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Chinese Medical Journal 2024年第8期137卷 997-999页

作者： Bing Zhang Pengfei Ji Langang Peng Mengen Zhai Jiayou Tang Lin Zhao Yan Jin Baoling Xu Xiangni Lyu Linhe Lu Yenong Zhou Zhenxiao Jin Weixun Duan xiuling yang Wei Yi Jincheng Liu Department of Cardiovascular Surgery Xijing HospitalAir Force Medical UniversityXi’anShaanxi 710032China

Heart transplantation is an effective treatment for endstage heart failure;however,problems such as the severe shortage of donor hearts,rejection,the toxic effects of immunosuppressants,and serious postoperative complications remain.[1]Heart xenotransplantation is one of the most promising alternatives to address the shortage of allogeneic donor ***,the recipient survival rate and quality of life are affected by major obstacles,including immune rejection,complement and coagulation dysfunction,and infection.[2,3]Owing to the continuous improvement of gene editing strategies for donor pigs and anti-immune rejection strategies for non-human primate recipients.

关键词： donor treatment shortage

1例合并附壁血栓的缺血性心肌病心衰患者的用药分析及药学服务

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Journal of Chinese Pharmaceutical Sciences 2024年第1期33卷 63-68页

作者：袁叶杨珍珍于博杨秀岭河北医科大学第二医院河北石家庄050000

本研究中临床药师参与了1例缺血性心肌病合并心衰患者的治疗过程,对患者既往病史及用药史进行了梳理,针对患者有过胃肠道出血史且目前处于慢性心衰急性加重失代偿期,对其抗栓治疗方案进行了分析,并对用药过程中血钾管理和他汀药物选择... 详细信息

本研究中临床药师参与了1例缺血性心肌病合并心衰患者的治疗过程,对患者既往病史及用药史进行了梳理,针对患者有过胃肠道出血史且目前处于慢性心衰急性加重失代偿期,对其抗栓治疗方案进行了分析,并对用药过程中血钾管理和他汀药物选择提出优化建议。记录患者每日查房病情发展情况,与医师沟通学习缺血性心肌病心衰患者治疗的经验知识,关注细节、对比联系,从用药有效性、安全性、患者依从性方面进行了密切关注,在药物比较选择、不良反应和用药教育等方面,为患者安全用药提供药学服务。

关键词：缺血性心肌病心力衰竭附壁血栓血钾管理文献分析临床药师

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轻型注意力卷积无人机影像车辆检测模型研究

测绘与空间地理信息 2024年第4期47卷 73-76页

作者：杨秀伶重庆水利电力职业技术学院重庆402160

提出一种能够部署于无人机终端的轻量级端到端车辆检测模型。在骨干网络中,首先,使用焦点机制对输入的原始图像进行无损下采样;然后,利用带有轻型注意力模块的深度可分离卷积核组成特征提取层;最后,在特征金字塔中通过跨尺度多层融合来... 详细信息

提出一种能够部署于无人机终端的轻量级端到端车辆检测模型。在骨干网络中,首先,使用焦点机制对输入的原始图像进行无损下采样;然后,利用带有轻型注意力模块的深度可分离卷积核组成特征提取层;最后,在特征金字塔中通过跨尺度多层融合来提高三个层级输出特征图内的信息复杂程度。将开源无人机影像数据集VisDrone与多个时期采集的无人机道路影像混合,经过增强处理后作为训练集对模型进行训练。实验结果表明,本文所提出模型对于各类车辆目标均表现出稳定的检测性能,在综合检测精度方面明显优于几组对照模型,同时训练后模型体量较小,能够在测试环境的嵌入式硬件终端上部署并开展实时检测。

关键词：无人机车辆检测轻量级模型注意力机制深度可分离卷积

LEEP宫颈锥切术联合干扰素治疗宫颈上皮内瘤变的疗效

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菏泽医学专科学校学报 2024年第2期36卷 37-39,42页

作者：杨秀玲定陶区妇幼保健院山东菏泽274100

目的探讨干扰素联合LEEP宫颈锥切术治疗宫颈上皮内瘤变的疗效。方法采用便利抽样法选择我院收治的宫颈上皮内瘤变患者90例,根据治疗方案的不同将其分为观察组和对照组,每组45例。两组患者均在我院实施LEEP宫颈锥切术治疗,观察组患者在... 详细信息

