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Mitochondrial targeting sequence of magnetoreceptor MagR:More than just targeting

Zoological Research 2024年第3期45卷 468-477页

作者： Yanqi Zhang Peng Zhang Junjun Wang Jing Zhang Tianyang Tong xiujuan Zhou Yajie Zhou Mengke Wei Chuanlin Feng Jinqian Li Xin Zhang Can Xie Tiantian Cai High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China University of Science and Technology of China HefeiAnhui 230026China Department of Anatomy School of Basic MedicineAnhui Medical UniversityHefeiAnhui 230032China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230039China Key Laboratory of Tropical Translational Medicine of Ministry of Education NHC Key Laboratory of Tropical Disease ControlSchool of Tropical Medicine and The Second Affiliated HospitalHainan Medical UniversityHaikouHainan 571199China International Magnetobiology Frontier Research Center Science IslandHefeiAnhui 230031China Institute of Quantum Sensing Zhejiang UniversityHangzhouZhejiang 310027China

Iron-sulfur clusters(ISC)are essential cofactors for proteins involved in various biological processes,such as electron transport,biosynthetic reactions,DNA repair,and gene expression *** assembly protein IscA1.or MagR)is found within the mitochondria of most ***(MagR)is a highly conserved A-type iron and iron-sulfur cluster-binding protein,characterized by two distinct types of iron-sulfur clusters,[2Fe-2S]and[3Fe-4S],each conferring unique magnetic *** forms a rod-like polymer structure in complex with photoreceptive cryptochrome(Cry)and serves as a putative magnetoreceptor for retrieving geomagnetic information in animal *** the N-terminal sequences of MagR vary among species,their specific function remains *** the present study,we found that the N-terminal sequences of pigeon MagR,previously thought to serve as a mitochondrial targeting signal(MTS),were not cleaved following mitochondrial entry but instead modulated the efficiency with which iron-sulfur clusters and irons are ***,the N-terminal region of MagR was required for the formation of a stable MagR/Cry ***,the N-terminal sequences in pigeon MagR fulfil more important functional roles than just mitochondrial *** results further extend our understanding of the function of MagR and provide new insights into the origin of magnetoreception from an evolutionary perspective.

关键词： Magnetoreceptor(MagR) N-terminal sequence Mitochondrial targeting signal Iron-sulfur cluster

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SH2B1.Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and Mice

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Research 2024年第3期2023卷 369-389页

作者： xiujuan Du Yuhua Yan Juehua Yu Tailin Zhu Chu-Chung Huang Lingli Zhang Xingyue Shan Ren Li Yuan Dai Hui LV Xiao-Yong Zhang Jianfeng Feng Wei-Guang Li Qiang Luo Fei Li Developmental and Behavioral Pediatric Department Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and Ministry of Education-Shanghai Key Laboratory for Children's Environmental HealthXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Developmental and Behavioral Pediatric Department Shanghai Xinhua Children's HospitalShanghai 200092China National Clinical Research Center for Aging and Medicine at Huashan Hospital Institute of Science and Technology for Brain-lnspired IntelligenceMinistry of Education-Key Laboratory of Computational Neuroscience and Brain-lnspired IntelligenceFudan UniversityShanghai 200433China State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science Institutes of Brain Science and Human Phenom InstituteFudan UniversityShanghai 200032China Shanghai Key Laboratory of Brain Functional Genomics(Ministry of Education) School of Life SciencesEast China Normal UniversityShanghai 200062China Department of Rehabilitation Medicine Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China Center for Experimental Studies and Research The First Affliated Hospital of Kunming Medical UniversityKunming 650032China Shanghai Research Center for Brain Science and Brain-lnspired Intelligence Shanghai201210China Institute of Cognitive Neuroscience School of Psychology and Cognitive ScienceEast China Normal UniversityShanghai 200062China.

