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NF_3 decomposition over some metal oxides in the absence of water

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Journal of Natural Gas Chemistry 2010年第5期19卷 463-467页

作者： Xianjun Niu liang sun yananwang Haioeng Wu xiufeng xu School of Chemistry and Biology Yantai University Yantai 264005 Shandong China

NF3 decomposition in the absence of water over Al2O3, Fe2O3, Co3O4 and NiO, and transition metal oxides （Fe203, CO3O4 and NiO） coated Al2O3 reagents was investigated. The results show that Al2O3 is an active reagent for NF3 decomposition with 100% conversion lasting for 8.5 h at 400 ℃. Fe203, Co3O4 and NiO coated Al2O3 reagents are superior to bare Al2O3, and 5%Co3O4/Al2O3 has a high reactivity with NF3 full conversion maintaining for 10.5 h. It is suggested that the presence of transition metal oxide is beneficial to the reactivity of Al2O3, and results in a significant enhancement in the fluorination of Al2O3.

关键词： NF3 decomposition metal oxides Al2O3 reactivity

LAL test and RPT for endotoxin detection of CPT-11/DSPE-mPEG_(2000) nanoformulation: What if traditional methods are not applicable?

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Asian Journal of Pharmaceutical Sciences 2018年第3期13卷 289-296页

作者： yanan Jin Juanjuan Jia Chan Li Jianqi xue Jiabei sun Kaiyuan wang Yaling Gan Jing xu Yaqin Shi Xingjie liang College of Chemistry & Environmental Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University National Institutes for Food and Drug Control No. 5 Huatuo Rd. Daxing District Laboratory of Controllable Nanopharmaceuticals Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology of China Laboratory of Molecular Iron Metabolism College of Life Science Hebei Normal University National Institutes for Food and Drug Control University of Chinese Academy of Sciences

Endotoxin detection is an important step in drug characterization. Herein we found that a chemotherapeutic drug nanoformulation composed of irinotecan hydrochloride(CPT-11) and an amphiphilic molecule DSPE-mPEG_(2000) can interfere with the limulus amebocyte lysate assay(LAL). Furthermore, the rabbit pyrogen test(RPT) results indicated that at a relatively high dosage, the drug irinotecan hydrochloride can induce a hypothermia effect which may render the RPT results ambiguous in determination of the safety of the drug *** findings demonstrate limitations of endotoxin detection in micellar drugs,and call for the necessity of developing reliable endotoxin detection methods that can overcome the interference of nanomaterials in order to better ensure the drug safety of patients in future pharmaceutical drug development.

关键词： Irinotecan hydrochloride Endotoxin detection Micelle DSPE-mPEG2000 Limulus amebocyte lysate assay Rabbit pyrogen test

Primed macrophages directly and specifically reject allografts

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Cellular & Molecular Immunology 2020年第3期17卷 237-246页

作者： Zhulang Chu Chenming sun Lina sun Chang Feng Fan Yang yanan xu Yong Zhao State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina

Monocytes and macrophages have long been associated with acute and chronic allograft rejection;this is mediated by their abilities to promote inflammation,kill target cells via antibody-dependent cytotoxicity and modulate adaptive *** present study showed that allogeneic antigen-primed macrophages acutely rejected skin grafts with specificity after adoptive transfer into MHC-matched immunodeficient *** ability of primed macrophages to reject allografts essentially requires the help of CD4^(+) T cells and does not require the help of CD8^(+) T ***,the primed,perforin-deficient macrophages rejected the skin grafts in a significantly delayed pattern compared with WT macrophages,indicating that the perforin pathway of the primed macrophages is likely involved in the rejection ***,primed macrophages are endowed with adaptive immunitylike features,such as specificity,with the help of CD4^(+) T cells during the immune response to *** present study challenges our traditional views of macrophage functions and highlights the biological functions of macrophages beyond innate immunity in mammals.

关键词： Macrophages Specificity Graft rejection Innate immunity Transplantation

NF_3在Co-Al复合氧化物上的分解反应

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石油化工 2011年第4期40卷 435-438页

作者：孙亮王亚楠徐秀峰烟台大学应用催化研究所山东烟台264005

采用共沉淀法制备了n（Co）：n（Al）=0．1～4．0的Co—Al复合氢氧化物，再经焙烧得到Co-Al复合氧化物，对Co-Al复合氧化物进行了XRD和N2吸附-脱附表征。在固定床反应器中，在无水条件下考察了Co—Al复合氧化物的脱氟活性。实验结果表... 详细信息

