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Science China Chemistry 2024年第2期67卷 732-740页

作者： Shuchi Zhang Dengyun Miao Yi Ding Mengyuan Li Shujing Guo Yujuan Zhang xiulian Pan Xinhe Bao State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China University of Chinese Academy of Sciences Beijing100049China Shaanxi Yanchang Petroleum(Group)Co. Ltd.&Dalian Institute of Chemical Physics Xi’an Clean Energy(Chemical Industry)Research InstituteXi’an710000China

Direct conversion of syngas to aromatics over metal oxide and zeolite(OXZEO) composite catalysts is promising.However,the selectivity of more valuable products such as benzene,toluene and xylenes(BTX) is limited due to undesired secondary methylation of BTX.Herein,we report that the introduction of SAPO-34 into MnCrO_(x)-ZSM-5 catalyst enhances significantly the formation of BTX without sacrificing the aromatics selectivity.Under optimized conditions,the fraction of BTX in aromatics reaches 64.7% versus 28.9% over the catalyst without SAPO-34.A number of model reaction tests and characterizations reveal that SAPO-34 consumes partially the intermediates such as ketene,by converting them to light olefins.Thus,the methylation of BTX by ketene to heavy aromatics is inhibited over the external acid sites of ZSM-5,leading to an enhanced BTX selectivity in the products.This hybrid catalyst provides an efficient method for highly selective synthesis of BTX from syngas.

关键词： selective syngas conversion OXZEO aromatics BTX multi-functional catalysts

Phosphatidic acid-enabled MKL1 contributes to liver regeneration:Translational implication in liver failure

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Acta Pharmaceutica Sinica B 2024年第1期14卷 256-272页

作者： Jiawen Zhou Xinyue Sun Xuelian Chen Huimin Liu xiulian Miao Yan Guo Zhiwen Fan Jie Li Yong Xu Zilong Li State Key Laboratory of Natural Medicines Department of PharmacologyChina Pharmaceutical UniversityNanjing 211198China Institute of Biomedical Research Liaocheng UniversityLiaocheng 252200China Department of Pathology Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Infectious Diseases Nanjing Drum Tower Hospital Affiliated with Nanjing University Medical SchoolNanjing 210008China Institute of Viruses and Infectious Diseases Nanjing UniversityNanjing 210008China

Liver regeneration following injury aids the restoration of liver mass and the recovery of liver function.In the present study we investigated the contribution of megakaryocytic leukemia 1(MKL1),a transcriptional modulator,to liver regeneration.We report that both MKL1 expression and its nuclear translocation correlated with hepatocyte proliferation in cell and animal models of liver regeneration and in liver failure patients.Mice with MKL1 deletion exhibited defective regenerative response in the liver.Transcriptomic analysis revealed that MKL1 interacted with E2F1 to program pro-regenerative transcription.MAPKAPK2 mediated phosphorylation primed MKL1 for its interaction with E2F1.Of interest,phospholipase d2 promoted MKL1 nuclear accumulation and liver regeneration by catalyzing production of phosphatidic acid(PA).PA administration stimulated hepatocyte proliferation and enhanced survival in a MKL1-dependent manner in a pre-clinical model of liver failure.Finally,PA levels was detected to be positively correlated with expression of pro-regenerative genes and inversely correlated with liver injury in liver failure patients.In conclusion,our data reveal a novel mechanism whereby MKL1 contributes to liver regeneration.Screening for small-molecule compounds boosting MKL1 activity may be considered as a reasonable approach to treat acute liver failure.

