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Different Acupuncture Therapies for Postherpetic Neuralgia:An Overview of Systematic Reviews and Meta-analysis

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Chinese Journal of Integrative Medicine 2025年第1期31卷 55-67页

作者： XIA Yun-fan sun Ruo-han li Shi-min WANG Yi-yi li rong-rong FANG Jian-qiao The Third Clinical Medical College of Zhejiang Chinese Medical University Hangzhou310000China Department of Rehabilitation Medicine Hangzhou Third People’s Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou310000China Department of Acupuncture the Third Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310000China

Background: Postherpetic neuralgia(PHN) is the most common complication of herpes zoster infection and affects patients' quality of life. Acupuncture therapy is regarded as a competitive method of treatment for analgesia. Objective: To summarize evidence from systematic reviews(SRs) and evaluate the effectiveness and safety of different acupuncture therapies for treating PHN. Methods: Eight electronic databases were searched from their inception to August 5, 2022, including 4 international electronic databases(PubMed, EMBASE, the Cochrane library, and Web of Science) and 4 Chinese databases(Chinese Biomedical Database, China National Knowledge Infrastructure, VIP Database and Wanfang Database).Methodological quality was assessed by A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2).The Risk of Bias in Systematic Review(ROBIS) tool was used to assess the risk of bias in SRs. Evidence level was assessed by the Grading of Recommendations Assessment, Development, and Evaluation(GRADE)approach. Results: Totally, 7 SRs were included, including 128 studies and 9,792 patients. In AMSTAR 2, most of the SRs were of low or critically low levels since they had more than 1 critical deficiency. In ROBIS, 1 SR(14.29%)was rated as high risk, and the other 6(85.71%) were rated as low risk. In the GRADE system, 9 outcomes(28.13%)were valued as high level, 5(15.63%) as moderate level, 1(3.13%) as low, and 17(53.13%) as very low. In the effectiveness of acupuncture therapy, the group "moxibustion vs. original medical treatment" [mean difference(MD)=–1.44, 95% confidence interval(CI): –1.80 to –1.08, I2=99%, P<0.00001] was of the highest heterogeneity and the group "bloodletting vs. original medical treatment"(MD=–2.80, 95% CI: –3.14 to –2.46, I2=0, P<0.00001)was of the lowest heterogeneity. Six SRs have reported the safety of their studies and no serious events were shown in the treatment and control groups. Conclusions: Acupuncture therapy seems to be effective in treating PH

关键词： acupuncture postherpetic neuralgia systematic review Chinese medicine

维普期刊数据库

Advances in gastrointestinal vascular bleeding disorders:Successful sirolimus treatment in colonic angioectasia

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World Journal of Gastroenterology 2025年第4期31卷 123-136页

作者： Qi sun Xiao-Ying Wang Dong-Hao li Bai-rong li Xin-Zhuo Tu Zhi-Meng Jiang Shou-bin Ning Tao sun Department of Gastroenterology Air Force Medical CenterBeijing 100142China College of life Science Northwest UniversityXi’an 710069Shaanxi ProvinceChina Department of Pathology Air Force Medical CenterBeijing 100142China

BACKGROUND Gastrointestinal(GI)vascular bleeding disorders pose significant clinical challenges due to their complex pathogenesis and varied treatment *** advancements in diagnostic and therapeutic techniques,optimal mana-gement strategies remain elusive,necessitating further *** To assess research trends and clinical advancements in GI vascular bleeding disorders,highlighting key themes and therapeutic *** A bibliometric analysis was conducted using the Web of Science Core Collection database,reviewing publications from 2000 to 2024 to identify trends,highfrequency keywords,and key contributions from leading research *** addition,a case study highlighted the effective application of sirolimus in managing colonic angioectasia in a patient with recurrent GI bleeding who had not responded to previous *** The analysis reviewed 470 scholarly articles from 203 countries,involving 2817 authors across 1502 *** United States led in publication contributions,with strong collaborations with countries like China,England,and Germany.A significant trend was observed in the shift from traditional endoscopic interventions to pharmacological therapies,particularly highlighting the successful use of sirolimus in treating colonic angioectasia. High-frequency keywords such as “angiodysplasia”,“colon”, and “management” were identified, indicating key research themes. The study also noted a growinginterest in drug therapies, as evidenced by the increasing prominence of keywords like “thalidomide” since *** study links bibliometric analysis and clinical insights, highlighting the shift to pharmacological managementin GI vascular bleeding disorders to improve patient outcomes.

