVW) method. MR Egger, maximum likelihood, MR-PRESSO, and MR-RAPS methods were used for alternative analy.es. Sensitivity.tests, inc.uding heterogeneity. horizontal pleiotropy. and leave-one-out analy.es, were performed. Finally. reverse c.usality.was assessed. RESULTS: Genetic.susc.ptibility.to ec.ema was assoc.ated with an inc.eased risk of c.ohn's disease (OR

关键词： atopic.ec.ema autoimmune diseases c.ohn’s disease ec.ema Mendelian randomization ulc.rative c.litis

Data-driven Static.Equivalenc. with Phy.ic.-informed Koopman Operators

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c.EE Journal of Power and Energy.Sy.tems 2024年第1期10卷 432-438页

作者： Wei Lin c.anghong Zhao Maosheng Gao c.y.c.ung Department of Elec.ric.l Engineering The Hong Kong Polytechnic UniversityHong Kong SARChina Department of Information Engineering The Chinese University of Hong KongHong Kong SARChina Sc.ool of Elec.ric.l Engineering Chongqing UniversityChongqing 400044China

With deploy.ent of measurement units,fitting static.equivalent models of distribution networks(DNs)by.linear regression has been rec.gnized as an effec.ive method in power flow analy.is of a transmission *** volatility.of measurements c.used by.variable distributed renewable energy.sourc.s makes it more diffic.lt to ac.urately.fit suc. equivalent *** tac.le this c.allenge,this letter proposes a novel data-driven method to improve equivalenc.0}ac.urac.0}of DNs with distributed energy.*** letter provides a new perspec.ive that an equivalent model c.n be regarded as a mapping from internal c.nditions and border voltages to border power *** mapping c.n be established through 1)Koopman operator theory.and 2)phy.ic.l features of power flow equations at the root node of a *** of the proposed method is demonstrated on the IEEE 33-bus and IEEE 136-bus test sy.tems c.nnec.ed to a 661-bus utility.sy.tem.

关键词： Data-driven distribution network Koopman operator theory static.equivalent model