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Acta Oceanologica Sinica 2022年第1期41卷 1-10页

作者： Baohong Chen Kaiwen Zhou Kang Wang Jigang Wang Sumin Wang xiuwu sun Jinmin Chen Cai Lin Hui Lin Third Institute of Oceanography Ministry of Natural ResourceXiamen 361005China Institute for Advanced Ocean Study Ocean University of ChinaQingdao 266003China

This research investigated eight stations in Clarion-Clipperton Fracture Zone(CCFZ)in the eastern tropical Pacific in 2017 to study the spatial distribution characteristics of nutrients and chlorophyll a(Chi a)concentration,and compared nutrient concentrations and molar ratios with those of other investigations 20 years ago in the same area.The study found that dissolved inorganic nutrient(N,P and Si)concentrations were lowest in the upper layer,and increased from surface to some depths,then they decreased a little to the bottom.N was the limited nutrient factor for the growth of phytoplankton community.Although nutrient concentrations and molar ratios have no obvious changes in 2017 comparing those in 1998-2003,supplemented from the equatorial Pacific,nutrient concentrations in the study area were higher than those in seamounts in the North Pacific and Station ALOHA.Furthermore,this study used Generalized Additive Models(GAMs)to infer the underlying bottom-up factors controlling phytoplankton abundance(Chi a concentration),showing that depth,salinity and PO^-P concentration were major factors controlling the growth of phytoplankton community.Furthermore,this study can provide basic data and theoretical support for the development of polymetallic nodule area and its long-term impact assessment on the environment.

关键词： nutrients Chla GAMs CCFZ Pacific

The particle fluxes in sediment traps from Niulang Guyot area in the Northwest Pacific Ocean

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Acta Oceanologica Sinica 2022年第11期41卷 34-44页

作者： xiuwu sun Jinmin Chen Baohong Chen Cai Lin Yang Liu Jiang Huang Zhong Pan Kaiwen Zhou Qing He Fangfang Kuang Hui Lin Laboratory of Marine Ecological and Environment Early Warning and Monitoring Third Institute of OceanographyMinistryof Natural ResourcesXiamen 361005China Ocean Dynamics Laboratory Third Institute of OceanographyMinistry of Natural ResourcesXiamen 361005China

The flux of settling particles in the ocean has been widely explored since 1980s due to its important role in biogenic elements cycling,especially in the transport of particulate organic carbon(POC)in the deep sea.However,research in the seamount area of the oligotrophic subtropical Northwest Pacific Ocean is lacking.In this work,two sediment traps were deployed at the foot and another two at the hillside of Niulang Guyot from August2017 to July 2018.The magnitude and composition of particle fluxes were measured.The main factors influencing the spatial variations of the fluxes were evaluated.Our results indicated a low particulate flux from Niulang Guyot area in the Northwest Pacific Ocean,reflecting low primary productivity of the oligotrophic ocean.The total mass flux(TMF)decreased from 2.57 g/(m^(2)·a)to 0.56 g/(m^(2)·a)with increasing depth from 600 m to 4850 m.A clear seasonal pattern of TMF was observed,with higher flux in summer than that in winter.The peak flux of 26.52 mg/(m^(2)·d)occurred in August at 600 m,while the lowest value of 0.07 mg/(m^(2)·d)was shown in February at 4850 m.The settling particles at the deep layers had similar biochemical composition,with calcium carbonate(CaCO_(3))accounting for up to 90%,followed by organic matter and opal,characteristics of Carbonate Ocean.The POC flux decreased more rapidly in the twilight layer because of faster decomposition,remineralization,and higher temperature.A small fraction of POC was transported into the deep ocean by biological pump.Particle fluxes were mainly controlled by the calcareous ballasts besides the primary productivity of the surface water.The advection may be another important factor affecting the flux in the seamount area.The combination of settled matters rich in foraminiferal tests with topography and currents may be the reason for regulating the local abundance of benthos on seamounts.Our results will fill in the knowledge gap of sedimentation flux,improve the understanding of ecosystem in Niulang Guyot area,and eventually provide d

