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Facile synthesis and characterization of uniform CdS colloidal spheres

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Chinese Chemical Letters 2012年第9期23卷 1091-1094页

作者： xiu Jie yang Xin Ping Li xiang Tao Bai Li Qiang Zheng Key Laboratory of Colloid and Interface Chemistry of Ministry of Education Shandong UniversityChina Jinan 250100

Uniform CdS colloidal spheres have been successfully synthesized via a simple hydrothermal method. X-ray diffraction （XRD） analyses indicate that the products exhibit a hexagonal structure. Scanning electron （SEM） and transmission electron microscopy （TEM） are used to characterize CdS colloidal spheres. The final size of the spheres may be selected from a range of 71± 2 nm to approximately 181 ± 5 nm by changing the amount of polyvinylpyrrolidone （PVP） and hexamethylenetetramine （HMT）. The CdS colloidal spheres are not obtained in the absence of either of the capping agents. A synergistic effect between HMT and PVP is proposed to be crucial for the formation of colloidal spheres.

关键词： Microstructure Nanomaterials CdS Colloidal spheres Hydrothermal synthesis

短柱肖菝葜中的3个2,3-二酮喹喔啉类生物碱及其肝保护活性

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药学学报 2024年第2期59卷 413-417页

作者：杜茸茸郭馨怡秦文杰孙华段秀梅苑祥杨桠楠李昆张培成中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室北京100050 北京振东光明药物研究院北京100085 山西振东制药股份有限公司山西长治047100

从短柱肖菝葜(Heterosmilax yunnanensis Gagnep.)中分离得到3个2,3-二酮喹喔啉类生物碱,通过一维和二维核磁共振、高分辨质谱、紫外光谱和红外光谱确定其化学结构,分别鉴定为1-[5′-(3″-羟基-3″-甲基)戊二酸单酰基]核糖醇基-2,3-二酮... 详细信息

从短柱肖菝葜(Heterosmilax yunnanensis Gagnep.)中分离得到3个2,3-二酮喹喔啉类生物碱,通过一维和二维核磁共振、高分辨质谱、紫外光谱和红外光谱确定其化学结构,分别鉴定为1-[5′-(3″-羟基-3″-甲基)戊二酸单酰基]核糖醇基-2,3-二酮-1,2,3,4-四氢-6,7-二甲基喹喔啉(1)、1-[2′-(3″-羟基-3″-甲基)戊二酸单酰基]核糖醇基-2,3-二酮-1,2,3,4-四氢-6,7-二甲基喹喔啉(2)和1-核糖醇基-2,3-二酮-1,2,3,4-四氢-6,7-二甲基喹喔啉(3)。其中化合物1和2是新化合物,化合物3是首次从短柱肖菝葜中分离得到,通过肝保护活性筛选,发现化合物3具有良好的肝保护活性。

关键词：短柱肖菝葜百合科 2,3-二酮喹喔啉肝保护活性

左归降糖清肝方对db/db小鼠2型糖尿病合并非酒精性脂肪肝病脂质代谢的影响

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中国中药杂志 2024年第6期49卷 1587-1593页

作者：周敏黎柳邹俊驹刘秀吴勇军向琴喻嵘湖南中医药大学湖南长沙410208

基于INSR/AMPK/SREBP⁃2信号通路,观察左归降糖清肝方对db/db小鼠2型糖尿病(type 2 diabetes mellitus,T2DM)合并非酒精性脂肪肝病(non⁃alcoholic fatty liver disease,NAFLD)脂质代谢的影响,探讨其治疗T2DM合并NAFLD的作用机制。随机将24只db/db小鼠分为4组:模型组,阳性药物组,左归降糖清肝方低、高剂量组。采用6只C57小鼠作为空白组。左归降糖清肝方高、低剂量组分别予左归降糖清肝方15、7.5 g·kg^(-1)灌胃,阳性药物组予二甲双胍0.067 g·kg^(-1)灌胃,空白组和模型组予等体积蒸馏水灌胃,连续6周。灌胃结束后,检测小鼠空腹血糖(fasting blood glucose,FBG),进行口服葡萄糖耐量实验以及血脂、肝功能水平,肝组织病理学分析脂质蓄积情况。Western blot检测胰岛素受体(insulin receptor,INSR)、AMP依赖的蛋白激酶[adenosine 5′⁃monophosphate(AMP)⁃activated protein kinase,AMPK]、p⁃AMPK、甾醇调节元件结合蛋白2(sterol⁃regulatory element⁃binding protein 2,SREBP⁃2)蛋白表达。结果显示,与模型组相比,经左归降糖清肝方治疗的小鼠体质量、肝重系数、空腹血糖、血清总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)和低密度脂蛋白(low⁃density lipopro⁃tein,LDL)以及肝功能水平降低。肝组织病理学显示,与模型组相比,经左归降糖清肝方治疗的小鼠肝组织脂滴空泡明显减少、紫红色糖原颗粒明显增加。Western blot检测结果表明,与空白组比较,模型组INSR、p⁃AMPK/AMPK蛋白表达水平均显著下调,SREBP⁃2蛋白表达水平均显著上调。与模型组比较,左归降糖清肝方高剂量组INSR、p⁃AMPK/AMPK蛋白表达水平均显著上调,SREBP⁃2蛋白表达水平显著下调;左归降糖清肝方低剂量组INSR、p⁃AMPK/AMPK蛋白表达水平有上调趋势,SREBP⁃2蛋白表达水平有下调趋势,但差异无统计学意义。上述研究表明,左归降糖清肝方可能通过激活INSR/AMPK/SREBP⁃2信号通路,改善db/db小鼠胰岛素抵抗和脂质代谢。

