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Localized surface plasmon resonance improves transdermal photodynamic therapy of hypertrophic scars

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Nano Research 2022年第5期15卷 4258-4265页

作者： Yunsheng Chen Zhixi Yu Xinxian Meng Hua li xiyang Sun Dannong He Yixin Zhang Zheng Zhang Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200011China Hongqiao International Institute of Medicine Tongren HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200336China Shanghai National Engineering Research Center for Nanotechnology Shanghai 200237China

Photodynamic therapy(PDT)is an emerging therapeutic strategy for hypertrophic scars(HS),which is heavily dependent on reactive oxygen species(ROS)***,the unsatisfactory delivery and excitation of 5-aminolevulinic acid(ALA,a commercial photosensitizer in dermatology)result in an insufficient ROS generation,and thus limit the clinical application of PDT treating HS(HS-PDT).Consequently,sophisticated transdermal co-delivery nanoethosomes(named A/A-ES)with ALA and Au nanotriangles(AuNTs)in cores are prepared via an in-situ seed-mediated growth method,and then applied to improve HS-PDT through localized surface plasmon resonance(LSPR)-enhanced ROS generation.A/A-ES display a satisfactory performance in co-delivery in HS tissue with sufficient protoporphyrin IX production and LSPR effect in cytoplasm,which is beneficial for ALA excitation as well as ROS *** vitrolvivo studies reveal that A/A-ES significantly improve HS-PDT in promoting to fibroblast apoptosis and collagen remodeling through LSPR-enhanced ROS ***,this study provides a feasible strategy that integrates transdermal delivery and LSPR to enable the beneficial effects of HS-PDT through boosting the delivery and excitation of ALA.

关键词： hypertrophic scars localized surface plasmon resonance nanoethosomes photodynamic therapy reactive oxygen species transdermal co-delivery

Nucleic acids induced peptide-based AIE nanoparticles for fast cell imaging

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Chinese Chemical Letters 2021年第4期32卷 1571-1574页

作者： Wenjun li Yaping Zhang Yanchao Wang Yue Ma Dongyuan Wang Heng li xiyang Ye Feng Yin Zigang li State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055China Pingshan Translational Medicine Center Shenzhen Bay LaboratoryShenzhen 518055China Shenzhen Youwei Technology Holdings Group Co. LtdShenzhen 518055China Department of Chemistry Tsinghua University Shenzhen International Graduate SchoolShenzhen 518055China Department of Gynecology.Shenzhen People's Hospital Shenzhen 518020China

Herein,we utilized nucleic acids induced peptide co-assembly strategy to develop novel nucleic acids induced peptide-based AIE(NIP-AIE)*** fluorescent of AIE could be observed when a little amount of nucleic acids was added into the peptide solution,and the intensity could be regulated by the concentration of nucleic *** AIE nanoparticle with good biocompatibility could achieve fast cell *** is also proved that the fluorescence intensity of AIE decreased with time,which indicates that the reducible cross-linkers of Wpc peptide by GSH and nanoparticles gradually disintegrate in *** on the different of AIE fluorescence signals which regulated by the formation and disintegration of nanoparticles,this AIE system is expected to be used for real-time monitoring of drug release from peptide-based nano carriers in vivo or in vitro,and may provide a new platform for the construction of other organic AIE nanoparticles.

关键词： Peptide-based AIE nanoparticles Nucleic acids Cell imaging

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某尾矿库内外排水隧洞合流水力计算分析

现代矿业 2023年第5期39卷 92-93,99页

作者：琚海桥于忠锋杨智民琚向阳李曦阳高青峰栾川县三强钼钨有限公司长沙有色冶金设计研究院有限公司

结合某尾矿库的实际汇水面积和地形条件,采用上游设拦洪坝截洪和库内另设排洪系统的联合排洪系统。对库内外特征标高分别进行调洪库容计算,均采用无压均匀流公式对排洪系统的泄流能力进行了计算,并进行了调洪演算分析。结果表明,隧洞合... 详细信息

