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How Do Young Children Manage Their Reputation among Peers?

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International Journal of Mental Health Promotion 2023年第7期25卷 847-854页

作者： Jingmiao Zhang Yuning Zhu xiuli liu School of Educational Science and Technology Anshan Normal UniversityAnshan114000China School of Psychology Northeast Normal UniversityChangchun130000China

Young children’s reputation management is closely related to their social development.The purpose of our study is to examine the interaction between theory of mind and partner choice on children’s reputation management.Participants consisted of 270 children who were 3 to 5 years old.First,we measured participants’theory of mind capabilities using the unexpected location task and unexpected content task and then randomly divided the participants into the control group,non-partner–choice group,and partner-choice group.We measured reputation management by comparing children’s willingness to share and sharing behavior between these groups.Thefindings are as follows:(1)Children from ages 3 to 5 demonstrated reputation management,and their reputation management followed a significant developmental trend.The reputation management of 4-to 5-year-old children was significantly better than that of 3-year-old children.(2)Scores on the theory of mind tasks positively predicted children’s reputation management.(3)Partner choice affected children’s reputation management.In the partner-choice group,children’s reputation management was more apparent.(4)Partner choice did moderate the relationship between theory of mind and children’s reputation management.In the partner-choice group,theory of mind had a stronger predictive effect on children’s reputation management.

关键词： Theory of mind partner choice reputation management children

Tumor microenvironment in pancreatic ductal adenocarcinoma:Implications in immunotherapy

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World Journal of Gastroenterology 2022年第27期28卷 3297-3313页

作者： Caitlyn Smith Wei Zheng Jixin Dong Yaohong Wang Jinping Lai xiuli liu Feng Yin Department of Pathology and Anatomical Sciences University of Missouri School of MedicineColumbiaMO 65212United States Department of Pathology Emory University School of MedicineAtlantaGA 30322United State Eppley Institute for Research in Cancer and Allied Diseases Fred and Pamela Buffett Cancer CenterUniversity of Nebraska Medical CenterOmahaNE 68198United States Department of Pathology Microbiology and ImmunologyVanderbilt University Medical CenterNashvilleTN 37232United States Department of Pathology and Laboratory Medicine Kaiser Permanente Sacramento Medical CenterSacramentoCA 95825United States Department of Pathology and Immunology Washington UniversitySt.LouisMO 63110United States Department of Pathology and Anatomical Sciences University of MissouriColumbiaMO 65212United States

Pancreatic ductal adenocarcinoma is one of the most aggressive and lethal cancers.Surgical resection is the only curable treatment option,but it is available for only a small fraction of patients at the time of diagnosis.With current therapeutic regimens,the average 5-year survival rate is less than 10%in pancreatic cancer patients.Immunotherapy has emerged as one of the most promising treatment options for multiple solid tumors of advanced stage.However,its clinical efficacy is suboptimal in most clinical trials on pancreatic cancer.Current studies have suggested that the tumor microenvironment is likely the underlying barrier affecting immunotherapy drug efficacy in pancreatic cancer.In this review,we discuss the role of the tumor microenvironment in pancreatic cancer and the latest advances in immunotherapy on pancreatic cancer.

关键词： Pancreatic ductal adenocarcinoma Tumor microenvironment Immunotherapy Clinical trial Chemotherapy Treatment

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海河流域产业用水量变化驱动因素分析

资源科学 2024年第3期46卷 621-634页

作者：秦明慧刘秀丽中国科学院数学与系统科学研究院北京100190 中国科学院大学北京100049 中国科学院预测科学研究中心北京100190 中国科学院大学数字经济监测预测预警与政策仿真教育部哲学社会科学实验室北京100190

【目的】为制定海河流域产业节水策略提供参考依据,亟需系统辨识海河流域经济系统中细分产业用水量变化的主要驱动因素并量化其驱动作用。【方法】本文首先编制了2007、2012、2017年海河流域49个部门可比价水资源投入占用产出时间序列表... 详细信息

