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光通信技术 2016年第2期40卷 46-48页

作者：张志利王红伟徐庆继天津中德职业技术学院天津300350 中国电子科技集团公司第三十四研究所广西桂林541004

针对单纤双向光信号放大的光纤传感领域,设计了基于光开关的掺铒光纤放大器。介绍了双向掺铒光纤放大器的光路原理和电路原理,并进行了样机的实现实验。通过实验测试,实现了光信号的分时复用双向放大,双向增益一致性小于0.9dBm。

关键词：掺铒光纤放大器单纤双向光开关

Co(En)_3MoO_4晶体的水热合成与表征

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高等学校化学学报 1999年第8期20卷 1186-1188页

作者：王仁章李亚丰乔晓光杨国昱邢永恒曾庆新徐吉庆林永华邢燕贾恒庆吉林大学化学系长春130023 长春应用化学研究所

Co(En)\-3MoO\-4 was synthesized by using the method of hydrothermal synthesis and characterized by elemental analysis, IR, ESR and single\|crystal X\|ray methods. It crystallizes in hexagonal space group \%P3C1\% with \{\%a\%=1\^596 4(2) nm\}, \{\%b\%=1\^596 4(2) nm\}, \%c\%=\{0\^993 5(2)\} nm, \%α=β\%=90°, \%γ\%=120°, \%M\%\-c=399\^18, \%V\%=2\^192 6(6) nm\+3, \%D\%\-c=1\^814 g/nm\+3, \%Z\%=6, \%F\%(000)=1 218, \%R\%\-1=0\^070 3, \%R\%\-w=0\^220 7. According to separation of anion which acted on electrostatic potential, the anion and cation ions formed a type of organic and inorganic material.

关键词：杂多酸 Co(En)3MoO4 钴钼水热合成法晶体

锂离子电池健康状态估计及寿命预测研究进展综述

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高电压技术 2024年第3期50卷 1182-1195页

作者：熊庆邸振国汲胜昌西安交通大学电工材料电气绝缘全国重点实验室西安710049

随着锂离子电池的应用越来越广泛,锂电池健康状态的精确估计和剩余寿命的实时预测对于锂电池系统的安全运行和降低运维成本具有重要意义。锂电池内部复杂的物理化学反应和外部复杂工作条件,使得实现精准的健康状态估计和寿命预测具有挑... 详细信息

随着锂离子电池的应用越来越广泛,锂电池健康状态的精确估计和剩余寿命的实时预测对于锂电池系统的安全运行和降低运维成本具有重要意义。锂电池内部复杂的物理化学反应和外部复杂工作条件,使得实现精准的健康状态估计和寿命预测具有挑战性。该文综述近年来锂电池健康状态估计和剩余使用寿命预测方法的研究现状,分析基于物理/数学模型、数据驱动、模型法和数据驱动融合,以及多种数据驱动融合的锂电池健康状态估计方法的优缺点及适用条件,并对比分析不同数据驱动类型的锂电池寿命预测方法。指出锂电池健康状态估计及寿命预测尚存在的问题,并对未来研究方向进行展望,对完善锂电池健康状态估计和寿命预测算法理论体系、指导实际应用技术具有重要意义。

关键词：锂离子电池状态估计寿命预测电化学模型数据驱动技术

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商丘古城空间演变的文化生态环境分析

山西建筑 2010年第25期36卷 20-21页

作者：许继清刘利轩郑州大学建筑学院

运用文化生态学理论,对商丘古城空间演变的社会地理环境、社会经济环境、社会制度环境进行分析,指出地理环境是古城空间演变的直接动力,经济、制度环境是内在因素,正是基于这三种环境的影响,形成了商丘目前的空间形态。

关键词：古城文化生态学生态环境

Dcalycinumines A-E,Alkaloids with Cytotoxic Activities of Nasopharyngeal Carcinoma Cells from Daphniphyllum calycinum

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Chinese Journal of Chemistry 2024年第1期42卷 35-42页