关键词：左归降糖清肝方 2型糖尿病非酒精性脂肪性肝病 db/db小鼠脂质代谢

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碳毡厌氧折流板反应器处理农村黑水

中国环境科学 2024年第4期44卷 2054-2062页

作者：温仓祥戴喆秦查晓程方奎程鹤来蔡青秀吕锡武东南大学能源与环境学院江苏南京210096 东南大学无锡太湖水环境工程研究中心江苏无锡214135 江苏科技大学环境与化学工程学院江苏镇江212018 苏州科技大学环境科学与工程学院江苏苏州215009

评估了碳毡厌氧折流板反应器在室温下处理黑水(源分离的厕所污水)的能力,通过逐步缩短水力停留时间(HRT)以探索其最大性能.结果表明,在HRT为1.45d,有机负荷率为2.94kg COD/(m^(3)·d)的条件下实现了最大容积产气率(417±59)NL CH4/(m^(3... 详细信息

评估了碳毡厌氧折流板反应器在室温下处理黑水(源分离的厕所污水)的能力,通过逐步缩短水力停留时间(HRT)以探索其最大性能.结果表明,在HRT为1.45d,有机负荷率为2.94kg COD/(m^(3)·d)的条件下实现了最大容积产气率(417±59)NL CH4/(m^(3)·d),此时甲烷化率(40.5±5.02)%,总COD去除率(79.08±7.24)%.碳毡的加入富集了Methanospirillum属,通过氢营养型产甲烷途径实现高效厌氧消化性能.该反应器在室温下表现出优良的有机物处理效果,高甲烷产量与沼气纯度,尾水中富含可植物直接利用的氮磷营养盐,系统简单易维护,具有在农村地区实际应用的潜力.

关键词：产甲烷导电材料农村生活污水厌氧消化资源回收

Histogram-kernel Error and Its Application for Bin Width Selection in Histograms

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Acta Mathematicae Applicatae Sinica 2012年第3期28卷 607-624页

作者： xiu-xiang Wang Jian-fang Zhang Department of Mathematics Graduate University of Chinese Academy of SciencesBeijing 100049China Coltege of Management Graduate University of Chinese Academy of SciencesBeijing 100190China

Histogram and kernel estimators are usually regarded as the two main classical data-based nonparametric tools to estimate the underlying density functions for some given data sets. In this paper we will integrate them and define a histogram-kernel error based on the integrated square error between histogram and binned kernel density estimator, and then exploit its asymptotic properties. 3ust as indicated in this paper, the histogram-kernel error only depends on the choice of bin width and the data for the given prior kernel densities. The asymptotic optimal bin width is derived by minimizing the mean histogram-kernel error. By comparing with Scott＇s optimal bin width formula for a histogram, a new method is proposed to construct the data-based histogram without knowledge of the underlying density function. Monte Carlo study is used to verify the usefulness of our method for different kinds of density functions and sample sizes.

关键词： Histogram binned kernel density estimator bin width histogram-kernel error integrated square error

纳米羧化壳聚糖在污水无机阴离子去除中的研究

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化学工程师 2024年第1期38卷 33-37,91页

作者：解晓敏解秀祥临沂市生态环境局沂水县分局环境监控中心山东临沂276400

本文旨在研究合成纳米修饰的羧化壳聚糖吸附剂,并将其应用于去除污水中无机阴离子。采用两步法将铁纳米颗粒嫁接至羧化壳聚糖得到纳米羧化壳聚糖吸附剂,用傅立叶变换红外光谱(FTIR)和动态光散射法(DLS)进行表征。评估pH值、吸附剂浓度... 详细信息

本文旨在研究合成纳米修饰的羧化壳聚糖吸附剂,并将其应用于去除污水中无机阴离子。采用两步法将铁纳米颗粒嫁接至羧化壳聚糖得到纳米羧化壳聚糖吸附剂,用傅立叶变换红外光谱(FTIR)和动态光散射法(DLS)进行表征。评估pH值、吸附剂浓度、阴离子浓度和接触时间对吸附剂吸附阴离子的影响,结果表明,在酸性pH值范围内吸附的阴离子浓度较高。吸附剂浓度越高,吸附速率越高。在接触时间为10~60min时,吸附阴离子的量随接触时间的增加而增加,而在接触时间超过60min后,吸附阴离子的量基本不变。研究结果表明,壳聚糖改性吸附剂可以有效地去除水溶液中的NO_(3)^(-)、F^(-)和PO_(4)^(3-)等阴离子。

