检索结果-南通市图书馆

An Encoding-Decoding Framework Based on CNN for circ RNA-RBP Binding Sites Prediction

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2024年第1期33卷 256-263页

作者： Yajing GUO xiujuan LEI Yi PAN School of Computer Science Shaanxi Normal University Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Department of Computer Science Georgia State University

Predicting RNA binding protein(RBP) binding sites on circular RNAs(circ RNAs) is a fundamental step to understand their interaction mechanism. Numerous computational methods are developed to solve this problem, but they cannot fully learn the features. Therefore, we propose circ-CNNED, a convolutional neural network(CNN)-based encoding and decoding framework. We first adopt two encoding methods to obtain two original matrices. We preprocess them using CNN before fusion. To capture the feature dependencies, we utilize temporal convolutional network(TCN) and CNN to construct encoding and decoding blocks, respectively. Then we introduce global expectation pooling to learn latent information and enhance the robustness of circ-CNNED. We perform circ-CNNED across 37 datasets to evaluate its effect. The comparison and ablation experiments demonstrate that our method is superior. In addition, motif enrichment analysis on four datasets helps us to explore the reason for performance improvement of circ-CNNED.

关键词： Proteins RNA Neural networks Encoding Robustness Decoding Convolutional neural networks

同方期刊数据库

Joint alignment and steering to manage interference

在线全文

学校读者我要写书评

暂无评论

Digital Communications and Networks 2024年第2期10卷 429-438页

作者： Zhao Li xiujuan Liang Yinghou Liu Jia Liu Zheng Yan School of Cyber Engineering Xidian UniversityXi'an710126China Technol.on Commun.Net.Lab. The 54th Research Inst.of China Elec.Technol.Group Corp.Shijiazhuang050081China School of Computer Science and Technology Xidian UniversityXi'an710126China The Department of Communications and Networking(Comnet) Aalto University02150EspooFinland

In wireless communication networks,mobile users in overlapping areas may experience severe interference,therefore,designing effective Interference Management(IM)methods is crucial to improving network ***,when managing multiple disturbances from the same source,it may not be feasible to use existing IM methods such as Interference Alignment(IA)and Interference Steering(IS)*** is because with IA,the aligned interference becomes indistinguishable at its desired Receiver(Rx)under the cost constraint of Degrees-of-Freedom(DoF),while with IS,more transmit power will be consumed in the direct and repeated application of IS to each *** remedy these deficiencies,Interference Alignment Steering(IAS)is proposed by incorporating IA and IS and exploiting their advantages in *** IAS,the interfering Transmitter(Tx)first aligns one interference incurred by the transmission of one data stream to a one-dimensional subspace orthogonal to the desired transmission at the interfered Rx,and then the remaining interferences are treated as a whole and steered to the same subspace as the aligned ***,two improved versions of IAS,i.e.,IAS with Full Adjustment at the Interfering Tx(IAS-FAIT)and Interference Steering and Alignment(ISA),are *** former considers the influence of IA on the interfering user-pair's *** orthogonality between the desired signals at the interfered Rx can be maintained by adjusting the spatial characteristics of all interferences and the aligned interference components,thus ensuring the Spectral Efficiency(SE)of the interfering communication *** ISA,the power cost for IS at the interfered Tx is minimized,hence improving SE performance of the interfered *** the proposed methods are realized at the interfering and interfered Txs cooperatively,the expenses of IM are shared by both *** in-depth simulation results show that joint use of IA and

关键词： Interference Interference management Interference alignment Interference steering Spectral efficiency

Molecular Generation and Optimization of Molecular Properties Using a Transformer Model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Big Data Mining and Analytics 2024年第1期7卷 142-155页

作者： Zhongyin Xu xiujuan Lei Mei Ma Yi Pan School of Computer Science Shaanxi Normal UniversityXi'an 710119China Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Generating novel molecules to satisfy specific properties is a challenging task in modern drug discovery,which requires the optimization of a specific objective based on satisfying chemical ***,we aim to optimize the properties of a specific molecule to satisfy the specific properties of the generated *** Matched Molecular Pairs(MMPs),which contain the source and target molecules,are used herein,and logD and solubility are selected as the optimization *** main innovative work lies in the calculation related to a specific transformer from the perspective of a matrix *** intervals and state changes are then used to encode logD and solubility for subsequent *** the experiments,we screen the data based on the proportion of heavy atoms to all atoms in the groups and select 1.365,1.03,and 1.70 MMPs as the training,validation,and test sets,*** models are compared with the baseline models with respect to their abilities to generate molecules with specific *** show that the transformer model can accurately optimize the source molecules to satisfy specific properties.