结合某尾矿库的实际汇水面积和地形条件,采用上游设拦洪坝截洪和库内另设排洪系统的联合排洪系统。对库内外特征标高分别进行调洪库容计算,均采用无压均匀流公式对排洪系统的泄流能力进行了计算,并进行了调洪演算分析。结果表明,隧洞合流前后均为无压流且能满足排洪要求,为确保尾矿坝防排洪安全提供理论依据,可为类似工程提供一定参考。

关键词：尾矿库隧洞水力计算泄流量

丁基辛醇水杨酸酯在物理防晒产品中的应用研究

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广东化工 2022年第23期49卷 112-113,88页

作者：陆徐佳张浩洋郑中博贾兵刘陈陈李晞暘曹平湖州嘉亨实业有限公司研发中心浙江湖州313013

纯物理防晒相对于化学防晒更安全,温和不刺激。通过实验研究,丁基辛醇水杨酸酯可以显著提升物理防晒产品的防晒指数,同时有效降低产品在使用时的搓白现象。同时硅石的添加又为产品使用后期增加了爽滑、不粘腻的肤感。在配方中选择丁基... 详细信息

纯物理防晒相对于化学防晒更安全,温和不刺激。通过实验研究,丁基辛醇水杨酸酯可以显著提升物理防晒产品的防晒指数,同时有效降低产品在使用时的搓白现象。同时硅石的添加又为产品使用后期增加了爽滑、不粘腻的肤感。在配方中选择丁基辛醇水杨酸酯、硅石、氧化锌以及二氧化钛的协同组合。按照科学配比,相辅相成的作用称为SESP技术。物理防晒中使用这种SESP技术,优势明显。

关键词：丁基辛醇水杨酸酯防晒物理化学安全

双能量CT联合肌骨超声鉴别诊断焦磷酸钙沉积病与痛风性关节炎的价值

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实用医学杂志 2024年第17期40卷 2477-2482页

作者：张伟胡晰杨张云娜沈苓苓李民慧宋莎莎张健河北省沧州中西医结合医院医学影像科河北沧州061001 沧州市中心医院放射科河北沧州061000

目的探究双能量CT联合肌骨超声鉴别诊断焦磷酸钙沉积病与痛风性关节炎的价值。方法回顾性分析痛风性关节炎102例和焦磷酸钙沉积病102例患者的病历资料,分别记为痛风组和钙沉积组。所有患者均行双能量CT和肌骨超声检查,并以关节滑液或... 详细信息

目的探究双能量CT联合肌骨超声鉴别诊断焦磷酸钙沉积病与痛风性关节炎的价值。方法回顾性分析痛风性关节炎102例和焦磷酸钙沉积病102例患者的病历资料,分别记为痛风组和钙沉积组。所有患者均行双能量CT和肌骨超声检查,并以关节滑液或关节腔内晶体物质的穿刺结果作为金标准。评估双能量CT、肌骨超声诊断焦磷酸钙沉积病与痛风性关节炎的效能。结果痛风组患者的男性比例、血尿酸均高于钙沉积组(P <0.05)。痛风组患者中膝关节、第一跖趾关节、踝关节的受累率偏高,钙沉积组患者中膝关节、腕关节、肩关节的受累率偏高。痛风组患者的骨皮质不规则、软骨损伤、半月板退行性变的所占比例均低于钙沉积组(P <0.05)。痛风组患者的双轨征、痛风石、韧带内强回声、肌腱内强回声、骨侵蚀占比高于钙沉积组(P <0.05),软骨钙化低于钙沉积组(P <0.05)。双能量CT、肌骨超声及二者联合诊断焦磷酸钙沉积病和痛风性关节炎的灵敏度分别为86.27%、83.33%、94.12%,特异度分别为89.22%、88.24%、86.27%,阳性预测值分别为88.89%、87.63%、87.27%,阴性预测值分别为86.67%、84.11%、93.63%,准确率分别为87.75%、85.78%、90.20%,一致性Kappa值分别为0.755、0.716、0.804。结论双能量CT联合肌骨超声在焦磷酸钙沉积病与痛风性关节炎中的诊断效能良好,可用于辅助鉴别诊断两种疾病。