作者： qing Tang Xiao-Yong Dai Qiang Lin Zhi-Peng Ling Yi-Kun Hao Tian-Xi Zhu ji-Hui Zhang Yi-Bo Hou Yao-Lan Li Lai-Qiang Huang jing-Hao Wang Guo-Cai Wang Yu-Bo Zhang Guangdong Clinical Translational Centerfor Targeted Drug Department of PharmacologySchoolof MedicineJinan University GuangzhouGuangdong 510632China Institute of Traditional Chinese Medicine&Natural Products Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchCollegeof PharmacyJinan UniversityGuangzhouGuangdong511443China Institute of Biopharmaceutical and Health Engineering Shenzhen Key Laboratory of Gene and Antibody TherapyState Key Laboratory of Chemical OncogenomicsShenzhen International Graduate SchoolTsinghua UniversityShenzhenGuangdong 518055China The Guangzhou Key Laboratoryof Basic and Translational Research on Chronic Disease Department of PharmacyThe First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510630China

Fivenovel Daphniphyllum alkaloids,named dcalycinumines A-E(1-4,6),andeight previously described Daphniphyllum alkaloids(5,7-13)were isolated from Daphniphyllum *** 1 is the first Daphniphyllum alkaloid possessing a highly rearranged 6/6/6/7/5/6 hexacyclic architecture with a unique 3-methyl-1-azabicyclo[4,4,0]decane ring *** 2 represents a rare diamino Daphniphyllum alkaloid with an unprecedented 6/5/5/6/6/5 carbon skeleton featuring a unique 1-aza-6-azaspiro[4,5]decane unit,whereas 3 also represents a rare diamino Daphniphyllum alkaloid as a possible precursor of *** 4 is the second example of c-22-nor yuzurimine-type *** structures and absolute configurations were elucidated by HRESIMS,NMR spectroscopic analyses,EcD calculations,and single-crystal X-ray ***,compound 1 showed remarkable antitumor activities,which could inhibit the proliferation,migration and invasion of nasopharyngeal carcinoma cells,and promoted nasopharyngeal carcinoma cells apoptosis.

关键词： Daphniphyllum calycinum Natural products Daphniphyllum alkaloid Structural elucidation Biological activity Apoptosis Nasopharyngealcarcinoma

Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC(CTONG1804):a multicenter open-label phase II study

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Signal Transduction and Targeted Therapy 2024年第1期9卷 249-258页

作者： Si-Yang Liu Song Dong xue-Ning Yang Ri-Qiang Liao Ben-Yuan jiang Qun Wang Xiao-Song Ben Gui-Bin Qiao Jun-Tao Lin Hong-Hong Yan Li-xu Yan Qiang Nie Hai-Yan Tu Bin-Chao Wang jin-ji Yang qing Zhou Hong-Rui Li Ke Liu Wendy Wu Si-Yang Maggie Liu Wen-Zhao Zhong Yi-Long Wu Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Department of Thoracic Surgery Zhongshan HospitalFudan UniversityShanghaiChina Department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Department of Pathology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Fujian Key Laboratory of Advanced Technology for Cancer Screening and Early Diagnosis FuzhouChina Berry Oncology Corporation FuzhouChina Chinese Thoracic Oncology Group(CTONG) GuangzhouChina Department of Hematology The First Affiliated HospitalJinan UniversityGuangzhouChina

