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Effects of traditional Chinese medicine on treatment outcomes in severe COVID-19 patients:a single-centre study

Chinese Journal of Natural Medicines 2024年第1期22卷 89-96页

作者： XIAO Yongjiu li Binbin liU Chang HUANG xiuyu MA ling QIAN Zhirong ZHANG Xiaopeng ZHANG Qian li Dunqing CAI Xiaoqing YAN Xiangyong LUO Shuping XIANG Dawei XIAO Kun Emergency Department the 940th Hospital of Jiont Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050China Scientific Research Center the Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518000China School of Medicine Nankai universityTianjin 300000China Department of Cardiology the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050China Department of Radiation Oncology Fujian Medical University Union HospitalFuzhou 350000China Department of Traditional Chinese Medicine the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050China Department of Geriatric Diseases the Seventh Medical Center of Chinese PLA General HospitalBeijing 100700China Health and Sport Administration Muskingum UniversityOhioanUSA Laboratory of Vaccine and Antibody Engineering Beijing Institute of BiotechnologyBeijing 100071China Department of Pulmonary and Critical Care Medicine the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050China Center of Pulmonary&Critical Care Medicine Chinese People’s Liberation Army(PLA)General HospitalBeijing 100853China

As the search for effective treatments for COVID-19 continues,the high mortality rate among critically ill patients in Intensive Care Units(ICU)presents a profound challenge.This study explores the potential benefits of traditional Chinese medicine(TCM)as a supplementary treatment for severe COVID-19.A total of 110 critically ill COVID-19 patients at the Intensive Care Unit(ICU)of Vulcan Hill Hospital between Feb.,2020,and April,2020(Wuhan,China)participated in this observational study.All patients received standard supportive care protocols,with a subset of 81 also receiving TCM as an adjunct treatment.Clinical characteristics during the treatment period and the clinical outcome of each patient were closely monitored and analysed.Our findings indicated that the TCM group exhibited a significantly lower mortality rate compared with the non-TCM group(16 of 81 vs 24 of 29;0.3 vs 2.3 person/month).In the adjusted Cox proportional hazards models,TCM treatment was associated with improved survival odds(P<0.001).Furthermore,the analysis also revealed that TCM treatment could partially mitigate inflammatory responses,as evidenced by the reduced levels of proinflammatory cytokines,and contribute to the recovery of multiple organic functions,thereby potentially increasing the survival rate of critically ill COVID-19 patients.

关键词： COVID-19 Pneumonia Novel coronavirus Critically ill Traditional Chinese medicine Clinical outcome

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Association between QRS voltages and amyloid burden in patients with cardiac amyloidosis

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Chinese Medical Journal 2024年第3期137卷 365-367页

作者： Jing-Hui li Changcheng li Yucong Zheng Kai Yang Yan Huang Huixin Zhang Xianmei li xiuyu Chen linlin Dai Tian Lan Yang Sun Minjie Lu Shihua Zhao Department of Magnetic Resonance Imaging Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Radiology Taian City Central Hospital(The Affiliated Taian City Central Hospital of Qingdao University)Tai’anShandong 271099China Department of Radiology Tsinghua University HospitalTsinghua UniversityBeijing 100084China Department of Radiology The Fifth People’s Hospital of Huai’anHuai’anJiangsu 223001China Department of Radiology Geriatric Hospital of Nanjing Medical UniversityNanjingJiangsu 210000China Department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Pathology Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

To the Editor:Cardiac amyloidosis(CA)is an infiltrative cardiomyopathy characterized by extracellular deposition of misfolded insoluble amyloid fibrils.^([1])Electrocardiography(ECG)is an essential diagnostic test characterized by low QRS voltages in CA,observed in 20–74%of patients.^([2])Cipriani et al^([3])reported that low QRS voltages could independently predict cardiovascular death.But the mechanisms underlying low QRS voltages in CA remain unclear.

关键词： amyloid patients death.