关键词： Liver failure Liver regeneration Transcription regulation Transcription factor Hepatocytes Phosphatidic acid Phospholipase d2 Translational medicine

Progress in the preparation and physical properties of two-dimensional Cr-based chalcogenide materials and heterojunctions

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Frontiers of physics 2024年第2期19卷 105-130页

作者： xiulian Fan Ruifeng Xin Li Li Bo Zhang Cheng Li Xilong Zhou Huanzhi Chen Hongyan Zhang Fangping OuYang Yu Zhou School of Physics and Electronics Hunan Key Laboratory of Nanophotonics and DevicesCentral South UniversityChangsha 410083China Jincheng Research Institute of Opto-mechatronics Industry Jincheng 048000China Shanxi Key Laboratory of Advanced Semiconductor Optoelectronic Devices and Integrated Systems Jincheng 048000China School of Physical Science and Technology Xinjiang UniversityUrumqi 830046China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

Two-dimensional transition metal dichalcogenides(TMDs)exhibit promising application prospects in the domains of electronic devices,optoelectronic devices and spintronic devices due to their distinctive energy band structures and spin−orbit coupling properties.Cr-based chalcogenides with narrow or even zero bandgap,covering from semiconductors to metallic materials,have considerable potential for wide-band photodetection and two-dimensional magnetism.Currently,the preparation of 2D CrX_(n)(X=S,Se,Te)nanosheets primarily relies on chemical vapor deposition(CVD)and molecule beam epitaxy(MBE),which enable the production of high-quality large-area materials.This review article focuses on recent progress of 2D Cr-based chalcogenides,including unique crystal structure of the CrX_(n)system,phase-controlled synthesis,and heterojunction construction.Furthermore,a detailed introduction of room-temperature ferromagnetism and electrical/optoelectronic properties of 2D CrXn is presented.Ultimately,this paper summarizes the challenges associated with utilizing 2D Cr-based chalcogenides in preparation strategies,optoelectronics devices,and spintronic devices while providing further insights.

关键词： physical properties two-dimensional materials Cr-based chalcogenide controlled synthesis heterojunction eletronic and optoelectronic devices

Ornstein-Uhlenback type Omega model

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Frontiers of Mathematics in China 2016年第3期11卷 737-751页

作者： xiulian wang Wei wang Chunsheng ZHANG College of Mathematical Science Tianjin Normal University Tianjin 300387 China School of Mathematical Sciences and LPMC Nankai University Tianjin 300071 China

我们为一个保险公司与内在的 Ornstein-Uhlenbeck 类型剩余过程考虑终止模型并且获得一些有用结果。为在有经常的破产率和线性破产率的破产的期望的打折的惩罚功能的明确的表情被导出。基于剩余进程的随机的观察，我们特别在零点在破产... 详细信息

我们为一个保险公司与内在的 Ornstein-Uhlenbeck 类型剩余过程考虑终止模型并且获得一些有用结果。为在有经常的破产率和线性破产率的破产的期望的打折的惩罚功能的明确的表情被导出。基于剩余进程的随机的观察，我们特别在零点在破产为期望的打折的惩罚函数检验可辨性。最后，我们作为李和周的一个重要例子在职业时间给 Laplace 变换[副词。Appl。Probab， 2013， 45 (4 ) ：1049-1067 ] 。

关键词： ω模型 OU型 Laplace变换罚金折现期望盈余过程保险公司惩罚函数高级应用

Development of Rural Tourism Industry under the Background of New Rural Construction : A Case Study of Henghe of Boluo County in Huizhou City

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Asian Agricultural Research 2024年第3期16卷 14-17页

作者： Jialing DENG Yanping ZHONG xiulian LIN Huizhou Engineering Vocational College Huizhou 516023China

Henghe Town in Boluo County of Huizhou is taken as the research object for analysis.The research and analysis on the tourism industry in Henghe Town of Boluo County are conducted,and the basic situation of rural tourism construction in Henghe Town is sorted out.The forms of tourism industry in Henghe Town and the problems in rural tourism development are identified,and some targeted suggestions and countermeasures are proposed.It hopes to provide ideas and references for the construction of beautiful rural areas in mountainous areas of Guangdong Province,and theoretical reference and practical significance for the development of rural tourism in mountainous areas of Guangdong Province.

