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Effect of Kuanxiong Aerosol(宽胸气雾剂)on Patients with Angina Pectoris:A Non-inferiority Multi-center Randomized Controlled Trial

引用

Chinese Journal of Integrative Medicine 2018年第5期24卷 336-342页

作者： YANG Qiao-ning1 BAI Rui-na1 DONG Guo-ju1 GE Chang-jiang2 ZHOU Jing-min3 HUANG Li4 HE Yan 5 WANG Jun6 REN Ai-hua7 HUANG Zhan-quan8 ZHU Guang-li9 LU Shu10 XlONG Shang-quan11 xlan shao-xiang12 ZHU Zhi-jun13 SIll Da-zhuo1 LU Shu-zheng2 LI Li-zhi1 CHEN Ke-ji1 Cardiovascular Diseases Center Xiyuan Hospital China Academy of Chinese Medical Sciences Department of Cardiology Beijing Anzhen Hospital Beijing Institute of Respiratory Medicine Capital Medical University Department of Cardiology Zhongshan Hospital Fudan University Department of Cardiology China-Japan Friendship Hospital Department of Cardiology Longhua Hospital Shanghai University of Traditional Chinese Medicine Department of Cardiology Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine Department of Cardiology Zhejiang Hospital Department of Cardiology The First Affiliated Hospital of Zhejiang Chinese Medical University Department of Cardiology Guangxing Hospital Affiliated to Zhejiang Chinese Medical University Department of Cardiology Wuxi Traditional Chinese Medicine Hospital Nanjing University of Traditional Chinese Medicine Department of Cardiology People's Hospital Affiliated Fujian University of Traditional Chinese Medicine Department of Cardiology The First Affiliated Hospital of Guangzhou University of Chinese Medicine Department of Cardiology The 117th Hospital of People's Liberation Army of China

Objective： To evaluate the effect and safety of Kuanxiong Aerosol （宽胸气雾剂, KA） on patients with angina pectoris. Methods： Block randomization was performed to randomly allocate 750 patients into KA （376 cases） and control groups （374 cases）. During an angina attack, the KA group received 3 consecutive sublingual sprays of KA （0.6 mL per spray）. The control group received 1 sublingual nitroglycerin tablet （NT, 0.5 rag/tablet）. Log-rank tests and Kaplan-Meier estimations were used to estimate the angina remission rates at 6 time-points after treatment （1,2, 3, 4, 5, and 〉5 min）. Logistic regression analysis was performed to observe the factors influencing the rate of effective angina remission, and the remission rates and incidences of adverse reactions were compared for different Canadian Cardiovascular Society （CCS） classes of angina. Results： The 5-min remission rates in the KA and control groups were not significantly different （94.41% vs. 90.64%, P〉0.05）. The angina CCS class significantly influenced the rate of remission （95% confidence interval = 0.483-0.740, P〈0.01）. In the CCS subgroup analysis, the 3- and 5-min remission rates for KA and NT were similar in the CCS I and IV subgroups （P〉0.05）, while they were significantly better for KA in the CCS Ⅱ and Ⅲ subgroups （P〈0.05 or P〈0.01）. Furthermore, the inciden0ce of adverse reactions was significantly lower in the KA group than in the control group for the CCS Ⅱ and Ⅲ subgroups （9.29% vs. 26.22%, 10.13% vs. 20.88%, P〈0.05 or P〈0.01）. Conclusions： KA is not inferior to NT in the remission of angina. Furthermore, in CCS Ⅱ and Ⅲ patients, KA is superior to NT, with a lower incidence of adverse reactions. （Registration No. ChiCTR- IPR-15007204）

关键词： Kuanxiong Aerosol angina pectoris Canadian Cardiovascular Society classification of angina randomized controlled trial Chinese medicine

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Specific Lethal Effects of Trace Neutral Red on Amoeba discoides and Trichodina

引用

Animal Husbandry and Feed Science 2009年第11期1卷 29-32,36页

作者： xiang xlan-yuan WU shao-fang WANG An-tai College of Life Science Shenzhen University Shenzhen 518060 China

[ Objective] The aim of this study was to provide the reference for the artificial breeding of aquatic animals. [ Method] Amoeba discoides and Trichodina were treated by neutral red solution with different concentrations to observe the physiological activities of organelles in their death processes. Effects of neutral red solution on the growth of common aquatic animals such as Paramecium caudatum, Euglena viridis and Brachionus plicatilis were analyzed, and the specific lethal mechanism of trace neutral red to A. discoides and Trichodina was also preliminarily studied. [ Re- suit] The neutral red solution at a concentration of 0.5 mg/L damaged the physiological function of contractile vacuole in Trichodina and also had the specific lethal effect on Tdchodina, but it had no effect on the growth and reproduction of non-parasitic protozoa and B. p/icatilis. Neutral red so- lution with certain concentration led to disorder of the physiological functions of A. discoides, such as assimilation and rejection, which was a main factor that caused the death of A. discoides. [ Conclusion] With the advantages such as targeting, safety and easiness to be oxidized and decom- posed, neutral red is an ideal drug for treating the diseases caused by A. discoides and Trichodina, and its suitable concentration is 0. 5 mg/L.

关键词： Neutral red Amoeba discoides Trichodina Specific lethal effect

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