关键词： sediment trap flux seamount POC Northwest Pacific Ocean

钦州湾沉积物中重金属的多元统计分析:空间关系、生态风险和来源识别

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应用海洋学学报 2024年第1期43卷 135-146页

作者：王伟力林彩刘洋黄海宁陈金民孙秀武林辉自然资源部第三海洋研究所福建厦门361005 广西北部湾海洋资源环境与可持续发展重点实验室广西北海536000

海湾是海洋和陆地相互作用和人类活动最强烈的区域,沉积物中重金属的含量和分布都受到人类活动的影响。为了探究钦州湾沉积物中重金属的含量水平、污染程度和可能来源,本研究分析了钦州湾表层沉积物中Cu、Pb、Zn、Cd、Cr、Hg和As的含量... 详细信息

海湾是海洋和陆地相互作用和人类活动最强烈的区域,沉积物中重金属的含量和分布都受到人类活动的影响。为了探究钦州湾沉积物中重金属的含量水平、污染程度和可能来源,本研究分析了钦州湾表层沉积物中Cu、Pb、Zn、Cd、Cr、Hg和As的含量及空间分布,采用地质累计指数(Igeo)和潜在生态风险指数(PERI)定量分析了重金属的污染程度和生态风险,并利用自组织映射(SOM)和正定矩阵因子分解法(PMF)模型评估了重金属的可能来源。结果表明:钦州湾表层沉积物重金属中Zn的平均含量最高,Hg平均含量最低;除个别站位的Pb含量符合海洋沉积物质量第二类标准外,其他重金属含量均符合海洋沉积物质量第一类标准;Igeo结果表明钦州湾表层沉积物主要的污染元素为Pb、Hg和Cu;PERI结果表明Hg是钦州湾表层沉积物主要的生态风险元素。SOM和PMF模型结果表明钦州湾表层沉积物重金属主要受自然来源、农业活动、工业生产活动的共同影响,各来源的相对贡献率分别为39.65%、29.15%和31.20%。

关键词：海洋化学表层沉积物重金属生态风险 PMF模型来源钦州湾

On the integrity of a commercial cassette ultrafiltration membrane: implications for marine colloidal biogeochemistry

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Acta Oceanologica Sinica 2014年第9期33卷 109-116页

作者： LIN Liangshi CAI Yihua sun xiuwu CHEN Min State Key Laboratory of Marine Environmental Science and College of Ocean and Earth Science Xiamen University Third Institute of Oceanography State Oceanic Administration

The performance and integrity of a cassette cross-flow ultrafilter （Pellicon 2, Millipore） are examined with a suite of macromolecules of different molecular masses. The retention coefficient during the cross-flow ultrafiltration experiments increases with increasing molecular mass and reaches 90% with 10 kDa dextran in both milli-Q water and ultrafiltered seawater media. Based on a 90% retention coefficient, the molecular mass cut-off for the ultrafiltration membrane is defined at 10 kDa, which is ten times （1 kDa） that rated by the manufacturer. To further validate the accuracy of the laboratory calibration, the samples from the lower Zhujiang River and the Jiulong River Estuary are ultrafiltered with the cassette ultrafiltration membrane and the colloidal organic carbon abundances in these samples are quantified with the ultrafiltration per- meation model based on time series permeation subsamples. The colloidal organic carbon abundances are 5.8%-21.1% in the Jiulong River Estuary and 5.6%-11.0% in the lower Zhujiang River. These are consistent with the reported values for both estuaries as well as with the colloidal organic carbon abundances in ma- rine environments over the coastal and open oceans with 10 kDa cut-off membranes. Therefore, these field data support the laboratory calibration result and indicate the validity of the experimental and quantification procedure adopted. The discrepancy between the nominal molecular mass cut-off and the actual pore size of the ultrafiltration membrane should be of great concern for research in colloidal and nanoparticle biogeochemistry. Careflfl examination of the membrane integrity should be taken during ultrafiltration ex- oeriments in order to avoid misleading molecular mass cut-off information.

