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Chinese Physics Letters 2023年第3期40卷 74-81页

作者： Jiankai Zhu Luming Wang Jiaqi Wu Yachun Liang Fei Xiao Bo Xu Zejuan Zhang xiulian fan Yu Zhou Juan Xia Zenghui Wang Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China School of Physics and Electronics Hunan Key Laboratory of Nanophotonics and DevicesCentral South UniversityChangsha 410083China State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 610054China

Laser interferometry is an important technique for ultrasensitive detection of motion and *** push the limit of laser interferometry through noise optimization and device *** contribution of noises other than shot noise is reduced from 92.6%to 62.4%,demonstrating the possibility towards shotnoise-limited *** noise thermometry,we quantify the laser heating effect and determine the range of laser power values for room-temperature *** detailed analysis and optimization of signal transduction,we achieve 1.2 fm/Hz^(1/2)displacement measurement sensitivity at room temperature in twodimensional(2D)Ca Nb_(2)O_(6)nanomechanical resonators,the best value reported to date among all resonators based on 2D *** work demonstrates a possible pathway towards quantum-noise-limited measurement at room temperature.

关键词： noise interferometry optimization

Stable alkali halide vapor assisted chemical vapor deposition of 2D HfSe2 templates and controllable oxidation of its heterostructures

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Frontiers of physics 2024年第3期19卷 29-38页

作者： Wenlong Chu Xilong Zhou Ze Wang xiulian fan Xuehao Guo Cheng Li Jianling Yue fangping Ouyang Jiong Zhao Yu Zhou School of Physics Hunan Key Laboratory of Nanophotonics and DevicesCentral South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing100190China Department of Applied Physics The Hong Kong Polytechnic UniversityKowloonHong KongChina

Two-dimensional hafnium-based semiconductors and their heterostructures with native oxides have been shown unique physical properties and potential electronic and optoelectronic ***,the scalable synthesis methods for ultrathin layered hafnium-based semiconductor laterally epitaxy growth and its heterostructure are still restricted,also for the understanding of its formation ***,we report the stable sublimation of alkali halide vapor assisted synthesis strategy for high-quality 2D HfSe_(2) nanosheets via chemical vapor ***-crystalline ultrathin 2D HfSe_(2) nanosheets were systematically grown by tuning the growth parameters,reaching the lateral size of 6‒40μm and the thickness down to 4.5 *** scalable amorphous HfO_(2)and HfSe_(2)heterostructures were achieved by the controllable oxidation,which benefited from the approximate zero Gibbs free energy of unstable 2D HfSe_(2) *** crystal structure,elemental,and time dependent Raman characterization were carried out to understand surface precipitated Se atoms and the formation of amorphous Hf−O bonds,confirming the slow surface oxidation and lattice incorporation of oxygen *** relatively smooth surface roughness and electrical potential change of HfO_(2)−HfSe_(2) heterostructures indicate the excellent interface quality,which helps obtain the high performance memristor with high on/off ratio of 105 and long retention period over 9000 *** work introduces a new vapor catalysts strategy for the synthesis of lateral 2D HfSe_(2) nanosheets,also providing the scalable oxidation of the Hf-based heterostructures for 2D electronic devices.

关键词： chemical vapor deposition HfSe_(2)−HfO_(2) nanoelectronics

Progress in the preparation and physical properties of two-dimensional Cr-based chalcogenide materials and heterojunctions

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Frontiers of physics 2024年第2期19卷 105-130页

作者： xiulian fan Ruifeng Xin Li Li Bo Zhang Cheng Li Xilong Zhou Huanzhi Chen Hongyan Zhang fangping OuYang Yu Zhou School of Physics and Electronics Hunan Key Laboratory of Nanophotonics and DevicesCentral South UniversityChangsha 410083China Jincheng Research Institute of Opto-mechatronics Industry Jincheng 048000China Shanxi Key Laboratory of Advanced Semiconductor Optoelectronic Devices and Integrated Systems Jincheng 048000China School of Physical Science and Technology Xinjiang UniversityUrumqi 830046China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

