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Advanced Fiber Materials 2020年第2期2卷 93-104页

作者： Xiangyu Meng Wanlin Xu Zhihui Li Jianhui Yang Jingwu Zhao xixi zou Yueming Sun Yunqian Dai School of Chemistry and Chemical Engineering Southeast UniversityNanjingJiangsu 211189People’s Republic of China

Serious freshwater shortage and environmental pollution boost the rapid development of solar-driven water *** improved evaporation rate has achieved in recent years,undesirable impurity(e.g.,pollutant components)can also be inevitably evaporated and collected as impurity in produced *** work reports new ultra-light three-dimensional(3D)aerogels assembled by hierarchical Al_(2)O_(3)/TiO_(2) nanofibers and reduced graphene oxide(RGO)for excit-ing synchronized solar-driven evaporation and water *** Al_(2)O_(3)/TiO_(2) fibrous channels linked up the graphene hot-spots and water body for sufficient water supply and bulk water ***,featured with thermal insulation effect,the Al_(2)O_(3)/TiO_(2) nanofibers effectively locked the converted heat with less energy loss from *** introducing of Al_(2)O_(3)/TiO_(2) nanofibers into RGO aerogel led to the effective interfacial evaporation for a more rapid water evaporation rate(2.19 kg·m−2·h−1,normalized to evaporation area including both top and side surface),which was 36%higher than that of pristine RGO ***,simultaneous with the strong steam generation,Al_(2)O_(3)/TiO_(2) nanofibers in situ removed the pollutants within steam by photodegradation,achieving polluted wastewater purification with high con-taminant removal ratio of 91.3%.Our work on coupling Al_(2)O_(3)/TiO_(2) nanofibers into photothermal aerogel provides attractive solutions for the challenges of clean water scarcity and serious environmental pollution.

关键词： Graphene Nanofiber Aerogel Solar Photocatalysis

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硅烯在水化硅酸钙表面成核与生长的理论研究

中国材料进展 2020年第6期39卷 430-436页

作者：周扬郑浩杰邱钰雯邹茜茜黄家乐东南大学材料科学与工程学院江苏南京211189 江苏省建筑科学研究院有限公司高性能土木工程材料国家重点实验室江苏南京211103

硅烯作为一种新兴二维材料,与水化硅酸钙(C-S-H,硅酸盐水泥最主要的水化产物)同为硅质基底材料,将其与水化硅酸钙复合或能有效提高水化硅酸钙的韧性。基于分子动力学模拟技术,探索了单层硅烯在水化硅酸钙表面成核生长的可能性。模拟结... 详细信息

硅烯作为一种新兴二维材料,与水化硅酸钙(C-S-H,硅酸盐水泥最主要的水化产物)同为硅质基底材料,将其与水化硅酸钙复合或能有效提高水化硅酸钙的韧性。基于分子动力学模拟技术,探索了单层硅烯在水化硅酸钙表面成核生长的可能性。模拟结果显示,通过与沉积硅原子形成高强度的Si—O—Si键,水化硅酸钙表面的高反应活性非桥接氧原子(NBOs)促进了硅原子团簇的成核,已成核的硅原子团簇在水化硅酸钙表面均匀分布。随着硅原子的进一步沉积,已成核的硅原子团簇进一步生长,通过桥接键的形成和团簇形状的改变,相邻的小团簇发生合并,形成大团簇。最终,一片较为完整的单层硅烯在水化硅酸钙表面生长出来,且表面覆盖率高。在上述过程中,硅原子的沉积速率以及沉积温度对硅烯的成核和生长过程具有一定的影响。该研究为无机材料表面沉积二维材料开辟了前景,并揭示了其界面处的原子堆积机制。