关键词： cross-flow ultrafiltration membrane calibration colloidal organic carbon Iiulong RiverEstuary Zhujiang River Estuary

Speciation, distribution, and potential ecological risk assessment of heavy metals in Xiamen Bay surface sediment

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Acta Oceanologica Sinica 2014年第4期33卷 13-21页

作者： LIN Cai LIU Yang LI Wenquan sun xiuwu JI Weidong College of Ocean and Earth Science Xiamen University Third Institute of Oceanography State Oceanic Administration

Based on the survey of surface sediment in Xiamen Bay in October 2011, the speciation, distribution, and potential ecological risk assessment of heavy metals （Cu, Pb, Zn, Cd, and Cr） in this area were studied us-ing the sequential extraction method and ecological risk assessment method. The results indicated：（1） the total concentrations of these heavy metals were influenced by runoff, industrial wastewater, and sewage, and were all higher in the coastal area than the offshore area while the highest area of Pb was a little far-ther away from the coastal water due to atmosphere deposition;（2） sequential extractions suggested that Cu was mainly composed with residual and Fe/Mn-oxide bound fractions, Pb was bound to Fe/Mn-oxide, Zn and Cr were dominated by residual, and Cd bound to exchangeable and carbonate fractions; （3） the order of migration and transformation sequence was Cd＆gt;Pb＆gt;Cu＆gt;Zn＆gt;Cr and the degree of pollution was Cd＆gt;Pb＆gt;Cu＆gt;Zn＆gt;Cr;and （4） the ratios of the secondary and primary phases showed that Zn and Cr were both clean, Cu may be polluted, Pb was moderately polluted, while Cd was heavily polluted.

关键词： Xiamen Bay heavy metals speciation distribution ecological risk

Distribution of dissolved oxygen and causes of maximum concentration in the Bering Sea in July 2010

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Acta Oceanologica Sinica 2014年第6期33卷 20-27页

作者： sun xiuwu LIN Cai CHEN Yong ZHANG Yuanbiao WANG Jigang JI Weidong Third Institute of Oceanography State Oceanic Administration College of Ocean and Earth Sciences Xiamen University

According to data obtained in the Bering Sea during the 4th Chinese National Arctic Research Expedition, the distribution of dissolved oxygen （DO） was studied, causes of its maximum concentration were discussed, and the relationships between DO and other parameters, such as saliniW, temperature, and chlorophyll a were analyzed. The results showed DO concentration ranged from 0.53 to 12.05 mg/L in the Bering Sea basin. The upper waters contained high concentrations and the maximum occurred at the depth range from 20 to 50 m. The DO concentration decreased rapidly when the depth was deeper than 200 m and reached the minimum at the depth range from 500 to 1000 m, and then increased slowly with the depth increasing but still kept at a low level. On the shelf, the DO concentration ranged from 6.53 to 16.63 mg/L with a mean value of 10.75 mg/L, and showed a characteristic of decreasing from north to south. The DO concentration was higher in the area between the Bering Sea and Lawrence Island and was lower in the southeast and southwest of Lawrence Island at the latitude of 62°N. The formation of maximum DO concentration was concerned with phytoplankton photosynthesis and formation of the themocline. To the south of Sta. B07 in the Bering Sea basin, the oxygen produced by photosynthesis permeated to the deeper water and the themocline made it difficult to exchange vertically, and to the north of Sta. B07, the maximum DO concen- tration occurred above the themocline due to phytoplankton activities. On the shelf, the oxygen produced by phytoplankton photosynthesis gathered at the bottom of the thermocline and formed the DO maximum concentration. In the Bering Sea basin, the DO and salinity showed a weak negative correlation （r=0.40） when the salinity was lower than 33.1, a significant negative correlation （r=-0.92） when the salinity ranged from 33.1 to 33.7, and an irregular reversed parabola （r=0.95） when the salinity was greater than 33.7. Key words： Bering Sea, dissolved oxygen, maximum concentration, stratification, c