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The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions:insights from a single-arm,phase II trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2202-2214页

作者： Bo Cheng Caichen li Jianfu li Longlong Gong Peng liang Ying Chen Shuting Zhan Shan Xiong Ran Zhong Hengrui liang Yi Feng Runchen Wang Haixuan Wang Hongbo Zheng Jun liu Chengzhi Zhou Wenlong Shao Yuan Qiu Jiancong Sun Zhanhong Xie Zhu liang Chenglin Yang xiuyu Cai Chunxia Su Wei Wang Jianxing He Wenhua liang Department of Thoracic Surgery and Oncology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory HealthState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhouChina Medical Department Genecast Biotechnology Co.LtdWuxiChina Department of Radiation Oncology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Respiratory Medicine the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory HealthState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhouChina Department of Cardiothoracic Surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiangChina Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhenChina Department of VIP Inpatient Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaSun Yat-sen UniversityGuangzhouChina Department of Medical Oncology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina

Immune checkpoint inhibitors targeting the programmed cell death-1(PD-1)protein significantly improve survival in patients with advanced non-small-cell lung cancer(NSCLC),but its impact on early-stage ground-glass opacity(GGO)lesions remains unclear.This is a single-arm,phase II trial(NCT04026841)using Simon’s optimal two-stage design,of which 4 doses of sintilimab(200 mg per 3 weeks)were administrated in 36 enrolled multiple primary lung cancer(MPLC)patients with persistent high-risk(Lung-RADS category 4 or had progressed within 6 months)GGOs.The primary endpoint was objective response rate(ORR).T/B/NK-cell subpopulations,TCR-seq,cytokines,exosomal RNA,and multiplexed immunohistochemistry(mIHC)were monitored and compared between responders and non-responders.Finally,two intent-to-treat(ITT)lesions(pure-GGO or GGO-predominant)showed responses(ORR:5.6%,2/36),and no patients had progressive disease(PD).No grade 3-5 TRAEs occurred.The total response rate considering two ITT lesions and three non-intent-to-treat(NITT)lesions(pure-solid or solid-predominant)was 13.9%(5/36).The proportion of CD8^(+)T cells,the ratio of CD8^(+)/CD4^(+),and the TCR clonality value were significantly higher in the peripheral blood of responders before treatment and decreased over time.Correspondingly,the mIHC analysis showed more CD8^(+)T cells infiltrated in responders.Besides,responders’cytokine concentrations of EGF and CTLA-4 increased during treatment.The exosomal expression of fatty acid metabolism and oxidative phosphorylation gene signatures were down-regulated among responders.Collectively,PD-1 inhibitor showed certain activity on high-risk pulmonary GGO lesions without safety concerns.Such effects were associated with specific T-cell re-distribution,EGF/CTLA-4 cytokine compensation,and regulation of metabolism pathways.

关键词： lesions metabolism doses

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Genetic diversity and population structure of Robinia pseudoacacia from six improved variety bases in China as revealed by simple sequence repeat markers

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Journal of Forestry Research 2022年第2期33卷 611-621页

作者： Qi Guo Sen Cao li Dong xiuyu li Jiangtao Zhang Yuanshuai Zhang Zijie Zhang Yuhan Sun Cui Long Yingming Fan Chao Han Peiyao Han Xiaodi liu Yun li Beijing Advanced Innovation Center for Tree Breeding By Molecular Design Engineering Technology Research Center of Black Locust of National Forestry and Grassland AdministrationCollege of Biological Sciences and TechnologyNational Engineering Laboratory for Tree BreedingBeijing Forestry UniversityBeijing 100083P.R.China College of Agriculture Henan University of Science and TechnologyLuoyang 471023P.R.China Henan Academy of Forestry Zhengzhou 450008P.R.China Feixian County State Owned Daqingshan Forest Farm Linyi 273400P.R.China

Robinia pseudoacacia is an important afforesta-tion tree introduced to China in 1878.In the present study,we examined the genetic diversity among 687 strains rep-resenting four improved varieties and two secondary prov-enances,comprising 641 clones and 46 seedlings.Ninety-one simple sequence repeats(SSRs)were selected through segregation analysis and polymorphism characterization,and all sampled individuals were genotyped using well-characterized SSR markers.After excluding loci with non-neutral equilibrium,missing locus data and null alleles,we used 36 primer pairs to assess the genetic diversity of these germplasm resources,revealing vast genetic differentiation among the samples,with an average of 8.352 alleles per locus and a mean Shannon′s index of 1.302.At the popula-tion level,the partitioning of variability was assessed using analysis of molecular variance,which revealed 93%and 7%variation within and among collection sites,respectively.Four clusters were detected using structure analysis,indi-cating a degree of genetic differentiation among the six populations.Insights into the genetic diversity and structure of R.pseudoacacia provide a theoretical basis for the con-servation,breeding and sustainable development in China.

