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Spatiotemporal variation and freeze-thaw asymmetry of Arctic sea ice in multiple dimensions during 1979 to 2020

Acta Oceanologica Sinica 2024年第3期43卷 102-114页

作者： yu Guo Xiaoli Wang He Xu xiyong Hou CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China University of Chinese Academy of Sciences Beijing 100049China

Arctic sea ice is broadly regarded as an indicator and amplifier of global climate change.The rapid changes in Arctic sea ice have been widely concerned.However,the spatiotemporal changes in the horizontal and vertical dimensions of Arctic sea ice and its asymmetry during the melt and freeze seasons are rarely quantified simultaneously based on multiple sources of the same long time series.In this study,the spatiotemporal variation and freeze-thaw asymmetry of Arctic sea ice were investigated from both the horizontal and vertical dimensions during 1979–2020 based on remote sensing and assimilation data.The results indicated that Arctic sea ice was declining at a remarkably high rate of–5.4×10^(4) km^(2)/a in sea ice area(SIA)and–2.2 cm/a in sea ice thickness(SIT)during 1979 to 2020,and the reduction of SIA and SIT was the largest in summer and the smallest in winter.Spatially,compared with other sub-regions,SIA showed a sharper declining trend in the Barents Sea,Kara Sea,and East Siberian Sea,while SIT presented a larger downward trend in the northern Canadian Archipelago,northern Greenland,and the East Siberian Sea.Regarding to the seasonal trend of sea ice on sub-region scale,the reduction rate of SIA exhibited an apparent spatial heterogeneity among seasons,especially in summer and winter,i.e.,the sub-regions linked to the open ocean exhibited a higher decline rate in winter;however,the other sub-regions blocked by the coastlines presented a greater decline rate in summer.For SIT,the sub-regions such as the Beaufort Sea,East Siberian Sea,Chukchi Sea,Central Arctic,and Canadian Archipelago always showed a higher downward rate in all seasons.Furthermore,a striking freeze-thaw asymmetry of Arctic sea ice was also detected.Comparing sea ice changes in different dimensions,sea ice over most regions in the Arctic showed an early retreat and rapid advance in the horizontal dimension but late melting and gradual freezing in the vertical dimension.The amount of sea ice melting and freezing was disequilibrium in the Arc

关键词： Arctic sea ice sea ice area sea ice thickness spatiotemporal variation freeze-thaw asymmetry

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Application of the CatBoost Model for Stirred Reactor State Monitoring Based on Vibration Signals

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 647-663页

作者： Xukai Ren Huanwei yu Xianfeng Chen Yantong Tang Guobiao Wang xiyong Du School of Mechanical Engineering Tianjin UniversityTianjin300354China Quality Department Shaoxing Key Laboratory of Special Equipment Intelligent Testing and EvaluationShaoxing312071China

Stirred reactors are key equipment in production,and unpredictable failures will result in significant economic losses and safety issues.Therefore,it is necessary to monitor its health state.To achieve this goal,in this study,five states of the stirred reactor were firstly preset:normal,shaft bending,blade eccentricity,bearing wear,and bolt looseness.Vibration signals along x,y and z axes were collected and analyzed in both the time domain and frequency domain.Secondly,93 statistical features were extracted and evaluated by ReliefF,Maximal Information Coefficient(MIC)and XGBoost.The above evaluation results were then fused by D-S evidence theory to extract the final 16 features that are most relevant to the state of the stirred reactor.Finally,the CatBoost algorithm was introduced to establish the stirred reactor health monitoring model.The validation results showed that the model achieves 100%accuracy in detecting the fault/normal state of the stirred reactor and 98%accuracy in diagnosing the type of fault.

关键词： Stirred reactor fault diagnosis vibration signal CatBoost

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中国大陆海岸线与陆海两侧空间利用关联特征

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地球信息科学学报 2024年第6期26卷 1426-1438页

作者：郭玉侯西勇中国科学院烟台海岸带研究所烟台264003 中国科学院大学北京100049 中国科学院海岸带环境过程与生态修复重点实验室烟台264003 山东省海岸带环境过程重点实验室烟台264003

海岸线位于陆地与海洋交汇的关键地带,其利用模式与陆海两侧的空间规划与开发密切相关。本研究主要基于2022年SDGSAT-1卫星影像,兼顾海岸线两侧的陆域和海域空间,从中国海岸带整体、省(市区)海岸带、剖面线3个层面探究中国大陆海岸线与... 详细信息