This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive(N)and nivolumab–chemotherapy(N/C)combinations based on PD-L1 *** patients exhibited resectable clinical stage IIA–IIIB(AJCC 8th edition)NSCLC without EGFR/ALK *** received either mono-nivolumab(N)or nivolumab+nabpaclitaxel+carboplatin(N/C)for three cycles based on PD-L1 *** primary endpoint was the major pathological response(MPR).Key secondary endpoints included the pathologic complete response(pCR),objective response rate(ORR),and event-free survival(EFS).Baseline PD-L1 expression and perioperative circulating tumor DNA(ctDNA)status were correlated with pCR and ***-two patients were enrolled,with 46 undergoing *** MPR was 50.0%(26/52),with 25.0%(13/52)achieving pCR,and 16.7%and 66.7%for patients with PD-L1≥50%in N and N/C groups,***(25.0%)patients experienced grade 3 or higher immune-related adverse events during neoadjuvant *** with post-neoadjuvant ctDNA negativity was more likely to have pCR(39.1%)compared with those remained positive(6.7%,odds ratio=6.14,95%CI 0.84-Inf,p=0.077).With a median follow-up of 25.1 months,the 18-month EFS rate was 64.8%(95%CI 51.9–81.0%).For patients with ctDNA–***+,the 18m-EFS rate was 93.8%vs 47.3%(HR,0.15;95%CI 0.04,0.94;p=0.005).Immunochemotherapy may serve as an optimal neoadjuvant treatment even for patients with PD-L1 expression≥50%.ctDNA negativity following neoadjuvant treatment and surgery could help identify superior pathological and survival benefits,which requires further confirmation in a prospective clinical trial(NCT04015778).

关键词： chemotherapy NSCLC treatment

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罗马帝国应对低生育率的政策探析

史学集刊 2024年第3期 94-103页

作者：姬庆红兰州大学历史文化学院甘肃兰州730030

由于共和时期的对外征伐和内战仇杀,罗马公民人口呈减少趋势。帝国时期,精英阶层盛行不婚不育之风,人口生育率下降,公民家庭少子化现象严重。为解决人口危机,奥古斯都相继出台《反通奸法》《婚姻法》,倡导传统家庭观念,鼓励结婚多育并... 详细信息

由于共和时期的对外征伐和内战仇杀,罗马公民人口呈减少趋势。帝国时期,精英阶层盛行不婚不育之风,人口生育率下降,公民家庭少子化现象严重。为解决人口危机,奥古斯都相继出台《反通奸法》《婚姻法》,倡导传统家庭观念,鼓励结婚多育并惩罚不婚不育。后世诸帝大都奉行这类婚育法令,并加以补充和优化,特别是颁行了保障母子(女)权益、禁止弃婴及设立贫儿补助计划等法律,在一定程度上保障了妇女儿童的基本权益。为推行这些法令,帝王们通过发表演说、公开树立婚育典范、建造纪念碑和铸造钱币图案等形式宣传生育的重要性。这些生育政策旨在确保罗马公民的人口优势,维持帝国稳定与繁荣,具有政治性的功利动机,但在一定程度上缓解了人口出生率低的严峻形势,也带有一定的人道主义色彩。

关键词：罗马帝国低生育率贫儿补助金人道主义

Effects of certain phenolic acids on advanced glycation end products formation in glucose-lysine Maillard reaction models

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Food Science and Human Wellness 2024年

作者： He Li Meng-Yao jin Zi-Ze Liang Dan Li jia-Hao ji Lin Kong Zi-qing Zhao Rui-jie Wu School of Chemistry and Chemical Engineering， North University of China Shanxi jinshuo Biomedical Technology Co.Ltd.

Advanced glycation end products (AGEs)， a group of complex compounds generated by nonenzymatic interactions between amino acids， proteins and reducing sugars or lipids， accumulate in vivo and activate various signaling pathways closely related to the occurrence of various chronic metabolic diseases. This study aims to explore the structure-activity relationship between phenolic acids with different structure and affecting the AGEs generation， and to provide data support for AGEs control. Phenolic acids (4-hydroxybenzoic， protocatechuic， gallic， ρ-coumaric， caffeic， ferulic and sinapic acids) were employed to indicate the AGEs formation condition in Maillard reaction performed in the glucose-lysine model system. Three 1，2-dicarbonyl compounds were reacted with phenolic acids and then tested by liquid chromatography-mass spectrometry. The results showed that Nε-carboxy-methyl-lysine (CML)， Nε-carboxy-ethyl-lysine (CEL)， and pyrraline formation inhibited by phenolic acids varied from (8.7 ± 2.5)% to (33.2 ± 2.5)%， (10.5 ± 0.8)% to (57.1 ± 3.2)% and (1.3 ± 0.3)% to (23.3 ± 0.8)%， respectively. The ρ-coumaric acid has no inhibitory effect on CML and CEL formation. Gallic acid shows the best inhibitory effect on CML formation due to its strong antioxidant activity. Sinapic acid showed the best glyoxal (GO) trapping rate and thus had the stronger inhibitory effect on CML formation. Ferulic acid can react with mono-， di- tri-methylglyoxal (MGO) to form adduct products， showing the best MGO scavenging rate and a good inhibitory effect on CEL formation. The main role of phenolic acid is an antioxidant agent to inhibit pyrraline formation. The glucose itself or ammonia-induced degradation and ARP oxidation were lowered by protocatechuic， gallic and caffeic acids due to their antioxidant activities to form AGEs， while AGEs inhibited by ferulic and sinapic acids were mainly dependent on their trapping ability on 1，2-dicarbonyl compounds.

