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基于双气相CT扫描肺血管定量参数对慢性阻塞性肺疾病及高危人群的诊断价值研究

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中华放射学杂志 2024年第7期58卷 729-737页

作者：张金周秀秀周陶胡范丽萧毅吴燕燕刘士远徐州医科大学医学影像学院徐州221000 海军军医大学第二附属医院放射诊断科上海200003

目的探讨双气相CT肺血管定量参数的差值、相对值在慢性阻塞性肺疾病(COPD)诊断及高危人群预警中的价值。方法该研究为横断面研究。回顾分析2018年8月至2020年12月在海军军医大学第二附属医院接受双气相胸部CT检查的受试者624例,根据肺... 详细信息

目的探讨双气相CT肺血管定量参数的差值、相对值在慢性阻塞性肺疾病(COPD)诊断及高危人群预警中的价值。方法该研究为横断面研究。回顾分析2018年8月至2020年12月在海军军医大学第二附属医院接受双气相胸部CT检查的受试者624例,根据肺功能检查进行分组:正常组321例、保留比率的肺功能受损(PRISm)组204例及COPD组99例。双气相CT图像导入工作站得到肺血管定量参数:呼气相、吸气相全肺距胸膜9、12、15、18、21 mm水平的肺血管数量(N_(total))、横截面积小于5 mm2肺小血管数量(N_(CSA5))、血管面积(VA_(total))及全肺血管总体积(TBV)、全肺横截面积0.05),而呼气相与吸气相差值、呼气相与吸气相相对值在COPD组与正常组的差异有统计学意义(P<0.05)。结论双气相CT肺血管定量参数差值、相对值比单一吸气相血管参数更有助于区分COPD患者与正常人群的肺血管重塑变化,同时也补充PRISm人群的肺血管特征,为COPD及高危人群的早期预警提供依据。

关键词：肺疾病慢性阻塞性体层摄影术 X线计算机肺血管

支气管镜介入治疗肺毛霉病伴主支气管闭塞1例

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中华结核和呼吸杂志 2024年第6期47卷 550-553页

作者：吴秀秀王娟金艳坤林隆邱小建张杰王婷首都医科大学附属北京天坛医院呼吸与危重症医学科北京100070

肺部毛霉感染是毛霉病中最常见的感染类型之一,其中气管支气管肺毛霉病以累及气管支气管树为主要表现,病变可侵及气道黏膜、肌层,进而破坏软骨,具有发病急、进展快、病死率高等特点,临床治疗具有挑战性。本文报道1例肺毛霉感染并发左主... 详细信息

肺部毛霉感染是毛霉病中最常见的感染类型之一,其中气管支气管肺毛霉病以累及气管支气管树为主要表现,病变可侵及气道黏膜、肌层,进而破坏软骨,具有发病急、进展快、病死率高等特点,临床治疗具有挑战性。本文报道1例肺毛霉感染并发左主支气管闭塞患者的诊治过程,在以两性霉素B静脉注射联合泊沙康唑口服混悬液为主的全身治疗基础上,患者先后经历了多次支气管镜下介入治疗,包括镜下局部灌注两性霉素B、球囊扩张以及硅酮支架置入等,经过4个月的综合治疗,疗效满意。本文旨在阐明支气管镜介入治疗在肺毛霉病综合治疗过程中具有重要作用,特别是可以避免因阻塞性肺炎进展导致的死亡。

关键词：阻塞性肺炎主支气管感染类型泊沙康唑肺毛霉病气管支气管支气管镜两性霉素B

子痫风险预测联合脐动脉S/D比值对妊娠期糖尿病患者妊娠结局的预测价值

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中国现代医生 2024年第17期62卷 38-41,46页

作者：金海红王秀秀浙江省台州医院妇产科浙江台州317000

目的探讨子痫风险预测联合脐动脉收缩期峰值流速与舒张末期流速(peak systolic velocity/end diastolic velocity,S/D)比值对妊娠期糖尿病患者妊娠结局的预测价值。方法选取2021年1月至2023年1月笔者医院产科门诊收治的60例妊娠期糖尿病... 详细信息

目的探讨子痫风险预测联合脐动脉收缩期峰值流速与舒张末期流速(peak systolic velocity/end diastolic velocity,S/D)比值对妊娠期糖尿病患者妊娠结局的预测价值。方法选取2021年1月至2023年1月笔者医院产科门诊收治的60例妊娠期糖尿病(gestational diabetes mellitus,GDM)患者作为妊娠糖尿病组;同一时间,选取笔者医院产科门诊孕检正常的健康孕妇30例作为对照组。采用磁微粒化学发光法检测血清胎盘生长因子(placental growth factor,PIGF),超声检测,S/D比值同时按照是否合并不良妊娠结局分为妊娠结局良好组及不良妊娠结局组,比较PIGF及S/D比值;采用受试者操作特征(receiver operating characteristic,ROC)曲线分析PIGF联合S/D比值对GDM患者妊娠结局的预测价值进行预测分析。结果与对照组比较,妊娠糖尿病组患者PIGF降低,S/D升高(P<0.05)。对照组不良妊娠结局的发生率为20.00%,妊娠糖尿病组不良妊娠结局的发生率为46.67%,与对照组比较,妊娠糖尿病组不良妊娠结局的发生率升高(P<0.05)。与妊娠结局良好组比较,不良妊娠结局组的GDM患者PIGF水平降低,S/D比值升高(P<0.05)。ROC曲线分析PIGF、S/D比值对GDM患者不良妊娠结局敏感度及特异性分析发现,S/D比值诊断效果高于PIGF,但联合更高。结论妊娠期糖尿病患者中PIGF水平降低,S/D比值增加,且与患者不良妊娠结局相关,PIGF联合S/D比值对患者不良妊娠结局的诊断效能最高。

