检索结果-南通市图书馆

Rapid and sensitive analysis of melatonin by LC-MS/MS and its application to pharmacokinetic study in dogs

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2016年第2期11卷 273-280页

作者： Huimin Zhao Yifei Wang Yi Jin Shu Liu Haiyan Xu xiumei lu School of Pharmacy Shenyang Pharmaceutical University

A rapid and sensitive liquid chromatography tandem mass spectrometry method was established and validated for determination of melatonin in dog plasma using desvenlafaxine as an internal standard (IS). Plasma samples were pretreated by liquid–liquid extraction with ethyl acetate. Chromatographic separation was carried out on a C18 column at a flow rate of 0.2 ml/min by an isocratic mobile phase of methanol : 5 m M ammonium acetate : formic acid (40:60:0.1, v/v/v). Positive ion mode detection was performed using multiple reaction monitoring (MRM) at m/z 233.2→174.2 for melatonin and m/z 264.2→58.2 for *** method was linear in the concentration range of 0.020–10 ng/ml with a correlation coefficient ≥0.996. The intra-and inter-assay precision (%RSD) values were within 12.6% (LLOQ15.2%), and accuracy (%RE) ranged from -1.8% to 5.0% (LLOQ ±16.5%). The total analysis time was 3.0 min. The method was fully validated and successfully applied to a pharmacokinetic study of melatonin prolonged-release tablet in Beagle dogs. The values of half-life and Tmax were similar to the corresponding data reported before.

关键词： Melatonin LC-MS/MS Dog plasma Pharmacokinetics

Halteriomantispa grimaldii *** ***.:A new genus and species of the family Dipteromantispidae(Insecta:Neuroptera)from the mid-Cretaceous amber of Myanmar

在线全文

学校读者我要写书评

暂无评论

Zoological Systematics 2016年第2期41卷 165-172页

作者： Xingyue Liu xiumei lu Weiwei Zhang Department of Entomology China Agricultural UniversityBeijing 100193China Three Gorges Entomological Museum P.O.Box 4680Chongqing 400015China

The family Dipteromantispidae, previously with only two genera and three species, is one of the enigmatic groups of the Cretaceous Neuroptera by the mantispid-like appearance combined with strongly reduced hind wings specialized into a haltere-like structure. A new genus and species of Dipteromantispidae, namely Halteriomantispa grimaldii gen. et sp. nov., is herein described based on an exquisitely preserved specimen from the mid-Cretaceous amber of northern Myanmar. It represents the first record of Dipteromantispidae from the amber deposit of mid-Cretaceous （Albian-Cenomanian） of Myanmar. A brief discussion on the homology of forewing venations and female genital sclerites of Dipteromantispidae is given.

关键词： Neuropterida Mantispidae taxonomy Burmese amber Mesozoic

Nomenclatural validation of new genera and species of the superfamily Psychopsoidea(Insecta:Neuroptera) from the mid-Cretaceous amber of Myanmar

在线全文

学校读者我要写书评

暂无评论

Zoological Systematics 2016年第3期41卷 323-326页

作者： xiumei lu Weiwei Zhang Xingyue Liu Department of Entomology China Agricultural University Beijing 100193 China Three Gorges Entomological Museum P.O. Box 4680 Chongqing 400015 China

Two new genus-group names and two new species-group names of the lacewing superfamily Psychopsoidea from the mid-Cretaceous amber of Myanmar are herein validated, namely Fiaponeurapenghiani gen. ＆ sp. nov. and Burmop... 详细信息

关键词： Neuropterida Psychopsoidea Burmese amber new taxon nomenclature.

