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Characterization of a broad substrates specificity acyl-CoA:diacylglycerol acyltransferase 1 from the green tide alga Ulva prolifera

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Acta Oceanologica Sinica 2020年第10期39卷 42-49页

作者： Xiaowen Zhang Xiaoyuan Chi Yitao Wang Jian Zhang Yan Zhang dong xu Xiao Fan Chengwei Liang Naihao Ye Yellow Sea Fisheries Research Institute Chinese Academy of Fishery SciencesQingdao 266071China Function Laboratory for Marine Fisheries Science and Food Production Processes Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Shandong Peanut Research Institute Qingdao 266100China College of Marine Science and Biological Engineering Qingdao University of Science and TechnologyQingdao 266042China

Triacylglycerols(triglycerides,TAGs)are the major carbon and energy storage forms in various organisms,and important components of cellular membranes and signaling molecules;they have essential functions in multiple physiological processes and stress ***-CoA:diacylglycerol acyltransferase(DGAT)catalyzes the final and only committed acylation step in the synthesis of TAGs in *** present work identified and isolated a novel gene,UpDGAT1,from the green tide alga Ulva *** activity of UpDGAT1 was confirmed by heterologous expression in a Saccharomyces cerevisiae TAG-deficient quadruple *** of thin-layer chromatography and BODIPY staining indicated that UpDGAT1 was able to restore TAG synthesis and lipid body formation in the *** analysis of yeast cells revealed that UpDGAT1 showed broad substrate specificity,accepting saturated as well as mono-and polyunsaturated acyl-CoAs as *** salinity and high temperature stresses increased UpDGAT1 expression and TAG accumulation in *** present study provides clues to the functions of UpDGAT1 in TAG accumulation in,and stress adaptation of,***.

关键词： Ulva prolifera diacylglycerol acyltransferase triacylglycerol stress

A DIRECT DISCONTINUOUS GALERKIN METHOD FOR TIME FRACTIONAL DIFFUSION EQUATIONS WITH FRACTIONAL DYNAMIC BOUNDARY CONDITIONS

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Journal of Computational Mathematics 2024年第1期42卷 156-177页

作者： Jingjun Zhao Wenjiao Zhao Yang xu School of Mathematics Harbin Institute of TechnologyHarbin 150001China

This paper deals with the numerical approximation for the time fractional diffusion problem with fractional dynamic boundary *** well-posedness for the weak solutions is studied.A direct discontinuous Galerkin approach is used in spatial direction under the uniform meshes,together with a second-order Alikhanov scheme is utilized in temporal direction on the graded mesh,and then the fully discrete scheme is ***,the stability and the error estimate for the full scheme are analyzed in *** experiments are also given to illustrate the effectiveness of the proposed method.

关键词： Time fractional diffusion equation Numerical stability Convergence

Automatic Requirement Dependency Extraction Based on Integrated Active Learning Strategies

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Machine Intelligence Research 2024年第5期21卷 993-1010页

作者： Hui Guan Guorong Cai Hang xu Department of Computer Science and Technology Shenyang University of Chemical TechnologyShenyang110142China Key Laboratory of Industrial Intelligence Technology on Chemical Process Shenyang110142China

Since requirement dependency extraction is a cognitively challenging and error-prone task,this paper proposes an automatic requirement dependency extraction method based on integrated active learning *** this paper,the coefficient of variation method was used to determine the corresponding weight of the impact factors from three different angles:uncertainty probability,text similarity difference degree and active learning variant prediction divergence *** combining the three factors with the proposed calculation formula to measure the information value of dependency pairs,the top K dependency pairs with the highest comprehensive evaluation value are selected as the optimal *** the optimal samples are continuously added into the initial training set,the performance of the active learning model using different dependency features for requirement dependency extraction is rapidly ***,compared with other active learning strategies,a higher evaluation measure of requirement dependency extraction can be achieved by using the same number of ***,the proposed method using the PV-DM dependency feature improves the weight-F1 by 2.71%,the weight-recall by 2.45%,and the weight-precision by 2.64%in comparison with other strategies,saving approximately 46%of the labelled data compared with the machine learning approach.