【目的】为制定海河流域产业节水策略提供参考依据,亟需系统辨识海河流域经济系统中细分产业用水量变化的主要驱动因素并量化其驱动作用。【方法】本文首先编制了2007、2012、2017年海河流域49个部门可比价水资源投入占用产出时间序列表,以此为数据基础,构建了包含11个驱动因素指标的海河流域细分产业用水量结构分解分析模型。【结果】(1)2007-2017年,经济发展水平提高是促进海河流域用水总量增加的最主要原因,但其驱动作用随时间减弱。生产用水强度降低和部门产品最终需求结构变化分别是2007-2012年和2012-2017年流域用水总量降低的最主要原因。(2)灌溉用水强度和部门产品最终需求结构分别是2007-2012年和2012-2017年农产品部门用水量降低的最主要因素。(3)生产用水强度对工业部门用水量变化的驱动作用随时间减弱,对各工业部门产品最终需求的增长不断驱动工业部门用水量增加。(4)生产技术水平和最终需求总量结构变化对服务业部门用水量增加的驱动作用相较对农业部门和工业部门的驱动作用更强。【结论】2007-2017年,海河流域用水量的减少呈现由生产用水强度驱动为主转向最终需求结构驱动为主的变化趋势。从产业间对比来看,不同产业用水量变化的主要驱动因素存在明显产业特质性,建议基于产业用水量变化的主要驱动因素区别制定各产业节水措施。

关键词：驱动因素用水量结构分解分析投入占用产出表海河流域

Weak characteristic information extraction from early fault of wind turbine generator gearboxKeywords wind turbine generator gearbox, B-singular value decomposition, local mean decomposition, weak characteristic information extraction, early fault warning

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Frontiers of Mechanical Engineering 2017年第3期12卷 357-366页

作者： Xiaoli XU xiuli liu Key Laboratory of Modem Measurement & Control Technology(Ministry of Education) Beijing Information Science and Technology University Beijing 100192 China

Given the weak early degradation characteristic information during early fault evolution in gearbox of wind turbine generator, traditional singular value decomposition （SVD）-based denoising may result in loss of useful information. A weak characteristic information extraction based on μ-SVD and local mean decomposition （LMD） is developed to address this problem. The basic principle of the method is as follows： Determine the denoising order based on cumulative contribution rate, perform signal reconstruction, extract and subject the noisy part of signal to LMD and μ-SVD denoising, and obtain denoised signal through superposition. Experimental results show that this method can significantly weaken signal noise, effectively extract the weak characteristic information of early fault, and facilitate the early fault warning and dynamic predictive maintenance.

关键词： wind turbine generator gearbox μ-singular value decomposition local mean decomposition weak characteristic information extraction early fault warning

Generation ofαGal-enhanced bifunctional tumor vaccine

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3177-3186页

作者： Jian He Yu Huo Zhikun Zhang Yiqun Luo xiuli liu Qiaoying Chen Pan Wu Wei Shi Tao Wu Chao Tang Huixue Wang Lan Li Xiyu liu Yong Huang Yongxiang Zhao Lu Gan Bing Wang Liping Zhong National Center for International Research of Biotargeting Theranostics Guangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Talent Highland of Biotargeting TheranosticsGuangxi Medical UniversityNanning 530021China The First Affiliated Hospital Guangxi University of Chinese MedicineNanning 530023China The First People’s Hospital of Changde City Changde 415003China Department of Spine Surgery the Second Xiangya Hospital of Central South UniversityChangsha 410011China

Hepatocellular carcinoma(HCC)is a common malignant tumor with poor prognosis and high mortality.In this study,we demonstrated a novel vaccine targeting HCC and tumor neovascular endothelial cells by fusing recombinant MHCC97H cells expressing porcine a-1,3-galactose epitopes(a Gal)and endorphin extracellular domains(END)with dendritic cells(DCs)from healthy volunteers.END^(+)/Gal^(+)-MHCC97H/DC fusion cells induced cytotoxic T lymphocytes(CTLs)and secretion of interferon-gamma(IFN-γ).CTLs targeted cells expressing a Gal and END and tumor angiogenesis.The fused cell vaccine can effectively inhibit tumor growth and prolong the survival time of human hepatoma mice,indicating the high clinical potential of this new cell based vaccine.

