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The effect of SiO_2 particle size on iron based F–T synthesis catalysts

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Chinese Journal of Chemical Engineering 2016年第7期24卷 937-943页

作者： xiuying guo Yijun Lu Peng Wu Kui Zhang Qinghua Liu Mingsheng Luo National Institute of Clean and Low Carbon Energy Beijing 102209 China

The effect of particle size of silica, as catalyst binder, on the chemical and mechanical properties of iron based FT catalyst was studied in this work. The samples were characterized using XRD, BET, TEM, FT-IR, and H2-TPR, re- spectively. The attrition resistance and the FT activity were tested. Si-8-Si-15 catalysts prepared with 8-15 nm silica sol show good attrition resistance （attrition loss 〈 4%）, especially Si-13 with an attrition loss of 1.89%. He- matite appeared in XRD patterns when silica sol above 15 nm is used. TEM micrographs show that no obvious SiO2 particles appear when silica sol particle with size less than 8 nm was used, but SiO2 particles coated with small ferrihydrite particles appear when silica sol above 8 nm was used. Si-O-Si vibration peak in FT-IR spectra increases with increasing silica sol size. Samples prepared with silica sol show good stability of FT reactions, and the average molecular weight of FT products increases with the increase of SiO2 particle.

关键词： SiO2 Fischer-Tropsch synthesisIron based FT catalystAttrition resistance

Research progress and prospects on hydrogen separation membranes

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Clean Energy 2023年第1期7卷 217-241页

作者： Congmin Liu Xin Zhang Junxiang Zhai Xuan Li xiuying guo Guangli He National Institute of Clean-and-Low-Carbon Energy New Energy Center National Institute of Clean-and-Low-Carbon EnergyFuture Science CityChangping DistrictBeijing 102211China National Institute of Clean-and-Low-Carbon Energy Equipment and Facilities Center National Institute of Clean-and-Low-Carbon EnergyFuture Science CityChangping DistrictBeijing 102211China

Membrane separation technologies,with a broad application prospect in the field of hydrogen separation,are characterized by the simplicity of the devices,high energy efficiency and environmental *** performance of separation membranes is the primary factor that determines the efficiency of hydrogen ***,the development of hydrogen separation membranes is always a research *** paper presents and reviews the research developments and features of organic membranes,inorganic membranes and hybrid matrix membranes for hydrogen ***,the characterization methods of key index parameters of membrane materials are ***,the performance parameters of different types of membrane are ***,the trend of technological development of different types of membrane materials is forecast.

关键词： H_(2)separation membranes permeability selectivity

经鼻颅底手术患者术中鼻腔细菌培养及临床分析

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西安交通大学学报（医学版） 2024年第4期45卷 645-649页

作者：张小荣郭秀英张琳娟梅娜李瑞春冒平高珂宋莉西安交通大学第一附属医院麻醉手术部陕西西安710061 西安交通大学第一附属医院神经外科陕西西安710061

目的分析临床经鼻颅底手术术区细菌存留情况及其与术后颅内感染的相关性。方法将经鼻颅底肿瘤(蝶鞍区及鞍上)切除术患者的手术过程分为鼻腔通道准备(第1阶段)、肿瘤切除(第2阶段)和颅底重建(第3阶段)3个阶段,在每个阶段的起始时点,于... 详细信息

目的分析临床经鼻颅底手术术区细菌存留情况及其与术后颅内感染的相关性。方法将经鼻颅底肿瘤(蝶鞍区及鞍上)切除术患者的手术过程分为鼻腔通道准备(第1阶段)、肿瘤切除(第2阶段)和颅底重建(第3阶段)3个阶段,在每个阶段的起始时点,于蝶窦前壁或鞍底斜坡隐窝处黏膜各取样1次进行细菌培养,分析手术不同阶段细菌培养阳性率及其与术后颅内感染的相关性。结果共纳入患者105例,共取样315例次,3个阶段取样的中位时间点分别为手术开始后20.3、45.1、131.3 min。细菌培养的阳性结果第1阶段、第2阶段、第3阶段分别为9例(2.9%)、8例(2.5%)、23例(7.3%),其中第1阶段或第2阶段与第3阶段阳性例数差异均有统计学意义(P=0.013;P=0.007),而第1阶段与第2阶段差异无统计学意义(P=0.955)。共检出表皮葡萄球菌24例,金黄色葡萄球菌7例,溶血性链球菌3例,肺炎克雷伯杆菌2例,大肠杆菌4例。3阶段至少1次阳性结果的有36例(11.4%),术后17例(16.2%)脑脊液漏,12例(11.4%)颅内感染。细菌培养阳性患者发生颅内感染的危险性是阴性患者的3.1倍(OR=3.1,95%CI:0.9~10.6),但差异尚无统计学意义;脑脊液漏患者发生颅内感染的危险性是非脑脊液漏的61.4倍(OR=61.4,95%CI:11.2~337.1),差异有统计学意义(P<0.001)。术区鼻腔和术后脑脊液培养结果的菌种一致率为57.1%。结论经鼻颅底手术术区细菌培养阳性率随手术时间延长而明显增高,是术后颅内感染的潜在风险指标。