关键词： New countryside Rural tourism Henghe Town in Boluo County

窄谱中波紫外线联合其他方法治疗白癜风的研究进展

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中华皮肤科杂志 2024年第1期57卷 75-78页

作者：曾蕊徐秀莲中国医学科学院北京协和医学院皮肤病医院病理科南京210042

窄谱中波紫外线(NB-UVB)是治疗泛发型白癜风的一线方案,但单一治疗效果有限,疗程长.NB-UVB联合其他治疗能缩短疗程,提高疗效,是目前临床上常用的治疗模式.本文就NB-UVB联合其他方法如糖皮质激素、阿法诺肽、钙调磷酸酶抑制剂、JAK抑制... 详细信息

窄谱中波紫外线(NB-UVB)是治疗泛发型白癜风的一线方案,但单一治疗效果有限,疗程长.NB-UVB联合其他治疗能缩短疗程,提高疗效,是目前临床上常用的治疗模式.本文就NB-UVB联合其他方法如糖皮质激素、阿法诺肽、钙调磷酸酶抑制剂、JAK抑制剂、富血小板血浆、CO_(2)点阵激光、外科手术治疗白癜风的研究进展进行综述,旨在为临床提供更多治疗选择.

关键词：白癜风紫外线疗法窄谱中波紫外线联合治疗

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2022—2023年辽金史研究述评

中国史研究动态 2024年第2期 39-47页

作者：李秀莲燕山大学东北亚古丝路文明研究中心河北秦皇岛066004

2022—2023年国内辽金史研究收获颇丰,据不完全统计,刊发学术文章近千篇,其中考古与文物相关的文章几乎占半数以上。出版学术专著、考古报告、文集等50余部。涉及的问题广泛而深入,有宏大叙事,有微观精研,有旧问题的深挖与再发现,有新... 详细信息

2022—2023年国内辽金史研究收获颇丰,据不完全统计,刊发学术文章近千篇,其中考古与文物相关的文章几乎占半数以上。出版学术专著、考古报告、文集等50余部。涉及的问题广泛而深入,有宏大叙事,有微观精研,有旧问题的深挖与再发现,有新研究领域的拓展,有质疑争鸣,有新史料的发掘,等等。面对推陈出新的学术成果,万字的述评挂一漏万已是必然,努力尝试以点带面,管窥全豹。一、北族文明的演进与中华民族共同体形成研究辽金历史是民族交融、汇聚成中华民族历史的重要组成,是中华民族共同体形成的重要环节。

关键词：学术专著以点带面民族交融考古报告中华民族共同体学术文章宏大叙事

GGPPS基因在植物色香性状改良中的应用研究进展

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南京林业大学学报（自然科学版） 2024年第1期48卷 1-10页

作者：王良桂曾贵敏杨秀莲岳远征南京林业大学风景园林学院江苏省风景园林重点实验室南方现代林业协同创新中心江苏南京210037 南京林业大学林草学院江苏南京210037

色彩和香味是影响园林植物观赏品质的重要因子,对植物的观赏价值具有决定性的影响。类胡萝卜素是植物重要色素物质,单萜是植物关键芳香成分,牻牛儿基牻牛儿基焦磷酸合成酶基因(GGPPS)位于两者合成途径的关键交叉节点,对植物颜色、香味... 详细信息

色彩和香味是影响园林植物观赏品质的重要因子,对植物的观赏价值具有决定性的影响。类胡萝卜素是植物重要色素物质,单萜是植物关键芳香成分,牻牛儿基牻牛儿基焦磷酸合成酶基因(GGPPS)位于两者合成途径的关键交叉节点,对植物颜色、香味相关代谢物的形成具有重要影响。本研究对GGPPS蛋白的结构与分类、进化聚类情况,并对GGPPS基因的转录调控和其他调控因子进行综述,总结了GGPPS基因影响植物色彩与香味形成的作用机制,探讨了其在植物色彩及香味性状改良方面的应用潜力,认为今后可利用多组学手段挖掘相关转录因子并解析GGPPS基因调控植物色香的分子网络,以期为植物观赏性状的遗传改良工作提供新的基因资源和研究思路。