Two-dimensional transition metal dichalcogenides(TMDs)exhibit promising application prospects in the domains of electronic devices,optoelectronic devices and spintronic devices due to their distinctive energy band structures and spin−orbit coupling ***-based chalcogenides with narrow or even zero bandgap,covering from semiconductors to metallic materials,have considerable potential for wide-band photodetection and two-dimensional ***,the preparation of 2D CrX_(n)(X=S,Se,Te)nanosheets primarily relies on chemical vapor deposition(CVD)and molecule beam epitaxy(MBE),which enable the production of high-quality large-area *** review article focuses on recent progress of 2D Cr-based chalcogenides,including unique crystal structure of the CrX_(n)system,phase-controlled synthesis,and heterojunction ***,a detailed introduction of room-temperature ferromagnetism and electrical/optoelectronic properties of 2D CrXn is ***,this paper summarizes the challenges associated with utilizing 2D Cr-based chalcogenides in preparation strategies,optoelectronics devices,and spintronic devices while providing further insights.

关键词： physical properties two-dimensional materials Cr-based chalcogenide controlled synthesis heterojunction eletronic and optoelectronic devices

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如何在小学数学中培养学生的创新意识

当代家庭教育 2020年第29期 162-163页

作者：范秀莲甘肃省康乐县段家坪小学

现阶段,在新课标的要求下,小学数学教学中对学生创新意识的培养不断提高。不仅要求对相关数学知识点加强巩固和创新,为学生营造一个良好的学习氛围,还要求教学中能够帮助学生参与到数学学习的过程中,拓展思维和提升认知。本文结合多年... 详细信息

现阶段,在新课标的要求下,小学数学教学中对学生创新意识的培养不断提高。不仅要求对相关数学知识点加强巩固和创新,为学生营造一个良好的学习氛围,还要求教学中能够帮助学生参与到数学学习的过程中,拓展思维和提升认知。本文结合多年教学经验,对如何在小学数学中培养学生的创新意识展开分析,以期本文的建议能够为小学数学教学带来一定的帮助。

关键词：小学数学学生创新意识思考

骨形态发生蛋白4在肥胖小鼠心肌、动脉和脂肪组织的表达与炎症的相关性研究

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临床心血管病杂志 2016年第10期32卷 1043-1047页

作者：顾秀莲樊济海巢胜吾王玲李博宗刚军吴婷中国人民解放军第455医院心内科上海200000 中国人民解放军第101医院心内科

目的:探讨肥胖老鼠体内心脏、动脉与脂肪组织中骨形态发生蛋白4(BMP4)的表达及其与炎症程度的相关性。方法:将ob/ob小鼠分为实验组与干扰组,以C57BL/6小鼠为对照组。每组各8只,普通饮食喂养,干扰组尾静脉注射BMP4shRNA腺病毒,每周1次,持... 详细信息

目的:探讨肥胖老鼠体内心脏、动脉与脂肪组织中骨形态发生蛋白4(BMP4)的表达及其与炎症程度的相关性。方法:将ob/ob小鼠分为实验组与干扰组,以C57BL/6小鼠为对照组。每组各8只,普通饮食喂养,干扰组尾静脉注射BMP4shRNA腺病毒,每周1次,持续12周。12周后心脏采血处死,取心肌组织、腹主动脉及腹部脂肪组织。免疫组织化学染色定位半定量BMP4的表达水平。PCR荧光定量和免疫蛋白印迹法检测BMP4、白细胞介素(IL)-1β和IL-9mRNA与蛋白的表达水平。结果:实验组BMP4、IL-1β和IL-9的mRNA与蛋白在心肌组织和动脉血管的表达均显著高于干扰组和对照组,实验组和干扰组BMP4蛋白在脂肪组织中的表达要显著低于对照组(均P<0.05)。结论:BMP4在肥胖小鼠体内心肌组织和动脉血管中明显高表达,是促进局部炎症反应发生的独立危险因子。

关键词：骨形态发生蛋白4 肥胖炎症心血管疾病

Understanding nano effects in catalysis

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National Science Review 2015年第2期2卷 183-201页

作者： fan Yang Dehui Deng xiulian Pan Qiang Fu Xinhe Bao State Key Laboratory of Catalysis iChEM(Collaborative Innovation Center of Chemistry for Energy Materials)Dalian Institute of Chemical PhysicsChinese Academy of Sciences