在线全文

学校读者我要写书评

暂无评论

生鲜电商众筹预售与众包生产联合决策

系统工程理论与实践 2018年第6期38卷 1502-1511页

作者：邵腾伟吕秀梅重庆工商大学长江上游经济研究中心重庆400067 重庆工商大学财政金融学院重庆400067

顺应消费者参与消费体验追求产品质量安全保障,论文构建了社区化消费者与组织化生产者通过电商平台进行点对点的生鲜农产品供应链纵向一体化众筹预售与众包生产联合决策模型及机制.研究表明,与过去分散决策相比,联合决策对扩大网购需求... 详细信息

顺应消费者参与消费体验追求产品质量安全保障,论文构建了社区化消费者与组织化生产者通过电商平台进行点对点的生鲜农产品供应链纵向一体化众筹预售与众包生产联合决策模型及机制.研究表明,与过去分散决策相比,联合决策对扩大网购需求,提高供应链收益有显著协同效应,而决策机制可确保参与者的利益诉求在联合决策中公平表达.研究成果对促进我国生鲜农产品以销定产,消费者参与质量安全监督和农产品流通“最初一公里”与“最后一公里”问题解决及生鲜电商发展有参考价值.

关键词：生鲜农产品众筹预售众包生产联合决策

酚醛泡沫在现代建筑保温工程中的应用及改性研究进展

在线全文

学校读者我要写书评

暂无评论

合成树脂及塑料 2015年第5期32卷 87-89页

作者：卢秀梅河北城乡建设学校河北省石家庄市050031

综述了作为保温材料的酚醛泡沫在国内外的发展及应用情况。酚醛泡沫具有良好的阻燃性能,被发达国家作为优先选用的保温材料,同时在国内知名建筑上得到了很好的应用。采用纳米蒙脱土、聚氨酯预聚体、液体丁腈橡胶、硼酸等改性酚醛泡沫,... 详细信息

综述了作为保温材料的酚醛泡沫在国内外的发展及应用情况。酚醛泡沫具有良好的阻燃性能,被发达国家作为优先选用的保温材料,同时在国内知名建筑上得到了很好的应用。采用纳米蒙脱土、聚氨酯预聚体、液体丁腈橡胶、硼酸等改性酚醛泡沫,能不同程度地改变酚醛泡沫的孔结构、力学性能,从而达到提高其韧性的作用。因此,酚醛泡沫在外墙保温市场将具有良好的发展前景。

关键词：酚醛泡沫阻燃改性保温孔结构

Engineering neuroregenerative microenvironment via aligned hydrogel-assisted magnetic stimulation for complete spinal cord injury repair

在线全文

学校读者我要写书评

暂无评论

Engineered Regeneration 2024年第2期5卷 139-152页

作者： Chun-Yi Yang Zhe Meng Zhijun He Pengchao Ma Zhaohui Hou Kunkoo Kim Jingsong lu Kaiyuan Yang Guihuai Wang xiumei Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced Materials of Ministry of EducationSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Neurosurgery Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing102218China

Utilizing biomaterials in tissue engineering has shown considerable promise for tissue regeneration,particularly through delivering multimodel cell-regulatory signals,including the material-related signals and extrinsic *** this research,we developed a magnetic-responsive aligned nanofiber fibrin hydrogel(MAFG),integrating the structured alignment of nanofibers and the pliability of fibrin hydrogel with an external magnetic *** design aimed to enhance the regenerative response in spinal cord injury treatment.A medium-strength magnetic field,aligned with the spinal cord,was applied to aid motor function recovery in rats with spinal cord *** use of MAFG in this context not only intensified the effect of the magnetic field but also encouraged the activation and differentiation of native neural stem ***,this method effectively steered macrophage polarization towards a beneficial M2 phenotype,addressing immune dysregulation at the injury *** parallel application of magnetic field stimulation through MAFG in a spinal cord injury model contributed to the concurrent promotion of neurogenesis,angiogenesis,and immunomodulation,resulting in marked improvement in motor function in *** investigation underscores the therapeutic potential of magnetic field stimulation and highlights how aligning this stimulation with the spinal cord can significantly enhance the regenerative milieu at the injury site.

