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脑病用药递送策略及临床研究进展

中国药科大学学报 2024年第5期55卷 577-589页

作者：陆宁姝嵇涛卢瑛蓝许熙媛顾晓晨丁杨中国药科大学药剂系多靶标天然药物全国重点实验室南京211198 曼尼托巴大学药学院加拿大温尼伯MB R3E 0T5

血脑屏障的存在限制了药物的脑内有效递送,导致脑病疗效不佳,难以满足患者的临床需求。近年来,基于优效给药途径和新型递药系统等策略开发的创新制剂,能够突破血脑屏障的桎梏,显著提升药物的入脑效率及降低外周不良反应的发生率,为患者... 详细信息

血脑屏障的存在限制了药物的脑内有效递送,导致脑病疗效不佳,难以满足患者的临床需求。近年来,基于优效给药途径和新型递药系统等策略开发的创新制剂,能够突破血脑屏障的桎梏,显著提升药物的入脑效率及降低外周不良反应的发生率,为患者带来重大治疗意义。本文对脑病用药在临床研究中存在的关键问题进行分析,详尽综述了脑病治疗领域内全球创新药物制剂的发展及研发策略,并展望未来治疗策略的应用前景,以期为新一代药物研发提供新思路和方法。

关键词：脑病用药药物递送血脑屏障开发策略临床进展

Impact of noninvasive positive pressure ventilation on the gene expression of ubiquitin system of skeletal muscle in patients with acute exacerbation of chronic obstructive pulmonary disease

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Discussion of Clinical Cases 2016年第4期3卷 1-5页

作者： Hui Wang Jingping Yang xiyuan xu Tieying Tian Department of Respiratory and Critical Medicine The Third Affiliated Hospital of Inner Mongolia Medical UniversityBaotouInner MongoliaChina

Objective:To investigate the change and relativity of noninvasive positive pressure ventilation(NIPPV)on the gene expression of ubiquitin system of skeletal muscle in patient with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:80 patients with AECOPD were divided into two groups based on whether the NIPPV treatment was given or not,38 cases in the study group and 42 in the control *** blood gas analysis and pulmonary function were monitored and recorded before and 14 days after treatment.A skeletal muscle biopsy was performed 14 days after *** mRNA expression of ribosomal protein S21(RPS21)and ubiquitin in skeletal muscle cell were measured by ***:After 14 days treatment,the levels of PaCO_(2),PaO_(2),PH and FEV_(1)% in the NIPPV group improved much better than in the control group(p<.05).The gene expression of RPS21 and ubiquitin was obviously lower in the study group than in the control group(p<.05).The level of RPS21 was negatively related with PaO_(2),PH and FEV1%,and the level of ubiquitin was negatively related with PaO_(2) and FEV1%,but positively correlated with PaCO_(2).The area under the ROC curves of RPS21,ubiquitin,PaCO_(2) and FEV_(1)% were 0.771,0.885,0.821 and 0.734 respectively in the study *** cut-off points were 103.978,8.128,45.350 and 51.350 *** sensitivity evaluation of acid poisoning was 90.9%,and the specificities for each were 75%,75%,50% and 50%.Conclusions:NIPPV is effective for AECOPD patients through the gene expression of ubiquitin system of skeletal muscle.

关键词： Noninvasive positive pressure ventilation Acute exacerbation of chronic obstructive pulmonary disease Skeletal muscle Gene expression

Research on FCS-MPC Strategy with Peak Current Limitation for Fault-Tolerant NPC Three-Level PV Grid-Connected Inverter Under Unbalanced Grid Voltages

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Research on FCS-MPC Strategy with Peak Current Limitation fo...

第32届中国控制与决策会议

作者： Minan Tang xiyuan xu Binbin HAO Kaiyue Zhang School of Automation and Electrical Engineering Lanzhou Jiaotong University

For the problems of power fluctuation and over-current in grid-connected inverters under unbalanced grid voltage,a fault ride through control strategy based on finite control set-model predictive control（FCS-MPC） with peak current limitation is proposed for fault-tolerant NPC three-level photovoltaic grid-connected ***,the current reference value is calculated with the goal of balancing the current,eliminating active and reactive power ***,the quantitative relationship between the power reference set value and the peak output current value is deduced to guide the power reference value setting under unbalanced grid *** addition,the grid-connected model predictive current control strategy based on the reference voltage cost function method is used to realize the accurate tracking of the reference *** results show that the proposed method can realize the control objectives of output current balance,active power constant,and reactive power constant under unbalanced grid voltage,and the current peak is limited effectively under the three control objectives.