关键词：内镜经鼻入路细菌培养颅内感染消毒

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Cryoablation Combined with TACE for Treating Large Hepatocellular Carcinoma： Tumor Load and Cellular Immunity

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Chinese Journal of Clinical Oncology 2005年第6期2卷 842-848页

作者： Haipeng Yu Lanlan Yang Zhi guo Wenge Xin Fang Liu xiuying guo Baoguo Li Department of Interventional Therapy Cancer Institute ＆ Hospital of TianjinMedical University Tianjin 300060China. Department of Digestive Medicine TheSecond Hospital of Jilin UniversityChangchun 130041 China.

OBJECTIVE To study the effectiveness on the tumor load and cellular immune function of percutaneous cryoablation （argon-helium cryoablative system, AHCS） combined with transarterial chemoembolization （TACE） for treating large hepatocellular carcinomas （HCCs） with diameters over 10 ca. METHODS A total of 48 HCC patients were treated with AHCS after TACE. Tumor sizes ranged from 10 to 14 cm. All cases were a hypervascular type. There were 38 Child A cases and 10 Child B cases. Forty were AFP positive and 8 negative. The patients were randomized with therapy group consisting of 26 cases and the control group 22 cases. The therapy group received AHCS 4 weeks following TACE treatment. Reexamination included pathology, tumor markers, T-lymphocyte subgroup levels and computed tomography or MRI. The necrosis rate of the tumor load was calculated by Cavalieri＇s theory. EORTC QLQ-C30 was used in quality of life evaluation. RESULTS The average tumor-load reduction rate （necrosis rate） was 8.07% after TACE, and 28.65% after AHCS. Coagulation necrosis was produced in the target area. The tumor markers deceased significantly after AHCS. Tumor-load reduction after AHCS was more significant than after TACE. Suppression of cellular immunity after TACE was significant. In contrast, CD3^＋, CD4^＋ and NK increased after AHCS and an abnormal T-lymphocyte distribution was corrected. Quality of life after AHCS increased according to the EORTC QLQ-C30 evaluation. No severe complications occurred. CONCLUSION Percutaneous AHCS cryoablation after TACE reduced the tumor load in the short term. At the same time, cellular immune function was increased after AHCS. TACE was critical in increasing the therapeutic efficacy of AHCS because of its embolisation of blood vessels preventing a Flow Effect. Reduction of the tumor load in the short term may conduce to increase cellular immunity. Percutaneous AHCS cryoablation combined with TACE can reduce the tumor load, improve cellular immunity and increas

关键词： cryoablation transarterial chemoembolization tumor load cellular immunity hepatocellular carcinoma.

The Effect of the MDM2-p53 Loop on the Sensitivity of Ovarian Cancer Cells to Cisplatin

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Chinese Journal of Clinical Oncology 2006年第2期3卷 87-91页

作者： Zhi guo Hong Ni Bin Li Wenge Xing Fang Liu Haipeng Yu Baoguo Li xiuying guo Department of Interventional Radiology TianJin Medical University Cancer Hospital Tianjin 300060 China. Institute of Hematology ＆ Blood Diseases Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Tianjin 300020 China.