关键词： Angiogenesis Neurogenesis Immunomodulation Magnetic-responsive hydrogel Magnetic stimulation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

毛细管区带电泳分离西孟坦对映异构体

分析化学 2005年第7期33卷 1003-1006页

作者：鹿秀梅张丹丹彭颖李发美沈阳药科大学药学院沈阳药科大学药学院沈阳110016

以βCD为手性选择剂,采用毛细管区带电泳成功分离了西孟坦对映异构体。考察了背景电解质中硼砂缓冲液的pH和浓度、βCD浓度、有机添加剂甲醇含量及分离电压对手性分离的影响,建立了毛细管电泳分离西孟坦对映异构体的方法。最佳分离条件... 详细信息

以βCD为手性选择剂,采用毛细管区带电泳成功分离了西孟坦对映异构体。考察了背景电解质中硼砂缓冲液的pH和浓度、βCD浓度、有机添加剂甲醇含量及分离电压对手性分离的影响,建立了毛细管电泳分离西孟坦对映异构体的方法。最佳分离条件为:20mmol/L硼砂缓冲液(pH11.0,含12mmol/LβCD)甲醇(50∶50,V/V);分离电压20kV。在此条件下西孟坦对映异构体可达基线分离。在25～50mg/L范围内,迁移时间的重复性(RSD)控制在1.9%之内,峰面积重复性的RSD小于4.0%,本方法可用于西孟坦对映异构体的手性分离和定量分析。

关键词：手性分离 D,L-西孟坦 L-西孟坦 β-环糊精毛细管区带电泳

对如何更好地在西藏贯彻落实党的民族经济政策的几点建议

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

西藏民族学院学报（哲学社会科学版） 2002年第3期23卷 28-34页

作者：卢秀敏西藏农牧学院宣传部西藏林芝860000

在中央援助政策实施过程中西藏存在地方政府的“缺位”和“越位”问题以及城乡差距持续扩大问题。只有解决好“政府”与“市场”的关系,积极探索市场经济条件下有效的援助措施,以及将中央财政补贴重点投向农牧区、农牧民,投资农牧区基... 详细信息

在中央援助政策实施过程中西藏存在地方政府的“缺位”和“越位”问题以及城乡差距持续扩大问题。只有解决好“政府”与“市场”的关系,积极探索市场经济条件下有效的援助措施,以及将中央财政补贴重点投向农牧区、农牧民,投资农牧区基础教育,提高人口文化素质,西藏经济才能实现可持续发展。

关键词：西藏政府作用农牧区发展

TLC Identification and Extraction Process of Rubiasin-1-methyl Ether from Yao Medicine Chuanlianzhu

在线全文

学校读者我要写书评

暂无评论

Medicinal Plant 2024年第3期15卷 35-38页

作者： Jingrong lu Jiangcun WEI xiumei MA Bing QING Meiyan QIU Wen ZHONG Guangxi International Zhuang Medicine Hospital Nanning 530201China

[Objectives]To establish a thin-layer chromatography(TLC)method for the determination of rubiadin-1-methyl ether in Yao Medicine Chuanlianzhu(Damnacanthus giganteus).[Methods]A silica gel G thin-layer plate was adopted for *** ether(60-90℃)-chloroform-methanol-water(7:15:3:1)was used as the developing solvent and inspected under ultraviolet lamp(365 nm).The content was determined by Inertsil ODS-3 C 18 column(4.60 mm×250 mm,5μm),mobile phase:acetonitrile-0.2%phosphoric acid gradient elution,detection wavelength 277 nm,flow rate 1.0 mL/min,column temperature 30℃,injection volume 10μL.[Results]The spots of 10 Chuanlianzhu samples from different origins showed the same color at the same position as the control,and the spots were clear and *** injection volume of rubiadin-1-methyl ether showed a good linear relationship in the range of 2.90-145μg(R=0.9996).The average recovery rate of rubiadin-1-methyl ether in the low,medium and high dose groups of Yao Medicine Chuanlianzhu was 98.72%,and RSD=1.78%.[Conclusions]This method can effectively identify Yao Medicine Chuanlianzhu medicinal materials and accurately determine the content of rubiadin-1-methyl ether in the medicinal *** provides a scientific basis for the development and utilization of Yao Medicine Chuanlianzhu medicinal resources.

关键词： Chuanlianzhu Thin-layer chromatography (TLC) Extraction process Rubiadin-1-methyl ether Content determination