关键词： GGPPS基因色彩香味萜类物质观赏植物

个人养老金制度激励机制的经验比较与方案设计——基于fsQCA的OECD国家案例分析

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宁夏社会科学 2024年第1期 126-138页

作者：黄秀莲褚福灵中央财经大学保险学院北京100081

为健全完善多层次养老保险体系,加快推进个人养老金制度发展,激励机制至关重要。结合fsQCA的定性分析和精算模型的定量分析,以OECD国家为案例样本,通过个人养老金制度激励机制的国际比较,总结有益经验,并提出激励机制设计方案。研究表明... 详细信息

为健全完善多层次养老保险体系,加快推进个人养老金制度发展,激励机制至关重要。结合fsQCA的定性分析和精算模型的定量分析,以OECD国家为案例样本,通过个人养老金制度激励机制的国际比较,总结有益经验,并提出激励机制设计方案。研究表明,缴费上限差异化、领取税率差异化以及必要的政府补贴是促进个人养老金制度发展的重要国际经验。基于公平与效率原则,设计递减目标替代率下三类激励方案:方案一为缴费上限收入差异化,收入每增加1000元/月,缴费上限约降低70元/月;方案二为领取税率收入差异化,收入低于16000元/月无需缴税,两个高收入层级领取税率为3.15%和12.74%;方案三为增加政府补贴,收入低于16000元/月可获得政府补贴,补贴比例为8.11%—30.26%。研究从激励机制视角,为我国个人养老金制度实施差异化财税政策提供了实证依据。

关键词：个人养老金制度激励机制国际案例分析国内方案设计

Combination of Evodiamine with Berberine Reveals a Regulatory Effect on the Phenotypic Transition of Colon Epithelial Cells Induced by CCD-18Co

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Chinese Medical Sciences Journal 2020年第3期35卷 195-206页

作者： Chao Huang Keming Xiang Bingjun Liang Weixuan Huang Fanjun Zhang Yuwan Shao xiulian wang Haosheng Liu Weizeng Shen Department of Traditional Chinese Medicine Affiliated Bao’an Hospital of ShenzhenSouthern Medical UniversityShenzhen 518100China Community Healthy Service Center Shenzhen Bao’an Traditional Chinese Medicine Hospital GroupShenzhen 518100China

Objective Transdifferentiation exists between stromal cells or between stromal cells and cancer cells.Evodiamine and berberine are predominant pharmacological components of Zuojin pill,a prescription of Traditional Chinese Medicine,playing crucial functions in remolding of tumor microenvironment.This study aimed to explore the effect of combination of evodiamine with berberine(cBerEvo)on the phenotypic transition of colon epithelial cells induced by tumor-associated fibroblasts,as well as the involved mechanisms.Methods Human normal colon epithelial cell line HCoEpiC cells were treated with the prepared conditioned medium of CCD-18 Co,a human colon myofibroblast line,to induce epithelial-mesenchymal transition.Phase contrast microscope was used to observe the morphological changes.Epithelial-mesenchymal transition markers including E-cadherin,vimentin and alpha-smooth muscle actin(α-SMA)were observed with immunofluorescence microscopy.Migration was assessed by wound healing assay.Western blotting was used to detect the expressions of E-cadherin,vimentin,α-SMA,Snail,ZEB1 and Smads.Results In contrast to the control,the tumor-associated fibroblasts-like CCD-18 Co cells induced downregulation of E-cadherin and up-regulation of vimentin,α-SMA,Snail and ZEB1(P<0.05),and promoted migration of HCoEpiCs(P<0.05),with over expression of Smads including Smad2,p-Smad2,Smad3,p-Smad3 and Smad4(P<0.05),which were abolished by a transforming growth factor-β(TGF-β)receptor inhibitor LY364947 and by cBerEvo in a concentration dependent manner.In addition,cBerEvo-inhibited ratios of p-Smad2/Smad2 and p-Smad3/Smad3 were also dose dependent.Conclusion The above results suggest that cBerEvo can regulate the differentiation of colon epithelial cells induced by CCD-18 Co through suppressing activity of TGF-β/Smads signaling pathway.

关键词： evodiamine berberine tumor microenvironment epithelial-mesenchymal transition TGF-βsignaling