Catalysis, as a key and enabling technology, plays an increasingly important role in ields ranging from energy, environment and agriculture to health care. Rational design and synthesis of highly eicient catalysts has become the ultimate goal of catalysis research. hanks to the rapid development of nanoscience and nanotechnology, and in particular a theoretical understanding of the tuning of electronic structure in nanoscale systems, this element of design is becoming possible via precise control of nanoparticles' composition, morphology, structure and electronic states. At the same time, it is important to develop tools for in situ characterization of nanocatalysts under realistic reaction conditions, and for monitoring the dynamics of catalysis with high spatial, temporal and energy resolution. In this review, we discuss coninement efects in nanocatalysis, a concept that our group has put forward and developed over several years. Taking the conined catalytic systems of carbon nanotubes, metal-conined nano-oxides and 2D layered nanocatalysts as examples, we summarize and analyze the fundamental concepts, the research methods and some of the key scientiic issues involved in nanocatalysis. Moreover, we present a perspective on the challenges and opportunities in future research on nanocatalysis from the aspects of:(1) controlled synthesis of nanocatalysts and rational design of catalytically active centers;(2) in situ characterization of nanocatalysts and dynamics of catalytic processes;(3) computational chemistry with a complexity approximating that of experiments; and (4) scale-up and commercialization of nanocatalysts.

关键词： nanocatalysis coninement carbon nanotubes graphene 2D materials inverse catalysts computational chemistry in situ characterizati

Phosphatidic acid-enabled MKL1 contributes to liver regeneration:Translational implication in liver failure

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Acta Pharmaceutica Sinica B 2024年第1期14卷 256-272页

作者： Jiawen Zhou Xinyue Sun Xuelian Chen Huimin Liu xiulian Miao Yan Guo Zhiwen fan Jie Li Yong Xu Zilong Li State Key Laboratory of Natural Medicines Department of PharmacologyChina Pharmaceutical UniversityNanjing 211198China Institute of Biomedical Research Liaocheng UniversityLiaocheng 252200China Department of Pathology Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Infectious Diseases Nanjing Drum Tower Hospital Affiliated with Nanjing University Medical SchoolNanjing 210008China Institute of Viruses and Infectious Diseases Nanjing UniversityNanjing 210008China

Liver regeneration following injury aids the restoration of liver mass and the recovery of liver *** the present study we investigated the contribution of megakaryocytic leukemia 1(MKL1),a transcriptional modulator,to liver *** report that both MKL1 expression and its nuclear translocation correlated with hepatocyte proliferation in cell and animal models of liver regeneration and in liver failure *** with MKL1 deletion exhibited defective regenerative response in the *** analysis revealed that MKL1 interacted with E2F1 to program pro-regenerative ***2 mediated phosphorylation primed MKL1 for its interaction with *** interest,phospholipase d2 promoted MKL1 nuclear accumulation and liver regeneration by catalyzing production of phosphatidic acid(PA).PA administration stimulated hepatocyte proliferation and enhanced survival in a MKL1-dependent manner in a pre-clinical model of liver ***,PA levels was detected to be positively correlated with expression of pro-regenerative genes and inversely correlated with liver injury in liver failure *** conclusion,our data reveal a novel mechanism whereby MKL1 contributes to liver *** for small-molecule compounds boosting MKL1 activity may be considered as a reasonable approach to treat acute liver failure.

关键词： Liver failure Liver regeneration Transcription regulation Transcription factor Hepatocytes Phosphatidic acid Phospholipase d2 Translational medicine

Liposomal codelivery of inflammation inhibitor and collagen protector to the plaque for effective anti-atherosclerosis

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Chinese Chemical Letters 2023年第1期34卷 239-244页

作者： Xiaotong Li Jiayi Gu Qingqing Xiao Ying Liu Ping Zhou Lifang fan xiulian Zhang Xiang Lu Jun Wu Zhengxia Liu Wei He School of Pharmacy China Pharmaceutical UniversityNanjing 211198China Department of Geriatrics The Second Affiliated HospitalNanjing Medical UniversityNanjing 210011China Key Laboratory for Aging&Disease Nanjing Medical UniversityNanjing 210011China Jiangsu Aosaikang Pharmaceutical Co. Ltd.Nanjing 211112China Department of Respiratory Disease Baoshan BranchShuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200120China Department of Geriatric Cardiology Jiangsu Provincial Key Laboratory of GeriatricsThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Geriatrics The Affiliated Sir Run Run Hospital of Nanjing Medical UniversityNanjing 211166China