关键词：妊娠期糖尿病胎盘生长因子收缩期峰值流速与舒张末期流速比值糖耐量降低妊娠结局

维普期刊数据库博看期刊

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经济负担对前列腺癌患者失志情况影响的研究

中国医院统计 2024年第2期31卷 145-148页

作者：金珍珍李萍余秀秀温州医科大学附属第一医院浙江温州325000

目的了解经济负担对前列腺癌患者失志情况的影响,为制定干预措施提供理论依据。方法采用便利抽样法选取2020年12月至2022年12月在某院住院治疗的249例前列腺癌患者为研究对象。采用癌症患者报告结局的经济毒性量表、失志综合征量表Ⅱ进... 详细信息

目的了解经济负担对前列腺癌患者失志情况的影响,为制定干预措施提供理论依据。方法采用便利抽样法选取2020年12月至2022年12月在某院住院治疗的249例前列腺癌患者为研究对象。采用癌症患者报告结局的经济毒性量表、失志综合征量表Ⅱ进行问卷调查。结果经济负担得分为(27.05±8.14)分,失志得分为(14.93±4.87)分;不同年龄、学历、家庭人均月收入、工作状态、确诊年限、肿瘤临床分期、合并症的患者失志得分存在显著性差异(P<0.05);前列腺癌患者经济负担得分与失志总分及各维度得分均呈正相关(P<0.01);前列腺癌患者的肿瘤临床分期、经济负担、学历及合并症是患者失志的主要影响因素(P<0.05)。结论前列腺癌患者经济负担较重,失志水平较高,应针对患者的确诊年限、经济负担、学历及合并症情况采取相应的干预措施,缓解患者的失志程度。

关键词：前列腺癌经济负担失志相关因素

Research on wavelength conversion of triangular pulses with variable symmetry based on SPM effect

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Optoelectronics Letters 2023年第8期19卷 449-454页

作者： YUAN jin LIU Qisong MEI Ying XU xiuxiu WANG Yujie BA Xinran State Key Laboratory of Media Convergence and Communication Communication University of ChinaBeijing 100044China

The generation of periodic triangular waveform with variable symmetrical coefficient based on a dual-parallel Mach-Zehnder modulator(DP-MZM) is demonstrated in this *** properly setting the modulation index and bias points of DP-MZM,desired symmetric/asymmetric triangular waveforms can be *** applying the generated triangular waveform into an amplitude modulator(AM),a single-period signal can be extracted to explore the optical wavelength conversion induced by the self-phase modulation(SPM) effect in a high nonlinear fiber(HNLF).Wavelength shifts of triangular waveforms with different coefficients(10%,20%,30%,40% and 50%) are *** addition,the influence of key parameters of HNLF on the wavelength conversion is analyzed in detail.

关键词： modulator triangular effect

p-Cresyl sulfate promotes the formation of atherosclerotic lesions and induces plaque instability by targeting vascular smooth muscle cells

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Frontiers of Medicine 2016年第3期10卷 320-329页

作者： Hui Han Yanjia Chen Zhengbin Zhu xiuxiu Su jingwei Ni Run Du Ruiyan Zhang Wei jin Department of Cardiology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Coronary atherosclerosis is a major complication of chronic kidney disease. This condition contributes to the increased mortality in dialysis patients.p-Cresyl sulfate （PCS） is a prototype of protein-bound uremic toxins that cannot be efficiently removed through routine dialysis procedures. In the present study, ApoE/- mice that underwent 5/6 nephrectomy were randomly divided into two groups, namely, vehicle-treated group （n = 20） and PCS-treated group （n = 20）. Mice were sacrificed for en face and immunohistological analyses after 8 or 24 weeks of high-fat diet. Rat aortic vascular smooth muscle cells （VSMCs） were treated with phosphate buffer solution or 500 ltmol/L PCS for in vitro evaluation. PCS-treated mice were observed to suffer increased atherosclerotic lesions after eight weeks of PCS administration. Moreover, 24 weeks of PCS administration also markedly increased the vulnerability index of aortic plaques. PCS was also observed to facilitate the migration and proliferation of VSMCs during the progression of the disease. Moreover, PCS disturbed the balance between matrix metalloproteinases and tissue inhibitor of metalloproteinases within the plaques. Thus, PCS played a vital role in promoting atherogenesis and disturbing the stability of formed plaques probably by targeting VSMCs.