关键词： Gastrointestinal bleeding Vascular anomalies Angioectasia Pharmacological Sirolimus

ZIF-90-loaded DNAzyme-responsive PROTAC for the self-powered degradation of NF-κB

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Science China Chemistry 2025年第2期68卷 687-693页

作者： Min Hou liang sun Tianyu Ren Mingda li Chao Hu rong liu Shuang Gu Mingyan Jiang Jian-Hui Jiang Jianjun He College of Physics and Chemistry Hunan First Normal UniversityChangsha 410205China Hunan Provincial Key Laboratory of Animal Models and Molecular Medicine College of Biomedical SciencesCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Xiangtan Central Hospital Xiangtan 411199China

Transcription factors(TFs)play vital roles in regulating gene *** or mutated TFs are implicated in a wide array of diseases,highlighting their potential as drug ***,TFs are considered undruggable by conventional inhibitor-based *** recently emerged proteolysis targeting chimeras(PROTACs)have exhibited great potential in tackling *** particular,DNA-ligand chimeras that arm E3 ligase-recruiting ligands to TF-binding double-strand DNA represent a promising strategy for the targeted proteolysis of ***,we report a DNAzyme-inducible PROTAC(DzTAC)that selectively degrades NF-κB in a zinc ion-dependent *** further applied zinc-imidazolate metal–organic framework90(ZIF-90)to encapsulate DzTAC(ZIF-90@DzTAC),facilitating its delivery into cancer cells while self-supplying Zn2+via adenosine triphosphate(ATP)-triggered ZIF-90 ***,ZIF-90@DzTAC can enhance the treatment efficacy of doxorubicin-based chemotherapy in tumor-bearing *** developed DzTAC provides specific modulation over TF activity and opens an avenue for more functional nucleic acid-based control over targeted protein degradation.

关键词： inducible proteolysis DNAzyme transcription factor ZIF-90 NF-κB

Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen Jing sun Xue-Ting Bai Qian zhang Zi-Han li Yi-Xin zhang rong-Xuan Xu Wei Wu Zhi-Han Yao Chun-Wen Pu Xiao-Feng li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,Pline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

Catching cancer signals in the blood:Innovative pathways for early esophageal cancer diagnosis

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World Journal of Gastroenterology 2025年第10期31卷 1-6页

作者： Yue Zhao Zhan zhang Jian-Hao Qiu rong-Yang li Zhen-Guo sun Department of Thoracic Surgery Qilu Hospital of Shandong UniversityJinan 250063Shandong ProvinceChina Department of Thoracic Surgery The First Affiliated Hospital of Shandong First Medical UniversityShandong Provincial Qianfoshan HospitalJinan 250063Shandong ProvinceChina

In recent years,significant progress has been made in the application of DNA methylation for the early detection of esophageal cancer(EC).As an epigenetic modification,DNA methylation allows for noninvasive screening by detecting the methylation status of circulating tumor *** have shown that the methylation of genes such as SHOX2,SEPTIN9,EPO,and RNF180 significantly improves diagnostic sensitivity and ***,SEPTIN9 has been approved by the Food and Drug Administration for colorectal cancer screening,while SHOX2 and EPO show promising results in EC,and RNF180 has potential in gastrointestinal *** editorial reviews the study by liu et al,which demonstrated the potential of combining the methylation of these four genes for early EC *** addition to their roles in early diagnosis,DNA methylation markers are gaining attention because of their roles in predicting recurrence and in postoperative *** monitoring changes in methylation levels,these markers can provide valuable insights into treatment efficacy and long-term *** research progresses,liquid biopsy technology is expected to become an essential tool in the precision diagnosis and treatment of EC,benefiting patients significantly.