OBJECTIVE To explore whether MDM2 transfection can alter the MDM2-p53 autoregulatory feedback loop so as to change the sensitivity of ovarian cancer cell lines to cisplatin. METHODS The ovarian cancer cell line A2780 expressing wild-type P53 and the ovarian cancer cell line SKOV-3 with the p53 null type were stably transfected with pCMV-MDM2 or pCMV as a control. The blocked expression of P53 was determined by Western blots. Cytotoxicity was assessed using the MTT assay and the trypan blue exclusion assay. Flow cytometry was used to detect changes in the cell cycle and removal of platinum -DNA adducts was measured by atomic absorption spec-troscopy. RESULTS (1) Parental A2780 and A2780-V cells (IC50= 15.14±1.39 μmol) have similar cisplatin sensitivities, whereas sensitivity to cisplatin in A2780-M cells (IC50=7.98±1.32 μmol) was 2 to 3 fold greater (P=0.001). The trypan blue exclusion assay demonstrated that cisplatin killed a higher percentage of A2780-M cells compared to A2780-V cells. There was no significant change following MDM2 transfection in SKOV-3 cells. (2) After cisplatin treatment, A2780-M cells showed a pronounced S-phase arrest, however, A2780 cells with the intact wild-type P53, arrested primarily at the G2/M transition. (3) Platinum uptake was similar for all of the A2780 cell lines after ciaplatin treatment, but the removal of plat-inum-DNA adducts was reduced in the A2780-M cells compared with A2780-V cells. CONCLUSION MDM2 increases cisplatin cytotoxicity in ovarian cancer cells by blocking the expression of p53 through the MDM2-p53 autoregulatory feedback loop.

关键词： MDM2 pp53 drug sensitivity ovarion cancer cells.

Intensive Insulin Therapy of the Patients with Diabetic Multiple Organ Failure

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美国中华健康卫生杂志 2005年第4期8卷 46-49页

作者： ZHANG Shenglan ZHANG xiuying WANG Bin guo Hui HONG Ling General Hospital of Jinan Command PLA Jinan 250031 China

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创新性的拖动机构

制造技术与机床 2015年第9期 56-58页

作者：郭秀英沈阳第一机床厂辽宁沈阳110142

多品种、细长轴类工件的加工过程需配置2—4个中心架，而中心架的相对位置是变化的。传统的中心架拖动机构复杂、成本高。因此推出一款创新性的拖动机构用于中心架移动，其超长燕尾导轨副具有结构紧凑的特点，仅配一套动力源尽显低成本... 详细信息

多品种、细长轴类工件的加工过程需配置2—4个中心架，而中心架的相对位置是变化的。传统的中心架拖动机构复杂、成本高。因此推出一款创新性的拖动机构用于中心架移动，其超长燕尾导轨副具有结构紧凑的特点，仅配一套动力源尽显低成本的特点。配以自行开发的智能软件，获得了高性价比。

关键词：拖动机构超长燕尾导轨副低成本动力源智能软件创新性

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创新性的外铣装置

制造技术与机床 2016年第2期 142-146页

作者：郭秀英沈阳第一机床厂辽宁沈阳110142

针对中速机曲轴的粗加工问题,推出一款创新性外铣装置;通过对自身技术的论述,显示本装置的创新性、高刚性,旨在推进制造业的创新,强大自主品牌。

关键词：外铣装置创新性高刚性三种工作姿态

新型高性能Cu/HMS催化剂的合成及其在草酸二甲酯催化加氢合成乙二醇反应中的应用

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化学学报 2009年第15期67卷 1731-1736页

作者：尹安远郭秀英戴维林范康年复旦大学化学系上海市分子催化和功能材料重点实验室上海200433

采用原位合成法合成了介孔Cu/HMS催化剂,并以草酸二甲酯催化加氢合成乙二醇为探针反应考察了不同焙烧温度对反应催化性能的影响,结果表明焙烧温度为650℃时合成的催化剂在该反应中表现出最佳的催化性能.在反应温度为200℃、压力为3MPa... 详细信息

采用原位合成法合成了介孔Cu/HMS催化剂,并以草酸二甲酯催化加氢合成乙二醇为探针反应考察了不同焙烧温度对反应催化性能的影响,结果表明焙烧温度为650℃时合成的催化剂在该反应中表现出最佳的催化性能.在反应温度为200℃、压力为3MPa、氢酯比为50、液时空速为0.74h-1的条件下,草酸二甲酯的转化率达到100%,并且乙二醇的选择性达到97%.采用X射线粉末衍射、N2低温吸附、H2-TPR、N2O滴定、X射线光电子能谱及傅利叶变换红外光谱对系列催化剂进行了系统表征,阐述了焙烧温度对催化性能影响的本质原因.研究表明焙烧温度能够影响活性铜物种的分散度和铜物种与载体间的相互作用,从而影响草酸二甲酯催化加氢的催化性能.

关键词： Cu/HMS 草酸二甲酯乙二醇催化加氢