关键词： Bering Sea dissolved oxygen maximum concentration stratification chlorophyll a

前置基础课程教学在临床病理科住院医师规范化培训中的实践研究

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中华医学教育探索杂志 2024年第4期23卷 563-567页

作者：林勇孙珊珊张樨吴友莉叶双慧许森林姚小红阁晓初卡修武段光杰陆军军医大学第一附属医院病理科/全军临床病理学研究所重庆400038

为探究前置基础课程教学在临床病理科住院医师规范化培训中的作用,本基地自主设计构建了以解部学和组织胚胎学为主干的前置基础课程教学体系,开展各年级学员小讲座和导师系统授课2个层次的理论教学,以及取材教学及病例教学2个维度的实... 详细信息

为探究前置基础课程教学在临床病理科住院医师规范化培训中的作用,本基地自主设计构建了以解部学和组织胚胎学为主干的前置基础课程教学体系,开展各年级学员小讲座和导师系统授课2个层次的理论教学,以及取材教学及病例教学2个维度的实践操作培训,探索出以“讲教结合、实践操作、归纳总结、考核评估、回顾反馈”为核心的教学模式。通过探索与实践,取得了较好的教学效果。结果显示,试验组理论结业成绩为(458.80±17.60),实践结业成绩为(415.40±19.30),高于对照组的(444.50±20.90)和(398.80±23.70),差异有统计学意义。对2019至2021级28名学员实施效果反馈调查显示,学员对该教学模式的满意度达96.43%。该教学模式的建立和应用为临床病理科住院医师规范化培训教学方法改革提供了新的思路。

关键词：诊断病理学规范化培训解剖学组织胚胎学

Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm

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Cellular & Molecular Immunology 2021年第5期18卷 1305-1307页

作者： Jinghe Zhang Haibo Wu XiaoHong Yao Dingyu Zhang Yonggang Zhou Binqing Fu Wei Wang Heng Li Zhe Wang Ziming Hu Yong Ren Rui sun Zhigang Tian xiuwu Bian Haiming Wei Department of Pathology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhuiChina Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Life Science and Medical CenterUniversity of Science and Technology of ChinaHefeiAnhuiChina Intelligent Pathology Institute Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhuiChina Institute of Pathology Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina Wuhan Jinyintan Hospital(Wuhan Hospital for Infectious Diseases) WuhanHubeiChina General Hospital of Central Theater Command PLAWuhanChina

Coronavirus disease 2019(COVID-19)is an unprecedented pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).As of 22 February 2021,the worldwide pandemic has resulted in more than 110 million cases and 2.4 million deaths.1 Clinical investigation of COVID-19 patients has shown that a systemic cytokine storm can occur,especially in severe cases.2 Treatment of the SARS-CoV-2-associated cytokine storm with tocilizumab3 or anakinra4 has been shown to immediately improve the clinical outcome in most severe and critical COVID-19 patients.These data highlight the systemic cytokine storm as an important exacerbating event in severe COVID-19;however,our understanding of the molecular mechanisms involved in the initiation of the SARS-CoV-2-associated cytokine storm is limited.In the present study,we uncovered a reasonable explanation for cytokine storm initiation through the analysis of 13 autopsy samples from severe COVID-19 patients.

