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Parietal cortex contributions to information granules following memory consolidation

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Chinese Science Bulletin 2010年第24期55卷 2671-2676页

作者： wang xiuzhen ZHONG Ning LU ShengFu LI KunCheng LANG ShuLei Learning & Cognition Laboratory International WIC Institute Beijing University of Technology Beijing 100022 China Harbin Normal University Harbin 150301 China Department of Life Science and Informatics Maebashi Institute of Technology Maebashi Japan Department of Radiology Xuanwu Hospital Capital Medical University Beijing 100053 China

Previous studies have focused on changes in cerebral cortex activity accompanying memory formation and *** the role of the parietal cortex in memory retrieval is well established,it is not well understood how parietal cortex memory consolidation for mathematical rules is related to granularity of stored information(i.e.,degree of detail or precision).Changes in parietal cortex activity associated with memory consolidation were analyzed using the Ebbinghaus paradigm and functional magnetic resonance imaging(fMRI).Over the course of 1 week,participants learned Boolean arithmetic tasks involving stimulus-response mapping rules containing either low-or high-granularity *** images were collected on day 1(i.e., low-granularity condition)and day 7(i.e.,high-granularity condition).The present data suggested that with practice,stored information was converted from a low-granularity to a high-granularity *** following rule learning,it was hypothesized that the process of consolidation would involve an increased degree of rule representation *** for this process was reflected in parietal cortex *** finding was consistent with the hypothesis that mnemonic reconstruction in the parietal cortex is required for memory consolidation,and results suggested that information granules are formed during memory *** present results could increase the understanding of the relationship between memory consolidation and information granularity.

关键词：信息颗粒大脑皮质记忆功能性磁共振成像信息粒度功能磁共振成像大肠杆菌 fMRI

Enhanced hydrogen storage properties of Mg by the synergistic effect of grain refinement and NiTiO_(3)nanoparticles

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Journal of Magnesium and Alloys 2022年第12期10卷 3542-3552页

作者： Nianhua Yan Xiong Lu Zhiyu Lu Haijie Yu Fuying Wu Jiaguang Zheng xiuzhen wang Liuting Zhang School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang212003China Analysis and Testing Center Jiangsu University of Science and TechnologyZhenjiang212003China

As a promising hydrogen storage material,the practical application of magnesium is obstructed by the stable thermodynamics and sluggish *** this paper,three kinds of NiTiO3catalysts with different mole ratio of Ni to Ti were successfully synthesized and doped into nanocrystalline Mg to improve its hydrogen storage *** results indicated that all the Mg-NiTiO3composites showed prominent hydrogen storage ***,the Mg-NiTiO3/TiO2composite could take up hydrogen at room temperature and the apparent activation energy for hydrogen absorption was dramatically decreased from 69.8±1.2(nanocrystalline Mg)k J/mol to 34.2±0.2 k J/*** addition,the hydrogenated sample began to release hydrogen at about 193.2℃and eventually desorbed 6.6 wt%*** desorption enthalpy of the hydrogenated Mg-NiTiO3-C was estimated to be 78.6±0.8 k J/mol,5.3 k J/mol lower compared to 83.9±0.7 k J/mol of nanocrystalline ***,the sample revealed splendid cyclic stability during 20 *** obvious recession occurred in the absorption and desorption kinetics and only 0.3 wt%hydrogen capacity degradation was *** structural analysis demonstrates that nanosizing and catalyst doping led to a synergistic effect on the enhanced hydrogen storage performance of Mg-NiTiO3-C composite,which might serve as a reference for future design of highly effective hydrogen storage materials.