海岸线位于陆地与海洋交汇的关键地带,其利用模式与陆海两侧的空间规划与开发密切相关。本研究主要基于2022年SDGSAT-1卫星影像,兼顾海岸线两侧的陆域和海域空间,从中国海岸带整体、省(市区)海岸带、剖面线3个层面探究中国大陆海岸线与陆海两侧空间利用的关联特征。结果表明:①中国大陆海岸线开发利用比例较高,未利用岸线仅占35.11%;在已开发的岸线类型中,养殖围堤岸线占比最大,其次是港口码头岸线;②在土地利用方面,建设用地面积最大,其在天津和上海占有较大比重;人工湿地次之,在辽宁和山东占比较高。对于海域利用,渔业用海在山东和福建占比较大;交通运输用海在上海占比最大;能源开发用海在上海、天津和河北占有较大比重;③从开发利用强度来看,海岸线利用程度综合指数、土地利用程度综合指数和海域利用程度综合指数两两之间均存在明显的正相关关系。与向海一侧相比,海岸线利用程度与陆域土地利用活动之间的相关性更强;空间上,3个指数高值和低值所在的地区基本一致,高值区主要分布在天津和河北等北方省份,低值区主要分布在浙江和福建等南方省份;④从海岸线角度观海望陆:未利用岸线向陆一侧林地占比最高、土地利用程度综合指数值最低,而在未利用岸线向海一侧,旅游娱乐用海的占比高于其他岸线类型;港口码头岸线陆海两侧利用程度综合指数均为最高,陆侧以建设用地为主,海侧以能源开发用海和交通运输用海为主;养殖和盐田围堤岸线海侧的生态保护用海占比高于其他岸线类型。研究结果可为科学规划和管理海岸线、优化陆海空间结构等提供科学数据和决策支持。

关键词：大陆海岸线陆海两侧土地利用海域利用关联特征 SDGSAT-1卫星剖面线中国

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A redox-responsive self-assembling COA-4-arm PEG prodrug nanosystem for dual drug delivery suppresses cancer metastasis and drug resistance by downregulating hsp90 expression

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药学学报:英文版 2023年第7期13卷 3153-3167页

作者： Yi Zhou Yingling Miao Qiudi Huang Wenwen Shi Jiacui Xie Jiachang Lin Pei Huang Chengfeng yue yuan Qin xiyong yu He Wang Linghao Qin Jianhai Chen Nanfang Hospital Southern Medical UniversityGuangzhou 510515China Key Laboratory of Molecular Target and Clinical Pharmacology and the State Key Laboratory of Respiratory Disease and the Fifth Affiliated Hospital School of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou 511436China Center of Cancer Research The Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China

Metastasis and resistance are main causes to affect the outcome of the current anticancer therapies.Heat shock protein 90(Hsp90)as an ATP-dependent molecular chaperone takes important role in the tumor metastasis and resistance.Targeting Hsp90 and downregulating its expression show promising in inhibiting tumor metastasis and resistance.In this study,a redox-responsive dual-drug nanocarrier was constructed for the effective delivery of a commonly used chemotherapeutic drug PTX,and a COAmodified 4-arm PEG polymer(4PSC)was synthesized.COA,an active component in oleanolic acid that exerts strong antitumor activity by downregulating Hsp90 expression,was used as a structural and functional element to endow 4PSC with redox responsiveness and Hsp90 inhibitory activity.Our results showed that 4PSC/PTX nanomicelles efficiently delivered PTX and COA to tumor locations without inducing systemic toxicity.By blocking the Hsp90 signaling pathway,4PSC significantly enhanced the antitumor effect of PTX,inhibiting tumor proliferation and invasiveness as well as chemotherapy-induced resistance in vitro.Remarkable results were further confirmed in vivo with two preclinical tumor models.These findings demonstrate that the COA-modified 4PSC drug delivery nanosystem provides a potential platform for enhancing the efficacy of chemotherapies.

关键词： 3-O-(Z)-Coumaroyloleanolic acid Cancer metastasis Drug resistance Hsp90 Codelivery Prodrug nanosystem Chemotherapies Redox responsiveness

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Gli1 promotes epithelial-mesenchymal transition and metastasis of non-small cell lung carcinoma by regulating snail transcriptional activity and stability

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Acta Pharmaceutica Sinica B 2022年第10期12卷 3877-3890页

作者： Xueping Lei Zhan Li Yihang Zhong Songpei Li Jiacong Chen yuanyu Ke Sha Lv Lijuan Huang Qianrong Pan Lixin Zhao Xiangyu Yang Zisheng Chen Qiudi Deng xiyong yu Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology the NMPA and State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China Department of Respiratory and Critical Care Medicine the Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuan 511518China GMU-GIBH Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou 511436China