Fluid intelligence is a cognitive domain that encompasses general reasoning, pattern recognition, and problem-solving abilities independent of task-specific experience. Understanding its genetic and neural underpinnings is critical yet challenging for predicting human development, lifelong health, and well-being. One approach to address this challenge is to map the network of correlations between intelligence and other constructs. In the current study, we performed a genome-wide association study using fluid intelligence quotient scores from the UK Biobank to explore the genetic architecture of the associations between obesity risk and fluid intelligence. Our results revealed novel common genetic loci (SH2B1. TUFM, ATP2A1. and FOXO3) underlying the association between fluid intelligence and body metabolism. Surprisingly, we demonstrated that SH2B1.variation influenced fluid intelligence independently of its effects on metabolism but partially mediated its association with bilateral hippocampal volume. Consistently, selective genetic ablation of Sh2b1.in the mouse hippocampus, particularly in inhibitory neurons, but not in excitatory neurons, significantly impaired working memory, short-term novel object recognition memory, and behavioral flexibility, but not spatial learning and memory, mirroring the human intellectual performance. Single-cell genetic profiling of Sh2B1.regulated molecular pathways revealed that Sh2b1.deletion resulted in aberrantly enhanced extracellular signal-regulated kinase (ERK) signaling, whereas pharmacological inhibition of ERK signaling reversed the associated behavioral impairment. Our cross-species study thus provides unprecedented insight into the role of SH2B1.in fluid intelligence and has implications for understanding the genetic and neural underpinnings of lifelong mental health and well-being.

关键词： metabolism impaired reversed

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Unexpected divergence in magnetoreceptor MagR from robin and pigeon linked to two sequence variations

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Zoological Research 2024年第1期45卷 69-78页

作者： Shun Wang Peng Zhang Fan Fei Tianyang Tong xiujuan Zhou Yajie Zhou Jing Zhang Mengke Wei Yanqi Zhang Lei Zhang Yulong Huang Lin Zhang Xin Zhang Tiantian Cai Can Xie Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230039China High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesScience IslandHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230036China Department of Anatomy Anhui Medical UniversityHefeiAnhui 230032China Department of Mechanical and Aerospace Engineering University at BuffaloState University of New YorkBuffaloNY 14260 USA International Magnetobiology Frontier Research Center Science IslandHefeiAnhui 230031China

Birds exhibit extraordinary mobility and remarkable navigational skills,obtaining guidance cues from the Earth’s magnetic field for orientation and long-distance *** species also show tremendous diversity in navigation strategies,with considerable differences even within the same taxa and among individuals from the same *** highly conserved iron and iron-sulfur cluster binding magnetoreceptor(MagR)protein is suggested to enable animals,including birds,to detect the geomagnetic field and navigate ***,MagR is also implicated in other functions,such as electron transfer and biogenesis of iron-sulfur clusters,raising the question of whether variability exists in its biochemical and biophysical features among species,particularly *** the current study,we conducted a comparative analysis of MagR from two different bird species,including the migratory European robin(Erithacus rubecula)and the homing pigeon(Columba livia).Sequence alignment revealed an extremely high degree of similarity between the MagRs of these species,with only three sequence ***,two of these variations underpinned significant differences in metal binding capacity,oligomeric state,and magnetic *** findings offer compelling evidence for the marked differences in MagR between the two avian species,potentially explaining how a highly conserved protein can mediate such diverse functions.

关键词： Homing and migration Animal navigation Magnetoreceptor(MagR) Diverse navigation pattern Conserved protein

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Varicella-Zoster Virus Encephalitis with Hyponatremia in an Immunocompetent Elderly Patient:A Case Report

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Journal of Clinical and Nursing Research 2024年第9期8卷 53-58页

作者： Luxuan Yang Wenyong Zhang xiujuan Shen Meiqi Liu Dan Xiao Department of Infection Disease Fifth Affiliated Hospital of Soochow University(The Affiliated Infectious Diseases Hospital of Soochow University)Suzhou 215000Jiangsu ProvinceChina

As a common cause of viral encephalitis,varicella-zoster virus(VZV)may invade the central nervous system of immunosuppressed patients during ***,we report a rare case of an immunocompetent patient with VZV encephalitis who developed severe hyponatremia and was considered to have a suspected primary *** patient was diagnosed with the support of second-generation sequencing and had persistent hyponatremia after being *** rare,this case suggests that VZV encephalitis may occur in unexpected patients and present with unusual clinical manifestations,requiring advanced detection methods and clinical expertise for resolution.

