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3D Lamellar-Structured Graphene Aerogels for Thermal Interface Composites with High Through-Plane Thermal Conductivity and Fracture Toughness

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Nano-Micro Letters 2021年第2期13卷 13-27页

作者： Pengfei Liu Xiaofeng Li Peng Min xiyuan chang Chao Shu Yun Ding Zhong-Zhen Yu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although thermally conductive graphene sheets are efficient in enhancing in-plane thermal conductivities of polymers,the resulting nanocomposites usually exhibit low through-plane thermal conductivities,limiting their application as thermal interface materials.Herein,lamellarstructured polyamic acid salt/graphene oxide(PAAS/GO)hybrid aerogels are constructed by bidirectional freezing of PAAS/GO suspension followed by lyophilization.Subsequently,PAAS monomers are polymerized to polyimide(PI),while GO is converted to thermally reduced graphene oxide(RGO)during thermal annealing at 300℃.Final graphitization at 2800℃ converts PI to graphitized carbon with the inductive effect of RGO,and simultaneously,RGO is thermally reduced and healed to high-quality graphene.Consequently,lamellar-structured graphene aerogels with superior through-plane thermal conduction capacity are fabricated for the first time,and its superior through-plane thermal conduction capacity results from its vertically aligned and closely stacked high-quality graphene lamellae.After vacuum-assisted impregnation with epoxy,the resultant epoxy composite with 2.30 vol% of graphene exhibits an outstanding through-plane thermal conductivity of as high as 20.0 W m^−1 K^−1,100 times of that of epoxy,with a record-high specific thermal conductivity enhancement of 4310%.Furthermore,the lamellar-structured graphene aerogel endows epoxy with a high fracture toughness,~1.71 times of that of epoxy.

关键词： Anisotropic aerogels Graphene Thermal conductivity Epoxy composites Fracture toughness

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Protective effect of modified Huangqi Chifeng decoction(加味黄芪赤风汤)on immunoglobulin A nephropathy through toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-kappa B signaling pathway

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Journal of Traditional Chinese Medicine 2024年第2期44卷 324-333页

作者： LI Liusheng ZHAO Mingming chang Meiying SI Yuan ZHAO Jinning YANG Bin ZHANG Yu Department of Oncology Beijing Hospital of Integrated Traditional Chinese and Western MedicineBeijing 100039China Department of Nephropathy Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Xin-Huangpu Joint Innovation Institute of Chinese Medicine Guangzhou 510070China Department of Pathology xiyuan Hospital China Academy of Chinese Medical SciencesBeijing 100091China Department of Experimental Research Center Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China

OBJECTIVE:To examine the nephroprotective mechanism of modified Huangqi Chifeng decoction(加味黄芪赤风汤,MHCD)in immunoglobulin A nephropathy(IgAN)rats.METHODS:To establish the IgAN rat model,the bovine serum albumin,lipopolysaccharide,and carbon tetrachloride 4 method was employed.The rats were then randomly assigned to the control,model,telmisartan,and high-,medium-,and low-dose MHCD groups,and were administered the respective treatments via intragastric administration for 8 weeks.The levels of 24-h urinary protein,serum creatinine(CRE),and blood urea nitrogen(BUN)were measured in each group.Pathological alterations were detected.IgA deposition was visualized through the use of immunofluorescence staining.The ultrastructure of the kidney was observed using a transmission electron microscope.The expression levels of interleukin-6(IL-6),monocyte chemoattractant protein-1(MCP-1),and transforming growth factor-β1(TGF-β1)were examined by immunohistochemistry and quantitative polymerase chain reaction.Levels of toll-like receptor 4(TLR4),myeloid differentiation factor 88(MyD88),and nuclear factor-kappa B(NF-κB)P65,were examined by immunohistochemistry,Western blotting,and quantitative polymerase chain reaction.RESULTS:The 24-h urine protein level in each group increased significantly at week 6,and worsen from then on.But this process can be reversed by treatments of telmisartan,and high-,medium-,and low-dose of MHCD,and these treatments did not affect renal function.Telmisartan,and high-,and medium-dose of MHCD reduced IgA deposition.Renal histopathology demonstrated the protective effect of high-,medium-,and low-dose of MHCD against kidney injury.The expression levels of MCP-1,IL-6,and TGF-β1 in kidney tissues were downregulated by low,medium and high doses of MHCD treatment.Additionally,treatment of low,medium and high doses of MHCD decreased the protein and mRNA levels of TLR4,MyD88,and NF-κB.CONCLUSIONS:MHCD exerted nephroprotective effects on IgAN rats,and MHCD regulated the expressions of key targets in TLR4/MyD88/NF-