Metastasis is crucial for the mortality of non-small cell lung carcinoma(NSCLC) patients.The epithelial-mesenchymal transition(EMT) plays a critical role in regulating tumor metastasis.Glioma-associated oncogene 1(Gli1) is aberrantly active in a series of tumor tissues. However, the molecular regulatory relationships between Gli1 and NSCLC metastasis have not yet been identified. Herein,we reported Gli1 promoted NSCLC metastasis. High Gli1 expression was associated with poor survival of NSCLC patients. Ectopic expression of Gli1 in low metastatic A549 and NCI-H460 cells enhanced their migration, invasion abilities and facilitated EMT process, whereas knock-down of Gli1 in high metastatic NCI-H1299 and NCI-H1703 cells showed an opposite effect. Notably, Gli1 overexpression accelerated the lung and liver metastasis of NSCLC in the intravenously injected metastasis model. Further research showed that Gli1 positively regulated Snail expression by binding to its promoter and enhancing its protein stability, thereby facilitating the migration, invasion and EMT of NSCLC. In addition, administration of GANT-61, a Gli1 inhibitor, obviously suppressed the metastasis of NSCLC. Collectively, our study reveals that Gli1 is a critical regulator for NSCLC metastasis and suggests that targeting Gli1 is a prospective therapy strategy for metastatic NSCLC.

关键词： Non-small cell lung carcinoma Metastasis Epithelialemesenchymal transition Glioma-associated oncogene 1 Promote Snail Protein stability GANT-61

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The cellular immunotherapy of integrated photothermal anti-oxidation Pde Se nanoparticles in inhibition of the macrophage inflammatory response in rheumatoid arthritis

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Acta Pharmaceutica Sinica B 2021年第7期11卷 1993-2003页

作者： Chuping Zheng Aiping Wu Xinyun Zhai Hong Ji Zhikang Chen Xu Chen xiyong yu Key Laboratory of Molecular Target&Clinical Pharmacology and the State Key Laboratory of Respiratory Disease Pharmacological Group School of Pharmaceutical Sciences&the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China The First Affiliated Hospital Jinan UniversityGuangzhou 510632China Nankai University School of Materials Science&EngineeringTianjin Key laboratory of Rare earth materials&applicationsCenter of Rare earth&Inorganic functional materialsTianjin 300350China

Reducing the inflammatory response is a major goal in the therapy of rheumatoid arthritis(RA).Herein,we integrated palladium nanoparticles(Pd NPs)with selenium nanoparticles(Se NPs)and obtained a multiple nanosystem(Pd@Se-HA NPs)that could simultaneously scavenge hydroxyl radicals(·OH)and provide a photothermal effect.The Pd@Se-HA NPs were constructed by a simple selfassembly method in which Se NPs were electrostatically bonded to Pd NPs;hyaluronic acid(HA)was linked to the NPs by ester bonding to provide macrophage targeting ability.The experiments show that the combined therapy of eliminating·OH with Se NPs and utilizing PTT with Pd NPs could effectively reduce the inflammatory response in macrophages more effectively than either individual NP treatment.In addition,the outer layer of HA could specifically target the CD44 receptor to enhance the accumulation of Pd@Se NPs at the lesion,further enhancing the therapeutic effect.After treatment for 15 days,the Pd@Se-HA NPs nearly eliminated the inflammatory response in the joints of mice in an induced RA model,and prevented joint damage and degradation.

关键词： Rheumatoid arthritis Inflammatory response Photothermal therapy Anti-oxidation therapy Core-shell structure

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MiR-142-3p enhances chemosensitivity of breast cancer cells and inhibits autophagy by targeting HMGB1

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Acta Pharmaceutica Sinica B 2020年第6期10卷 1036-1046页

作者： Lu Liang Jijun Fu Siran Wang Huiyu Cen Lingmin Zhang Safur Rehman Mandukhail Lingran Du Qianni Wu Peiquan Zhang xiyong yu Key Laboratory of Molecular Target&Clinical Pharmacology and the State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences&the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China Department of Prosthodontics the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150001China

MiR-142-3p has been reported to act as a tumor suppressor in breast cancer.However,the regulatory effect of miR-142-3p on drug resistance of breast cancer cells and its underlying mechanism remain unknown.Here,we found that miR-142-3p was significantly downregulated in the doxorubicin(DOX)-resistant MCF-7 cell line(MCF-7/DOX).MiR-142-3p overexpression increased DOX sensitivity and enhanced DOXinduced apoptosis in breast cancer cells.High-mobility group box 1(HMGB1)is a direct functional target of miR-142-3p in breast cancer cells and miR-142-3p negatively regulated HMGB1 expression.Moreover,overexpres sion of HMGB1 dramatically reversed the promotion of apoptosis and inhibition of autophagy mediated by miR-142-3p up-regulation.In conclusion,miR-142-3p overexpression may inhibit autophagy and promote the drug sensitivity of breast cancer cells to DOX by targeting HMGB 1.The miR-142-3 p/HMGB1 axis might be a novel target to regulate the drug resistance of breast cancer patients.