采用共沉淀法制备了n（Co）：n（Al）=0．1～4．0的Co—Al复合氢氧化物，再经焙烧得到Co-Al复合氧化物，对Co-Al复合氧化物进行了XRD和N2吸附-脱附表征。在固定床反应器中，在无水条件下考察了Co—Al复合氧化物的脱氟活性。实验结果表明，随n（Co）：n（Al）的增大，Co—Al复合氧化物的比表面积和孔体积减小；当n（Co）：n（Al）=0，1时，Co—Al复合氧化物具有较大的比表面积和孔体积；随m（Co）：n（Al）的减小，Co—Al复合氧化物的脱氟活性逐渐提高，NF3全转化时间逐渐延长，脱氟反应速率受扩散控制；脱氟反应后，Co—Al复合氧化物转化为CoF2和AlF3。

关键词：三氟化氮分解反应钴-铝复合氧化物脱氟剂

Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology

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Cancer Biology & Medicine 2019年第1期16卷 189-204页

作者： xuchao Zhang Zhiyong liang Shengyue wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou xiufeng Liu Jianyong Shao Yanhong Tai Zheng wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou xuening Yang Jie wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe xu Qingyuan Zhang Ruihua xu Lin Shen Yilong Wu Guangdong Lung Cancer Institute Medical Research Center Cancer Center of Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences Affiliated Guangdong Provincial People's Hospital South China University of Technology Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences National Research Center for Translational Medicine Shanghai Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Lung Tumor Clinical Medical Center Shanghai Chest Hospital Shanghai Jiao Tong University Division of Respiratory Medicine Jinling Hospital Nanjing University School of Medicine Department of Oncology Jilin Cancer Hospital Department of Pathology National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Pathology West China Hospital Sichuan University Department of Pathology Zhongshan Hospital Fudan University Department of Hematology First Affiliated Hospital Institute of Hematology School of Medicine Jinan University Laboratory of Oncology Affiliated Hospital of the Academy of Military Medical Sciences Department of Oncology First Clinical College of South China University of Technology/Guangdong Lung Cancer Institute People's Liberation Army Cancer Center of Bayi Hospital Affiliated to Nanjing University of Chinese Medicine Department of Pathology Sun Yat-sen University Cancer Center Department of Pathology Affiliated Hospital of the Academy of Military Medical Sciences Department of Pathology Beijing Hospital Department of Breast Cancer Pathology and Research Laboratory of Cancer Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Tianjin’s Clinical Research Center for Cancer Department of Pathology Jinling Hospital Nanjing University School of Medicine State Key Laboratory of Molecular Oncology Department of Medical Oncology National Cancer Center/Canc

Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules ***, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation.

关键词： Next-generation sequencing technology cancer consensus

基于SPEI和MI分析陕西省干旱特征及趋势变化

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中国农业科学 2019年第23期52卷 4296-4308页

作者：丁怡博徐家屯李亮蔡焕杰孙亚楠西北农林科技大学旱区农业水土工程教育部重点实验室西北农林科技大学中国旱区节水农业研究院西北农林科技大学水利与建筑工程学院

【目的】目前干旱研究多为基于历史干旱事件分析成因与变化趋势,而结合过去与未来长时间序列数据更能揭示干旱变化特点。寻找在基于CMIP5模型输出未来气象数据时模拟干旱指数方法并探究陕西省过去与未来干旱变化特点,为陕西省未来农业... 详细信息

【目的】目前干旱研究多为基于历史干旱事件分析成因与变化趋势,而结合过去与未来长时间序列数据更能揭示干旱变化特点。寻找在基于CMIP5模型输出未来气象数据时模拟干旱指数方法并探究陕西省过去与未来干旱变化特点,为陕西省未来农业水资源管理提供依据。【方法】根据陕西省18个气象站历史数据以及CMIP5模式输出未来气象数据,比较了3种模型模拟参考作物蒸发蒸腾量(ET),并基于参考作物蒸发蒸腾量(ET)和降水数据计算标准降水蒸发指数(SPEI)和相对湿润指数(MI)反映干旱程度,比较过去(1958—2018年)与未来(2019—2100年)干旱的时空变化特点。【结果】多元线性回归模型(Multiple Linear Regression, MLR)能较准确的模拟参考作物蒸发蒸腾量(ET)(RMSE=0.457 mm·d);在RCP2.6和RCP8.5情景下未来干旱指数呈现上升趋势,在RCP8.5情景下,21世纪40年代存在干旱指数的突变年份;陕西省未来干旱程度降低,年内干旱分布更加不均匀;未来时期夏玉米生长季干旱程度减小,冬小麦生长季干旱程度增加。【结论】在不同RCP情景下,未来干旱变化特征存在差异,相同RCP情景下,SPEI和MI反映的干旱特征变化基本一致,但部分时段存在变化差异。为有效应对气候变化对旱作作物产量造成的负面影响,应当增强土壤蓄水保墒能力,尤其加强冬小麦生长季的抗旱工作。