关键词： PV grid-connected inverter fault-tolerant finite control set-model predictive control unbalanced grid voltages peak current

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我国博士生教育中多个利益主体的博弈行为

学位与研究生教育 2007年第4期 66-70页

作者：徐希元南京大学研究生院

运用博弈论理论具体分析了我国博士生教育过程中相关利益主体之间的委托代理关系,以新的视角揭示了"目标冲突"和"信息不对称"是形成"道德风险"、影响博士生培养质量的两大突出因素,提出了以提高博士生培养质量为"均衡点"的行为策略。

关键词：博士生教育利益主体重复博弈委托代理行为策略

基于启发式规则与AHP-CRITIC算法的配电网故障恢复策略

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电力系统保护与控制 2020年第14期48卷 1-9页

作者：汤旻安张凯越许希元兰州交通大学自动化与电气工程学院甘肃兰州730070

智能配电网的自愈控制对提高整个电力系统的供电可靠性至关重要。针对含分布式电源的配电网故障恢复问题,提出了基于启发式规则与AHP-CRITIC算法的配电网故障恢复策略。首先,通过广度优先搜索的方法遍历停电区域内所有具有黑启动能力的... 详细信息

智能配电网的自愈控制对提高整个电力系统的供电可靠性至关重要。针对含分布式电源的配电网故障恢复问题,提出了基于启发式规则与AHP-CRITIC算法的配电网故障恢复策略。首先,通过广度优先搜索的方法遍历停电区域内所有具有黑启动能力的分布式电源,形成孤岛供电。其次,对剩余失电区域采用启发式规则,以生成用于配电网故障恢复的候选方案集。最后,考虑故障恢复的目标,引入负荷容量裕度、负荷转移量、负荷恢复比例、开关操作次数和电压降落五个评价指标,分别计算候选方案的各评价指标。并使用改进的AHP方法和CRITIC方法对方案进行评估。同时引入综合权重并计算各方案与理想点之间的偏离度,确定最优故障恢复方案以恢复剩余失电区域供电。通过算例分析验证了所提方法在解决配电网故障恢复问题上的有效性。

关键词：配电网故障恢复分布式电源启发式规则改进AHP法 CRITIC

Relationship between the expression of TLR4 and TIRAP and sepsis in peripheral blood

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Discussion of Clinical Cases 2016年第4期3卷 9-13页

作者： Minglu Qi Jingping Yang xue Yin Si Chen xiyuan xu The Third Affiliated Hospital of Inner Mongolia Medical University BaotouInner MongoliaChina

Objective:To explore the relationship between the expression of TLR4 and TIRAP and sepsis ***:The study selected 30 healthy examinees as the control group and 53 patients with sepsis as the observation *** patients in the observation group were assessed by Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ).40 patients with APACHE Ⅱ score≤20,were classified into the low-score sepsis group;13 patients with APACHE Ⅱ score>20,were classified into the high-score sepsis *** levels of TLR4 and TIRAP in venous serum were detected in all subjects by enzyme-linked immunosorbent assay(ELISA).Results:The levels of TLR4 and TIRAP in serum were 0.886±0.058 ng/ml and 5.216±0.410 ng/ml in the control group;2.253±0.379 ng/ml and 9.540±2.294 ng/ml in the low-score sepsis group;4.494±0.709 ng/ml and 19.206±1.755 ng/ml in the high-score sepsis *** observation group(low-score and high-score sepsis groups)was significantly different from the control group(p=.000),and the low-score sepsis group was significantly different from the high-score sepsis group(p=.000).With APACHE II score of 20 as the cut-off point,the low-score sepsis group was consisted of low-risk patients and the high-score group was consisted of the high-risk,which can indicate the sepsis *** to Pearson’s correlation analysis,the level of TLR4 was positively correlated with sepsis severity(r=0.931,p<.05),the level of TIRAP was also positively correlated with the sepsis severity(r=0.972,p<.05);the level of TLR4 was positively correlated with the level of TIRAP(r=0.936,p<.05).Conclusions:The levels of TLR4 and TIRAP in septic patients can be used to predict and determine the severity of sepsis.

