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Targeted screening of an anti-inflammatory polypeptide from Rhopilema esculentum Kishinouye cnidoblasts and elucidation of its mechanism in alleviating ulcerative colitis based on an analysis of the gut microbiota and metabolites

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Food Science and Human Wellness 2024年第3期13卷 1336-1347页

作者： Ziyan Wang Qiuyue Shi Ying Feng Jiaojiao Han Chenyang Lu Jun Zhou Zhonghua Wang xiurong su State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo UniversityNingbo 315000China School of Marine Science Ningbo UniversityNingbo 315000China Key Laboratory of Aquaculture Biotechnology(Ningbo University) Ministry of EducationNingbo UniversityNingbo 315000China College of Life Sciences Tonghua Normal UniversityTonghua 134000China Shandong Beiyou Biotechnology Co. Ltd.Weifang 261000China

Ulcerative colitis(UC)is a recurrent inflammatory bowel disease that imposes a severe burden on families and society.In recent years,exploiting the potential of marine bioactive peptides for the treatment of diseases has become a topic of intense research interest.This study revealed the mechanism underlying the protective effect of the dominant polypeptide PKKVV(Pro-Lys-Lys-Val-Val)of Rhopilema esculentum cnidoblasts against DSS-induced UC through a combined analysis of the metagenome and serum metabolome.Specifically,the polypeptide composition of R.esculentum cnidoblasts was determined by matrix-assisted laser desorption ionization time-of-flight mass spectrometry(MALDI-TOF/TOF-MS).Molecular docking showed that the dominant peptide PKKVV could bind better with tumor necrosis factor-α(TNF-α)than the original ligand.subsequent animal experiments suggested that PKKVV could modulate disorganized gut microorganisms in mice with UC;affect serum metabolites through the arachidonic acid,glycerophospholipid and linoleic acid metabolism pathways;and further alleviate UC symptoms.This study provides a reference for the comprehensive development of marine bioactive substances and nonpharmaceutical treatments for UC.

关键词： Ulcerative colitis Rhopilema esculentum Kishinouye Cnidoblasts Marine bioactive polypeptides Metagenome Serum metabolome

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Food-derived bio-functional peptides for the management of hyperuricemia and associated mechanism

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Food Science and Human Wellness 2024年第4期13卷 1767-1786页

作者： Yanxin Wang Mingxia Ma Yumeng Huang Siqing Fan Jie Peng Shiming Li xiurong su Yanbo Wang Chenyang Lu State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products and School of Marine Science Ningbo UniversityNingbo 315211China School of Food and Health Beijing Technology and Business UniversityBeijing 100048China Department of Food Science Rutgers UniversityNew BrunswickNJ 08901USA College of Life Sciences Huanggang Normal UniversityHuanggang 438000China Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China

Hyperuricemia,a metabolic disorder related to uric acid metabolism dysregulation,has become a common metabolic disease worldwide,due to changes in lifestyle and dietary structure.In recent years,owing to their high activity and few adverse effects,food-derived active peptides used as functional foods against hyperuricemia have attracted increasing attention.This article aims to focus on the challenge associated with peptide-specific preparation methods development,functional components identification,action mechanism(s)clarification,and bioavailability improvement.The current review proposed recent advances in producing the food-derived peptides with high anti-hyperuricemia activity by protein source screening and matched enzymatic hydrolysis condition adjusting,increased the knowledge about strategies to search antihyperuricemia peptides with definite structure,and emphasized the necessity of combining computer-aided approaches and activity evaluations.In addition,novel action mechanism mediated by gut microbiota was discussed,providing different insights from classical mechanism.Moreover,considering that little attention was paid previously on the structure-activity relationships of anti-hyperuricemia peptides,we collected the sequences from published studies and make a preliminary summary about the structure-activity relationships,which in turn provided guides for enzymatic hydrolysis optimization and bioavailability improvement.Hopefully,this article could promote the development,application and commercialization of food-derived anti-hyperuricemia peptides in the future.