关键词：标准降水蒸发指数(SPEI) 相对湿润指数(MI) 蒸发蒸腾量(ET0) 多元回归神经网络典型浓度路径(RCP) 趋势检验(Mann-Kendall) 陕西省

膜曝气生物膜-生态浮床组合装置开发及其水体净化效果研究

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水利水电技术 2019年第6期50卷 142-149页

作者：练继建孙亚楠马超徐奎陈亮天津大学水利工程仿真与安全国家重点实验室

生物生态法是目前国内外治理河湖水体富营养化的主要方法,但使用单一净化装置的处理效果均不甚理想,故将生物生态法中的生物膜法、曝气富氧法和生态浮床法相结合,开发了一套新型膜曝气生物膜-生态浮床立式组合净化装置。试验结果表明,... 详细信息

生物生态法是目前国内外治理河湖水体富营养化的主要方法,但使用单一净化装置的处理效果均不甚理想,故将生物生态法中的生物膜法、曝气富氧法和生态浮床法相结合,开发了一套新型膜曝气生物膜-生态浮床立式组合净化装置。试验结果表明,组合装置较水体自净和单一净化装置可显著提高水体净化效果。具体表现在:组合装置、生物膜反应器、生态浮床和河水自净作用对NH+4-N的去除率分别为98.0%、96.6%、66.6%和48.5%,组合装置较河水自净作用的去除率可提高49.5%;对TN的去除率分别为34.7%、26.9%、19.3%和9.6%,去除率可提高25.1%;对TP的去除率分别为60.7%、33.9%、86.9%和38.5%,去除率可提高22.2%;对COD Mn的去除率分别为78.3%、53.1%、58.4%和40.2%,去除率可提高38.1%。同时,组合装置对叶绿素a同样具有最强的抑制作用且可大幅提高水体透明度,减少水体黑臭现象的发生,这一结果为该装置应用于受污染河道的水体修复提供了科学依据。

关键词：组合净化装置生态浮床膜曝气生物膜反应器(MABR) 净化效果

Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 227-252,I0011-I0014页

作者： Hui-Chuan sun Jian Zhou Zheng wang xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li xueli Bai Yuan Ji Li xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi wang Lu wang Shunxiang wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin wang Tingbo liang Jiahong Dong Xiaoping Chen xuehao wang Shusen Zheng Jia Fan 无 Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina Department of Medical Oncology of PLA Cancer Center Jinling HospitalNanjingChina Department of Infectious Disease Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Liver Surgery The First Affiliated Hospital of USTCHefeiChina Minimally Invasive Interventional Division Sun Yat-sen University Cancer CenterGuangzhouChina Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Radiation Oncology Beijing Tsinghua Changgung HospitalBeijingChina Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Department of Pathology Fudan University Shanghai Cancer CentreShanghaiChina Department of Liver Surgery Sun Yat-sen University Cancer CentreGuangzhouChina Department of Hepatobiliary Surgery Clinical Medical CollegeYangzhou UniversityYangzhouChina Department of Hepatobiliopancreatic Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Division of Hepatobiliary Surgery Department of General SurgeryRuijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Hepatobiliary and Splenic Surgery Shengjing Hospital Affiliated to China Medical UniversityShenyangChina The Department of Hepatobiliary Oncology of sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Sarcoma CenterPeking University Cancer Hospital and InstituteBeijingChina Department of Hepatobili

Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response *** has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’***,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being *** the evidence for conversion therapy in HCC and develop consensus statements to guide clinical *** review:Many research centers in China have accumulated significant experience implementing HCC conversion *** findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related *** order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical *** consensus statements on the implementation of conversion therapy for HCC were *** statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC.

关键词： Hepatocellular carcinoma(HCC) conversion therapy surgical resection systematic treatment locoregional treatment consensus China

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社会工作助推高校心理危机干预模式探析

药学教育 2024年第2期40卷 13-16页

作者：梁亚男孙建平李霞王国杰徐娟哈尔滨医科大学药学院哈尔滨医科大学学工部哈尔滨150086

社会工作坚持契合需求为解决问题的前提,对特殊群体进行救助和服务,从内探索症结,从外分析影响,令高校心理危机干预工作呈现从细分到整合,从治疗到预防的发展趋势,实现外部、内部的双向成长和转变。文章以融合思维为导向,以社会工作理... 详细信息

社会工作坚持契合需求为解决问题的前提,对特殊群体进行救助和服务,从内探索症结,从外分析影响,令高校心理危机干预工作呈现从细分到整合,从治疗到预防的发展趋势,实现外部、内部的双向成长和转变。文章以融合思维为导向,以社会工作理论和实践方法为依靠,探索“社会工作+心理危机干预”助推高校心理危机干预工作科学发展新模式。

关键词：社会工作高校心理危机干预预防和发展