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Recent advances in metal-free CDs/g-C_(3)N_(4) photocatalysts:Synthetic strategies,mechanism insight,and applications

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Journal of Materials Science & Technology 2023年第19期150卷 11-26页

作者： Xingxing Yang Lina Sheng Yongli Ye Jiadi sun Zaijun Li Xiao Ning Jin Cao xiulan sun State Key Laboratory of Food Science and Technology School of Food Science and TechnologyCollaborative Innovation Center of Food Safety and Quality ControlJiangnan UniversityWuxi 214122China Yixing Institute of Food and Biotechnology Co. LtdYixing 214200China School of Chemical and Material Engineering Jiangnan UniversityWuxi 214122China National Institutes for Food and Drug Control Beijing 100050China

Carbon dots/graphite carbon nitride(CDs/g-C_(3)N_(4)),a novel composite photocatalyst,has shown great po-tential for applications in energy regeneration and environmental remediation owing to its following advantages:metal-free,low cost,easily tunable,and excellent photocatalytic performance.Hence,we reviewed the development of synthetic strategies,photocatalytic enhancement mechanisms,and pho-tocatalytic applications of CDs/g-C_(3)N_(4) in this study.First,the three composite strategies of CDs and g-C_(3)N_(4)-self-assembly,solvothermal,and calcination polymerization are outlined,and their advantages and disadvantages are described in detail.Moreover,the photocatalytic enhancement mechanism of the com-posite strategies was elucidated according to the variation trends of CDs/g-C_(3)N_(4) band structure,electronic properties,light absorption range,and interfacial charge transfer.Then,the applications of CDs/g-C_(3)N_(4) in hydrogen evolution,pollutant degradation,CO_(2) reduction,and bacterial disinfection in recent years are reviewed systematically.Finally,the current obstacles and future research directions of CDs/g-C_(3)N_(4) are discussed from the perspective of preparation technology and practical applications,respectively.

关键词： Photocatalysis Graphite carbon nitride Carbon dots Synthetic strategy Photocatalytic application

Sphingosine-1-phosphate,a novel TREM2 ligand,promotes microglial phagocytosis to protect against ischemic brain injury

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1885-1898页

作者： Tengfei Xue Juan Ji Yuqin sun Xinxin Huang Zhenyu Cai Jin Yang Wei Guo Ruobing Guo Hong Cheng xiulan sun Department of Pharmacology Neuroprotective Drug Discovery Key LaboratoryJiangsu Key Laboratory of NeurodegenerationNanjing Medical UniversityNanjing 211166China Nanjing University of Chinese Medicine the Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210004China The First Affiliated Hospital of Nanjing Medical University Nanjing 210029China

The mechanism of sphingosine-1-phosphate(S1P)-mediated phagocytosis remains unknown.Here,we found that S1P or FTY720(an analog of S1P)promoted microglial phagocytosis in stroke independent of S1PRs.First,we used computer simulation of molecular docking to predict that S1P might be a ligand for triggering receptor expressed on myeloid cells 2(TREM2).Next,microscale thermophoresis(MST),surface plasmon resonance(SPR)and liquid chromatography–tandem mass spectrometry(LC–MS/MS)were performed to reveal that S1P was a novel TREM2 ligand.Then,we confirmed the pro-phagocytosis of S1P targeting in Trem2-Dap12 transfected CHO cells and TREM2 knockdown microglia.Point mutation analysis showed that D104 was the critical binding residue.Trem2^(−/−)mice were used to demonstrate the role of S1P-induced phagocytosis targeting on TREM2 in protecting against ischemic brain injury.Finally,further studies revealed that apolipoprotein E(APOE)loaded with S1P was released by microglia and bound to apoptotic neurons via LDL receptor related protein 1B(LRP1B)and thereby induced microglia to phagocytose apoptotic neurons.Overall,the present work reveals for the first time that S1P acts as a novel endogenous ligand of TREM2 to effectively promote microglial phagocytosis.Our findings provide a new lead compound for developing immunomodulator targeting on TREM2.

关键词： S1P TREM2 Microglia Phagocytosis Stroke APOE LRP1B Apoptotic neurons

Research on the mechanical fault diagnosis method based on sound signal and IEMD-DDCNN

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International Journal of Intelligent Computing and Cybernetics 2023年第3期16卷 629-646页

作者： Haoning Pu Zhan Wen xiulan sun Lemei Han Yanhe Na Hantao Liu Wenzao Li Chengdu University of Information Technology ChengduChina Education Department of Sichuan Province Education Informatization and Big Data CenterChengduChina Network and Data Security Key Laboratory of Sichuan Province UESTCChengduChina