关键词： Hyperuricemia Peptide Enzyme hydrolysis Mechanism Structure-activity relationship Bioavailability

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Protective effects and microarray-based mechanism of sea cucumber hydrolysates against high-glucose induced nephrotoxicity in mouse glomerulus mesangial cells

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未来食品学报(英文) 2024年第3期4卷 233-240页

作者： Lingxin Geng Jiaojiao Han Jun Zhou Ye Li Tinghong Ming Zhen Zhang Chenyang Lu xiurong su State Key Laboratory for Quality and Safety of Argo-products School of Marine ScienceNingbo UniversityNingbo 315211China

Diabetic nephropathy(DN)is a common type of end-stage renal disease and glomerular mesangial cells(GMCs)are widely used as a cell model for DN.This study firstly investigated the inhibitory effects of the Apostichopus japonicus and Acaudina leucoprocta hydrolysates on cellular growth under high-glucose treatment,better inhibitory effect of A.japonicus hydrolysate was observed compared to that of A.leucoprocta hydrolysate.subsequently,the global transcription profiles obtained via microarray analysis showed that 6070 and 7015 genes were identified in the A.japonicus and A.leucoprocta groups compared with the model group,respectively.Among them,transcriptions of the slc30a4,slc35dl,tppp3,tp53inpl,bcl-2,apafl,alox12b and adrala genes were restored from the levels of the model group to those of the control group,contributed to cell mitosis and proliferation in both treatment groups.In addition,other apoptosis-related genes,such as bcl-6,clu,foxo3 and akt,showed opposite trends between two groups,which might cause the difference in inhibitory effect.We preliminarily proposed that the regulation effects of A.japonicus and A.leucoprocta on the genes involved in cellular mitosis,proliferation and apoptosis,might contribute to their inhibitory activity on GMCs under high-glucose environment.

关键词： Diabetic nephropathy Apostichopus japonicus Acaudina leucoprocta Hydrolysate Rat mesangial cell Microarray

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Tuna dark muscle peptides modulate host iron metabolism in the intestine through the gut microbiota and ameliorate iron deficiency anemia

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Food Science and Human Wellness 2024年

作者： Jiaojiao Han Jiayi Xiong Zhixiang Bai Yang Qin Chenyang Lu Jun Zhou Ye Li Tinghong Ming Zhen Zhang xiurong su State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo University School of Marine Science Ningbo University

Iron deficiency anemia (IDA) is a nutritional deficiency disease with a high incidence rate worldwide. Bioactive peptides are safe and effective， have multiple functions and can serve as potential candidates for alleviating IDA. In this study， the anti-anemia effects of tuna dark muscle peptides were explored in a diet-induced IDA mouse model. The results showed that tuna dark muscle peptides alleviated the IDA phenotype， oxidative stress and iron metabolism. In addition， tuna dark muscle peptides reversed gut microbiota dysbiosis in IDA mice. Furthermore， the transplanted fecal microbiota from tuna dark muscle peptide-treated mice also alleviated IDA symptoms and regulated iron metabolism and the gut microbiota， indicating that the anti-anemic effects were at least partially mediated by the gut microbiota. Thus， we identified a new and safe prebiotic material to alleviate IDA and provided ideas for the development of peptides. At the same time， these data also provided a theoretical basis for fecal microbiota transplantation (FMT) to alleviate IDA.

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Protective effect of marine animals hydrolysis-peptides on adjuvant-induced arthritis in mice by gut microbiota and SCFAs

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Food Science and Human Wellness 2024年

作者： Zhen Zhang Shasha Tang Ziyan Wang Jiaojiao Han Jun Zhou Chenyang Lu Bin Liu Xiaoling sun Rongxian Yu Rixin Wang xiurong su School of Marine Science Ningbo University State Key Laboratory for Quality and Safety of Argo-products Ningbo University Vigor Technology Group

Marine fauna provides a plentiful repository of peptides and bioactive proteins. Peptides and proteins isolated from marine animals have been studied and applied in the development of food supplements， drugs， and cosmeceutical products because of their special bioactivities， such as anti-inflammatory and antioxidant effects This study focused on exploring the alleviating effects of five major marine animal-derived peptides (Apostichopus japonicus， Acaudina leucoprocta， Melanogrammus aeglefinus， Phascolosoma esculenta and Rhopilema esculentum) on adjuvant-induced arthritis (AIA). The treatment with five marine animals-derived peptides downregulated the expression levels of pro-inflammatory cytokines of IL-1β， IL-17 and TNF-α in the bones of the mice with AIA and alleviated the rough surface of bone tissues significantly. A. japonicus-treatment ameliorates inflammation by restoring NF-κB pathway in AIA mice. High-throughput sequencing of the gut microbiota based on 16S rRNA sequencing revealed that A. japonicus peptide-treated AIA mice showed alterations and imbalance of intestinal flora and an increased abundance of Lactobacillus and Clostridium. Furthermore， metabolomic analysis showed that the level of SCFAs in the feces was enhanced to different degrees in mice treated with five major marine animal-derived peptides. Taken together， we propose that major marine animal-derived peptides can alleviate arthritis by improving the imbalance in the gut flora and increasing SCFA production to varying degrees.