关键词：硅烯水化硅酸钙分子动力学成核生长

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凝血因子Ⅷ的长效缓释温敏型水凝胶的研制

中国医药工业杂志 2022年第10期53卷 1439-1445页

作者：邹茜茜郜珍叶张伟捷吴飞金拓上海交通大学药学院上海200240

凝血因子Ⅷ(F8)作为治疗血友病常用药物之一,存在半衰期短(10~14h)的缺点,其注射剂需每周多次给药。为获得F8的长效缓释制剂,该研究通过热开环聚合法得到具反向热敏性质的三嵌段聚合物PLGA-PEG-PLGA作为温敏水凝胶基质,制备了一种新型... 详细信息

凝血因子Ⅷ(F8)作为治疗血友病常用药物之一,存在半衰期短(10~14h)的缺点,其注射剂需每周多次给药。为获得F8的长效缓释制剂,该研究通过热开环聚合法得到具反向热敏性质的三嵌段聚合物PLGA-PEG-PLGA作为温敏水凝胶基质,制备了一种新型长效缓释的温度敏感型水凝胶载F8制剂,在4℃及以下呈溶液,37℃附近呈凝胶,并考察了其体外活性及体内外释放行为。结果显示,体外释放试验中,d1突释了约17.4%的载药量,总共实现了3周左右的释放,22d时F8的累积释放率达到92%;制剂成胶前后F8活性达到97%以上,且释放过程中释放液中的F8活性仍能维持在60%以上,提示温敏水凝胶中的F8能维持稳定。体内释放曲线表明,大鼠在给药后1h达到血药浓度峰值,为(113.21±14.50)ng/ml,整个缓释周期内,血药浓度可维持在最低治疗浓度(10ng/ml)以上长达15d。该研究成功开发了一种F8长效缓释制剂,具有临床应用潜力。

关键词：凝血因子Ⅷ 温敏水凝胶长效缓释

粒细胞-巨噬细胞集落刺激因子缓释微球的研制

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中国医药工业杂志 2021年第12期52卷 1615-1620,1621页

作者：于如月邹茜茜朱琳吴飞金拓上海交通大学药学院上海200240

粒细胞-巨噬细胞集落刺激因子(granulocyte-macrophage colony-stimulating factor,GM-CSF)存在半衰期短(约1 h)、易失活和不易透过胃肠道黏膜的特点,几乎不能口服,其注射剂也需要每日多次给药,患者顺应性较差。聚乙二醇(PEG)化、蛋白... 详细信息

粒细胞-巨噬细胞集落刺激因子(granulocyte-macrophage colony-stimulating factor,GM-CSF)存在半衰期短(约1 h)、易失活和不易透过胃肠道黏膜的特点,几乎不能口服,其注射剂也需要每日多次给药,患者顺应性较差。聚乙二醇(PEG)化、蛋白质的脂化及常规微球制备方法都对蛋白构象和生物活性有一定破坏,同时存在严重突释和蛋白聚集体形成导致的不完全释放问题。本研究选择GM-CSF为模型蛋白,通过本实验室发明的双水相冷冻相分离方法首先将蛋白制备成葡聚糖(DEX)颗粒预制剂,进而通过s/o/w法制备了DEX颗粒复合PLGA微球。担载GM-CSF的DEX颗粒制成的PLGA微球在d1突释载药量的19%~23%,40 d内连续缓慢释放至载药量的83%~90%,释出的GM-CSF对人红系白血病(TF-1)细胞的增殖活性保持在90%以上。用w/o/w复乳法制得的担载GM-CSF的PLGA微球在d1突释载药量的30%,23 d内缓慢释放至载药量的53%,前6 d释出的GM-CSF的细胞增殖活性为60%,之后下降至50%。2种方法制备的微球的体外释放曲线证明PLGA微球本身在释放过程中可平稳缓释GM-CSF,GM-CSF-DEX颗粒在微球体系中可有效保护GM-CSF的生物活性,同时实现4周以上的平稳缓释。