关键词： Requirement dependency dependency extraction dependency features integrated active learning strategies coefficient of variation

Bioinspired Fluorescent Polymers: Synthesis, Processing, and Applications

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Chinese Journal of Chemistry 2023年第4期41卷 458-468页

作者： Hongxue xu Wei Zhang Mingfeng Wang School of Science and Engineering The Chinese University of Hong KongShenzhenGuangdong518172 China

The discovery of fluorescent proteins has inspired a lot of interest to develop synthetic polymers with similar structures and *** this review article,we first give a brief introduction for the discovery,the structural characteristics and optical properties of fluorescent proteins,using green fluorescent protein(GFP)as an *** the body part of article,we summarize recent advances in molecular design,synthesis and processing of bioinspired fluorescent polymers with unique optical properties such as high fluorescence quantum yield and robust *** major approaches highlighted here include the recombination of organic chromophores and proteins,and synthesis of the bioinspired polymers containing a single fluorophore in each polymer *** optical properties and applications of some representative bioinspired fluorescent polymers in bioimaging,sensing and imaging-guided therapy are also elucidated.

关键词： Green fluorescent protein Fluorescence Proteins Chromophores Polymers

Soil Salinity and Soil Water Content Estimation Using Digital Images in Coastal Field:A Case Study in Yancheng City of Jiangsu Province,China

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Chinese Geographical Science 2022年第4期32卷 676-685页

作者： xu Lu MA Hongyuan WANG Zhichun School of Geography Geomatics and PlanningJiangsu Normal UniversityXuzhou 221116China Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun 130012China

Soil is the essential part for agricultural and environmental sciences,and soil salinity and soil water content are both the important influence factors for sustainable development of agriculture and ecological *** camera,as one of the most popular and convenient proximal sensing instruments,has its irreplaceable position for soil properties *** this study,we collected 52 soil samples and photographs at the same time along the coast in Yancheng City of Jiangsu *** carefully analyzed the relationship between soil properties and image brightness,and found that soil salt content had higher correlation with average image brightness value than soil water *** the brightness levels,the high correlation coefficients between soil salt content and brightness levels concentrated on the high brightness values,and the high correlation coefficients between soil water content and brightness levels focused on the low brightness *** significance levels(P)determined different brightness levels related to soil properties,hence P value setting can be an optional way to select brightness levels as the input variables for modeling soil *** these information,random forest algorithm was applied to develop soil salt content and soil water content inversion models using randomly 70%of the dataset,and the rest data for testing *** results showed that soil salt content model had high accuracy(R_(v)^(2)=0.79,RMSE_(v)=12 g/kg,and RPD_(v)=2.18),and soil water content inversion model was barely satisfied(R_(v)^(2)=0.47,RMSE_(v)=3.04%,and RPD_(v)=1.38).This study proposes a method of modeling soil properties with a digital *** unmanned aerial vehicle(UAV),it has potential popularization and application value for precise agriculture and land management.

关键词： soil salinity soil water content coastal soil digital image

A“Transformers”-like nanochain for precise navigation and efficient cancer treatment

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Aggregate 2024年第4期5卷 426-433页

作者： Sichao Tian Qian Zeng Zhanglu Hu Weidong Zhang Zhuo Ao dong Han Qing-Hua xu Department of Chemistry National University of SingaporeSingaporeSingapore National University of Singapore(Suzhou)Research institute SuzhouChina Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijingChina School of Pharmacy Second Military Medical UniversityShanghaiChina School of Future Technology University of Chinese Academy of SciencesBeijingChina College of Life Sciences Beijing University of Chinese MedicineBeijingChina

