检索结果-南通市图书馆

重症甲型H1N1流感病毒肺炎患者多脏器病理研究

在线全文

学校读者我要写书评

暂无评论

天津医药 2012年第2期40卷 118-121,I0002页

作者：茹永新杨敬平李月川贾玮赵勇李睿徐喜媛赵轼轩庞天翔中国医学科学院血液病医院、血液学研究所 300020 内蒙古医学院第三附属医院天津市胸科医院内科

目的:研究重症甲型H1N1流感病毒肺炎患者的临床病理学特点。方法:分析12例重症甲型H1N1流感患者临床表现特点;5例患者临床死亡5min内穿刺获取支气管、肺、心肌、腓肠肌和肝脏组织,对各组织分别行苏木素-伊红染色、吉姆萨染色,透射电子... 详细信息

目的:研究重症甲型H1N1流感病毒肺炎患者的临床病理学特点。方法:分析12例重症甲型H1N1流感患者临床表现特点;5例患者临床死亡5min内穿刺获取支气管、肺、心肌、腓肠肌和肝脏组织,对各组织分别行苏木素-伊红染色、吉姆萨染色,透射电子显微镜标本制备;分别用光镜和透射电子显微镜观察各个脏器的病理学变化。结果:支气管黏膜和肺泡上皮广泛损伤,Ⅱ型肺泡上皮细胞和成纤维细胞增生,肺组织实变和纤维化显著。心肌和腓肠肌局灶性损伤和坏死,部分区域纤维化。肝细胞广泛脂肪化,小叶中央静脉和汇管区周围坏死。支气管、肺、肝、心肌和腓肠肌损伤坏死区域有大量病毒,轻度损伤和结构完整部位病毒数量少。结论:甲型H1N1流感病毒不仅能够直接感染呼吸系统引起单纯性病毒性肺炎和严重肺损伤,而且能侵犯多个器官,导致重症患者多脏器功能衰竭和死亡。

关键词：流感病毒A型,H1N1亚型肺炎,病毒性病理学,临床显微镜检查,电子,透射支气管肺心肌肌,骨骼肝

介入化疗及栓塞术联合放射治疗中晚期原发性肝癌

在线全文

学校读者我要写书评

暂无评论

胃肠病学和肝病学杂志 1999年第1期8卷 60-62页

作者：高中度许锡元茅爱武周希法张丽君上海同仁医院上海市200050 常州市肿瘤医院放疗科

为观察介人化疗及栓塞术联合放射治疗中晚期肝癌的近期疗效及副作用方法本文采用６４例确诊的无手术指征的中晚期肝癌，随机分为介人加放疗组与单纯放疗组各３２例，介入法采用动脉插管至肝固有动脉，灌注５－ＦＵ１０００ｍｇ＋卡铂３... 详细信息

为观察介人化疗及栓塞术联合放射治疗中晚期肝癌的近期疗效及副作用方法本文采用６４例确诊的无手术指征的中晚期肝癌，随机分为介人加放疗组与单纯放疗组各３２例，介入法采用动脉插管至肝固有动脉，灌注５－ＦＵ１０００ｍｇ＋卡铂３００ｍｇ＋表阿霉素３０ｍｇ，栓塞剂为４０％碘化油或明胶海绵。放疗采用高能Ｘ线（１８ｍｖ），肿块１０ｃｍ以下采用局野外照射，１０ｃｍ以上采用全肝移动条照射。结果介人加放疗组总有效率（ＣＲ＋ＰＲ）为５９．３％（１９／３２），单纯放疗组总有效率（ＣＲ＋ＰＲ）为３１．３％（１０／３２），两组比较有显著差异（Ｐ＜０．０５）。介人加放疗组平均生存期为１４７个月，单纯放疗组平均生存期为１１．８个月。互年生存率介人加放疗组为６０．８％，单纯放疗组为４４．１％，前者明显高于后者结论采用介人加放射综合治疗原发性肝癌较单纯放射治疗可明显地提高治疗的有效率，生存期及生存率。是中晚期肝癌理想的有效治疗手段之一。

关键词：肝癌介入化疗放射疗法

The 2022 report of synergetic roadmap on carbon neutrality and clean air for China:Accelerating transition in key sectors