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Modulation of gut microbiota and serum metabolome by Apostichopus japonicus derived oligopeptide in high-fructose diet-induced hyperuricemia in mice

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Food Science and Human Wellness 2024年

作者： Jun Zhou Ziyan Wang Zhixuan Zhang Jiaojiao Han Ying Feng Jing Zhang Zhen Zhang Ye Li Tinghong Ming Chenyang Lu Rixin Wang xiurong su School of Marine Science Ningbo University Faculty of Food Science Zhejiang Pharmaceutical College Key Laboratory of Aquacultural Biotechnology Ministry of Education Ningbo University College of Life Sciences Tonghua Normal University State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo University

Fructose consumption has risen dramatically in recent decades due to the use of sucrose and high fructose corn syrup in beverages and processed foods， contributing to rising rates of hyperuricemia. The purpose of this experiment was to explore the anti-hyperuricemia effects of an active oligopeptide (GPSGRP) derived from sea cucumber in fructose induced hyperuricemia mouse model， and to clarify the underlying mechanism in sight of gut microbiota and serum metabolites. Peptide GPSGRP treatment rebalanced uric acid metabolism and alleviated inflammatory response in mice. In addition， treatment with GPSGRP decreased the abundance of Bacteroides and Proteobacteria at the phylum level， Muribaculum， Prevotella and Bacteroides at the genus level， and inhibited the related pathways of purine metabolism and glycolysis/gluconeogenesis metabolism. Moreover， serum metabolites， including linoleic acid， indole and its derivatives， arachidonic acid and uridine， as well as related metabolic pathways， such as tricarboxylic acid cycle， ketone production and sugar production， were altered in response to GPSGRP treatment. This study provides a valuable reference for the application and development of marine biological peptides in uric acid management.

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Chinese Torreya grandis cv.Merrillii seed oil affects obesity through accumulation of sciadonic acid and altering the composition of gut microbiota

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Food Science and Human Wellness 2022年第1期11卷 58-67页

作者： Huan Wang Ye Li Rui Wang Huaifei Ji Chenyang Lu xiurong su State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety ofAgro-products Ningbo UniversityNingbo 315211China Collage of Food and Pharmaceutical Sciences Ningbo UniversityNingbo 315800China Collage of Marine Science Ningbo UniversityNingbo 315800China

Torreya grandis cv.Merrillii(Taxace,Torreya)is mainly distributed across the hilly areas of subtropical China and is well known for its nutritional value.In this study,the ameliorative effects of T.grandis seed oil on lipid metabolism were investigated,and the underlying mechanism was explored from the perspective of gut microbiota.Mice experiments showed that the rate of body mass gain in the group where the mice were fed a high-fat diet(HFD)and supplemented with 550 mg/(kg·day)T.grandis seed oil(HFD+TO550 group)was 42.27%,while it was 62.25%in the HFD group.Compared with the HFD group,the liver and fat indices,total cholesterol,triglycerides,and low-density lipoprotein cholesterol were reduced in the oil-supplement groups.Moreover,the oil supplement significantly changed the fatty acid composition and alleviated pathological damage to the liver caused by the high-fat diet.Additionally,the distinct clustering of bacteria in the composition of gut microbiota was observed in the oil treatment group compared with that in the HFD group.T.grandis seed oil significantly increased the abundance of the beneficial bacteria and short-chain fatty acid producers,including Lactobacillus,Bifidobacterium,Faecalibaculum and Allobaculum.Our results suggest that the supplements of T.grandis seed oil could alleviate hyperlipidemia caused by HFD.These positive effects are considered to be related with sciadonic acid(SCA)and are partially mediated by alterations in gut microbiota composition and functionality.

关键词： Torreya grandis cv.Merrillii seed oil Obesity Lipid metabolism Gut microbiota

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Food-derived bio-functional peptides for the management of hyperuricemia and associated mechanism

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Food Science and Human Wellness 2023年

作者： Yanxin Wang Mingxia Ma Yumeng Huang Siqing Fan Jie Peng Shiming Li xiurong su Yanbo Wang Chenyang Lu State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products and School of Marine Science Ningbo University Department of Food Science Rutgers University College of Life Sciences Huanggang Normal University Food Safety Key Laboratory of Zhejiang Province School of Food Science and Biotechnology Zhejiang Gongshang University School of Food and Health Beijing Technology and Business University