关键词： Varicella-zoster virus encephalitis Immunocompetent Hyponatremia

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技术具身中的生命终结与可能的伦理选择

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医学与哲学 2024年第12期45卷 29-33页

作者：詹秀娟安徽大学哲学学院安徽合肥230039

通过分析现代医疗技术对生命终结问题产生的变化与可能影响,指出生命终结需要决断,临终者不能安然离去,根本源于技术的本质,身体在技术具身中成为被摆置的对象,现代医疗偏离了初衷。应伦理先行,基于对生命的伦理关切,主动地思考技术时... 详细信息

通过分析现代医疗技术对生命终结问题产生的变化与可能影响,指出生命终结需要决断,临终者不能安然离去,根本源于技术的本质,身体在技术具身中成为被摆置的对象,现代医疗偏离了初衷。应伦理先行,基于对生命的伦理关切,主动地思考技术时代生命终结的可能方式,提高生命质量与死亡质量;探索中国孝道文化与临终关怀理念的内在契合性,为避免两者的现代偏离,构建传统孝道与技术的良性交互,以安宁疗护予以伦理关怀,帮助临终者有尊严地与世界告别。

关键词：技术具身生命终结临终关怀安宁疗护孝道

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和而不同文明互鉴——评《古希腊悲剧在中国的跨文化戏剧实践研究》

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中国比较文学 2024年第2期135卷 275-280页

作者：陈秀娟河南工学院人文素质教育中心

中国戏曲舞台上的西方戏剧,最常见的当数莎士比亚戏剧,学界关于“莎戏曲”的研究蔚为可观。虽然古希腊悲剧与莎剧同属西方经典,对古希腊悲剧戏曲改编的相关研究却几乎无人问津。北京大学出版社近期出版的陈戎女专著《古希腊悲剧在中国... 详细信息

中国戏曲舞台上的西方戏剧,最常见的当数莎士比亚戏剧,学界关于“莎戏曲”的研究蔚为可观。虽然古希腊悲剧与莎剧同属西方经典,对古希腊悲剧戏曲改编的相关研究却几乎无人问津。北京大学出版社近期出版的陈戎女专著《古希腊悲剧在中国的跨文化戏剧实践研究》(下称《实践研究》),改变了这一现状。

关键词：古希腊悲剧莎士比亚戏剧北京大学出版社戏曲舞台西方戏剧戏曲改编跨文化戏剧近期出版

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Liquid-liquid interface‐assisted growth of two‐dimensional organic semiconductor single crystals:Mechanisms,properties,and applications

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Information ＆ Functional Materials 2024年第2期1卷 220-241页

作者： Jinwen Wang Tingyi Yan Lingyun Li Zheng Ren xiujuan Zhang Jiansheng Jie Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhouJiangsuChina Jiangsu Key Laboratory for Carbon‐Based Functional Materials&Devices Soochow UniversitySuzhouJiangsuChina Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhouJiangsuChina Macao Institute of Materials Science and Engineering MUST‐SUDA Joint Research Center for Advanced Functional MaterialsMacao University of Science and TechnologyTaipaMacaoChina

Two‐dimensional organic semiconductor single crystals(2D OSSCs)represent the promising candidates for the construction of high‐performance electronic and optoelectronic devices due to their ultrathin thicknesses,free of grain boundaries,and long‐range ordered molecular *** recent years,substantial efforts have been devoted to the fabrication of the large‐sized and layer‐controlled 2D OSSCs at the liquid‐liquid *** unique interface could act as the molecular flat and defect‐free substrate for regulating the nucleation and growth processes and enabling the formation of large‐sized ultrathin 2D ***,this review focuses on the liquid-liquid interface‐assisted growth methods for the controllable preparation of 2D OSSCs,with a particular emphasis on the advantages and limitations of the corresponding ***,the typical methods employed to control the crystal sizes,morphologies,structures,and orientations of 2D OSSCs at the liquid-liquid interface are discussed in ***,the recent progresses on the 2D OSSCs‐based optoelectronic devices,such as organic field‐effect transistors,ambipolar transistors,and phototransistors are ***,the key challenges and further outlook are proposed in order to promote the future development of the 2D OSSCs in the field of the next‐generation organic optoelectronic devices.