关键词： Sepsis Toll-like receptor-4 Toll/interleukin-1 receptor adapter protein

Expressions of G2A and OGR1 in peripheral blood cells of patients with hypoxia-induced pulmonary hypertension

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Discussion of Clinical Cases 2017年第3期4卷 16-20页

作者： Min Wu Jingping Yang xiyuan xu Zhimin Guo Baoying Bu The Third Affiliated Hospital of Inner Mongolia Medical University Baogang HospitalBaotouChina

Objective: To detect the expression changes of proton-sensing receptor G protein-coupled receptor 2A (G2A) and ovarian cancer G protein-coupled receptors 1 (OGR1) in human peripheral blood cells of patients with hypoxia-induced pulmonary hypertension (HPH). Methods: Thirty-one patients with HPH were enrolled for IPH group, 16 males and 15 females, aged (65.19 ± 5.86) years;and 30 healthy people were enrolled for control group (NC group), 15 males and 15 females, aged (63.47 ± 6.16) years. The peripheral blood samples were collected and the mRNA expressions of G2A and OGR1 were determined by using real-time fluorescent quantitative PCR. The pulmonary arterial pressure (PAP) of HPH group was detected with echocardiography for the analysis of blood gas and pulmonary function testing. Human peripheral blood was collected to detect the mRNA levels of G2A, OGR1 and the serum levels of tumor necrosis factor-α (TNF-α). Results: PaCO2 was increased significantly in HPH group than that in NC group (p < .05). The percentage of forced expiratory volume in 1 s in predicted value (FEV1 pro%) and the ratio of FEV1/forced vital capacity (FVC) in HPH group were significant lower than those in NC group (p < .05). The expressions of peripheral blood G2A mRNA and TNF-α in HPH group were increased dramatically than those in NC group (p < .05). The expressions of OGR1 mRNA in peripheral blood had no difference between HPH group and NC group. The expressions of G2A mRNA and TNF-α in HPH group were positively related to pulmonary artery pressure significantly. Conclusions: The expression of proton-sensing receptor G2A and the level of TNF-α were increased in peripheral blood cells of patients with pulmonary hypertension. The expressions of TNF-α and G2A had positive correlations with pulmonary artery pressure.

关键词： Hypoxia-induced pulmonary hypertension Proton-sensing receptor G2A OGR1 TNF-α

Successful treatment of severe burn patients with multiple organ dysfunction syndrome:A case report

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Discussion of Clinical Cases 2014年第1期1卷 1-11页

作者： Lingfeng Wang Ling-feng Wang Yongdong Li xiyuan xu Ji Chen Weiqing Wang Zaiqing Huang Lihua Zhang Inner Mongolia Institute of Burns The Third Affiliated Hospital of Inner Mongolia Medical UniversityHohhotChina

Multiple organ dysfunction syndrome is the presence of altered organ function of two or more organ systems in acute ill patients with severe trauma,burn,shock and *** this case,the patient with burn area amounted to 95%and the third-degree burn was up to 90%.He underwent gastrointestinal tract,blood clotting,lung,brain,heart,liver dysfunction,and cardiac arrest for 30 minutes during the courses of treatment,and was discharged from the hospital after 108 days on the basis of comprehensive treatment and repeated skin grafting.

关键词： Multiple organ dysfunction syndrome Burns Clinical

基于三矢量的储能型准Z源光伏逆变器模型预测电流控制

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储能科学与技术 2020年第4期9卷 1159-1166页

作者：汤旻安杨尚梅许希元兰州交通大学自动化与电气工程学院甘肃兰州730070

本工作针对传统模型预测电流控制存在电流脉动较大而导致电流控制精度较低的问题,提出一种应用于储能型准Z源逆变器(energy-storage quasi-Z source inverter,ES-qZSI)的三矢量模型预测电流控制。首先以d、q轴电流为控制变量,根据最近... 详细信息

本工作针对传统模型预测电流控制存在电流脉动较大而导致电流控制精度较低的问题,提出一种应用于储能型准Z源逆变器(energy-storage quasi-Z source inverter,ES-qZSI)的三矢量模型预测电流控制。首先以d、q轴电流为控制变量,根据最近三矢量原则构造6个虚拟电压矢量,以便逆变器输出电压矢量范围可以覆盖任意方向和幅值,提高了系统的电流控制精度。然后利用d、q轴最小电流误差原则计算各离散电压矢量的作用时间,最后经6次电流预测,得到作用于逆变器的最优电压矢量。仿真结果显示,与传统模型预测控制方法相比,该方法的电流畸变率降低了2.92%,电流脉动更小,逆变器的输出性能更优越。

关键词：储能型准Z源逆变器三矢量模型预测控制虚拟电压矢量电流畸变率电流脉动