关键词： molecular optimization transformer Matched Molecular Pairs(MMPs) logD solubility

Drug-Target Interactions Prediction Based on Signed Heterogeneous Graph Neural Networks

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2024年第1期33卷 231-244页

作者： Ming CHEN Yajian JIANG xiujuan LEI Yi PAN Chunyan JI Wei JIANG College of Information Science and Engineering Hunan Normal University School of Computer Science Shaanxi Normal University Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Computer Science Department BNU-HKBU United International College

Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and targets while ignoring relational types information. Considering the positive or negative effects of DTIs will facilitate the study on comprehensive mechanisms of multiple drugs on a common target, in this work, we model DTIs on signed heterogeneous networks, through categorizing interaction patterns of DTIs and additionally extracting interactions within drug pairs and target protein pairs. We propose signed heterogeneous graph neural networks(SHGNNs), further put forward an end-to-end framework for signed DTIs prediction, called SHGNN-DTI,which not only adapts to signed bipartite networks, but also could naturally incorporate auxiliary information from drug-drug interactions(DDIs) and protein-protein interactions(PPIs). For the framework, we solve the message passing and aggregation problem on signed DTI networks, and consider different training modes on the whole networks consisting of DTIs, DDIs and PPIs. Experiments are conducted on two datasets extracted from Drug Bank and related databases, under different settings of initial inputs, embedding dimensions and training modes. The prediction results show excellent performance in terms of metric indicators, and the feasibility is further verified by the case study with two drugs on breast cancer.

关键词： Drugs Training Proteins Measurement Message passing Prediction methods Graph neural networks

Nd^(3)+:YAG-Al_(2)O_(3) nanocrystalline transparent ceramics with high inflexion concentration quenching of Nd^(3+) prepared by amorphous crystallization

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Advanced Ceramics 2024年第8期13卷 1242-1253页

作者： xiujuan Wan Guangfan Tan Liang Cai Jie Fu Jianqiang Li Yingchun Zhang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100080China State Key Lab for Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Rare earth ion-doped Y_(3)Al_(5)O_(1.)(YAG)-based transparent ceramics have been used as important laser gain media for a long time,yet the doping concentration of active ions is limited due to concentration quenching,wherein the inflexion concentration quenching of Nd^(3+)is recognized as 1.0 at%.In this work,YAG-Al_(2)O_(3) nanocrystalline transparent ceramics with a concentration of Nd^(3+)(O-5.0 at%)were fabricated via amorphous crystallization,and the crystal structure evolution,morphology,and optical properties were systematically investigated by differential scanning calorimetry(DSC),X-ray powder diffraction(XRD),transmission electron microscopy(TEM),magnetic resonation(MAS),nuclear magnetic resonation(NMR),and fluorescence *** doping of Nd^(3+)can promote the transition of Al[5]and Al[6]to Al[1.],indicating improvements in the ability of the amorphous material to form Nd^(3+):Y_(2)O_(3)-Al_(2)O_(3) vitrified beads,and 1.5 at%Nd^(3+):YAG-Al_(2)O_(3) nanocrystalline transparent ceramics can be obtained by crystallization at 1.50℃ with a matrix composed of YAG and concomitant δ-Al_(2)O_(3) and θ-Al_(2)O_(3).The nanocrystalline transparent ceramics show an internal transmitance of 89.56%at 1.64 nm,and the strongest emission peak corresponds to the energy transfer from 4F_(3/2) to 4l_(1./2) of Nd^(3+)with a fluorescence lifetime of 231.s when pumped by an 808 nm ***,spectral broadening begins to occur,indicating the onset of concentration quenching,when the concentration of Nd^(3+)exceeds 1.5 at%,substantially higher than the 1.0 at% observed in YAG ***-Al_(2)O_(3) nanocrystalline transparent ceramics obtained by amorphous crystalization can be utilized as the matrix to increase the inflexion point of doping concentration quenching of Nd^(3+),and this material may have great potential as a laser gain medium.

关键词： Y_(3)Al_(5)O_(1.)(YAG)-Al_(2)O_(3) nanocrystalline transparent ceramics laser gain medium Nd^(3+)

LaMnO_(3)/Co_(3)O_(4) nanocomposite for enhanced triethylamine sensing properties

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rare Earths 2024年第4期42卷 733-742页

作者： Jian Zhang Yanping Chen Ling Li Xue Chen Wenya An xiujuan Qian Yuye Tao School of Science Shandong Jianzhu UniversityJinan250100China

LaMnO_(3) modified Co_(3)O_(4) nanocomposites were prepared by simple hydrothermal method co mbined with sol-gel *** gas sensitivity properties of pure Co_(3)O_(4) and LaMnO_(3)/Co_(3)O_(4) with different composite proportions are *** is found that 0.6-LMO/Co_(3)O_(4) sensor has higher sensitivity to triethylamine(TEA)than pure Co_(3)O_(4) sensor,which is improved by 9.27 *** the working temperature is reduced from 1.0 to 1.0℃.Besides,it has excellent gas selectivity and *** improvement of the gas sensitivity of LaMnO_(3)/Co_(3)O_(4) sensor may be due to the fact that LaMnO_(3) is an effective catalyst,and the catalytic performance perhaps is beneficial to improving the sensing *** addition,the formation of p-p heterojunctions may be the key factor to improve the gas sensing *** work provides a new Co_(3)O_(4)-based gas sensing material for the detection of TEA.