关键词： Esophageal cancer DNA methylation Circulating tumor DNA Early detection liquid biopsy Treatment monitoring

Effects of Ti-and Nb-based transition element from single to multiple compound oxides and carbon-based composite additives on Mg-MgH2 hydrogen storage material

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Tungsten 2025年第1期7卷 32-49页

作者： li-rong Xiao Chen Chen Shuo Wang Zi-Yin Dai Hideo Kimura Cui Ni Chuan-Xin Hou Xue-Qin sun Si-Jie Guo Wei Du Xiu-Bo Xie School of Environmental and Material Engineering Yantai University Bosch HUAYU Steering Systems (Yantai) Co. Ltd.Ytp/MFE University of Tennessee Knoxville shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of Aeronautics

MgH2is considered as a promising hydrogen storage material for its high hydrogen storage capacity,low cost and abundant resource ***,the low kinetics and high enthalpy formation of MgH2limit its wide *** the perspective of adding catalysts to enhance the hydrogen storage properties of Mg-MgH2,this article elaborated the main catalysts based on Ti and Nb transition elements,including single oxide catalysts,binary oxides catalysts（combined with Ni,Na,Sr,V,etc.）,multiple catalysts bound to carbon,and composite catalysts with Ti and Nb elements combined with MXene ***,the main pathways of various catalysts to reduce the reaction activity and broaden the hydrogen desorption channel were also *** Ti-based catalysts can enhance the reactive sites of the matrix by forming multivalent states,while Nb-based catalysts broaden the hydrogen reaction channels by forming tiny *** improving the size structure and enhancing the grain size stability,combined with carbon materials should be the future considerations.

关键词： Catalysts Mg-based hydrogen storage alloys Solid hydrogen storage Transition metal elements

Global trends and research hotspots in esophageal strictures:A bibliometric study

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World Journal of Gastrointestinal Surgery 2025年第3期17卷 370-384页

作者： Xiao-Ying Wang Hong-Yu Chen Qi sun Man-Hua li Meng-Nan Xu Tao sun Zi-Han Huang Dong-lin Zhao Bai-rong li Shou-bin Ning Chong-Xi Fan College of life Science Northwest UniversityXi’an 710069Shaanxi ProvinceChina Department of Gastroenterology Air Force Medical CenterAir Force Medical UniversityBeijing 100142China The Air Force Clinical College Anhui Medical UniversityHefei 230032Anhui ProvinceChina

BACKGROUND Esophageal stricture is a prevalent condition affecting the digestive system,primarily marked by dysphagia and the obstruction of food passage through the *** narrowing of the esophageal lumen can significantly impact a person’s ability to eat and drink comfortably,often leading to a decrease in nutritional intake and quality of *** To explore the current research status and future trends of esophageal stricture through bibliometric *** literature on esophageal stricture from 2004 to 2023 was retrieved from the Web of Science Core *** analysis was performed using Excel,VOSviewer,CiteSpace,and *** study provides data on annual production trends,countries/regions,influential authors,institutions,journals,references,and *** The study included 1485 publications written by 7469 authors from 1692 institutions across 66 countries/regions,published in 417 *** United States,China,and Japan are the major contributors to this field,with many quality *** Ho-young,Diseases of the Esophagus,Gastrointestinal Endoscopy,and Mayo Clinic are the top authors,journals,co-cited journals,and institutions,*** most frequent keywords are stent,endoscopy,management,etiology,and prevention;regenerative medicine,endoscopic injection,and autologous tissue transplantation are the latest research *** keywords reflect continuous advancements in technical innovation,treatment strategies,preventive measures in the esophageal stricture research field,and a sustained focus on improving patient *** contrast,the basic sciences were *** This study provides an insightful analysis of the developments in the field of esophageal stricture over the past twenty years,with stent placement is currently a hot research topic.