Hyperuricemia， a metabolic disorder related to uric acid metabolism dysregulation， has become a common metabolic disease worldwide， due to changes in lifestyle and dietary structure. In recent years， owing to their high activity and few adverse effects， food-derived active peptides used as functional foods against hyperuricemia have attracted increasing attention. This article aims to focus on the challenge associated with peptide-specific preparation methods development， functional components identification， action mechanism(s) clarification， and bioavailability improvement. The current review proposed recent advances in producing the food-derived peptides with high anti-hyperuricemia activity by protein source screening and matched enzymatic hydrolysis condition adjusting， increased the knowledge about strategies to search anti-hyperuricemia peptides with definite structure， and emphasized the necessity of combining computer-aided approaches and activity evaluations. In addition， novel action mechanism mediated by gut microbiota was discussed， providing different insights from classical mechanism. Moreover， considering that little attention was paid previously on the structure-activity relationships of anti-hyperuricemia peptides， we collected the sequences from published studies and make a preliminary summary about the structure-activity relationships， which in turn provided guides for enzymatic hydrolysis optimization and bioavailability improvement. Hopefully， this article could promote the development， application and commercialization of food-derived anti-hyperuricemia peptides in the future.

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氨氯地平阿托伐他汀钙片治疗老年高血压合并冠心病的临床效果

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临床研究 2024年第5期32卷 75-79页

作者：王苏冉秀荣商丘市第一人民医院全科医学科河南商丘476000

目的探讨老年高血压合并冠心病(CHD)患者采用氨氯地平阿托伐他汀钙片治疗的临床效果。方法选取2022年7月至2023年12月商丘市第一人民医院收治的共计80例老年高血压合并CHD患者,以随机数表法分成研究组(n=40)与对照组(n=40),对照组实... 详细信息

目的探讨老年高血压合并冠心病(CHD)患者采用氨氯地平阿托伐他汀钙片治疗的临床效果。方法选取2022年7月至2023年12月商丘市第一人民医院收治的共计80例老年高血压合并CHD患者,以随机数表法分成研究组(n=40)与对照组(n=40),对照组实行氨氯地平治疗,研究组实行氨氯地平阿托伐他汀钙片治疗,比较两组临床疗效、血压水平、心功能、血脂水平及不良反应发生情况。结果研究组治疗有效率(95.00%)高于对照组(77.50%),差异具有统计学意义(P <0.05);治疗后两组收缩压(SBP)、舒张压(DBP)较治疗前降低,差异具有统计学意义(P <0.05),治疗后研究组SBP、DBP低于对照组,差异具有统计学意义(P <0.05);治疗后两组左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)较治疗前降低,左心室射血分数(LVEF)较治疗前提高,差异具有统计学意义(P <0.05),治疗后研究组LVEDD、LVESD低于对照组,LVEF高于对照组,差异具有统计学意义(P <0.05);治疗后两组低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)水平较治疗前降低,高密度脂蛋白胆固醇(HDL-C)水平较治疗前升高,差异具有统计学意义(P <0.05),治疗后研究组LDL-C、TC水平低于对照组,HDL-C水平高于对照组,差异具有统计学意义(P <0.05);研究组不良反应发生率(5.00%)低于对照组(25.00%),差异具有统计学意义(P <0.05)。结论氨氯地平阿托伐他汀钙片用于老年高血压合并CHD患者的治疗,能够促进临床疗效提升,改善心功能、血脂状况,降低血压水平,安全性较高。

关键词：老年高血压冠心病氨氯地平阿托伐他汀钙片心功能

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旋转导向系统研究现状与发展趋势

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钻采工艺 2024年第3期47卷 1-8页

作者：苏义脑窦修荣高文凯彭烈新张磊刘珂奚筱宛中国石油集团工程技术研究院有限公司油气钻完井技术国家工程研究中心

井眼轨道控制技术是石油钻井工程成套技术中的关键环节,旋转导向系统可在钻柱旋转钻进过程中根据地质和工程目标实时调整井眼轨迹,有效提高井眼轨道控制精度和钻进效率,进一步把钻井技术推向自动化、信息化的新阶段。国外历经近30年发展... 详细信息

井眼轨道控制技术是石油钻井工程成套技术中的关键环节,旋转导向系统可在钻柱旋转钻进过程中根据地质和工程目标实时调整井眼轨迹,有效提高井眼轨道控制精度和钻进效率,进一步把钻井技术推向自动化、信息化的新阶段。国外历经近30年发展,已形成种类齐全化、功能多样化和尺寸系列化的旋转导向系统产品。文章通过对旋转导向系统的发展过程进行简单回顾和总结,特别是在对当前实现商业化应用的各种旋转导向产品性能特点分析、技术现状对比的基础上,提出推动我国旋转导向系统发展建议,以便于正确认识当前的技术现状、展望未来发展趋势和把握研究方向,为我国油气资源安全高效开发提供有力的工程技术支撑。

关键词：旋转导向系统推靠式指向式混合式钻头导向

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