在线全文

学校读者我要写书评

暂无评论

Environmental Science and Ecotechnology 2024年第3期19卷 4-18页

作者： Yu Lei Zhicong Yin Xi Lu Qiang Zhang Jicheng Gong Bofeng Cai Cilan Cai Qimin Chai Huopo Chen Renjie Chen Shi Chen Wenhui Chen Jing Cheng xiyuan Chi Hancheng Dai Xiangzhao Feng Guannan Geng Jianlin Hu Shan Hu Cunrui Huang Tiantian Li Wei Li Xiaomei Li Jun Liu Xin Liu Zhu Liu Jinghui Ma Yue Qin Dan Tong xuhui Wang xuying Wang Rui Wu Qingyang Xiao Yang Xie Xiaolong xu Tao xue Haipeng Yu Da Zhang Ning Zhang Shaohui Zhang Shaojun Zhang Xian Zhang Xin Zhang Zengkai Zhang Bo Zheng Yixuan Zheng Jian Zhou Tong Zhu Jinnan Wang Kebin He Center of Air Quality Simulation and System Analysis Chinese Academy of Environmental PlanningBeijing100041China Center for Carbon Neutrality Chinese Academy of Environmental PlanningBeijing100041China Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing210044China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China Institute for Carbon Neutrality Tsinghua UniversityBeijing100084China Ministry of Education Key Laboratory for Earth System Modelling Department of Earth System ScienceTsinghua UniversityBeijing100084China State Key Joint Laboratory for Environment Simulation and Pollution Control College of Environmental Sciences and Engineering and Center for Environment and HealthPeking UniversityBeijing100871China National Center for Climate Change Strategy and International CooperationBeijing100035China Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing100029China School of Public Health Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of HealthFudan UniversityShanghai200032China School of Economics and Management Beijing University of Chemical TechnologyBeijing100029China Department of Earth System Science University of CaliforniaIrvineCA92697USA National Meteorological Center China Meteorological AdministrationBeijing100081China College of Environmental Sciences and Engineering Peking UniversityBeijing100871China Policy Research Center for Environment and Economy Ministry of Ecology and Environment of the People's Republic of ChinaBeijing100029China Jiangsu Key Laboratory of Atmospheric Environment Monitoring

China is now confronting the intertwined challenges of air pollution and climate *** the high synergies between air pollution abatement and climate change mitigation,the Chinese government is actively promoting synergetic control of these two *** Synergetic Roadmap project was launched in 2021 to track and analyze the progress of synergetic control in China by developing and monitoring key *** Synergetic Roadmap 2022 report is the first annual update,featuring 20 indicators across five aspects:synergetic governance system and practices,progress in structural transition,air pollution and associated weather-climate interactions,sources,sinks,and mitigation pathway of atmospheric composition,and health impacts and benefits of coordinated *** to the comprehensive review presented in the 2021 report,the Synergetic Roadmap 2022 report places particular emphasis on progress in 2021 with highlights on actions in key sectors and the relevant *** milestones include the proportion of non-fossil power generation capacity surpassing coal-fired capacity for the first time,a decline in the production of crude steel and cement after years of growth,and the surging penetration of electric ***,in 2022,China issued the first national policy that synergizes abatements of pollution and carbon emissions,marking a new era for China's pollution-carbon *** changes highlight China's efforts to reshape its energy,economic,and transportation structures to meet the demand for synergetic control and sustainable ***,the country has witnessed a slowdown in carbon emission growth,improved air quality,and increased health benefits in recent years.

关键词： Synergetic roadmap Carbon neutrality Clean air

社区获得性肺炎并脓毒症患者Caspase-12基因多态性及表达的研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际呼吸杂志 2020年第13期40卷 1032-1037页

作者：卜宝英顾鑫亮宣鹏飞武敏徐喜媛杨敬平内蒙古医科大学第三附属医院呼吸与危重症医学科包头014010 包钢三医院急诊科包头014010

目的:分析由社区获得性肺炎导致的脓毒症患者外周血Caspase-12基因多态性,及Caspase-12基因和Caspase-12前体蛋白的表达,了解上述指标在脓毒症发病中的作用。方法:选取2016年2月至2018年5月于内蒙古医科大学第三附属医院呼吸与危重症医... 详细信息