关键词：粒细胞-巨噬细胞集落刺激因子冷冻相分离缓释微球蛋白生物活性

基于全基因组鉴定与分析金钗石斛GRAS基因家族

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贵州农业科学 2023年第3期51卷 105-116页

作者：杨涛马庆邹西西陈念邹颉贵州中医药大学贵州贵阳550025

【目的】探明金钗石斛(Dendrobium nobile)GRAS基因家族的结构与功能,为研究GRAS家族在金钗石斛生长发育过程中的功能提供参考。【方法】采用全基因组鉴定及分析技术对金钗石斛GRAS家族成员进行鉴定,并进行生物信息学和基因表达模式分... 详细信息

【目的】探明金钗石斛(Dendrobium nobile)GRAS基因家族的结构与功能,为研究GRAS家族在金钗石斛生长发育过程中的功能提供参考。【方法】采用全基因组鉴定及分析技术对金钗石斛GRAS家族成员进行鉴定,并进行生物信息学和基因表达模式分析。【结果】金钗石斛基因组中有53个GRAS基因(DnGRAS1~DnGRAS53),大部分GRAS基因不含有内含子,仅DnGRAS1、DnGRAS5、DnGRAS9、DnGRAS10、DnGRAS19、DnGRAS376个GRAS基因有内含子,分布在PAT1、LISCL、SHR、SCR 4个亚族当中;金钗石斛GRAS基因不均匀的分布在染色体上,普遍存在于基因密度较高的区域,并未出现染色体内的串联重复现象,其中,仅有16对GRAS基因具有共线性,具有高度同源性;GRAS基因含有赤霉素响应、低温响应、生长素响应、防御与应激响应等与生长发育相关的顺式作用元件。DnGRAS21和DnGRAS39基因在根中表达最高,在茎、叶、花中也有不同程度表达。【结论】GRAS家族基因在根部表达量较高。推测GRAS家族基因可能在根中起重要的调控作用,从而影响金钗石斛根的生长发育。

关键词：金钗石斛 GRAS 生物信息学转录组数据分析调控

Analysis of a Convective Storm Crossing Poyang Lake in China

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Journal of Meteorological Research 2020年第3期34卷 529-545页

作者： Haibo zou Shuwen ZHANG Yanan LIU Weidong ZHANG xixi YANG College of Atmosphere Sciences Lanzhou UniversityLanzhou 730000 Institute of Meteorological Sciences of Jiangxi Province Jiangxi Meteorological BureauNanchang 330046

A convective storm crossing Poyang Lake(PL)in China during 1200-1600 UTC on 13 May 2015 is *** results show that this storm occurs ahead of a 500-hPa trough with weak low-level temperature advection and a convectively stable layer between 925 and 850 hPa,and the tail of the storm is enhanced when its spearhead sweeps over PL after the *** to the heating and moistening of PL,the convectively stable layer over PL is destabilized;and instead,a deep(below 700 hPa)convectively unstable layer is ***,both the radiative cooling and the storm-induced cooling result in a rapid air(near-surface)and land temperature decrease in the surrounding ***,a large lake-land temperature difference(about 6℃)occurs,which is conducive to generating land-lake breeze and enhancing the convergence of the low-level ***,the PL-induced deep convectively unstable layer and the enhanced low-level convergence jointly strengthen the crossing *** further confirm this,two simulations(with or without PL)are conducted with the Weather Research and Forecast(WRF)*** simulation with PL successfully reproduces the evolution of the storm crossing PL,while the simulation without PL *** the simulation with PL,a highμse tongue at 850 hPa associated with the storm moves eastward and downward,and merges with the PL-induced lake boundary layer,forming a deep convectively unstable layer under 700 ***,in the simulation without PL,the stable layer constantly maintains under 900 *** addition,the 900-hPa wind difference between the simulations with and without PL shows a land-lake breeze circulation that strengths the convergence of the low-level wind.

