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Cyanine conjugates in cancer theranostics

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Bioactive Materials 2021年第3期6卷 794-809页

作者： Yang Li Yiming Zhou xiuli yue Zhifei Dai Department of Biomedical Engineering College of EngineeringPeking UniversityBeijing 100871China School of Environment Harbin Institute of TechnologyHarbin 150001China

Cyanine is a meritorious fluorogenic core for the construction of fluorescent probes and its phototherapeutic potential has been enthusiastically explored as ***,the covalent conjugation of cyanine with other potent therapeutic agents not only boosts its therapeutic efficacy but also broadens its therapeutic ***,we summarize miscellaneous cyanine-therapeutic agent conjugates in cancer theranostics from literature published between 2014 and *** application scenarios of such theranostic cyanine conjugates covered common cancer therapeutic modalities,including chemotherapy,phototherapy and targeted ***,cyanine conjugates that serve as nanocarriers for drug delivery are introduced as *** an additional section,we analyze the potential of these conjugates for clinical ***,this review is aimed to stimulate research interest in exploring unattempted therapeutic agents and novel conjugation strategies and hopefully,accelerate clinical translation in this field.

关键词： Cyanine conjugate Cancer theranostics Therapeutic agent Nanocarrier Clinical translation

Product Form Solution of a Queuing-Inventory System with Lost Sales and Server Vacation

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Journal of Systems Science & Complexity 2024年第2期37卷 729-758页

作者： yue Dequan ZHANG Yuying XU xiuli yue Wuyi School of Science Yanshan UniversityQinhuangdao 066004China School of Economics and Management Yanshan UniversityQinhuangdao 066004China The Kyoto College of Graduate Studies for Informatics Kyoto City 606-8225Japan

In this study,the authors consider an M/M/1 queuing system with attached inventory under an(s,S)control *** server takes multiple vacations whenever the inventory is *** is assumed that the lead time and the vacation time follow exponential *** authors formulate the model as a quasi-birth-and-dearth(QBD)process and derive the stability condition of the ***,the stationary distribution in product form for the joint process of the queue length,the inventory level,and the server’s status is ***,the conditional distributions of the inventory level when the server is on and operational,and when it is off due to a vacation,are *** the stationary distribution,the authors obtain some performance measures of the *** authors investigate analytically the effect of the server’s vacation on the performance ***,several numerical examples are presented to investigate the effects of some parameters on the performance measures,the optimal policy,and the optimal cost.

关键词： Cost function multiple vacations product form solution queuing-inventory system (s S)control policy

Ultrasound contrast agents from microbubbles to biogenic gas vesicles

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Medical Review 2023年第1期3卷 31-48页

作者： Wenlong Zeng xiuli yue Zhifei Dai Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijingChina School of Environment Harbin Institute of TechnologyNo.92 Xidazhi StreetNangang DistrictHarbin 150001Heilongjiang ProvinceChina Department of Biomedical Engineering College of Future TechnologyPeking UniversityNo.5 Yiheyuan RoadHaidian DistrictBeijing 100871China

Microbubbles have been the earliest and most widely used ultrasound contrast agents by virtue of their unique features:such as non-toxicity,intravenous inject-ability,ability to cross the pulmonary capillary bed,and significant enhancement of echo signals for the duration of the examination,resulting in essential preclinical and clinical *** use of microbubbles functional-ized with targeting ligands to bind to speciﬁc targets in the bloodstream has further enabled ultrasound molecular ***,it is very challenging to utilize targeted microbubbles for molecular imaging of extra-vascular targets due to their size.A series of acoustic nanomaterials have been developed for breaking free from this ***,biogenic gas vesicles,gas-ﬁlled protein nanostructures from microorganisms,were engineered as theﬁrst biomolecular ultrasound contrast agents,opening the door for more direct visual-ization of cellular and molecular function by ultrasound *** ordered protein shell structure and unique gasﬁlling mechanism of biogenic gas vesicles endow them with excellent stability and attractive acoustic ***’s more,their genetic encodability enables them to act as acoustic reporter *** article reviews the upgrading progresses of ultrasound contrast agents from microbubbles to biogenic gas vesicles,and the opportu-nities and challenges for the commercial and clinical translation of the nascentﬁeld of biomolecular ultrasound.