关键词： Hydrogen storage NiTiO3 Nanocrystalline Mg Reversibility Synergistic effect

基于个性化护理的认知行为干预对妊娠期糖尿病患者生活质量的影响

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糖尿病新世界 2024年第12期27卷 143-146页

作者：李秀梅刘爱霞王秀珍山东省青州市人民医院产科山东青州262500 山东省青州市人民医院感染性疾病科山东青州262500

目的分析基于个性化护理的认知行为干预对妊娠期糖尿病患者生活质量影响。方法选取2020年1月—2023年1月青州市人民医院收治的80例妊娠期糖尿病患者为研究对象,根据不同的护理方法分为对照组(n=40)和干预组(n=40),对照组实施常规护理,... 详细信息

目的分析基于个性化护理的认知行为干预对妊娠期糖尿病患者生活质量影响。方法选取2020年1月—2023年1月青州市人民医院收治的80例妊娠期糖尿病患者为研究对象,根据不同的护理方法分为对照组(n=40)和干预组(n=40),对照组实施常规护理,干预组实施基于个性化护理的认知行为干预。比较两组心理状态评分(焦虑、抑郁)、血糖指标(空腹血糖、餐后2 h血糖)、自我效能感(认知维度、情感维度、实践维度)、生活质量评分(社会功能、物质生活、生理功能、心理功能)。结果护理后,干预组血糖指标、心理状态评分均低于对照组,差异有统计学意义(P均<0.05);干预组自我效能感评分、生活质量评分均高于对照组,差异有统计学意义(P均<0.05)。结论基于个性化护理的认知行为干预应用于妊娠期糖尿病患者的效果确切,可改善其血糖水平和心理状态,提高其自我效能感和生活质量。

关键词：个性化护理认知行为干预妊娠期糖尿病生活质量

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An Intronic Variant of CHD7 Identified in Autism Patients Interferes with Neuronal Differentiation and Development

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Neuroscience Bulletin 2021年第8期37卷 1091-1106页

作者： Ran Zhang Hui He Bo Yuan Ziyan Wu xiuzhen wang Yasong Du Yuejun Chen Zilong Qiu Institute of Neuroscience State Key Laboratory of NeuroscienceKey Laboratory of Primate NeurobiologyCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai200031China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai201210China University of the Chinese Academy of Sciences Beijing100049China Shanghai Mental Health Center School of MedicineShanghai Jiao Tong UniversityShanghai200030China

Genetic composition plays critical roles in the pathogenesis of autism spectrum disorder(ASD).Especially,inherited and de novo intronic variants are often seen in patients with ***,the biological significance of intronic variants is difficult to ***,among a Chinese ASD cohort,we identified a recurrent inherited intronic variant in the CHD7 gene,which is specifically enriched in East Asian ***7 has been implicated in numerous developmental disorders including CHARGE syndrome and *** investigate whether the ASD-associated CHD7 intronic variant affects neural development,we established human embryonic stem cells carrying this variant using CRISPR/Cas9 methods and found that the level of CHD7 mRNA significantly decreased compared to *** differentiation towards the forebrain neuronal lineage,we found that neural cells carrying the CHD7 intronic variant exhibited developmental delay and maturity ***,we found that TBR1,a gene also implicated in ASD,was significantly increased in neurons carrying the CHD7 intronic variant,suggesting the intrinsic relevance among ASD ***,the morphological defects found in neurons carrying CHD7 intronic mutations were rescued by knocking down TBR1,indicating that TBR1 may be responsible for the defects in CHD7-related ***,the CHD7 intronic variant generated three abnormal forms of transcripts through alternative splicing,which all exhibited loss-of-function in functional *** study provides crucial evidence supporting the notion that the intronic variant of CHD7 is potentially an autism susceptibility site,shedding new light on identifying the functions of intronic variants in genetic studies of autism.