Purpose–The purpose of this paper is to provide a shorter time cost,high-accuracy fault diagnosis method for water pumps.Water pumps are widely used in industrial equipment and their fault diagnosis is gaining increasing attention.Considering the time-consuming empirical mode decomposition(EMD)method and the more efficient classification provided by the convolutional neural network(CNN)method,a novel classification method based on incomplete empirical mode decomposition(IEMD)and dual-input dual-channel convolutional neural network(DDCNN)composite data is proposed and applied to the fault diagnosis of water pumps.Design/methodology/approach–This paper proposes a data preprocessing method using IEMD combined with mel-frequency cepstrum coefficient(MFCC)and a neural network model of DDCNN.First,the sound signal is decomposed by IEMD to get numerous intrinsic mode functions(IMFs)and a residual(RES).Several IMFs and one RES are then extracted by MFCC features.Ultimately,the obtained features are split into two channels(IMFs one channel;RES one channel)and input into DDCNN.Findings–The Sound Dataset for Malfunctioning Industrial Machine Investigation and Inspection(MIMII dataset)is used to verify the practicability of the method.Experimental results show that decomposition into an IMF is optimal when taking into account the real-time and accuracy of the diagnosis.Compared with EMD,51.52% of data preprocessing time,67.25% of network training time and 63.7%of test time are saved and also improve accuracy.Research limitations/implications–This method can achieve higher accuracy in fault diagnosis with a shorter time cost.Therefore,the fault diagnosis of equipment based on the sound signal in the factory has certain feasibility and research importance.Originality/value–This method provides a feasible method for mechanical fault diagnosis based on sound signals in industrial applications.

关键词： Fault identification Neural nets DDCNN IEMD MFCC

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代谢重编程对小胶质细胞功能的调节作用

南京医科大学学报（自然科学版） 2024年第1期44卷 105-114页

作者：李磊孙秀兰南京医科大学神经保护药物研究重点实验室江苏省神经退行性疾病重点实验室江苏南京211166

免疫细胞通过改变营养物质的摄取和代谢酶的活性,以支持免疫激活的代谢需求,这一过程被称为免疫细胞的代谢重编程。小胶质细胞是脑内重要的免疫细胞之一,其表达大多数能源代谢途径底物的基因。越来越多研究证实小胶质细胞代谢具有高度... 详细信息

免疫细胞通过改变营养物质的摄取和代谢酶的活性,以支持免疫激活的代谢需求,这一过程被称为免疫细胞的代谢重编程。小胶质细胞是脑内重要的免疫细胞之一,其表达大多数能源代谢途径底物的基因。越来越多研究证实小胶质细胞代谢具有高度灵活性,且调控代谢可调节小胶质细胞免疫功能,进而影响神经炎性疾病的发展与转归。本文综述了小胶质细胞在不同微环境下的代谢特征,以及小胶质细胞代谢重编程对其免疫功能的调节及机制。

关键词：代谢重编程小胶质细胞神经炎症

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安徽省高职院校教师职业认同调查研究

芜湖职业技术学院学报 2024年第1期26卷 75-81页

作者：孙秀兰阜阳职业技术学院教务处安徽阜阳236031

教师职业认同是教师个体心理归属和自我提高的原始动力,也是教师专业发展的内驱动力。调研发现,安徽省高职教师职业认同总体水平较高,在性别、婚姻状况、学历、职称、工作年限、学校类型、平均月收入等变量上,职业认同表现出一致性;在... 详细信息

教师职业认同是教师个体心理归属和自我提高的原始动力,也是教师专业发展的内驱动力。调研发现,安徽省高职教师职业认同总体水平较高,在性别、婚姻状况、学历、职称、工作年限、学校类型、平均月收入等变量上,职业认同表现出一致性;在年龄、职务、学校所在城市等变量上,职业认同及其因子则呈现出显著性差异。

关键词：安徽高职院校教师职业认同

高职院校“双师型”教师职业认同及提升策略研究

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安徽职业技术学院学报 2024年第1期23卷 86-91页

作者：孙秀兰阜阳职业技术学院公共基础教育学院安徽阜阳236000

高职院校“双师型”教师是培养高素质技术技能人才的良匠之师,职业认同水平会影响教师的专业自主发展和人才培养质量。调研发现,安徽省高职院校“双师型”教师的职业认同水平较高,但是没有随年龄、工作年限、月收入的增加和职称的晋升... 详细信息

高职院校“双师型”教师是培养高素质技术技能人才的良匠之师,职业认同水平会影响教师的专业自主发展和人才培养质量。调研发现,安徽省高职院校“双师型”教师的职业认同水平较高,但是没有随年龄、工作年限、月收入的增加和职称的晋升而明显提升,影响教师职业认同的因素主要可以归纳为社会因素和学校因素等方面,因此建议从国家、学校和个人三个层面实施相应的策略以提高“双师型”教师职业认同水平。