关键词： acoustic nanomaterials acoustic reporter genes biogenic gas vesicles microbubbles ultrasound contrast agents ultrasound molecular imaging

Prussian blue nanoparticle-loaded microbubbles for photothermally enhanced gene delivery through ultrasound-targeted microbubble destruction

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Science Bulletin 2016年第2期61卷 148-156页

作者： Xiaoda Li xiuli yue Jinrui Wang Xiaolong Liang Lijia Jing Li Lin Yongbo Yang Shanshan Feng Yajun Qian Zhifei Dai School of Municipal and Environmental Engineering School of Life Science and Technology Harbin Institute of Technology College of Engineering Peking University Third HospitalPeking University

By adsorbing chitosan(CS)-functionalized Prussian blue(PB) nanoparticles(CS/PB NPs) complexing DNA onto the surface of gas encapsulated microbubbles(MBs), a multifunctional gene delivery system of MBs@CS/PB/DNA was fabricated for photothermally enhanced gene transfection through ultrasound-targeted microbubble destruction. CS/PB NPs of(2.69 ± 0.49) nm could complex DNA effectively when the mass ratio was2:1. It was found that MBs@CS/PB/DNA could enhance ultrasound imaging greatly both in vitro and in vivo. In addition, MBs@CS/PB/DNA could be disrupted by applying a higher-intensity ultrasound irradiation to release CS/PB/DNA, which could effectively transform the nearinfrared(NIR) light into heat to assist the uptake of CS/PB/DNA by cells. With the aid of ultrasound irradiation and NIR light irradiation, the gene transfection efficiency was significantly enhanced to(43.08 ± 1.13) %, much higher than polyethylenimine. Moreover, MBs@CS/PB/DNA showed excellent biocompatibility, encouraging the further exploration of MBs@CS/PB/DNA to be a platform for combined ultrasound image, photothermal therapy, drug delivery, and gene therapy.

关键词： Ultrasound imaging MicrobubbleGene delivery Prussian blue nanoparticle

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可降解生态地膜在滕州马铃薯上的应用研究

东北农业科学 2024年第2期49卷 75-80页

作者：韩文贺陈强李超韩文浩岳秀利胡继东宗兆才滕州市界河镇农业综合服务中心山东滕州277531 滕州市农业技术推广中心山东滕州277599 枣庄市农业农机技术推广中心山东枣庄277899 中化现代农业(山东)有限公司山东滕州277599 济南中科广源环保科技有限公司山东济南250100

本研究选用3款不同降解时间的生态地膜在滕州马铃薯上开展应用试验。结果表明,可降解生态地膜在马铃薯生长前期、未降解时,保温保墒性能与普通聚乙烯地膜一致,能够满足马铃薯生长的覆膜需求;出现降解现象后,降解过程持续、稳定,至马铃... 详细信息

本研究选用3款不同降解时间的生态地膜在滕州马铃薯上开展应用试验。结果表明,可降解生态地膜在马铃薯生长前期、未降解时,保温保墒性能与普通聚乙烯地膜一致,能够满足马铃薯生长的覆膜需求;出现降解现象后,降解过程持续、稳定,至马铃薯收获时拉力性能明显降低,局部粉碎;覆盖生态可降解地膜的马铃薯全生育期长势良好,产量与覆盖普通聚乙烯地膜处理的差异不明显,具有良好的推广应用前景。

关键词：滕州马铃薯可降解地膜试验

Ultrasmall pH-responsive silicon phthalocyanine micelle for selective photodynamic therapy against tumo

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Journal of Innovative Optical Health Sciences 2022年第6期15卷 87-99页

作者： Yiming Zhou Wenlong Zeng Mengxuan Wang Rui Li xiuli yue Zhifei Dai Department of Biomedical Engineering College of Future Technology Peking UniversityBeijing 100871P.R.China School of Environment Harbin Institute of Technology Harbin 150001P.R.China

Targeted photodynamic therapy(TPDT)based on the photosensitizers responsive for tumor micr oenvironment is promising because of the better anti-tumor effect and less phototoxicity against normal tissue than the traditional *** based stimuli responsive photo-sensitizers have been widely explored for *** on the acidic microenvironments in solid tumors,an ultrasmall pH-responsive silicon phthalocyanine nanomicelle(PSN)(smaller than 10 nm)was designed for selective PDT of *** had high drug loading efficacy(more than 28%)and exhibited morphological transitions,enhanced fuorescence and improved singlet∞x-ygen yield under acidic *** was renal dlearable and could rapidly accumulate and be retained at tumor sites,achieving a tumor-inhibiting ffect better than phthalocyanine micelle without pH *** of mice treated with PSN for PDT were completely ablated without ***,we have developed a phthalocyanine-based pH responsive micelle with excellent tumor targeting ability,which is expected to realize the selective PDT of tumor.