关键词：焦磷酸钙沉积病痛风性关节炎双能量CT 肌骨超声诊断

The enhanced genomic 6mA metabolism contributes to the proliferation and migration of TSCC cells

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International Journal of Oral Science 2022年第1期14卷 100-112页

作者： Lei Xi Ying Yang Ying Xu Fangming Zhang Jinghui li xiyang liu Zhenxi Zhang Quan Du State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijingChina Department of Stomatology Beijing Friendship HospitalCapital Medical UniversityBeijingChina

In contrast to the well-established genomic 5-methylcytosine(5mC),the existence of N^(6)-methyladenine(6 mA)in eukaryotic genomes was discovered only *** studies found that it was actively regulated in cancer cells,suggesting its involvement in the process of ***,the contribution of 6 mA in tongue squamous cell carcinoma(TSCC)still remains *** this study,a pan-cancer type analysis was first performed,which revealed enhanced 6mA metabolism in diverse cancer *** study was then focused on the regulation of 6 mA metabolism,as well as its effects on TSCC *** these aspects,genome 6mA level was found greatly increased in TSCC tissues and cultured *** knocking down 6mA methylases N6AMT1 and METTL4,the level of genomic 6mA was decreased in TSCC *** led to suppressed colony formation and cell *** contrast,knockdown of 6mA demethylase ALKBH1 resulted in an increased 6 mA level,enhanced colony formation,and cell *** study suggested that regulation of the NF-κB pathway might contribute to the enhanced migration of TSCC ***,in the case of TSCC,we have shown that genomic 6mA modification is involved in the proliferation and migration of cancer cells.

关键词： metabolism involvement cancer

Genetic variation of height growth rhythm between clones of Larix kaempferi × L. gmelini based on logistic models

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Journal of Forestry Research 2018年第5期29卷 1387-1394页

作者： Chunming li Hui Xia Hui Bai Hongmei Wang Yajuan Xing xiyang Zhao Xiaomei Sun State Key Laboratory of Tree Genetics and Breeding Research Institute of Forestry Chinese Academy of ForestryBeijing 100091 People's Republic of China State Key Laboratory of Tree Genetics and Breeding(Northeast Forestry University) School of ForestryNortheast Forestry University Harbin 150040 People's Republic of China Forestry Research Institution of Heilongjiang Province Harbin 150081 People's Republic of China Key Laboratory of Tree Breeding and Cultivation of State Forestry Administration Research Institute of ForestryChinese Academy of Forestry Beijing 100091 People's Republic of China

Fifty-three larch interspecific hybrid clones（Larix kaempferi × ***） and their parent clones were used for growth curve analysis of height *** growth curves of the 55 clones were ＇S＇-shaped and 36 exhibited similar curves as the male *** coefficients of the logistic models were higher than 0.943,indicating that our results were effective in the simulation of the growth *** analysis showed significant differences in height of different clones （P／0.01）.Average date of maximum height growth was Day 173,and average duration of rapid growth lasted for 50 *** average increase in height was 9.7cm d^（-1） and daily average increase was 0.2 *** ratio of GR to the total annual increase in height ranged from 51.2 to 68.8%,with the average being 59.8%.There was a positive correlation between k values and plant heights which benefited from the evaluation of early plant *** was also a positive correlation between GR（growth stage）,GD（plant height） and annual increase in *** results are informative to the evaluation of the elite clone selection and provide a theoretical basis for breeding and management.