关键词： aGal Endoglin Dendritic cells Fusion cells Hepatocellular carcinoma Tumor neovascular endothelial cells Cytotoxic T lymphocytes Immunotherapy

1961-2020年中国华北地区干湿演变特征及与ENSO、PDO的关系

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干旱区资源与环境 2024年第5期38卷 140-151页

作者：贾艳青刘秀丽韩山师范学院地理科学与旅游学院潮州521041 山西财经大学资源型经济转型发展研究院太原030012

为准确识别气候变化条件下气象干湿特征及与大气环流的关系,基于华北地区64个气象站点的实测数据,以标准化降水蒸散发指数(SPEI)为干湿指标,采用气候倾向率、Mann-Kendall趋势分析等方法,研究了1961~2020年中国华北地区干湿的时空变化特... 详细信息

为准确识别气候变化条件下气象干湿特征及与大气环流的关系,基于华北地区64个气象站点的实测数据,以标准化降水蒸散发指数(SPEI)为干湿指标,采用气候倾向率、Mann-Kendall趋势分析等方法,研究了1961~2020年中国华北地区干湿的时空变化特征,分析了厄尔尼诺-南方涛动(ENSO)与太平洋年代际振荡(PDO)对华北干湿变化的影响。结果表明:1)近60年华北地区降水量有10~20a的周期变化,SPEI指数在波动中未表现出明显的线性增长,近20年华北干旱化的趋势有所缓解。2)轻度干旱(湿润)、中等干旱(湿润)发生的频率较高,严重干旱(湿润)、极端干旱(湿润)发生的频率较低。华北地区多数站点湿润发生频率大于干旱发生频率。3)在空间分布上,华北干湿频次具有明显的空间分异,湿润高频区在山西东部、河北中南部、河南北部、山东丘陵西部,京津地区、河北中北部和山西西部干旱频次相对较高。4)华北干湿交替发生并受到多重周期性规律控制。华北SPEI序列在4a、23a和34a左右尺度波动十分明显。5)华北20a左右的干湿交替变化是大气环流异常的结果。EI Ni1o期间干旱多发;La Ni1a期间湿润多发。华北湿润和干旱分别对应PDO冷暖位相,华北SPEI与海温距平(SSTA)在年际和夏季尺度上显著负相关,夏季和冬季华北SPEI与PDO显著负相关。

关键词： SPEI 干湿变化 ENSO PDO 华北地区

Potential and challenges of tannins as an alternative to in-feed antibiotics for farm animal production

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Animal Nutrition 2018年第2期4卷 137-150页

作者： Qianqian Huang xiuli liu Guoqi Zhao Tianming Hu Yuxi Wang College of Animal Science and Technology Yangzhou University Veterinary Research Institute Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences College of Animal Science and Technology Northwest A&F University Lethbridge Research and Development Centre Agriculture and Agri-Food Canada

Naturally occurring plant compounds including tannins, saponins and essential oils are extensively assessed as natural alternatives to in-feed antibiotics.Tannins are a group of polyphenolic compounds that are widely present in plant region and possess various biological activities including antimicrobial,anti-parasitic, anti-viral, antioxidant, anti-inflammatory, immunomodulation, etc.Therefore, tannins are the major research subject in developing natural alternative to in-feed antibiotics.Strong protein affinity is the well-recognized property of plant tannins, which has successfully been applied to ruminant nutrition to decrease protein degradation in the rumen, and thereby improve protein utilization and animal production efficiency.Incorporations of tannin-containing forage in ruminant diets to control animal pasture bloat, intestinal parasite and pathogenic bacteria load are another 3 important applications of tannins in ruminant animals.Tannins have traditionally been regarded as "anti-nutritional factor" for monogastric animals and poultry, but recent researches have revealed some of them, when applied in appropriate manner, improved intestinal microbial ecosystem, enhanced gut health and hence increased productive performance.The applicability of plant tannins as an alternative to in-feed antibiotics depends on many factors that contribute to the great variability in their observed efficacies.