关键词： Breast cancer MCF-7 cell line HMGB1 MiR-142-3p Drug resistance Chemosensitivity

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A simple and visualized method to screen for effective siRNAs by using green fluorescence protein (GFP) as a reporter

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Frontiers in Biology 2008年第4期3卷 428-432页

作者： Zhixin SHAN Qiuxiong LIN Yongheng FU Chunyu DENG Xiaohong LI xiyong yu Research Center of Medical Sciences Guangdong Provincial People’s HospitalGuangzhou 510080China

To screen for effective small interference RNA(siRNA),a simple and visualized method was developed using the green fluorescence protein(GFP)as a reporter.Candidate siRNAs targeting macrophage migration inhibition factor genes(MIF)were identified.By using the pEGFP-N3 vector,the MIF-GFP expression plasmid,pEGFP-MIF,was constructed with the same Kozak consensus translation initiation site and start code ATG for the MIF-EGFP coding sequence.Based on the siRNA expression vector pSilencer-4.1,3 candidate MIF siRNA expression plasmids were constructed and co-transfected with the pEGFP-MIF into the HEK293 cells,respectively.The GFP expression in HEK293 cells could be viewed by fluorescence microscopy and the MIF mRNA expressions were determined by real-time quantitative PCR.The 3 candidate MIF siRNA expression plasmids were also co-transfected with the MIF expression plasmid into the HEK293 cells,respectively,and the MIF mRNA expressions were determined by real-time quantitative PCR.The results show that the down-regulated expression of the MIF mRNA was consistent with the GFP expression and the same effective MIF siRNAs were screened by using the pEGFP-MIF or MIF expression plasmid with the candidate MIF siRNAs expression plasmids.Therefore,by using the GFP as a reporter,a useful method was provided to screen for effective siRNAs targeting specific genes co-expressed with the GFP.This may be a good strategy for screening for effective siRNAs targeting different genes.

关键词： RNA interference real-time quantitative PCR green fluorescence protein vector

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高等医学院校实验室危化品管理的现状及对策

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化工管理 2024年第3期 101-104页

作者：赵小亚常继硕余细勇广州医科大学药学院广东广州510182

高等医学院校实验室是生物医药研究的重要场所,危化品在实验室中使用较为广泛。危化品的种类繁多且具有性质复杂的特性,导致管理难度大及存在较多安全隐患。管理好危化品、防范事故风险是高校实验室安全管理的重中之重。文章分析了高等... 详细信息

高等医学院校实验室是生物医药研究的重要场所,危化品在实验室中使用较为广泛。危化品的种类繁多且具有性质复杂的特性,导致管理难度大及存在较多安全隐患。管理好危化品、防范事故风险是高校实验室安全管理的重中之重。文章分析了高等医学院校实验室危化品的管理现状并提出对策,以期改善实验室危化品的管理,保障师生安全。

关键词：实验室危化品安全管理

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纺织印染行业大吨位电梯存在问题及对策分析

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中国特种设备安全 2024年第3期40卷 60-64页

作者：黄超亮宋梅马奇达杜锡勇陈瑜绍兴市特种设备检测院绍兴312071 绍兴市特种设备智能检测与评价重点实验室绍兴312071

大吨位电梯的垂直搬运配以叉车的水平搬运,解决了纺织印染行业生产物料的空间搬运问题。然而,随着车间楼层的提高以及生产节奏的加快,物料搬运工作量几何级增长,大吨位电梯-叉车物料运输系统在使用中的事故率也随之增多。本文分析了该... 详细信息

大吨位电梯的垂直搬运配以叉车的水平搬运,解决了纺织印染行业生产物料的空间搬运问题。然而,随着车间楼层的提高以及生产节奏的加快,物料搬运工作量几何级增长,大吨位电梯-叉车物料运输系统在使用中的事故率也随之增多。本文分析了该行业货梯大量事故案例,总结了大吨位电梯在设计、制造、安装、销售、使用等各个环节存在的问题,针对性提出解决策略和生产建议。

关键词：大吨位电梯纺织印染行业智能化

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