关键词：高职院校 “双师型”教师职业认同

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品质导向的粮油食品精准加工分子基础与调控

中国食品学报 2024年第5期24卷 1-18页

作者：金征宇江连洲王兴国谭斌顾正彪孙秀兰李晓玺江南大学食品学院江苏无锡214122 东北农业大学食品学院哈尔滨150030 国家粮食和物资储备局科学研究院北京100037 华南理工大学食品科学与工程学院广州510640

粮油是国家最重要的战略物资,粮油食品产业在国民经济中起着基础作用,深度关系着国计民生和国民健康。粮食和油料中营养组分丰富及其多尺度结构复杂,且加工方式多变,进而影响粮油食品的感官、安全特性和消化吸收、营养健康效应。本文通... 详细信息

粮油是国家最重要的战略物资,粮油食品产业在国民经济中起着基础作用,深度关系着国计民生和国民健康。粮食和油料中营养组分丰富及其多尺度结构复杂,且加工方式多变,进而影响粮油食品的感官、安全特性和消化吸收、营养健康效应。本文通过系统梳理粮油食品发展现状及产业战略意义,品质导向的粮油食品加工与制造发展现状及面临的挑战,提出从粮油食品的加工过程控制,营养组分多尺度结构变化与结构重构,多维度品质特性调控3个角度,系统解析基于品质导向的粮油食品精准加工的结构基础与调控机制,重点探讨粮油食品中主要营养组分的加工适应性、互作机制,粮油食品加工对感官品质、健康品质和安全品质等品质特性的影响,多维品质与加工过程构效关系与关联调控机制等制约粮油食品未来发展的研究方向,以期建立品质导向的粮油食品精准加工的理论基础、技术方法和新型绿色加工策略,为创制感官、安全和健康品质协同提升的营养健康粮油食品提供理论支撑,推动我国粮油食品加工产业的高质量发展。

关键词：粮油食品营养组分相互作用精准加工多维品质调控

Overview on Technology of Degrading and Eliminating Mycotoxins in Agro-products and its Application

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Asian Agricultural Research 2013年第12期5卷 99-103页

作者： Yun LI xiulan sun Institute of Quality Standards and Testing Technology for Agro-products Chinese Academy of Agricultural Sciences/Key Laboratory of Quality Safety of Agro-products in Ministry of Agriculture Jiangnan University

Based on the perspective of risk control,this article introduces related technology of eliminating mycotoxins in agricultural products and the current situation of application,including traditional physical,chemical and biological methods as well as the contemporary situation of relatively advanced technology at home and abroad,which provides reference for the policy-making and technology application of mycotoxin control in agro-products in China.

关键词： Mycotoxin Risk Elimination technology Application

基于氧化应激和线粒体功能障碍的伏马毒素B1诱导线虫神经毒性机制

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食品与生物技术学报 2024年第3期43卷 26-35页

作者：叶永丽张晓娟唐莉莉王加生张银志孙秀兰江南大学食品学院江苏无锡214122 美国佐治亚大学公共卫生学院佐治亚雅典30602

为研究线粒体功能和氧化应激在伏马毒素B1(fumonisin B1,FB1)诱导神经毒性中的作用,以秀丽隐杆线虫为模型,对FB1处理后的线虫行为表型以及包括氧化应激和线粒体功能相关指标变化进行分析。结果表明,20~200μg/mL的FB1暴露24 h以剂量依... 详细信息

为研究线粒体功能和氧化应激在伏马毒素B1(fumonisin B1,FB1)诱导神经毒性中的作用,以秀丽隐杆线虫为模型,对FB1处理后的线虫行为表型以及包括氧化应激和线粒体功能相关指标变化进行分析。结果表明,20~200μg/mL的FB1暴露24 h以剂量依赖方式诱导细胞色素氧化酶、超氧化物歧化酶(superoxide dismutase,SOD)和过氧化氢酶(catalase,CAT)相关基因(cyp35A2、sod-1、sod-3、ctl-2和ctl-3)的异常表达。此外,100~200μg/mL的FB1处理降低了线虫线粒体密度,并显著降低了三磷酸腺苷(adenosine triphosphate,ATP)水平和线粒体膜电位(P<0.05)。200μg/mL的FB1处理显著抑制了线虫线粒体呼吸链复合物I和Ⅴ的表达,提高了线粒体分裂基因drp-1的表达水平。相关性分析显示,氧化应激和线粒体功能相关指标的表达与线虫行为学表型具有显著相关性。综上,FB1可能通过参与线虫氧化应激、线粒体呼吸链和线粒体动力学过程诱导神经毒性。

关键词：伏马毒素B1 秀丽隐杆线虫氧化应激线粒体功能障碍神经毒性

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