目的探讨干扰素联合LEEP宫颈锥切术治疗宫颈上皮内瘤变的疗效。方法采用便利抽样法选择我院收治的宫颈上皮内瘤变患者90例,根据治疗方案的不同将其分为观察组和对照组,每组45例。两组患者均在我院实施LEEP宫颈锥切术治疗,观察组患者在此基础上联合应用干扰素治疗。比较两组患者血性白带消失时间、创面愈合时间及阴道流液时间,治疗前后白细胞介素4等宫颈微环境指标水平。术后随访一年比较两组患者复发率与人乳头瘤病毒转阴率。结果观察组患者血性白带消失时间、创面愈合时间以及阴道流液时间短于对照组(P0.05;观察组患者治疗后白细胞介素4低于对照组,白细胞介素12以及γ-干扰素水平高于对照组(P均<0.05)。术后随访一年发现观察组患者复发率更低,人乳头瘤病毒转阴率更高(P<0.05)。结论在LEEP宫颈锥切术治疗宫颈上皮内瘤变的基础上联合应用干扰素治疗,能够显著改善患者宫颈微环境,有利于患者术后恢复,能够增加人乳头瘤病毒清除率,可改善患者预后。

关键词：宫颈上皮内瘤变干扰素 LEEP宫颈锥切术疗效

Rock paper scissors: CRISPR/Cas9-mediated interference with geminiviruses in plants

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Science China(Life Sciences) 2019年第10期62卷 1389-1391页

作者： xiuling yang Huanbin Zhou Xueping Zhou State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural Sciences Beijing 100193China State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhou 310058China

Geminiviruses are a group of circular single-stranded DNA viruses that constitute the largest family of plant viruses. Many diseases resulting from geminivirus infections, such as maize streak disease, cassava mosaic disease, tomato yellow leaf curl disease and cotton leaf curl diseases, cause significant problems in terms of economic losses, posing a serious threat to global crop productivity (Hanley-Bowdoin et al., 2013;yang et al., 2019). As obligate intracellular parasites, geminiviruses cannot be controlled chemically. Conventional strategies to control geminiviruses rely heavily on the application of pesticides to limit insect vector populations, but it causes environmental concerns. To date, developing novel crop germplasms with durable disease resistance to geminiviruses is still the best strategy to manage viral infections due to its environmental friendliness. However, traditional breeding programs are time-intensive and labor-consuming processes, and transgene-based modern approaches by overexpressing the geminiviral proteins (e.g., the truncated form of the replication initiator protein) failed to confer resistance to geminiviruses due to activated virusinduced transgene silencing.

关键词： mosaic disease insect vector disease resistance

Natural continuous influent nitrifier immigration effects on nitrification and the microbial community of activated sludge systems

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Journal of Environmental Sciences 2018年第12期30卷 159-167页

作者： Lifang Yu Ren Li Robert Delatolla Ru Zhang xiuling yang Dangcong Peng School of Environmental and Municipal Engineering Xi'an University of Architecture and Technology Department of Civil Engineering University of Ottawa

Two sequencing batch reactors（SBRs） were operated for 100 days under aerobic conditions,with one being fed with unsterilized municipal wastewater（USBR）, and the other fed with sterilized municipal wastewater（SSBR）. Respirometric assays and fluorescence in situ hybridization（FISH） results show that active nitrifiers were present in the unsterilized influent municipal wastewater. The maximum ammonia utilization rate（AUR） and nitrite utilization rate（NUR） of the unsterilized influent were 0.32 ± 0.12 mg NH4＋-N/（L·hr） and0.71 ± 0.18 mg NO2--N/（L·hr）. Based on the maximum utilization rates, the estimated seeding intensity for the ammonia oxidizing bacteria（AOB） and nitrite oxidizing bacteria（NOB） of the USBR was 0.08 g AOB/（g AOB·day） and 0.20 g NOB/（g NOB·day） respectively. The fraction of nitrifiers/total bacteria in the influent was 5.35% ± 2.1%, the dominant AOB was Nitrosomonas spp., Nitrosococcus mobilis hybridizated with Nsm156, and the dominant NOB was Nitrospira hybridizated with Ntspa662. The influent nitrifiers potentially seeded the activated sludge of the bioreactor and hence demonstrated a mitigation of the acclimatization times and instability during start-up and early operation. The AUR and NUR in the USBR was 15% and 13% higher than the SSBR respectively during the stable stage, FISH results showed that nitrifiers population especially the Nitrospira in the USBR was higher than that in the SSBR. These results indicate that the natural continuous immigration of nitrifiers from municipal influent streams may have some repercussions on the modeling and design of bioreactors.