关键词： glomerulonephritis IGA toll-like receptor 4 myeloid differentiation factor 88 NF-kappa B signal transduction inflammation renal fibrosis modified Huangqi Chifeng decoction

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巨噬细胞极化在组织修复过程中的可视化分析

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中国组织工程研究 2025年第7期29卷 1486-1496页

作者：常金霞刘羽飞牛少辉王唱曹建春北京中医药大学北京市100029 中国中医科学院西苑医院北京市100091 北京中医药大学东方医院北京市100078

背景:巨噬细胞在组织修复和再生过程的各个阶段展现出促炎、抗炎、促纤维化、促伤口愈合等多重活性,巨噬细胞的异质性及其平衡极化对器官修复具有决定性作用。目的:通过可视化分析方法探究巨噬细胞极化在组织修复领域的研究热点和发展趋... 详细信息

背景:巨噬细胞在组织修复和再生过程的各个阶段展现出促炎、抗炎、促纤维化、促伤口愈合等多重活性,巨噬细胞的异质性及其平衡极化对器官修复具有决定性作用。目的:通过可视化分析方法探究巨噬细胞极化在组织修复领域的研究热点和发展趋势,以及该领域全球科研与临床工作者的研究水平。方法:利用文献计量分析方法,采用Citespace文献可视化分析软件和VOSviewer工具,在Web of Science Core Collection的科学引文索引扩展(SCI-Expanded)和社会科学引文索引扩展(SSCI-Expanded)数据库中检索2013-2023年间的相关文献,通过动态图谱形式呈现分析结果,揭示研究的主要趋势和焦点。结果与结论:在2013-2023年,有关巨噬细胞极化在组织修复领域的发文量迅速增加,尤其从2017年增加显著;中国研究者的发文量居于第一位(642篇),美国研究者较早关注到该领域;Elisseeff Hennifer H教授对该领域研究有非常高的贡献;上海交通大学是发文量最多的机构;近年来“透明质酸”“调控”等关键词出现频率较高。巨噬细胞极化在组织修复领域的研究主要集中在其多功能性的调节机制、与其他细胞类型的相互作用以及在特定病理条件下的表现,研究热点涵盖了巨噬细胞在创面、心血管疾病、慢性炎症、肿瘤微环境及再生医学中的作用。通过深入理解巨噬细胞的多功能性和极化机制可以开发新的治疗策略,促进组织修复和再生,提高患者治疗效果。

关键词：文献计量学巨噬细胞极化组织修复 VOSviewer Citespace

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基于滑移流模型的真空容器内羽流流场数值仿真

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航天器环境工程 2024年第2期41卷 129-137页

作者：高文林博颖吴东亮李西园陶东兴柳晓宁杨晓宁北京卫星环境工程研究所北京100094 可靠性与环境工程技术重点实验室北京100094

预示真空容器内羽流的力、热分布规律是制定大型真空羽流试验方案、提升试验环境模拟有效性的关键前提之一。针对“嫦娥七号”飞跃器点火试验,利用考虑H_(2)O与CO_(2)吸附的滑移流计算流体力学(CFD)方法,对真空容器内羽流流场压力、温... 详细信息

预示真空容器内羽流的力、热分布规律是制定大型真空羽流试验方案、提升试验环境模拟有效性的关键前提之一。针对“嫦娥七号”飞跃器点火试验,利用考虑H_(2)O与CO_(2)吸附的滑移流计算流体力学(CFD)方法,对真空容器内羽流流场压力、温度及气体组分时空分布的初期变化进行了仿真计算。结果表明,流场整体温度与H_(2)O组分质量分数均随时间推移呈急剧上升后平稳下降趋势,而压力则随时间推移呈波动上升趋势。基于该结论提出了试验优化建议。该方法为真空容器内羽流流场仿真提供了新思路,可为后续相关试验方案设计提供支撑。