目的:分析由社区获得性肺炎导致的脓毒症患者外周血Caspase-12基因多态性,及Caspase-12基因和Caspase-12前体蛋白的表达,了解上述指标在脓毒症发病中的作用。方法:选取2016年2月至2018年5月于内蒙古医科大学第三附属医院呼吸与危重症医学科确诊的社区获得性肺炎并脓毒症患者34例为脓毒症组,22名健康者为对照组。以Caspase-12的T125C特异碱基为引物,对外周血基因组DNA进行扩增、测序及多态性鉴定。RT-PCR法检测Caspase-12 mRNA表达,蛋白质印迹法检测Caspase-12前体蛋白表达。结果:脓毒症组Caspase-12的T125C基因位点未检出多态性。脓毒症组血Caspase-12 mRNA及Caspase-12前体蛋白表达明显高于对照组(t=6.44、4.62,P<0.001)。入院第一天Caspase-12 mRNA与Caspase-12前体蛋白表达水平显著正相关(r=0.70,P<0.0001)。Caspase-12 mRNA和Caspase-12前体蛋白表达的曲线下的面积分别为0.901和0.719。将Caspase-12 mRNA和Caspase-12前体蛋白的截断点分别设为0.907和0.578,脓毒症诊断的敏感度和特异度分别为78.0%、65.2%和89.9%、70.4%。结论:本研究未检测到Caspase-12 T125C基因多态性。社区获得性肺炎导致脓毒症患者Caspase-12 mRNA和Caspase-12前体蛋白表达显著升高,与脓毒症有明显相关性,且对脓毒症的预警具有一定价值。

关键词：脓毒症 Caspase-12 基因多态性

面向手术导航3D/2D配准的无监督跨域迁移网络

在线全文

学校读者我要写书评

暂无评论

计算机应用 2024年第9期44卷 2911-2918页

作者：王熙源张战成徐少康张宝成罗晓清胡伏原苏州科技大学电子与信息工程学院江苏苏州215009 上海极睿医疗科技有限公司上海201799 中部战区总医院骨科武汉430070 江南大学人工智能与计算机学院江苏无锡214122

3D/2D配准是手术导航的关键技术,现有基于深度学习的配准方法通过网络提取图像特征,继而回归出相应的姿态变换参数。此类方法依赖于真实的样本以及对应的3D标签用于训练,然而这部分专家标注的医疗数据十分稀缺。替代的方案用数字重建放... 详细信息

3D/2D配准是手术导航的关键技术,现有基于深度学习的配准方法通过网络提取图像特征,继而回归出相应的姿态变换参数。此类方法依赖于真实的样本以及对应的3D标签用于训练,然而这部分专家标注的医疗数据十分稀缺。替代的方案用数字重建放射影像(DRR)图像训练网络,由于图像特征跨域的差异,在X射线图像上难以保持原有的配准精度。针对上述问题,设计基于自注意力的无监督跨域迁移网络(UCDTN),无须依赖X射线图像与其对应的3D空间标签作为训练样本,将源域所捕获的图像特征与空间变换间的对应关系迁移到目标域,借助公共特征减小域间特征的差距、降低跨域所带来的负面影响。实验结果表明,UCDTN预测结果的平均配准误差(mTRE)为2.66 mm;与未经跨域迁移训练的模型相比,mTRE指标降低了70.61%,验证了UCDTN在跨域配准任务上的有效性。

关键词：图像配准手术导航跨域迁移深度学习自注意力

A Motion Simulation of Bionic Jellyfish Based on Shape Memory Alloy

在线全文

学校读者我要写书评

暂无评论

A Motion Simulation of Bionic Jellyfish Based on Shape Memor...

第36届中国控制会议

作者： Zhuo Wang xiyuan Lin Xiaoning Feng Hongde Qin Shenfang xu Science and Technology on Underwater Vehicle Laboratory Harbin Engineering University College of computer Science and Technology Harbin Engineering University

ISBN: (纸本)9781538629185

Based on the research object of jellyfish,a kind of bionic jellyfish robot driven by shape memory alloy was designed,which could imitate the jet propulsion of the ***,the propulsion mode and morphological characteristics of jellyfish are ***,the characteristics of shape memory alloy sre studied,and the structure for the six leg drive based on shape memory alloy is *** driving methods of the shape memory alloy are researched and ***,the motion model for jellyfish is *** with the bell volume of jellyfish change,the movement numerical simulation of the jellyfish results are obtained through *** with three different groups of jellyfish parameters,through motion simulation of jellyfish,the optimal size is selected.

关键词： Bionic jellyfish Shape memory alloy Motion simulation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

益肾通脉方治疗急性脑梗死的临床研究

中国卫生标准管理 2016年第6期7卷 125-127页

作者：张树泉徐西元陈玲韩晗侯斌郭延林黄硕泰安市中医医院神经内科山东泰安271000

目的观察应用益肾通脉方治疗急性脑梗死的临床疗效。方法将160例急性脑梗死证属肾虚血瘀痰阻的患者随机分为治疗组和对照组各80例,治疗组在常规西药治疗基础上给予益肾通脉方,对照组给予常规西药治疗。疗程4周。观察治疗前及治疗后2周、... 详细信息