关键词：壳聚糖纳米改性吸附模型污水处理

A Scheme for Generating Cluster States via Raman Interaction

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Communications in Theoretical Physics 2007年第1期47卷 53-58页

作者： yang Rong-Can LI Hong-Cai LIN xiu HUANG Zhi-Ping CHEN Mei-xiang School of Physics and Optoelectronics Technology Fujian Normal University Fuzhou 350007 China

A scheme for generating cluster states via Raman interaction is proposed. In the scheme, we firstly prepare cluster states of multi-cavities with information encoded in the coherent states and then generate cluster states of multiatoms, which encode the information in the ground states of A-type atoms. The advantages of our scheme are that the atomic spontaneous radiation can be efficiently reduced since the cavity frequency is largely detuned from the atomic transition frequency and the Hadamard gate operation of the coherent states is replaced by measuring the coherent states.

关键词： cluster states Raman interaction A-type three-level atom coherent states

Effects of Buyang Huanwu Decoction on antioxidant and drug-metabolizing enzymes in rat liver

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Chinese Journal of Natural Medicines 2014年第6期12卷 449-454页

作者： FAN Xing-Hua SHI Wei-Zhou CHENG Yun-xiang yang xiu-Fen Department of Pharmacology College of Pharmacy Guangxi University of Chinese Medicine Department of pharmacy Liuzhou Worker's Hospital

AIM: To study the effect of Buyang Huanwu Decoction(BYHWD) on the antioxidant enzymes and drug-metabolizing enzymes in rat liver. METHOD: Following treatment of rats with BYHWD at 6.42, 12.83, or 25.66 g·kg–1 per day for 15 days, microsomes and cytosols isolated from the liver tissues were prepared by differential centrifugation according to standard procedures. The activities of the antioxidant enzymes and cytochrome b5, NADPH-cytochrome P450 reductase, CYP3 A, CYP2E1, UGT, and GST of the rat livers were determined by UV-Vis spectrophotometer. RESULTS: The activities of ALT, AST, antioxidant enzymes, and the Hepatosomatic Index in serum were not significantly affected. In cytosols, the activity of CAT was significantly increased at the dosage of 12.83 g·kg–1, and all the other antioxidant activities and MDA levels were not affected by this treatment. BYHWD had no effect on cytochrome b5, NADPH-cytochrome P450 reductase, CYP3 A, and UGT. At the highest dose(25.66 g·kg–1), the activity of CYP2E1 was significantly inhibited, and the activities of GST and the level of GSH were increased. CONCLUSION: BYHWD is safe for the liver, and has the functions of detoxification and antioxidant. Patients should be cautioned about the herb-drug interaction of BYHWD and CYP2E1 substrates.

关键词： Buyang Huanwu Decoction Antioxidant Drug-metabolizing enzymes

Effect of anti-VEGF treatment on retinopathy of prematurity in Zone Ⅱ Stage 3^+

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International Journal of Ophthalmology(English edition) 2018年第4期11卷 641-644页

作者： xiu-Mei yang Yue-xiang Zhao Zong-Hua Wang Lu Liu Department of Ophthalmology PLA Army General Hospital Department of Cardiology Nanlou Clinical Division of Chinese PLA General Hospital

AIM： To evaluate the effect of intravitreal ranibizumab injection for retinopathy of prematurity（ROP） in Zone Ⅱ Stage 3^＋.METHODS： Data was collected for ROP patients with Zone Ⅱ Stage 3^＋ who received intravitreal ranibizumab injections between October 2014 and Janu ary 2017 at the Department of Ophthalmology in our hospital. No prior laser or other intravitreal treatment was done. Prior to the intervention and at each follow-up visit, fundus examination was performed. Gestational age at birth, sex, birth weight, ROP zone, ROP stage, post menstrual age（PMA） at treatment, and follow-up pe riod were recorded. The final clinical status of the retina was evaluated for each patient. The primary outcome mea sures included ROP recurrences requiring re-treatment, complete or incomplete peripheral ***： Eighty-six eyes of 46 premature infants with Zone Ⅱ Stage 3~＋ ROP were enrolled in the study. The mean gestational age at birth was 28.18±1.67（range： 25 to 33）wk and the mean birth weight was 1070.57±226.85（range： 720.00 to 1650.00） g. The mean PMA at treatment was 38.32±2.99（range： 32.29 to 46.00）wk. Seventy-one eyes（82.56%） were treated success fully with intravitreal ranibizumab as monotherapy. Fifteen eyes（17.44%） developed recurrent disease. The mean interval between the treatment and retreatment was 5.96±3.22（range： 1.86 to 11.71）wk. All eyes vascularized into zone Ⅲ at the end of the study and among them 62 eyes（72.09%） achieved complete vascu ***： Intravitreal ranibizumab injection is an effective treatment in Zone Ⅱ Stage 3^＋ ROP patients. More patients with longer follow-up duration are necessary to confirm the safety and efficacy of this treatment.

关键词： retinopathy of prematurity ranibizumab plus disease