关键词： Poyang Lake(PL) lake-enhanced precipitation lake–land breeze convective instability

Exceptional strength-ductility synergy of additively manufactured CoCrNi medium-entropy alloy achieved by lattice defects in heterogeneous microstructures

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Journal of Materials Science & Technology 2022年第32期127卷 61-70页

作者： Jianying Wang Jianpeng zou Hailin Yang Lijun Zhang Zhilin Liu xixi Dong Shouxun Ji State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Light Alloy Research Institute College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China Brunel Centre for Advanced Solidification Technology(BCAST) Brunel University LondonUxbridgeMiddlesex UB83PHUnited Kingdom

The selective laser melting(SLM)with subsequent cold rolling and annealing is used to produce high-density lattice defects and grain refinement in the CoCrNi medium-entropy alloys(MEAs).The superior comprehensive mechanical properties have been achieved in the as-SLMed CoCrNi alloy after rolling and *** as-SLMed alloys delivered the yield strength of 693.4 MPa,the ultimate tensile strength of 912.7 MPa and the fracture strain of 54.4%.After rolling with 70%reduction in thickness and annealing at 700℃for 2 *** yield strength,ultimate tensile strength and fracture strain reached 1161.6 MPa,1390.8 MPa and 31.5%,*** exceptional strength-ductility synergy is mainly attributed to the refined hierarchical microstructures with coarsening grains at a level of 30μm and ultrafine grains at a level of 1μm,and the heritage of dislocation-formed sub-grains and other lattice *** investigation demonstrates that the SLM with subsequent rolling and annealing is beneficial to fabricate high strength and ductile MEAs with single face-centered cubic(fcc)structure.

关键词： Medium-entropy alloys Selective laser melting Strength-ductility synergy Defects Microstructure

Ultrastrong and ductile(CoCrNi)_(94)Ti_(3)Al_(3)medium-entropy alloys via introducing multi-scale heterogeneous structures

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Journal of Materials Science & Technology 2023年第4期135卷 241-249页

作者： Jianying Wang Jianpeng zou Hailin Yang xixi Dong Peng Cao Xiaozhou Liao Zhilin Liu Shouxun Ji State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Brunel Centre for Advanced Solidification Technology(BCAST) Brunel University LondonUxbridgeMiddlesex UB83PHUnited Kingdom Department of Chemical and Materials Engineering The University of Auckland1142New Zealand School of Aerospace Mechanical&Mechatronic EngineeringThe University of SydneySydneyNSW 2006Australia Light Alloy Research Institute College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China

The coarsening-grained single-phase face-centered cubic(fcc)medium-entropy alloys(MEAs)normally exhibit insufficient strength for some engineering ***,superior mechanical properties with ultimate tensile strength of 1.6 GPa and fracture strain of 13.1%at ambient temperature have been achieved in a(CoCrNi)_(94)Ti_(3)Al_(3)MEA by carefully architecting the multi-scale heterogeneous *** microscopy characterization indicates that the superior mechanical properties mainly originated from the favorable heterogeneous fcc matrix(1-40μm)and the coherent sphericalγ’precipitates(10-100 nm),together with a high number density of crystalline defects(2-10 nm),including dislocations,small stacking faults,Lomer-Cottrell locks,and ultrafine deformation twins.

关键词： Medium-entropy alloys Mechanical properties Heterogeneous structure γ’nanoprecipitates Crystalline defects

World Integrated Medicine Master Wu Xianzhong

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World Journal of Integrated Traditional and Western Medicine 2019年第4期5卷 1-9页

作者： zou Jianhua Cao xixi Zhou Ajian Center for Translation World Federation of Chinese Medicine SocietiesBeijing 100101China Beijing University of Chinese Medicine Beijing 100029China