关键词： p-cresyl sulfate atherosclerosis plaque stability vascular smooth muscle cell

Lysosome-targeting red fluorescent probe for broad carboxylesterases detection in breast cancer cells

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Chinese Chemical Letters 2022年第9期33卷 4229-4232页

作者： Yanyan Sun Xiaonan Zhou Liyuan Sun xiuxiu Zhao Yongrui He Ge Gao Weina Han jin Zhou School of Pharmacy School of Rehabilitation MedicineWeifang Medical UniversityWeifang 261053China Weifang Maternal and Child Health Hospital Maternal and Child Health Hospital of Weifang Medical UniversityWeifang 261011China

Available online The abnormal carboxylesterase(CES)expression is closely related to many diseases such as hyperlipidemia,atherosclerosis,obesity,liver cancer,type 2 diabetes mellitus and gastrointestinal stromal *** detection of a single enzyme in practical samples is often constrained by the structural diversity of ***,the development of broad-carboxylesterase responsive fluorescent probe,which can detect the presence of wide variety of CESs,may provide overall or category information from another point of view,supplementing the deficiency of single detection for CES *** lysosome is involved in various cell processes,such as cell signaling,apoptosis,secretion,and energy *** to date,lysosome-targeted fluorescent probes,especially those with red emission(over 550 nm,with relatively low biological harmfulness),for CES detection are still rare.A lysosomes-targeted red fluorescent probe CES-Lyso was designed to monitor intracellular a variety of carboxylesterases alteration with wonderful selectivity and sensitivity,which was further applied to distinguish different derived breast cancer cells and monitor carboxylesterase activity in the anticancer drug treatment.

关键词： Fluorescent probe Carboxylesterases Broad detection Breast cancerLysosome-targeting Red fluorescence

防撞鸟巢式护理联合腹部按摩在新生儿高胆红素血症患儿中的应用

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临床医学工程 2024年第10期31卷 1259-1260页

作者：张会敏卢瑞存杨秀秀金艳董闪闪郑州大学附属儿童医院/河南省儿童医院/郑州儿童医院新生儿内科河南郑州450018

目的探讨防撞鸟巢式护理联合腹部按摩在新生儿高胆红素血症患儿中的应用效果。方法58例接受蓝光治疗的新生儿高胆红素血症患儿随机分为两组。参照组实施常规护理干预,研究组实施防撞鸟巢式护理联合腹部按摩干预。比较两组的哭闹时间、... 详细信息

目的探讨防撞鸟巢式护理联合腹部按摩在新生儿高胆红素血症患儿中的应用效果。方法58例接受蓝光治疗的新生儿高胆红素血症患儿随机分为两组。参照组实施常规护理干预,研究组实施防撞鸟巢式护理联合腹部按摩干预。比较两组的哭闹时间、高胆红素血症消退时间、睡眠时间以及不良反应。结果研究组的哭闹时间、高胆红素血症消退时间均短于参照组,睡眠时间长于参照组(P<0.05)。研究组的不良反应总发生率为3.45%,低于参照组的27.59%(P<0.05)。结论防撞鸟巢式护理联合腹部按摩可明显延长新生儿高胆红素血症患儿的睡眠时间,缩短其哭闹时间和高胆红素血症消失时间,减少不良反应的发生。

关键词：新生儿高胆红素血症防撞鸟巢式护理腹部按摩效果不良反应

Manifesting viscosity changes in lipid droplets during iodined CT contrast media treatment by the real-time and in situ fluorescence imaging

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Chinese Chemical Letters 2023年第4期34卷 246-250页

作者： Ning Ding Xueliang Liu Aixia Meng xiuxiu Zhao Gang Ma Weina Han Peng Dong Jianchun Li jin Zhou School of Pharmacy School of Medical ImagingSchool of Basic Medical SciencesWeifang Key Laboratory of Pharmaceutical Chemical Biology for CancerWeifang Medical UniversityWeifang 261053China Weifang People’s Hospital Weifang 261000China

Computed tomography(CT) is one of the most commonly used non-invasive clinical imaging modalities to predict, diagnose and treat the disease. Iodinated contrast media(ICM) is a form of intravenous radiocontrast agent containing iodine, which enhances the visibility of hollow tissue structures in medical CT imaging. ICM may cause allergic reactions, contrast-induced nephropathy, hyperthyroidism and possibly metformin accumulation. It is significant to find out the risk factors, pathogenesis, diagnosis, prevention, and treatment of adverse reactions caused by ICM. Revealing the changes of the lipid droplets(LDs)viscosity in pathophysiological processes such as cancer and iodined contrast media induced adverse reaction is not only important for monitoring the occurrence and development of some pathophysiological processes but also vital for the deep insight of the biological effects of LDs in these pathophysiological processes. A lipid droplets targeted fluorescent probe DN-1 was devised to sense cellular viscosity alteration with high selectivity and sensitivity, which was applied to distinguish cancer cells and normal cells and reveal viscosity changes during iodined CT contrast media treatment.

关键词： Fluorescent probe Viscosity Lipid droplets Iodined contrast media Distinguishment of cancer and normal cells