关键词： Silicon phthalocyanine pH-responsive ultrasmall micelle tangeted photodynamic therapy

Simultaneous enhancement of energy storage performance and thermal stability of NaNbO_(3)-based ceramics via multi-scale modulation

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Journal of Materiomics 2024年第3期10卷 670-681页

作者： Peng Nong Dafu Zeng yue Pan Qinpeng Dong Mingzhao Xu Xiang Wang Jiaming Wang Huanfu Zhou Xu Li xiuli Chen Key Laboratory of Nonferrous Materials and New Processing Technology Ministry of EducationSchool of Materials Science and EngineeringGuilin University of TechnologyGuilin541004China

More and more attention is being paid to the environmental friendliness of the dielectric capacitors,which have a rapid charging and discharging speed and steady ***,the low recoverable energy storage density(W_(rec))limits the practical application of dielectric capacitors in solid-state energy storage *** this paper,(1-x)(0.92NaNbO_(3)-0.08Bi(Mg_(0.5)Ti_(0.5)O_(3))-xSrTiO_(3))(x=0.05,0.10,0.15,0.20)energy storage ceramics were fabricated based on various strategies such as nanodomain engineering,component and grain size *** excellent energy storage performance(W_(rec)~6.0 J/cm^(3),η~81.0%)was obtained in ***_(3)could enhance the internal disorder,improve the relaxation properties and increase the breakdown field strength of ***-cantly domain relaxor behavior,as evidenced by Vogel-Fulcher(V-F)model,provides strong evidence for restraining early polarization *** addition,Pulse charge/discharge tests have illustrated that the sample has excellent and stable charge/discharge performance(CD~1,068.9 A/cm^(2),PD~96.1 MW/cm^(3),t0.9 z 0.99 ms)It is concluded that there is a huge prospect of NN-BMT-0.15ST ceramics as a kind of pulsed-power-storing electronics.

关键词： NaNbO_(3) Breakdown field strength Lead-free ceramics Energy storage Power density

重复经颅磁刺激联合治疗在脑卒中患者偏瘫肩痛中的应用进展

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中国医学创新 2024年第23期21卷 169-172页

作者：熊凤仙和智娟岳秀丽方河苑李勤刘玉凤郭冬梅谭凤钰云南中医药大学云南昆明650500 昆明市中医医院康复科云南昆明650000 昆明市中医医院老年病科云南昆明650000

偏瘫肩痛(HSP)是脑卒中患者常见的并发症之一,严重影响患者的康复进程和生活质量。重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)作为一种无创的神经调控技术,已广泛用于治疗各种神经系统疾病。本文综述了rTMS的... 详细信息

偏瘫肩痛(HSP)是脑卒中患者常见的并发症之一,严重影响患者的康复进程和生活质量。重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)作为一种无创的神经调控技术,已广泛用于治疗各种神经系统疾病。本文综述了rTMS的作用机制及rTMS联合其他治疗对HSP患者的疼痛缓解、运动功能及生活质量改善等方面的潜在效益,以期为该类患者提供最佳的治疗策略,促进患者的身体康复。

关键词：重复经颅磁刺激联合治疗脑卒中偏瘫肩痛

FRET-based two-photon benzo[a]phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy

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Chinese Chemical Letters 2024年第7期35卷 325-328页

作者： Yiling Li Zekun Gao Xiuxiu yue Minhuan Lan xiuli Zheng Benhua Wang Shuang Zhao Xiangzhi Song College of Chemistry&Chemical Engineering Central South UniversityChangsha 410083China Key Laboratory of Photochemical Conversion and Optoelectronic Materials and City U-CAS Joint Laboratory of Functional Materials and Devices Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410083China

To overcome the conflict between the long-wavelength excitation and high singlet oxygen quantum yield of photosensitizers,we conjugated a two-photon fluorophore,tetrahydroquinoxaline coumarin(TQ),and an efficient photodynamic therapeutic agent,benzo[a]phenothiazinium(NBS-NH_(2)),through a hexamethylene linker to build a two-photon photosensitizer,*** TQ-NBS,TQ served as an energy donor and NBS-NH_(2) acted as an energy acceptor;and TQ-NBS was a F?rster resonance energy transfer(FRET)cassette with a 92.8%*** large two-photon absorption cross-section of TQ allowed photosensitizer TQ-NBS to work in a 900 nm two-photon excitation(TPE)mode,which greatly benefited the deep tissue penetration in PDT ***,the excellent phototoxicity and near-infrared fluorescence of NBS-NH2was kept in TQ-NBS under a TPE mode via a FRET *** TQ-NBS exhibited a high phototoxic efficacy in living cells and tumor-bearing mice.

关键词： Photodynamic therapy Two-photon excitation FRET-based photosensitizer Singlet oxygen Near-infrared fluorescence