Plaque plays a central role in atherosclerosis(AS)progression,whereas inflammation and destruction of the plaque microenvironment contribute to plaque *** a result,a therapy regime,which combines anti-inflammation and inhibition-degradation of plaque matrix,appears to be a promising strategy to combat ***,we report a p H-sensitive liposome co-loading with the anti-inflammatory agent(oridonin,ORD)and plaque-collagen protector(marimastat)for anti-AS *** was first conjugated with hyaluronic acid(HA)to target the inflammation contributor,pro-inflammatory ***,the conjugate assembled onto the MATT-loaded *** co-loaded system(150 nm)significantly improved pharmacokinetics over the liposomes without anchoring the conjugate and accumulated effectively in the *** preparation administration allowed efficient anti-AS activities in high-fat diet(HFD)-Apoe-/-mice by decreasing the pro-inflammatory cytokine expression in the serum,lessening the lesion area,alleviating the plaque collagen degradation,promoting macrophage polarization from phenotypic M1 to M2,reducing T helper(Th)17 cells(Th17)/T regulatory cells(Tregs)and Th1/Th2 ratio,***,the serum determination in AS patients demonstrated high expression of the inflammatory cytokines,indicating our finding may offer a potential guideline for clinical practice.

关键词： Atherosclerosis Plaque Inflammation Collagen Macrophages Co-delivery Liposomes

Gas-phase electrocatalytic reduction of carbon dioxide using electrolytic cell based on phosphoric acid-doped polybenzimidazole membrane

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Journal of Energy Chemistry 2014年第6期23卷 694-700页

作者： Dunfeng Gao fan Cai Qinqin Xu Guoxiong Wang xiulian Pan Xinhe Bao State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

Carbon dioxide transformation to fuels or chemicals provides an attractive approach for its utilization as feedstock and its emission reduction. Herein, we report a gas-phase electrocatalytic reduction of CO2 in an electrolytic cell, constructed using phosphoric acid-doped polybenz- imidazole （PBI） membrane, which allowed operation at 170 ℃ Pt/C and PtMo/C with variable ratio of Pt/Mo were studied as the cathode catalysts. The results showed that PtMo/C catalysts significantly enhanced CO formation and inhibited CH4 formation compared with Pt/C catalyst. Characterization by X-ray diffraction, X-ray photoelectron spectroscopy and transmission electron microscopy revealed that most Mo species existed as MoO3 in PtMo/C catalysts and the interaction between Pt and MoOx was likely responsible for the enhanced CO formation rate although these bicomponent catalysts in general had a larger particle size than Pt/C catalyst.

关键词： carbon dioxide gas-phase electrocatalytic reduction platinum-molybdenum catalyst Faradaic efficiency formation rate

住房福利模式的走向:大众化还是剩余化?——基于40个大城市的实证研究

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公共管理学报 2020年第1期17卷 110-120,173页

作者：马秀莲范翻中央党校(国家行政学院)社会和生态文明教研部北京100091 中国人民大学经济学院北京100872

中国住房市场化改革以来业已成型的带有生产主义特征的剩余型住房福利模式,是否在后金融危机时代发生转向:从生产主义到发展主义,从剩余型模式到社会民主模式?本文运用Harloe的大众化/剩余化社会住房概念,对中国40个城市的公租房准入标... 详细信息

中国住房市场化改革以来业已成型的带有生产主义特征的剩余型住房福利模式,是否在后金融危机时代发生转向:从生产主义到发展主义,从剩余型模式到社会民主模式?本文运用Harloe的大众化/剩余化社会住房概念,对中国40个城市的公租房准入标准进行了定量分析。研究发现,多数城市对本地人至少放宽到当地城镇居民人均可支配收入水平,建立起了较为大众化的公租房体系,对外来人口则进一步附加工作、社保等严苛条件,使得公租房体系非常剩余化。本地人住房的大众化具备了向社会民主模式转变的基础;同时生产主义的"有用原则"导致外地人公租房体系和城镇化水平更高的城市公租房体系都非常剩余化。中国住房福利制度是生产主义和剩余型模式,虽然具备一定的向社会民主模式转变的基础,但仍然在经济发展优先和公民社会权的保障之间徘徊,住房福利制度改革需要进一步推进。

关键词：住房制度公租房福利模式大众化/剩余化模式保障房