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车床数控系统和驱动电路设计

广东工业大学学报 2000年第4期17卷 61-64页

作者：许吉庆陶洁刘文济南机械职工大学机电工程系山东济南250100

以实例说明了车床的数控系统和与其相配套的驱动电路的组成及工作原理 ,介绍了GMS90C32新型单片机作CPU的特点 ,阐述了集成块在驱动电路的应用 .

关键词：中央处理器存储器单片机车床数控系统驱动电路

Clinical manifestations,diagnosis and long-term prognosis of adult autoimmune enteropathy:Experience from Peking Union Medical College Hospital

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World Journal of Gastroenterology 2024年第19期30卷 2523-2537页

作者： Mu-Han Li Ge-Chong Ruan Wei-xun Zhou Xiao-qing Li Sheng-Yu Zhang Yang Chen Xiao-Yin Bai Hong Yang Yu-jie Zhang Peng-Yu Zhao ji Li jing-Nan Li Department of Gastroenterology Chinese Academy of Medical Sciences&Peking Union Medical College HospitalBeijing 100730China Department of Pathology Chinese Academy of Medical Scinences&Peking Union Medical College HospitalBeijing 100730China Department of Pathology Tianjin First Central HospitalNankai UniversityTianjin 300192China Affairs Office Chinese Academy of Medical Sciences&Peking Union Medical College Hospital(West campus)Beijing 100032China

BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE *** To improve overall understanding of this disease’s diagnosis and *** We retrospectively analyzed the clinical,endoscopic and histopathological characteristics and prognoses of 16 adult AIE patients in our tertiary medical center between 2011 and 2023,whose diagnosis was based on the 2007 diagnostic *** Diarrhea in AIE patients was characterized by secretory *** common endoscopic manifestations were edema,villous blunting and mucosal hyperemia in the duodenum and *** blunting(100%),deep crypt lymphocytic infiltration(67%),apoptotic bodies(50%),and mild intraepithelial lymphocytosis(69%)were observed in the duodenal ***,there were other remarkable abnormalities,including reduced or absent goblet cells(duodenum 94%,ileum 62%),reduced or absent Paneth cells(duodenum 94%,ileum 69%)and neutrophil infiltration(duodenum 100%,ileum 69%).Our patients also fulfilled the 2018 diagnostic criteria but did not match the 2022 diagnostic criteria due to undetectable anti-enterocyte *** patients received glucocorticoid therapy as the initial medication,of which 14/16 patients achieved a clinical response in 5(IQR:3-20)*** were administered to 9 patients with indications of steroid dependence(6/9),steroid refractory status(2/9),or intensified maintenance medication(1/9).During the median of 20.5 months of followup,2 patients died from multiple organ failure,and 1 was diagnosed with non-Hodgkin’s *** cumulative relapse-free survival rates were 62.5%,55.6%and 37.0%at 6 months,12 months and 48 months,*** Certain histopathological findings,including a decrease or disappearance of goblet and Paneth cells in intestinal biopsies,might be potential diagnostic criteria for adult *** long-term prognosis is still unsatisfac

关键词： Autoimmune enteropathy Clinical manifestations Diagnostic criteria Pathological features Long-term prognosis