关键词： cytokine storm acute

Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3940-3954页

作者： Ting Gao Lin Zhu Hainan Liu Xiaopeng Zhang Tingting Wang Yangbo Fu Hongzhen Li Qincai Dong Yong Hu Zhang Zhang Jing Jin Zijing Liu Weihong Yang Yaoning Liu Yanwen Jin Kaitong Li Yongjiu Xiao Junli Liu Huailong Zhao Yue Liu Ping Li Jibo Song Lu Zhang Yuwei Gao Sisi Kang Shoudeng Chen Qingjun Ma xiuwu Bian Wei Chen Xuan Liu Qing Mao Cheng Cao Institute of Biotechnology Academy of Military Medical SciencesBeijing 100850China Institute of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230601China Beijing Key Laboratory of Bio-products Safety Assessment Joinn Laboratories(China)Co.LtdBeijing 100176China The 940th Hospital of the People’s Liberation Army LanzhouGansu 730050China Department of Gastroenterology the 960th Hospital of the People’s Liberation ArmyZiboShandong 255300China Academy of Military Medical Science of PLA 666 Liuyingxi StChangchun 130122China Molecular Imaging Center Guangdong Provincial Key Laboratory of Biomedical ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China First Affiliated Hospital Army Medical UniversityChongqing 400038China

Excessive inflammatory responses contribute to the pathogenesis and lethality of highly pathogenic human coronaviruses,but the underlying mechanism remains unclear.In this study,the N proteins of highly pathogenic human coronaviruses,including severe acute respiratory syndrome coronavirus(SARS-CoV),middle east respiratory syndrome coronavirus(MERS-CoV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),were found to bind MASP-2,a key serine protease in the lectin pathway of complement activation,resulting in excessive complement activation by potentiating MBL-dependent MASP-2 activation,and the deposition of MASP-2,C4b,activated C3 and C5b-9.Aggravated inflammatory lung injury was observed in mice infected with adenovirus expressing the N protein.Complement hyperactivation was also observed in SARS-CoV-2-infected patients.Either blocking the N protein:MASP-2 interaction,MASP-2 depletion or suppressing complement activation can significantly alleviate N protein-induced complement hyperactivation and lung injury in vitro and in vivo.Altogether,these data suggested that complement suppression may represent a novel therapeutic approach for pneumonia induced by these highly pathogenic coronaviruses.

关键词： lung inflammation activation

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介孔活性炭的制备及其高湿储甲烷性能

天津大学学报 2013年第2期46卷 138-144页

作者：刘秀伍王亮金淑明段中余孙艳河北工业大学化工学院天津300130 天津大学化工学院天津300072

天然气是一种清洁能源,作为汽车代用燃料以及从天然气开采地到各用户单位之间的运输,都需要有效的存储技术.天然气水合物(NGH)能够降低甲烷存储的成本,而多孔材料孔内生成气体水合物能够有效提高储气密度,本研究目的是合成在孔内能够生... 详细信息

天然气是一种清洁能源,作为汽车代用燃料以及从天然气开采地到各用户单位之间的运输,都需要有效的存储技术.天然气水合物(NGH)能够降低甲烷存储的成本,而多孔材料孔内生成气体水合物能够有效提高储气密度,本研究目的是合成在孔内能够生成甲烷水合物的低成本高性能吸附剂.首先以农业废弃物玉米芯为原料,采用KOH活化法制备活性炭,其湿储甲烷最优合成条件为:在400,℃炭化30,min,碱炭质量比5∶1、850,℃活化1.0,h合成出C-8高性能活性炭,其孔容达到2.264,cm3/g,比表面积为2 993,m2/g,孔径分布主要集中在2～3,nm.合成的C-8是非常好的甲烷湿储吸附剂,在水炭比为3.68时在9.40,MPa下CH4达到最大吸附量为69.66%,是其干燥样品最大吸附量的3.25倍,并可以在较大压力范围内使存储的甲烷提供平稳的放气量,有望作为新型的甲烷水合物存储吸附剂应用于天然气汽车上.

关键词：玉米芯活性炭湿储甲烷气体水合物