关键词：真空容器羽流流场滑移边界计算流体力学数值仿真

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International standard of Traditional Chinese Medicine Techniques: Traditional Chinese Medicine guidelines for acute primary headache(2022)

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Journal of Traditional Chinese Medicine 2024年第4期 839-850页

作者： YAO Yuning CAO Kegang ZHANG Genming LIU Jianping CHEN Wei CAO Junling YANG Wenming YAN Yongmei GENG chang JU Yi ZHAO Dexi QU Miao LI Xiaoli SUN Li HAN Zhenyun HE Liyun CUI Fangyuan FU Caihong ZHOU Bo LIAO Shuqin Department of Geriatrics Jilin Academy of Traditional Chinese Medicine Department of Neurology Shenzhen Hospital of Beijing University of Chinese Medicine Institute of Basic Research in Clinical Medicine China Academy Of Chinese Medical Sciences Department of Rehabilitation Shunyi HospitalBeijing Traditional Chinese Medicine Hospital Department of Neurology Xiyuan Hospital of China Academy of Chinese Medical Sciences Department of Neurology Dongzhimen Hospital of Beijing University of Chinese Medicine Centre for Evidence-Based Chinese Medicine Beijing University of Chinese Medicine Encephalopathy center First Affiliated Hospital of Anhui University of Chinese Medicine Department of Neurology Affiliated Hospital of Shaanxi University of Chinese Medicine Department of Neurology Beijing Changping District Hospital of Traditional Chinese Medicine Neurology center Beijing Tiantan HospitalCapital Medical University Department of Neurology Affiliated Hospital of Changchun University of Chinese Medicine Department of Neurology Xuanwu HospitalCapital Medical University Department of Neurology Beijing University of Chinese Medicine Third Affiliated Hospital

OBJECTIVE: To summarize the evidence from Traditional Chinese Medicine(TCM) practice in the treatment of acute primary headache and provide clinical practice guidance. METHODS: The guidelines were developed in accordance with the World Health Organization guideline development manual. After the establishment of steering committee, panel and the registration and protocol formulation, the evidence on TCM for acute primary headache from published guidelines, clinical evidence, and expert experience and consensus were collected. The grading of recommendations assessment, development and evaluation method was used to grade the evidence and make the recommendations. RESULTS: Based on the available evidence, the guidelines recommended three TCM herbal decoctions, six Chinese patent medicines, and two kinds of external application of Chinese herbal medicines. Diagnostic recommendations based on the expert experience and consensus were also included in the guidelines. CONCLUSION: TCM diagnosis and treatment of decoction, Chinese patent medicine and external application for treating acute primary headache were recommended. We hope these guidelines will be helpful in standardize the TCM acute treatment of primary headache.

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鼻渊通窍颗粒联合抗生素治疗急性鼻窦炎有效性和安全性的系统评价和Meta分析

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辽宁中医杂志 2024年第1期51卷 9-15,I0002,I0003页

作者：谭畅吕健支英杰谢雁鸣中国中医科学院中医临床基础医学研究所北京100700 中国中医科学院西苑医院北京100091

目的对鼻渊通窍颗粒联合抗生素治疗急性鼻窦炎的有效性和安全性进行系统评价和Meta分析。方法检索万方、CNKI、VIP、CBM 4个中文数据库和PubMed、Cochrane Library、EMBASE、Web of science 4个英文数据库,结合“Cochrane偏倚风险评估... 详细信息