目的观察应用益肾通脉方治疗急性脑梗死的临床疗效。方法将160例急性脑梗死证属肾虚血瘀痰阻的患者随机分为治疗组和对照组各80例,治疗组在常规西药治疗基础上给予益肾通脉方,对照组给予常规西药治疗。疗程4周。观察治疗前及治疗后2周、8周、12周美国国立卫生研究院卒中量表(NIHSS)评分,血清神经元特异性烯醇化酶(NSE)含量,治疗后4周、12周Barthel评分(BI)变化,以及治疗前后临床疗效评定。结果总有效率治疗组为96.25%,对照组为82.50%,治疗组优于对照组(P<0.05)。治疗组NIHSS评分、NSE水平低于对照组(P<0.05),BI评分高于对照组(P<0.05)。结论益肾通脉方治疗证属肾虚血瘀痰阻型急性脑梗死疗效优。

关键词：益肾通脉方急性脑梗死临床疗效 NIHSS评分 Barthel评分(BI) NSE

High fidelity numerical simulations on the unsteady flow field of low-pressure turbine cascades with and without upstream disturbance at moderate Reynolds number

在线全文

学校读者我要写书评

暂无评论

Advances in Aerodynamics 2022年第1期4卷 203-217页

作者： Hongbo Zhu xiyuan Pang Feng Wu Chunxiao Zhang Yan Bao Hui xu School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China AECC Sichuan Gas Turbine Establishment Mianyang621000China Inner Mongolia Road and Bridge Group Co. LtdHuhhot010000China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai200240China

This paper numerically investigates the aerodynamic performance of the T106A low-pressure turbine based with different inflow conditions at moderate Reynolds number by using high performance computing based on high order unstructured *** different inflow conditions respectively of uniform and disturbed are considered,while for the latter a small circular cylinder is placed upstream of the cascade to generate wake turbulence as a long-standing disturbance.A high order Fourier-spectral/hp element method is employed to solve the flow dynamics in the cascade of high complex *** transition characteristics are quantified in terms of the distribution of cascade wall surface pressure and friction coefficient,the distribution of wake profile pressure loss and the evolution characteristics of boundary layer flow structures as *** numerical results show that the current numerical simulations accurately predict the flow transition performance of low-pressure turbine cascades and capture the effects of wake-generated disturbance on the cascade,which is shown to effectively modify the flow transition performance as compared with the uniform inflow case.

关键词： Fourier-spectral/hp element method Low pressure turbine Wake generated disturbance Aerodynamic characteristics

Dynamic Treatment Strategy of Chinese Medicine for Metastatic Colorectal Cancer Based on Machine Learning Algorithm

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第11期30卷 993-1000页

作者： xu Yu-ying LI Qiu-yan YI Dan-hui CHEN Yue ZHAI Jia-wei ZHANG Tong SUN Ling-yun YANG Yu-fei Department of Oncology Xiyuan Hospital China Academy of Chinese Medical Sciences School of Statistics Renmin University of China Graduate School Beijing University of Chinese Medicine

Objective: To establish the dynamic treatment strategy of Chinese medicine(CM) for metastatic colorectal cancer(m CRC) by machine learning algorithm, in order to provide a reference for the selection of CM treatment strategies for m CRC. Methods: From the outpatient cases of m CRC in the Department of Oncology at xiyuan Hospital, China Academy of Chinese Medical Sciences, 197 cases that met the inclusion criteria were screened. According to different CM intervention strategies, the patients were divided into 3 groups: CM treatment alone, equal emphasis on Chinese and Western medicine treatment(CM combined with local treatment of tumors, oral chemotherapy, or targeted drugs), and CM assisted Western medicine treatment(CM combined with intravenous regimen of Western medicine). The survival time of patients undergoing CM intervention was taken as the final evaluation index. Factors affecting the choice of CM intervention scheme were screened as decision variables. The dynamic CM intervention and treatment strategy for m CRC was explored based on the cost-sensitive classification learning algorithm for survival(CSCLSurv). Patients' survival was estimated using the Kaplan-Meier method, and the survival time of patients who received the model-recommended treatment plan were compared with those who received actual treatment plan. Results: Using the survival time of patients undergoing CM intervention as the evaluation index, a dynamic CM intervention therapy strategy for m CRC was established based on *** CM intervention strategies for m CRC can be selected according to dynamic decision variables, such as gender, age, Eastern Cooperative Oncology Group score, tumor site, metastatic site, genotyping, and the stage of Western medicine treatment at the patient's first visit. The median survival time of patients who received the modelrecommended treatment plan was 35 months, while those who receive the actual treatment plan was 26.0 months(P=0.06). Conclusions:

关键词： Chinese medicine cost sensitive classification learning for survival dynamic treatment strategy metastatic colorectal cancer