关键词： Autism CHD7 Intronic variant Inherited variant TBR1

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颈椎病的平乐正骨药物疗法

国际医药卫生导报 2024年第9期30卷 1523-1525页

作者：李雯霞李洁张晓辉王秀真河南省洛阳正骨医院(河南省骨科医院) 洛阳471000

平乐正骨治疗颈椎病的药物治疗方法以“补”和“温”为基础,包括内治法与外治法。内治法以补益通络舒筋法、活血通经法和祛风通痹法为主,外治法以舒筋散寒、活络通痹为主。在治疗中遵循平乐正骨“三原则”“四方法”,内外治并重,多手段... 详细信息

平乐正骨治疗颈椎病的药物治疗方法以“补”和“温”为基础,包括内治法与外治法。内治法以补益通络舒筋法、活血通经法和祛风通痹法为主,外治法以舒筋散寒、活络通痹为主。在治疗中遵循平乐正骨“三原则”“四方法”,内外治并重,多手段配合,可达到理想的治疗效果。本文详细论述了各种治法所用的药物及治疗原则,为临床用药提供参考。

关键词：颈椎病平乐正骨药物内外治法

Waterlogging risk assessment for winter wheat using multi-source data in the middle and lower reaches of Yangtze River

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International Journal of Agricultural and Biological Engineering 2018年第5期11卷 198-205页

作者： Yuanyuan Chen Jingfeng Huang Xiaodong Song Hongyan Wu Shaoxue Sheng Zhixiong Liu xiuzhen wang Key Laboratory of Agricultural Remote Sensing and Information System Zhejiang UniversityHangzhou 310058China Institute of Remote Sensing and Information Technology Application Zhejiang UniversityHangzhou 310058China Jiangsu Meteorological Bureau Nanjing 210008China Anhui Meteorological Information Center Anhui Meteorological BureauHefei 230031China Wuhan Regional Climate Center China Meteorological AdministrationWuhan 430074China Institute of Remote Sensing and Earth Sciences Hangzhou Normal UniversityHangzhou 311121China

Waterlogging is a serious agro-meteorological disaster caused by excessive soil water,which usually causes tremendous crop yield *** region of middle and lower reaches of Yangtze River in China is an important production base of winter wheat,and is an area prone to *** risk assessment of winter wheat waterlogging can provide more thorough understanding about the risk-prone environment related with food safety in this *** study combined a variety of environmental and agricultural factors and assessed the waterlogging risk of winter wheat from the aspects of sensitivity of hazard formative environments,hazard risk,and vulnerability of hazard-affected body using multi-source ***,it constructed a compound waterlogging risk assessment model to classify the study area into high,relatively high,moderate,and low risky areas,*** results showed that the proposed model could more comprehensively reflect the occurrence mechanism of winter wheat waterlogging by synchronizing geographical,agricultural,and meteorological *** waterlogging regionalization based on the model could reasonably represent the spatial distribution and differentiate regional characteristics of winter wheat waterlogging in the study area.

关键词： waterlogging hazard formative environments vulnerability risk assessment

BRCA2 promoter polymorphism is associated with breast cancer prognosis in Chinese women

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Chinese Medical Journal 2014年第11期127卷 2012-2015页

作者： Liu Lu Fang Yi Fan Jianlin Hu Jianming Xu Xiaoting Jin Xiaohong wang xiuzhen Deng Min wang Jing Liu Wei Department of Pathology First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China Department of Abdominal Surgical Oncology Cancer Hospital Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100021 China Department of Stomatology Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215004 China Department of Obstetrics and Gynaecology First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China Department of Radiation Oncology First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China Department of Anesthesiology First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China Department of Pathology Soochow University Suzhou Jiangsu 215006 China Department of Pathology Soochow University Suzhou Jiangsu215006 China