目的对鼻渊通窍颗粒联合抗生素治疗急性鼻窦炎的有效性和安全性进行系统评价和Meta分析。方法检索万方、CNKI、VIP、CBM 4个中文数据库和PubMed、Cochrane Library、EMBASE、Web of science 4个英文数据库,结合“Cochrane偏倚风险评估”工具,筛选鼻渊通窍颗粒治疗急性鼻窦炎的随机对照试验(RCT),评估纳入的随机对照试验文献的质量,并使用Revman5.4.1软件对最终纳入的研究进行荟萃分析。结果最终共纳入14项RCT研究,总样本量为1849例患者,试验组(西医常规治疗+鼻渊通窍颗粒)930例,对照组为西医常规治疗919例。Meta分析结果显示,常规治疗基础上联合鼻渊通窍颗粒的临床有效率(RR=1.19,95%CI[1.15,1.24],P<0.0001)优于常规治疗;不良反应方面,治疗组与对照组之间差异无统计学意义(RR=-0.57,95%CI[0.29,1.09],P=0.09);常规治疗基础上联合鼻渊通窍颗粒的临床症状总得分(MD=-5.86,95%CI[-6.98,-4.74],P<0.00001);鼻塞评分(MD=-1.16,95%CI[-1.48,-0.85],P<0.00001);鼻涕评分(MD=-1.38,95%CI[-2.01,-0.75],P<0.0001);头痛评分(MD=-0.95,95%CI[-1.01,-0.98],P<0.00001);嗅觉障碍评分(MD=-1.69,95%CI[-2.00,-1.38],P<0.00001)。结论基于现有证据,鼻渊通窍颗粒联合西医常规治疗可以提高急性鼻窦炎的临床疗效,降低临床症状评分,改善其症状,且未发生严重不良反应。GRADE系统进行评估总有效率、不良反应发生率证据质量等级评为低级别。建议今后需采用符合国际规范的样本量大、多中心及盲法设计严谨的试验,提高其证据质量等级来验证其有效性和安全性。

关键词：鼻渊通窍颗粒急性鼻窦炎系统评价 meta分析

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Integrated Chinese and Western medicine in the treatment of a patient with podocyte infolding glomerulopathy:A case report

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World Journal of Clinical Cases 2023年第19期11卷 4684-4691页

作者： Mei-Ying chang Yu Zhang Ming-Xu Li Fang Xuan Department of Nephrology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Department of Nephrology First Medical Center of Chinese PLA General HospitalNephrology Institute of the Chinese People’s Liberation ArmyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijing 100853China

BACKGROUND Podocyte infolding glomerulopathy(PIG)is a newly described and rare glomerular disease.To date,only approximately 40 cases have been reported globally.CASE SUMMARY A 26-year-old female patient presented to our hospital with a complaint of intermittent edema of both lower limbs over the past 2 years.The patient was diagnosed with PIG.She was prescribed corticosteroid therapy in other hospitals during the initial stage,to which she had responded poorly and had developed femoral head necrosis.Therefore,we administered immunosuppressants,reninangiotensin system inhibitors,combined with traditional Chinese medicine.The patient was followed for 1 year,during which her clinical condition improved.CONCLUSION Integrated Chinese and Western medicine may be effective for PIG treatment,which requires active intervention to improve prognosis.

关键词： Corticosteroid therapy Immunosuppressive agents Podocyte-infolding glomerulopathy Renin-angiotensin system Traditional Chinese medicine Case report

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Natural products for treatment of premature ovarian failure:a narrative review

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Journal of Traditional Chinese Medicine 2023年第3期43卷 606-617页

作者： LIU Xueling MA Kun TAO Wenhua XU Zhongkun LIU Gang HU Chunyan MAO Weiwei GU chang GUO Qi Department of Internal Medicine of Traditional Chinese Medicine Affiliated Hospital of Jiangsu UniversityZhenjiang 212000China School of Medical Jiangsu UniversityZhenjiang 212013China Department of Gynecology Xiyuan HospitalChinese Academy of Chinese Medical SciencesBeijing 100700China State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process Jiangsu Kanion Pharmaceutical Co.Ltd.Lianyungang 222047China

Premature ovarian failure(POF) is a female reproductive system disease caused by many factors and systems,which has seriously affected the quality of life of women of childbearing age.Clinically,the disease is difficult to treat while its incidence rate shows an increasing trend.In recent years,natural products used as multi-pathway,multi-target and efficient drugs,have become the focus of many research and clinical studies in China and abroad,and the effect of phytochemicals derived from edible plants and Chinese medicine herbs on POF were investigated in several papers.Using "premature ovarian failure" or "ovary" and related natural products as keywords,we retrieved and reviewed research articles from China National Knowledge Infrastructure Database,Wanfang,Pub Med,Web of Science and other literature databases.Up to October,2021,natural compounds with prophylactic or interference inhibition effects on POF mainly included flavonoids,polysaccharides,saponins,and polyphenols.Their effect on POF and ovarian function was closely related to their antioxidant,antiapoptotic,antiaging,immunoregulatory and estrogenlike activities.