Integrated multimodal imaging in theranostics nanomaterials offers extensive prospects for precise and noninvasive cancer *** controlling the structural evolution of plasmonic nanoparticles is crucial in the development of pho-tothermal ***,previous successes have been limited to static assemblies and single-component ***,an activatable plasmonic theranostics system utilizing self-assembled 1D silver-coated gold nanochains(1D nanochains)is pre-sented for precise tumor diagnosis and effective *** absorbance of the adaptable core–shell chain structure can shift from visible to near-infrared(NIR)regions due to the fusion between nearby Au@Ag nanoparticles induced by ele-vated H2O2 levels in the tumor microenvironment(TME),resulting in the creation of a novel 3D aggregates with strong NIR *** a high photothermal conversion efﬁciency of 60.2%at 808 nm,nanochains utilizing the TME-activated characteristics show remarkable qualities for photoacoustic imaging and signiﬁ-cantly limit tumor growth in *** study may pave the way for precise tumor diagnosis and treatment through customizable,optically tunable adaptive plasmonic nanostructures.

关键词： adjustable core–shell structure aggregation-induced emission metal nanochains photoacoustic imaging stimuli responsive therapy

Algebraic Properties of Powers of Edge Ideals of Vertex-Weighted Oriented Cycles

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Algebra Colloquium 2023年第4期30卷 649-666页

作者： Hong Wang Guangjun Zhu Li xu School of Mathematical Sciences Soochow UniversitySuzhouJiangsu 215006China

Let t be any positive integer and I(C_(n)) the edge ideal of a vertex-weighted oriented n-cycle graph C_(n).We provide explicit formulas for the regularity and depth of I(C_(n))^(t).In particular,we find that the regularity of I(C_(n))^(t)is a linear function;Ass(I(C_(n))^(t),the set of associated prime ideals of I(C_(n))^(t),equals Ass(I(C_(n))^(t);and the depth of I(C_(n))^(t)is a constant for *** also give some examples to show that these results are related to the direction selection of edges and the weight of vertices.

关键词： depth regularity powers of an ideal vertex-weighted oriented cycles

Metabolism and immunity in breast cancer

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Frontiers of Medicine 2021年第2期15卷 178-207页

作者： Deyu Zhang Xiaojie xu Qinong Ye Department of Medical Molecular Biology Beijing Institute of BiotechnologyBeijing 100850China

Breast cancer is one of the most common malignancies that seriously threaten women’s *** the process of the malignant transformation of breast cancer,metabolic reprogramming and immune evasion represent the two main fascinating characteristics of cancer and facilitate cancer cell *** cancer cells generate energy through increased glucose *** metabolism contributes to biological signal pathways and forms cell membranes except energy *** acids act as basic protein units and metabolic regulators in supporting cell *** tumor-associated immunity,poor immunogenicity and heightened immunosuppression cause breast cancer cells to evade the host’s immune *** the past few years,the complex mechanisms of metabolic reprogramming and immune evasion are deeply investigated,and the genes involved in these processes are used as clinical therapeutic targets for breast ***,we review the recent findings related to abnormal metabolism and immune characteristics,regulatory mechanisms,their links,and relevant therapeutic strategies.

关键词： breast cancer metabolism immunity cancer stem cells

Fabricating of Open-cell Porous Al-Si Alloy with Pressure Penetration Casting

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Journal of Materials Science & Technology 1999年第1期15卷 63-66页

作者： xu, Qingyan Chen, Yuyong Li, Qingchun Harbin Inst Technol Met Casting Lab Harbin 150001 Peoples R China

Open-cell porous Al alloy was fabricated by pressure penetration method and the fabrication of preform was studied in detail. When forming temperature is about 700 degree C and binder content is about 10%, preform with high compressive strength was obtained. Good porous Al alloy with pore size 0.5-1.6 mm and porosity 60%-80% can be obtained under 100 degree C super-heating of liquid metal and about 1.0 MPa applied pressure. The size of the largest sample is up to 100 mm in diameter and 100 mm in height. With the help of SEM it was found that the obtained material is a three-dimensional open-cell porous structure with well-distributed and connected with each other pores. Finally, theoretical analysis was carried out to explain the effect of fabricating process. (Edited author abstract) 4 Refs.

关键词： Aluminum alloys