关键词： Larix kaempferi ×L. gmelini Hybrid clones Logistic modeling Plant height variation

固定化SRB包埋颗粒组分优选及处理含SO_(4)^(2-)废水效果研究

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工业水处理 2024年第3期44卷 112-119页

作者：辛在军王玺洋李亮李娅邓觅姚忠江西省科学院微生物研究所江西南昌330096

赣南离子型稀土矿尾水存在SO42-含量高、pH偏低的问题,影响后续微生物对尾水其他组分(NH_(4)^(+)-N、NO_(3)^(-)-N)的处理,拟采用硫酸盐还原菌(SRB)包埋颗粒对水体中SO_(4)^(2-)进行去除,同时提升水体pH。通过对SRB包埋颗粒表面吸附材... 详细信息

赣南离子型稀土矿尾水存在SO42-含量高、pH偏低的问题,影响后续微生物对尾水其他组分(NH_(4)^(+)-N、NO_(3)^(-)-N)的处理,拟采用硫酸盐还原菌(SRB)包埋颗粒对水体中SO_(4)^(2-)进行去除,同时提升水体pH。通过对SRB包埋颗粒表面吸附材料、还原激活材料、内聚碳源和固体酸水解材料4个组分进行实验研究优选SRB包埋颗粒组分,结果表明,凹凸棒石粉作为SRB包埋颗粒表面吸附材料应用效果比较好,纳米零价铁对SRB的还原激活作用相对更好,内聚碳源及固体酸水解材料组合以玉米芯、花生壳与沸石粉、磁铁矿粉的组合效果比较理想。在此基础上筛选制备出4种包埋颗粒,通过厌氧三角瓶验证其对模拟废水中SO_(4)^(2-)的去除效果,发现制备的4种包埋颗粒经过10 d的实验对SO_(4)^(2-)的去除率都在60%以上,去除率最高的是花生壳-Fe_(3)O_(4)组合包埋颗粒,为80.20%。

关键词：硫酸盐还原菌还原激活碳源酸性矿山废水

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Early evaluation of growth traits of Larix kaempferi clones

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Journal of Forestry Research 2018年第4期29卷 1024-1032页

作者： Yanyan Pan Shuchun li Chenglu Wang Wenjun Ma Guiyou Xu lili Shao Kailong li xiyang Zhao Tingbo Jiang State Key Laboratory of Tree Genetics and Breeding School of Forestry Northeast Forestry University Harbin 150040 People's Republic of China Forestry Department of Jilin Province Tree Seedling Management Station Changchun 130000 People's Republic of China Wudaogou Forestry Center of liuhe County Tonghua 135300 People's Republic of China State Key Laboratory of Forest Genetics and Tree Breeding Key Laboratory of Tree Breeding and Cultivation of State Forestry Administration Research Institute of Forestry Chinese Academy of Forestry Beijing Beijing 100091 People's Republic of China

Early selection is an important method to shorten the breeding cycle for tree species, which may differ in the time for early selection. To evaluate the early selected time for Larix kaempferi, tree height and diameter at breast height of 57 L. kaempferi clones were measured over many different growth years. The results indicated that, except for age × clone interaction for diameter at breast height （P = 0.741）, there were significant differences among all variation sources （P 〈 0.01）. The coefficient of phenotypic variation ranged from 14.89 to 35.65% for height and from 19.17 to 23.86% for diameter at breast height in different growth years. The repeatability of height and of diameter at breast height among clones was high, ranging from 0.6181 to 0.8531 （height） and from 0.8443 to 0.8497 （diameter at breast height）, in different growth years. There were significant positive correlations between all pairs of growth traits except between height in the 2nd growth year and height in the 30th growth year; and between height in the 2nd growth year × diameter at breast height in the 30th growth year. With a comprehen- sive evaluation method and a selection ratio of 10%, L65, L1, L62, L9, L15, and L78 were selected as excellent clones in the 30th growth year. Their average values of height and diameter at breast height were 9.81 and 16.57% higher than the overall average, representing genetic gains of 6.46 and 13.99%, respectively. This study provides a theoretical foundation for the genetic improvement of L. kaempferi.

关键词： Larix kaempferi Genetic Variation.Comprehensive evaluation