关键词： Robinia pseudoacacia Genetic diversity Genetic differentiation Microsatellite Population structure Black locust

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数字服务贸易开放提升了制造业企业全要素生产率吗

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国际经贸探索 2024年第4期40卷 69-85页

作者：李平吴新琪党修宇山东理工大学山东理工大学经济学院上海大学经济学院

文章基于2014~2022年制造业上市公司的数据,研究发现数字服务贸易开放与制造业企业全要素生产率之间存在“U”型关系,在数字服务贸易开放初期,存在“生产率悖论”。机制检验表明,在数字服务贸易开放初期,企业运营低效率和供应链配置多... 详细信息

文章基于2014~2022年制造业上市公司的数据,研究发现数字服务贸易开放与制造业企业全要素生产率之间存在“U”型关系,在数字服务贸易开放初期,存在“生产率悖论”。机制检验表明,在数字服务贸易开放初期,企业运营低效率和供应链配置多元化是产生数字服务贸易开放中“生产率悖论”的重要原因;企业承担风险能力和ESG水平的提升会帮助制造业企业尽早摆脱数字服务贸易开放中“生产率悖论”区间。文章对于破解数字服务贸易开放中“生产率悖论”之谜,实现经济高质量发展有着重要启示。

关键词：数字服务贸易开放制造业企业全要素生产率生产率悖论供应链集中度企业运营效率

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Model eye tool for retinal optical coherence tomography instrument calibration

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Journal of Innovative Optical Health Sciences 2021年第3期4卷 60-67页

作者： Hongting Wang Wenli liu Zhixiong Hu xiuyu li Fei li liangcheng Duan Center for Medical Metrology National Institute of Metrology Beijing 100029P.R.China

Optical coherence tomography(OCT)has been extensively used as noninvasive tool for biological tissues owing to its three-dimensional imaging ability and high axial resolution.OCT quality assurance is vital in these occasions to keep the reliability and accuracy in medical diagnosis.It is necessary to develop a calibration tool for OCT product manufacture,calibration,and quality control.A practical tool is demanded in the OCT quality control and calibration of OCT.So far,there is no such a practical tool that can test all the key parameters of OCT.We design and fabricate a model eye tool,which has this function.The model eye comprises a doublet lens,a single filament,a piece of glass plate and the microsphere-embedded phantom.The doublets lens is bonded by two pieces of planoconvex lenses in the plane position.The first lens focuses parallel light onto the rear surface of the second lens.The rear surface marked with concentric circles serves as retina to measure the angular field of view(FOV).The small flat surface on the peak of the second lens is used to test signal to noise ratio(SNR).The single filament with 125μm diameter is used to check the co-alignment of preview and OCT scan.The empty chamber between the small plane of the second lens and the first surface of glass plate is used to measure the depth scaling of the OCT.The microspheres of 1μm diameter distributed uniformly in the phantom,which can test the lateral and the axial resolution of OCT equipment.Experimental results are presented to show the validity of the proposed tool.It is shown that the tool is able to be used in the calibration and quality control of retinal OCT.

关键词： Optical coherence tomography model eye microsphere-embedded phantom

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面向边缘计算的TCA1C DDoS检测模型

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计算机工程 2024年第1期50卷 198-205页

作者：申秀雨姬伟峰李映岐吴玄空军工程大学信息与导航学院陕西西安710077 93107部队辽宁沈阳110000 94701部队安徽安庆246000

边缘计算弥补了传统云计算数据传输开销大的不足,但边缘网络中存储和计算资源受限的特殊性限制了其部署复杂安全算法的能力,更易受到分布式拒绝服务(DDoS)攻击。针对目前边缘网络中DDoS攻击检测方法性能不高、未对卸载任务分类处理、对... 详细信息

边缘计算弥补了传统云计算数据传输开销大的不足,但边缘网络中存储和计算资源受限的特殊性限制了其部署复杂安全算法的能力,更易受到分布式拒绝服务(DDoS)攻击。针对目前边缘网络中DDoS攻击检测方法性能不高、未对卸载任务分类处理、对多属性的流量处理能力弱的问题,提出一种基于任务分类的Attention-1D-CNN DDoS检测模型TCA1C,对通信链路中的流量按不同的卸载任务进行分类,使单个任务受到攻击时不会影响整个链路中计算任务卸载的安全性,再对同一任务下的流量提取属性值并进行归一化处理。处理后的数据输入到Attention-1D-CNN,通道Attention和空间Attention学习数据特征对DDoS检测的贡献度,利用筛选函数剔除低于特征阈值的冗余信息,降低模型学习过程的复杂度,使模型快速收敛。仿真结果表明:TCA1C模型在缩短DDoS检测所用时间的情况下,检测准确率高达99.73%,检测性能优于DT、ELM、LSTM和CNN;当多个卸载任务在面临特定攻击概率时,卸载任务分类能有效降低不同任务的相互影响,使终端设备的计算任务在卸载过程中保持较高的安全性。