关键词： ambipolar transistors liquid‐liquid interface‐assisted growth organic field‐effect transistors organic phototransistors two‐dimensional organic semiconductor single crystal

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A Novel Agricultural Data Sharing Mode Based on Rice Disease Identification

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Plant Diseases and Pests 2024年第2期15卷 9-16页

作者： Mengmeng ZHANG xiujuan WANG Mengzhen KANG Jing HUA Haoyu WANG Feiyue WANG State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Beijing Engineering Research Center of Intelligent Systems and Technology Institute of AutomationChinese Academy of SciencesBeijing 100190China Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China State Key Laboratory for Management and Control of Complex System Institute of AutomationChinese Academy of SciencesBeijing 100190China

In this paper,a variety of classical convolutional neural networks are trained on two different datasets using transfer learning *** demonstrated that the training dataset has a significant impact on the training results,in addition to the optimization achieved through the model ***,the lack of open-source agricultural data,combined with the absence of a comprehensive open-source data sharing platform,remains a substantial *** issue is closely related to the difficulty and high cost of obtaining high-quality agricultural data,the low level of education of most employees,underdeveloped distributed training systems and unsecured data *** address these challenges,this paper proposes a novel idea of constructing an agricultural data sharing platform based on a federated learning(FL)framework,aiming to overcome the deficiency of high-quality data in agricultural field training.

关键词： Rice disease and pest identification Convolutional neural networks Distributed training Federated learning(FL) Open-source data sharing platform

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流动视角下城市“周末爸爸”的父职实践研究

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中国青年研究 2024年第5期 52-60,69页

作者：高修娟曾令峰安徽师范大学法学院

因外出工作而缺席的父亲是一个重要的缺席父亲群体,其父职实践面临特殊的处境。“双城”流动的城市“周末爸爸”家庭采取了“父亲流动,母亲留守”的模式。同时,“周末爸爸”能够经常回家,在身体缺席和身体在场之间不断切换。当在外工作... 详细信息

因外出工作而缺席的父亲是一个重要的缺席父亲群体,其父职实践面临特殊的处境。“双城”流动的城市“周末爸爸”家庭采取了“父亲流动,母亲留守”的模式。同时,“周末爸爸”能够经常回家,在身体缺席和身体在场之间不断切换。当在外工作时,他们会通过远程通信和家人频繁联系,以视频聊天的方式实践远程父职,这种远程父职以培养父子之间的情感联系为主。当周末或假期返家时,他们实践了较为密集的面对面父职,这种父职以陪玩为主,具有轻松愉快的特点。远程父职和面对面父职的频繁交替,使得“周末爸爸”具有关怀慈爱的父亲形象。周末爸爸的父职实践体现了流动性对父职转型的作用,本文尝试提出父职实践的流动性解释框架。

关键词：缺席父亲父职实践周末爸爸远程父职面对面父职

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谐振管对开口式热声发生器声学性能的影响研究

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华中科技大学学报（自然科学版） 2024年第1期52卷 14-19页

作者：吴殿伟谢秀娟杨少柒中国科学院理化技术研究所航天低温推进剂技术国家重点实验室北京100190 中国科学院大学北京100049

在传递矩阵模型中引入开口端非线性耗散模型对开口式行波热声发生器理论建模,得到了开口端阻抗实部、开口处体积流率及受末端几何形状影响的压力损失系数之间的关系.对系统谐振频率、内部压力幅值和出口外1.m处声压级的声学特性参数进... 详细信息

在传递矩阵模型中引入开口端非线性耗散模型对开口式行波热声发生器理论建模,得到了开口端阻抗实部、开口处体积流率及受末端几何形状影响的压力损失系数之间的关系.对系统谐振频率、内部压力幅值和出口外1.m处声压级的声学特性参数进行了理论分析,并对不同谐振管尺寸和不同锥管锥度进行了实验研究.分析讨论了谐振管长度和直径对系统谐振频率的影响,结果表明:理论模型可以反映谐振管尺寸对谐振频率的影响,计算值与实验值的误差小于5%.锥管可以有效减小开口端的能量损耗,进而显著提高热声装置内部的压力幅值和出口外1.m处声压级,在谐振管直径为46 mm、长度为730 mm及40°锥管情况下,出口外1.m处声压级可以达到1.0.2 dB.

关键词：开口式行波热声发生器谐振管谐振频率声压级压力损失系数

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