Background Breast cancer 2 （BRCA2） is an important breast cancer-susceptibility *** polymorphisms in BRCA2 may affect its transcription and be associated with cancer *** We identified five polymorphisms of the BRCA2 promoter region by in silico searching and direct sequencing：-254A/G （rs3092989）,-908A/G （rs206117）,-1134A/G （rs206115）,-1144C/T （rs206116）,and-1260CTTAGA/-（rs3072036）.The-908A/G,-1134A/G,-1144C/T,and-1260CTTAGA/-polymorphisms were genotyped by direct sequencing in 491 breast cancer patients,and the-254A/G polymorphism was genotyped by *** The-1144C/T polymorphism was associated with clinical *** of the TT genotype had longer disease-free intervals （DFIs,P=0.029）,especially among patients with sporadic unilateral breast cancer （P=0.010）.Linkage disequilibrium （LD） analysis showed that all the five single nucleotide polymorphisms （SNPs） were in LD （D＇〉0.8）.Carriers of haplotypes containing the-1144T allele showed longer DFIs （P=0.049）,and the result was more significant in patients with sporadic unilateral cancer （P=0.018）.There were no significant associations between the other polymorphisms and *** The results of this study suggest that homozygosity for the BRCA2 T（-1144） allele is associated with a longer DFI in Chinese women with breast *** functional studies are warranted to clarify this relationship.

关键词： breast cancer prognosis polymorphism promoter BRCA2

A COMPRESSION ALGORITHM FOR ECG BASED ON INTEGER LIFTING SCHEME WAVELET TRANSFORM

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Journal of Electronics(China) 2007年第5期24卷 674-678页

作者： Zhang Kunyan Guo Yinjing Lü Wenhong Sun Jinping wang xiuzhen College of Information and Electrical Engineering Shand~ng University of Science and Technology Qingdao 266510 China

In view of the shortcomes of conventional ElectroCardioGram (ECG) compression algo- rithms,such as high complexity of operation and distortion of reconstructed signal,a new ECG compression encoding algorithm based on Set Partitioning In Hierarchical Trees (SPIHT) is brought out after studying the integer lifting scheme wavelet transform in *** proposed algorithm modifies zero-tree structure of SPIHT,establishes single dimensional wavelet coefficient tree of ECG signals and enhances the efficiency of SPIHT-encoding by distributing bits rationally,improving zero-tree set and ameliorating classifying *** this improved algorithm,floating-point com- putation and storage are left out of consideration and it is easy to be implemented by hardware and *** results prove that the new algorithm has admirable features of low complexity, high speed and good performance in signal *** compression ratio is obtained with high signal fidelity as well.

关键词： Electro Cardio Gram (ECG) Integer lifting scheme Wavelet transform Set Partitioning InHierarchical Trees (SPIHT)

维生素D2联合阿奇霉素对社区获得性肺炎患儿血清免疫球蛋白及炎性因子的影响

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反射疗法与康复医学 2024年第8期5卷 145-147,151页

作者：刘维克王秀贞万洁亭李慧燕青岛市城阳区人民医院儿科山东青岛266001

目的探讨维生素D2联合阿奇霉素对社区获得性肺炎(CAP)患儿血清免疫球蛋白及炎性因子的影响。方法选取青岛市城阳区人民医院2023年1—12月收治的80例CAP患儿为研究对象,按照随机数字表法将其分为对照组和观察组,每组40例。对照组患儿予... 详细信息

目的探讨维生素D2联合阿奇霉素对社区获得性肺炎(CAP)患儿血清免疫球蛋白及炎性因子的影响。方法选取青岛市城阳区人民医院2023年1—12月收治的80例CAP患儿为研究对象,按照随机数字表法将其分为对照组和观察组,每组40例。对照组患儿予以阿奇霉素治疗,观察组患儿在对照组基础上予以维生素D2治疗。比较两组的症状改善情况、血清免疫球蛋白、炎性因子水平、不良反应。结果治疗后,观察组体温恢复时间、咳嗽改善时间、肺部啰音消失时间均短于对照组,组间差异有统计学意义(P0.05)。结论在CAP患儿中实施维生素D2联合阿奇霉素的效果显著,可促进患儿机体内血清免疫球蛋白指标上升,减轻炎症反应,缩短症状缓解时间,且安全性高。

关键词：社区获得性肺炎阿奇霉素维生素D2 血清免疫球蛋白炎性因子不良反应

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