关键词： Gas sensing Co_(3)O_(4) LaMnO_(3) Triethylamine Rareearths

Parent-offspring relationship recognition based on SSR and mtDNA confirmed resource supplement effect of Fenneropenaeus chinensis release

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2024年第2期43卷 156-160页

作者： Song Sun Ding Lyu Xianshi Jin xiujuan Shan Weiji Wang Key Laboratory of Sustainable Development of Marine Fisheries Ministry of Agriculture and Rural AffairsYellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdao 266071China Function Laboratory for Marine Fisheries Science and Food Production Processes Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

The resource of Fenneropenaeus chinensis has declined sharply due to excessive fishing intensity,ecological changes and *** order to supplement the fishing yield and restore resources of ***,the relevant authorities have carried out the activities of stock enhancement and *** can increase biomass and recover ***,compared with increasing biomass,there were still few reports on its effect on the recovery of *** recovery is a process related to whether the released individuals can form a reproductive *** to now,there has been a lack of evidence whether the released *** can complete the entire life history,and form reproduction *** this study,gravid female shrimp after spawning migration were captured from coastal waters of Haiyang,Qingdao,and Yellow *** identifying parentage relationships using simple sequence repeat(SSR)and mtDNA haplotype,it was finally confirmed that there were eight released individuals in the recapture *** was confirmed for the first time that at least part of the released *** can complete overwintering and reproductive migration,and maintain the migration habits as their wild ***,we infered that the released shrimp can reproduce under natural conditions,these *** can form reproductive populations theoretically if without human *** results indicated that enhancenment and release activities have a positive effect on resource recovery.

关键词： Fenneropenaeus chinensis release simple sequence repeat(SSR) mtDNA resource supplement

Graphene as adsorbent for highly efficient extraction of modified nucleosides in urine prior to liquid chromatography-tandem mass spectrometry analysis

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第4期35卷 490-495页

作者： Cheng Guo Xiaoxiao Zhang xiujuan Hong Yiqiu Hu Lingna Mao Kezhi Jiang Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Cancer Center Zhejiang UniversityHangzhou 310058China Key Laboratory of Organosilicon Chemistry and Material Technology College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China Department of General Practice The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

RNA modifications have been involved in numerous biological processes, and aberrations of these modifications are tightly associated with various diseases including cancer. Herein, we developed graphenebased solid-phase extraction and robust ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) combined with stable isotope-dilution for simultaneous enrichment and accurate determination of 1. modified nucleosides in human urine. We found graphene could effectively adsorb various modified nucleosides in human urine samples. With this method, we identified and quantified these modified nucleosides in urine samples collected from lung cancer patients and healthy *** revealed that the levels of 1. modified nucleosides were all diminished in urine from lung cancer patients, compared with healthy controls. It is worth noting that we demonstrated, for the first time, the presence of 5,2-O-dimethyluridine(m~5U_m) in human urine. Together, we established a robust analytical method for simultaneous determinations of 1. modified nucleosides in human urine, and our results revealed a close correlation between the concentrations of urinary modified nucleosides and the occurrence of lung cancer, implying the potential applications of these modified nucleosides as noninvasive biomarkers for the early detection of lung cancer. Moreover, this study will stimulate future investigations on the regulatory roles of RNA modifications in the initiation and progression of lung cancer.

关键词： Mass spectrometry RNA modification Modified nucleosides Graphene Biomarker Urine

Nanoscale“precision strike”:Tumor microenvironment-responsive smart micelles for efficient targeted drug delivery

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第9期17卷 8360-8367页

作者： Dong Wan Yarong Song xiujuan Lu Yanfeng Huang Jianxin Zhang Yonghui Liu Yi Liu Jie Pan School of Chemistry Tiangong UniversityTianjin 300387China School of Chemical Engineering and Technology Tiangong UniversityTianjin 300387China

To address the limitations of conventional nanotechnology-based drug delivery systems,this work developed enzyme and reduction dual-responsive polymeric *** micelles were synthesized with copolymers composed of TPGS_(3350)-PVGLIG-DOX(TPD)and FA-SS-DOX(FSD),which endow them with tumor-targeted drug delivery ***_(3350)contributes to extending the circulation of micelles in body,augmenting their accumulation in tumor tissues via the enhanced permeability and retention(EPR)*** localized the tumor site,matrix metalloproteinase 2(MMP2)cleaves the PVGLIG peptide moiety within the micelles,thereby releasing TPGS_(3350)and exposing the targeting ligand of *** approach enables the subsequent internalization of the micelles by tumor cells through folate receptor-mediated *** internalization,the high intracellular concentration of glutathione(GSH)triggers the reduction of the disulfide bond within the FA-SS-DOX,leading to the release of the anticancer-drug doxorubicin(DOX),which promotes apoptosis in the tumor cells and enhances the efficacy of chemotherapy.

关键词： cancer peptide micelle dual-responsive folate