关键词：边缘计算分布式拒绝服务攻击检测任务分类注意力机制 1D-CNN模块

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突泉县保护性耕作技术推广现状及问题分析

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中国农机装备 2024年第2期 110-112页

作者：李秀钰内蒙古兴安盟突泉县农牧技术推广中心突泉137500

保护性耕作的田块犁底层逐渐消失,因而土壤结构稳定,微生物活跃,土质肥沃,能够为农作物稳产提供基础保障,进而实现农作物高产及生态环境保护。结合突泉县地理位置和耕地结构,对保护性耕作技术在突泉县推广现状及问题进行分析,为保护性... 详细信息

保护性耕作的田块犁底层逐渐消失,因而土壤结构稳定,微生物活跃,土质肥沃,能够为农作物稳产提供基础保障,进而实现农作物高产及生态环境保护。结合突泉县地理位置和耕地结构,对保护性耕作技术在突泉县推广现状及问题进行分析,为保护性耕作的推广提供依据,为种植业的可持续发展提供技术支撑。

关键词：突泉县保护性耕作,推广应用分析

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^(18)F-FDOPA PET/CT评估放射化学治疗用于高级别脑胶质瘤效果

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中国医学影像技术 2024年第1期40卷 27-31页

作者：马国津李佳晶崔金利林秀玉长春中医药大学附属医院医学影像科吉林长春130021 吉林省人口生命科学技术研究院医学影像科吉林长春130021

目的观察以^(18)F-L-6-氟-3,4-二羟基苯丙氨酸(^(18)F-FDOPA)PET/CT评估放射及化学治疗(放疗及化疗)用于高级别脑胶质瘤效果的价值。方法回顾性分析84例接受精准放疗及同步化疗的高级别脑胶质瘤患者资料,根据疗效将其分为有效组(完全缓... 详细信息

目的观察以^(18)F-L-6-氟-3,4-二羟基苯丙氨酸(^(18)F-FDOPA)PET/CT评估放射及化学治疗(放疗及化疗)用于高级别脑胶质瘤效果的价值。方法回顾性分析84例接受精准放疗及同步化疗的高级别脑胶质瘤患者资料,根据疗效将其分为有效组(完全缓解+部分缓解+疾病稳定,n=60)及无效组(疾病进展,n=24)。比较组间及组内治疗前后肿瘤^(18)F-FDOPA PET/CT代谢参数,包括肿瘤代谢体积(MTV)、最大标准摄取值(SUV_(max))及平均标准摄取值(SUV_(mean));以Spearman相关性分析观察代谢参数与放化疗效果的相关性。结果治疗后有效组MTV、SUV_(max)及SUV_(mean)均低于无效组(P均<0.05)。有效组治疗前、后代谢参数差异有统计学意义(P均<0.05)。高级别脑胶质瘤MTV、SUV_(max)、SUV_(mean)与放化疗效果呈负相关(r=-0.63、-0.52、-0.50,P<0.001、P=0.007、P=0.010)。结论^(18)F-FDOPA PET/CT有助于评估放化疗用于高级别脑胶质瘤效果。

关键词：胶质瘤放射治疗药物治疗正电子发射断层显像

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公共服务满意度对农村居民获得感的影响

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热带农业工程 2024年第1期48卷 46-53页

作者：杜秀予李芬海南大学公共管理学院海南海口570228 海南省公共治理研究中心海南海口570228

文章基于OLS回归模型,探讨了公共服务满意度对农村居民获得感的作用,并对其收入异质性和影响路径进行了分析。研究发现:(1)公共服务满意度与农村居民获得感之间具有正相关关系;(2)公共服务满意度对农村不同收入群体的获得感存在不同的... 详细信息

文章基于OLS回归模型,探讨了公共服务满意度对农村居民获得感的作用,并对其收入异质性和影响路径进行了分析。研究发现:(1)公共服务满意度与农村居民获得感之间具有正相关关系;(2)公共服务满意度对农村不同收入群体的获得感存在不同的影响效应;(3)社会公平感作为调节变量,其在公共服务满意度与农村居民获得感中的调节作用得到了部分检验。由此提出:应以农村居民需求为导向不断提高公共服务满意度,以公共服务满意度为依托提升农村居民的获得感,以社会公平感为抓手增强农村居民的获得感。

关键词：公共服务满意度农村居民获得感收入异质性调节作用

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