关键词： Nitrifier immigration Influent wastewater Seeding effect Nitrification Nitrospira

HPLC-MS/MS法同时测定大鼠回肠中5-羟色胺和5-羟吲哚乙酸含量

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中国医院药学杂志 2024年第14期44卷 1651-1656页

作者：刘玥韩竺杭袁叶王丽楠张钰恬杨秀岭河北医科大学第二医院药学部河北石家庄050000

目的:建立同时测定大鼠回肠中5-羟色胺和5-羟吲哚乙酸含量的方法。方法:采用高效液相色谱-串联质谱(HPLC-MS/MS)法进行检测。色谱柱为X Bridge BEH C_(18)柱(100 mm×2.1 mm,2.5μm);流动相为0.1%甲酸水(A)-0.1%甲酸乙腈(B),梯度洗脱;... 详细信息

目的:建立同时测定大鼠回肠中5-羟色胺和5-羟吲哚乙酸含量的方法。方法:采用高效液相色谱-串联质谱(HPLC-MS/MS)法进行检测。色谱柱为X Bridge BEH C_(18)柱(100 mm×2.1 mm,2.5μm);流动相为0.1%甲酸水(A)-0.1%甲酸乙腈(B),梯度洗脱;流速为0.3 m L·min^(-1);柱温为40℃;进样量为5μL;电喷雾电离源(ESI),正离子模式下多反应监测。结果:5-羟色胺在25~1 000 ng·m L^(-1)范围内线性关系良好(r^(2)=0.999 1),定量下限为25 ng·m L^(-1);5-羟吲哚乙酸在50~2 000 ng·m L^(-1)范围内线性关系良好(r^(2)=0.999 5),定量下限为50 ng·m L^(-1)。5-羟色胺和5-羟吲哚乙酸的日内、日间精密度均小于10%,准确度在96.90%~105.22%范围内,提取回收率均大于90%,稳定性良好,基质影响较小。测得大鼠回肠中5-羟色胺的含量为(2 533.62±225.08) ng·g^(-1),5-羟吲哚乙酸的含量为(1 365.19±69.18) ng·g^(-1),5-羟色胺的转化率为0.54±0.03。结论:该实验建立的方法准确灵敏,快捷高效,能够准确测定大鼠回肠中5-羟色胺和5-羟吲哚乙酸的含量,为探究大鼠回肠中5-羟色胺的代谢情况提供可靠的方法支持。

关键词： HPLC-MS/MS 5-羟色胺 5-羟吲哚乙酸回肠神经递质

Occurrence and distribution of geminiviruses in China

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Science China(Life Sciences) 2022年第8期65卷 1498-1503页

作者： Fangfang Li Rui Qiao Zhanqi Wang xiuling yang Xueping Zhou State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province College of Life SciencesHuzhou UniversityHuzhou 313000China State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhou 310058China

Geminiviruses are a group of plant viruses that cause severe diseases in many economically important crops worldwide, leading to devastating losses to agricultural production. Here we summarize the occurrence and distribution of geminiviruses in China,which provides valuable information for further epidemiological studies and supports the development of effective disease management strategies.

关键词： geminiviruses occurrence distribution China

基于“耕读教育-智慧教学”的智慧农业专业教材建设改革与创新研究

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智慧农业导刊 2024年第14期4卷 1-4页

作者：梁芳胡菊杨秀玲李琳白彩虹邓旭玉林师范学院广西玉林537000

该研究基于“耕读教育-智慧教学”的理念,从教材建设目标、教材内容创新、数字化教材开发、校企合作教材编写以及评价体系改革等方面,探索在教材建设中“耕读教育”和“智慧教学”相结合的新模式,将耕读教育与专业实践教育有机智慧的结... 详细信息

该研究基于“耕读教育-智慧教学”的理念,从教材建设目标、教材内容创新、数字化教材开发、校企合作教材编写以及评价体系改革等方面,探索在教材建设中“耕读教育”和“智慧教学”相结合的新模式,将耕读教育与专业实践教育有机智慧的结合,从而提高学生对智慧农业专业理论知识的掌握程度和实际运用能力,开辟新时代耕读教育实践,智慧教学的新途径,有助于提高教材的质量和教学效果,培养出更多具备创新能力和实践能力的智慧农业专业人才。

关键词：耕读教育智慧教学教材建设智慧农业涉农高校

The βC1 Protein of Gem,n,v,rus--Betasatellite Complexes:A Target and Repressor of Host Defenses

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Molecular Plant 2018年第12期11卷 1424-1426页

作者： Fangfang Li xiuling yang David M.Bisaro Xueping Zhou State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193 China Department of Molecular Genetics Center for Applied Plant SciencesCenter for RNA Biologyand Infectious Diseases InstituteOhio State University ColumbusOH 43210USA State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhou 310058China

Geminiviruses are a family of plant viruses that cause devastating diseases in many economically important crops worldwide. These pathogens encapsidate circular,single-stranded DNAs (ssDNAs)of 2.5-3.0 kb that replicate through double-stranded DNA (dsDNA)*** of the genus Begomovirus,which comprises by far the largest number of species in the family,are transmitted by whiteflies and have genomes consisting of one or two DNAs.

关键词： βC1 Protein Host Defenses