INTRODUCTION OF WU XIANZHONG Academician Wu Xianzhong (born on August 28th,1925) graduated from Shenyang Medical College in *** 1959,he participated in the traditional Chinese medicine (TCM) courses held by Tianjin University of Traditional Chinese Medicine for doctors of western *** 1961,he graduated and was awarded the golden medal by National Health *** has been specialized in surgery of integrated Chinese and western medicine since the early 1960s and works as one of the pioneers in the field of integrated Chinese and western medicine in *** established Tianjin Hospital of Integrated Traditional Chinese and Western Medicine and the Institute of Acute Abdominal Diseases in Integrated Chinese and Western *** 1964 to 1977,he served as Director of Nankai *** 1978 to 1994,he served as Deputy Director,Director and Honorary President of Tianjin Medical College (known as Tianjin Medical University nowadays).

关键词： World Integrated traditional Chinese medicine(TCM) Wu Xianzhong

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妊娠合并单角子宫80例围产结局分析

中华妇产科杂志 2020年第8期55卷 510-515页

作者：邹雨晴陈茜茜冯燕浙江大学医学院附属妇产科医院产科杭州310006

目的探讨妊娠合并单角子宫产妇的围产结局。方法收集2009年1月至2018年12月于浙江大学医学院附属妇产科医院分娩的妊娠≥28周的单角子宫产妇共98例,排除死胎4例、双胎妊娠4例及临床资料不全者10例,共纳入单角子宫组80例。按照1∶2配比,... 详细信息

目的探讨妊娠合并单角子宫产妇的围产结局。方法收集2009年1月至2018年12月于浙江大学医学院附属妇产科医院分娩的妊娠≥28周的单角子宫产妇共98例,排除死胎4例、双胎妊娠4例及临床资料不全者10例,共纳入单角子宫组80例。按照1∶2配比,根据随机表选取年龄、分娩孕周及分娩方式与单角子宫组相同的同期分娩的160例无子宫畸形产妇作为对照组,对两组产妇的分娩方式、剖宫产术指征顺位、产后出血量、阴道分娩产程时间、新生儿出生体重和Apgar评分等围产结局进行回顾性分析。结果单角子宫组80例中阴道分娩10例,剖宫产术分娩70例,其中早产剖宫产术和足月剖宫产术的首要指征均为胎位异常,分别占7/18和50.0%(26/52);对照组160例中阴道分娩20例,剖宫产术分娩140例,其中早产剖宫产术的主要指征为前置胎盘、妊娠期肝内胆汁淤积症和瘢痕子宫,均占19.4%(7/36),足月剖宫产术的首要指征为胎位异常,占23.1%(24/104)。单角子宫组、对照组中阴道分娩者产后出血量分别为(319±161)、(261±152)ml,剖宫产术分娩者产后出血量分别为(257±106)、(272±123)ml,两组分别比较,差异均无统计学意义(P均>0.05)。单角子宫组、对照组中阴道分娩者的第一产程时间分别为(502±386)、(465±296)min,第二产程时间分别为(74±73)、(47±30)min,两组分别比较,差异均无统计学意义(P均>0.05)。单角子宫组、对照组新生儿出生体重分别为(3018±548)、(3080±562)g,两组比较,差异无统计学意义(P=0.42)。根据是否早产以及不同孕前体质指数对两组产妇的新生儿出生体重分别比较,差异均无统计学意义(P均>0.05)。单角子宫组与对照组早产儿出生后1分钟Apgar评分中位数为10(9.25~10)、10(10~10)分,5分钟Apgar评分中位数为10(10~10)、10(10~10)分,足月儿出生后1分钟Apgar评分中位数为10(10~10)、10(10~10)分,5分钟Apgar评分中位数为10(10~10)、10(10~10)分,两组分别比较,差异均无统计学意义(P均>0.05)。结论单角子宫妊娠在无其他剖宫产术指征时可阴道分娩,且可获得与非子宫畸形产妇相似的围产结局。但单角子宫妊娠易合并胎位异常,成为其主要的剖宫产术指征。

关键词：妊娠并发症泌尿生殖系统畸形子宫妊娠结局