关键词： Tannins Biological activities In-feed antibiotics Natural feed additives Farm animal

Nodal Promotes mir206 Expression to Control Convergence and Extension Movements During Zebrafish Gastrulation

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Journal of Genetics and Genomics 2013年第10期40卷 515-521页

作者： xiuli liu Yuanqing Ma Congwei Zhang Shi Wei Yu Cao Qiang Wang State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of ZoologyChinese Academy of Sciences Department of Outpatient Surgery Anguo City Hospital of Hebei Province

Nodal, a member of the transforming growth factor β （TGF-β） superfamily, has been shown to play a role in mesendoderm induction and gastrulation movements. The activity of Nodal signaling can be modulated by microRNAs （miRNAs） as previously reported, but little is known about which miRNAs are regulated by Nodal during gastrulation. In the present study, we found that the expression of mir206, one of the most abundant miRNAs during zebrafish early embryo development, is regulated by Nodal signaling. Abrogation of Nodal signal activity results in defective convergence and extension （CE） movements, and these cell migration defects can be rescued by supplying an excess of mir206, suggesting that mir206 acts downstream of Nodal signaling to regulate CE movements. Furthermore, in mir206 morphants, the expression of cell adhesion molecule E-cadherin is significantly increased, while the key transcriptional repressor of E-cadherin, snailla, is depressed. Our study uncovers a novel mechanism by which Nodal-regulated mir206 modulates gastrulation movements in connection with the Snail/E-cadherin pathway.

关键词： Nodal mir206 Convergence and extension snailla E-cadherin

Histological evaluation in ulcerative colitis

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Gastroenterology Report 2014年第3期2卷 178-192页

作者： Tom C.DeRoche Shu-Yuan Xiao xiuli liu Department of Pathology Wake Forest Baptist Medical CenterWinston-SalemNorth CarolinaUSA Department of Pathology University of ChicagoChicagoIllinoisUSA Department of Anatomic Pathology Cleveland ClinicClevelandOhioUSA

This review summarizes diagnostic problems,challenges and advances in ulcerative colitis(UC).It emphasizes that,although histopathological examination plays a major role in the diagnosis and management of UC,it should always be interpreted in the context of clinical,endoscopic,and radiological findings.Accurate diagnosis requires knowledge of the classic morphological features of UC,as well as a number of atypical pathological presentations that may cause mis-classification of the disease process,either in resection or biopsy specimens.These atypical pathological presentations include rectal sparing and patchiness of disease at initial presentation of UC in pediatric patients or in the setting of medically treated UC,cecal or ascending colon inflammation in left-sided UC,and backwash ileitis in patients with severe ulcerative pancolitis.Loosely formed microgranulomas,with pale foamy histiocytes adjacent to a damaged crypt or eroded surface,should not be interpreted as evidence of Crohn’s disease.Indeterminate colitis should only be used in colectomy specimens as a provisional pathological diagnosis.Patients with UC are at risk for the development of dysplasia and carcinoma;optimal outcomes in UC surveillance programs require familiarity with the diagnostic criteria and challenges relating to UC-associated dysplasia and malignancy.Colon biopsy from UC patients should always be evaluated for dysplasia based on cytological and architectural abnormalities.Accurate interpretation and classification of dysplasia in colon biopsy from UC patients as sporadic adenoma or UC-related dysplasia[flat,adenoma-like,or dysplasia-associated lesion or mass(DALM)]requires clinical and endoscopic correlation.Isolated polypoid dysplastic lesions are considered to be sporadic adenoma if occurring outside areas of histologically proven colitis,or adenoma-like dysplasia if occurring in the diseased segment.Recent data suggest that such lesions may be treated adequately by polypectomy in the absence of flat dysplasia in the patient.UC pat

关键词： ulcerative colitis histological evaluation dysplasia differential diagnosis