关键词： biological products primary ovarian insufficiency flavonoids review

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癸卯年春季五运六气对北京地区变应性鼻炎影响初探

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浙江中医药大学学报 2024年第4期48卷 492-497页

作者：高畅蔡婷婷王昭倩陈铚晗刘静中国中医科学院西苑医院北京100091

[目的]基于五运六气理论,探讨癸卯年春季运气特点对北京地区变应性鼻炎发病的影响。[方法]根据癸卯年春季立春至立夏期间运气消长变化,分析癸卯年岁火不及、阳明燥金司天、少阴君火在泉的运气分布,与春季北京地区的气候和以风媒花粉为... 详细信息

[目的]基于五运六气理论,探讨癸卯年春季运气特点对北京地区变应性鼻炎发病的影响。[方法]根据癸卯年春季立春至立夏期间运气消长变化,分析癸卯年岁火不及、阳明燥金司天、少阴君火在泉的运气分布,与春季北京地区的气候和以风媒花粉为主的季节性变应原播散情况之间的关联,总结这一时段北京地区变应性鼻炎的人群发病特点,进而探析诊治方法。[结果]变应性鼻炎的季节性发作与气候因素密切相关。癸卯年春季北京地区变应性鼻炎患者整体较往年存在过敏季提前且跨度广、鼻部症状更重、鼻腔黏膜充血明显三大差异。这与癸卯年水湿偏重,春分后主客运之火运与主气少阴君火、客气少阳相火加临,三火相叠,导致人群机体郁火内盛存在潜在关联。变应性鼻炎的发作离不开郁火病机,不单纯由肺脾肾三脏虚损引起。癸卯年春季的运气特点使得变应性鼻炎患者整体郁火更甚,郁火上犯鼻窍,故这一阶段鼻部症状较往年更为明显、特殊。因此,针对存在郁火辨证要素的变应性鼻炎患者,治疗酌情泻南补北、清上温下,可获满意疗效。[结论]癸卯年春季变应性鼻炎的发作有更为突出的火热征象,借助五运六气理论,可为变应性鼻炎的防治提供参考。

关键词：五运六气癸卯变应性鼻炎北京春季郁火

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泵后管线先降后升的长距离输水系统水锤防护

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排灌机械工程学报 2022年第12期40卷 1248-1253,1267页

作者：杜畅刘喜元张健汪宝罗陈旭云俞晓东河海大学水利水电学院江苏南京210098 嘉兴市杭嘉湖南排工程管理服务中心浙江嘉兴314000 浙江省水利水电勘测设计院浙江杭州310002

针对泵后管线先降后升的长距离大流量输水系统,当水泵发生抽水断电时泵后管线高点处易出现负压的特点,提出了一种调压塔联合末端调流阀的停泵水锤防护方案,并基于瞬变流计算的特征线法建立了全系统水力过渡过程的数学模型,模拟了系统停... 详细信息

针对泵后管线先降后升的长距离大流量输水系统,当水泵发生抽水断电时泵后管线高点处易出现负压的特点,提出了一种调压塔联合末端调流阀的停泵水锤防护方案,并基于瞬变流计算的特征线法建立了全系统水力过渡过程的数学模型,模拟了系统停泵水锤全过程.结合某实际输水工程,探究常规调压塔防护方案的调压塔最小面积,给出泵后设调压塔结合末端调流阀联动关闭的水锤防护方案的参数选取原则,对比常规调压塔防护方案与泵后设调压塔结合末端调流阀联动关闭的水锤防护方案对停泵水锤的影响.计算结果表明,常规调压塔防护方案调压塔面积达到1100 m^(2),投资成本巨大;调压塔结合末端调流阀联动关闭的防护方案末端调流阀关闭过快会引起管道正压过大,关闭过慢会导致管道水流回流能力不足,选取合适的末端调流阀关闭时间,在满足系统水锤防护标准的前提下,可以有效地减小调压塔面积.

关键词：长距离供水工程水锤联合防护大流量调压塔调流阀

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