关键词： Esophageal stricture Bibliometrics Stents VOSviewer CiteSpace

Application of DynaCT biliary soft tissue reconstruction technology in diagnosis and treatment of hepatolithiasis

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World Journal of Gastrointestinal Surgery 2025年第1期17卷 114-124页

作者： Yong-Qing Ye Pei-Heng li Zhao-Wei Ding Sheng-Feng zhang rong-Qi li Ya-Wen Cao Department of Hepatobiliary Surgery The Second People's Hospital of FoshanFoshan 528000Guangdong ProvinceChina Department of Oncology Foshan Nanhai District Fifth People's HospitalFoshan 528000Guangdong ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120Guangdong ProvinceChina Department of Hepatobiliary Surgery Foshan Hospital of Traditional Chinese MedicineFoshan 528000Guangdong ProvinceChina Department of Emergency Medicine Biomedical Innovation CenterThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina

BACKGROUND Hepatobiliary stone disease involves an intrahepatic bile duct stone that occurs above the confluence of the right and left hepatic ***-step percutaneous transhepatic cholangioscopic lithotripsy(PTCSL)using the percutaneous transhepatic one-step biliary fistulation(PTOBF)technique enables the clearing of intrahepatic stones and the resolution of ***,hepatolithiasis with associated strictures still has high residual and recurrence rates after one-step *** can achieve synchronized acquisition with a flat-panel detector during C-arm *** technical approach and application value of DynaCT biliary soft tissue reconstruction technology for the diagnosis and treatment of hepatolithiasis with bile duct stenosis were evaluated in this *** To explore the value of DynaCT biliary soft tissue reconstruction technology for the diagnosis and treatment of hepatolithiasis with bile duct stenosis,and to assess the feasibility and effectiveness of the PTOBF technique guided by DynaCT biliary soft tissue reconstruction *** The clinical data of 140 patients with complex biliary stenosis disease combined with bile duct stenosis who received PTOBF and were admitted to the First Affiliated Hospital of Guangzhou Medical University from January 2020 to December 2024 were *** patients were divided into two groups:DynaCT-PTOBF group(70 patients)and conventional PTOBF group(70 patients).These groups were compared in terms of the preoperative bile duct stenosis,location of the liver segment where the stone was located,intraoperative operative time,immediate stone retrieval rate,successful stenosis dilatation rate,postoperative complication rate,postoperative reoperation rate,stone recurrence rate,and stenosis recurrence *** DynaCT biliary soft tissue reconstruction technology was successfully performed in 70 *** DynaCTPTOBF group had a higher detection rate of target bile ducts where bile duct stone

关键词： Hepatolithiasis Biliary stenosis DynaCT One-step percutaneous transhepatic cholangioscopic lithotripsy

Recent progress in metal-organic frameworks(Part II—material application)

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Science China Chemistry 2025年

作者： Jiandong Pang Wentao Jiang Xue-Wen zhang Hao-Long Zhou Yuxiu sun Wei Gong bin Wang Fuyin Ma linwei He Long Chen Qiang Chen He-Qi Zheng Yuanjing Cui Wen-Jie Shi Chao zhang Mei Wang Yue-Biao zhang Jie-Peng zhang Chongli Zhong Yong Cui Shuao Wang Jian-rong li Guodong Qian Tong-Bu Lu Huan Pang Xian-He Bu Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology School of Chemistry and Chemical Engineering Yangzhou University School of Materials Science and Engineering Nankai University School of Physical Science and Technology ShanghaiTech University MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering School of Chemistry IGCMESun Yat-sen University Department of Chemistry Shantou University School of Chemical Engineering and Technology Tiangong University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences Soochow University College of Materials Science & Engineering Beijing University of Technology State Key Laboratory of Silicon and Advanced Semiconductor Materials Cyrus Tang Center for Sensor Materials and ApplicationsSchool of Materials Science & Engineering Zhejiang University

As a class of functional crystalline porous materials, metal-organic frameworks(MOFs) gained rapid development in the past three decades and a large number of MOFs with ordered structures, high surface areas, and functionalized channels have been investigated. MOFs and MOF-derived/composite materials show great potential in many application fields. In this review, we discussed the main applications of MOFs and MOF-derived/composite materials in small molecule storage, separation, luminescence, sensing, multitype catalysis, and energy storage. In addition, challenges and problems in the future research of MOFsrelated fields are also discussed.

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