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Detection In Situ of E-cadherin,β-catenin,TCF4 and CDX2 in Various Gastric Diseases

Chinese Journal of Cancer Research 2009年第3期21卷 185-193页

作者： xiu-wen yu qian xu yue-hua gong nan-nan dong yuan yuan Cancer Control Laboratory Cancer Institute the First Affiliated Hospital China Medical University Shenyang 110001 China

Objective： To investigate the expressions of E-cadherin, β-catenin, transcription factor 4 （TCF4）, which are related with Wnt/β-catenin signaling pathway, and Caudal-type Homeobox Protein 2 （CDX2） originated from intestine, in various gastric diseases and its influence on gastric carcinogenesis and differentiation. Methods： A total of 319 various gastric diseases samples from gastroscopy were detected in situ using immunohistochemistry, and data were analyzed with Х^2 test and Kendall＇s tau-b rank correlation coefficient analysis. Results： Along with the progression from superficial gastritis （SG） to atrophic gastritis （AG） to gastric cancer （GC）, the expressions of E-cadherin and β-catenin appeared a decreasing tendency in total, while β-catenin emerged a decreasing tendency in the cell membrane and an increasing in the nucleus, and the highly positive expression rate of intranuclear transcription factor TCF4 appeared an increasing tendency. The transcription factor CDX2 had a higher expression in AG and GC than that in SG. The expression rates of the four proteins above in intestinal type adenocarcinoma were all higher than those in diffuse type carcinoma. There were positive correlations between E-cadherin and β-catenin expressed in cytoplasm, between β-catenin expressed in cell membrane and β-catenin in cytoplasm, between β-catenin expressed in cytoplasm and β-catenin in nucleus, between β-catenin and TCF4 in nucleus, between TCF4 and CDX2 in nucleus, respectively （P〈0.05）. And β-catenin and CDX2 had no relevance in nucleus （P〉0.05）. Conclusion： We found that the four proteins were involved in gastric carcinogenesis and the differentiation to intestinal type adenocarcinoma.

关键词： Superficial gastritis (SG) Atrophic gastritis (AG) Gastric cancer (GC) E-cadherin β-catenin TCF4 CDX2

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幽门螺杆菌在胃癌及其癌前疾病中的原位检测及意义

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世界华人消化杂志 2008年第33期16卷 3740-3745页

作者：于秀文董楠楠宫月华徐倩袁媛中国医科大学附属第一医院普通外科研究所暨肿瘤研究所第三研究室辽宁省高校肿瘤病因与预防重点实验室辽宁省沈阳市110001

目的:探讨H pylori感染在胃癌及癌前疾病中的分布状态以及在胃癌的发生及分化中的作用以及免疫组化法检测H pylori感染的价值.方法:随机选取辽宁省庄河地区不同胃疾病胃黏膜活检标本327例,包括慢性浅表性胃炎63例、萎缩性胃炎62例,胃癌... 详细信息

目的:探讨H pylori感染在胃癌及癌前疾病中的分布状态以及在胃癌的发生及分化中的作用以及免疫组化法检测H pylori感染的价值.方法:随机选取辽宁省庄河地区不同胃疾病胃黏膜活检标本327例,包括慢性浅表性胃炎63例、萎缩性胃炎62例,胃癌202例,常规HE染色及免疫组织化学染色,观察黏膜、黏液H pylori感染密度.结果:不同胃疾病H pylori在胃黏膜定植状态为浅表性胃炎、萎缩性胃炎高于胃癌(χ2=96.998,87.542,均P2时,浅表性胃炎、萎缩性胃炎高于胃癌(χ2=20.252,46.248,均P<0.01),萎缩性胃炎高于浅表性胃炎(χ2=4.746,P<0.05),胃癌与癌周黏膜无统计学差异,肠型胃癌高于弥漫型胃癌(χ2=6.784,P<0.01).结论:不同胃疾病H pylori分布,浅表性胃炎、萎缩性胃炎高于胃癌,胃癌低于癌周黏膜,肠型高于弥漫型.黏液内游离H pylori密度评分胃癌组织与癌周黏膜无差异.免疫组化染色检测H pylori优于HE.

关键词：幽门螺杆菌免疫组织化学原位检测胃疾病分布状态

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粘蛋白MUC1 568A/G SNP与辽宁地区人群胃癌遗传易感性的关系

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遗传 2008年第9期30卷 1163-1168页

作者：徐倩孙丽萍宫月华徐莹董楠楠袁媛中国医科大学附属第一医院肿瘤研究所第三研究室暨普通外科研究所肿瘤病因与预防实验室沈阳110001

为了探讨粘蛋白(MUC1)基因568位点A/G单核苷酸多态性与胃癌遗传易感性的关系,采用序列特异性引物-聚合酶链反应(Sequence specific primers PCR,PCR-SSPs)检测来自辽宁地区人群138例胃癌患者及与其配比的131例对照个体MUC1568位点A/G多... 详细信息

为了探讨粘蛋白(MUC1)基因568位点A/G单核苷酸多态性与胃癌遗传易感性的关系,采用序列特异性引物-聚合酶链反应(Sequence specific primers PCR,PCR-SSPs)检测来自辽宁地区人群138例胃癌患者及与其配比的131例对照个体MUC1568位点A/G多态性,以ELISA法检测血清***抗体。结果显示:(1)对照人群MUC1基因568位点AA、AG、GG3种基因型分布频率分别为73.3%、22.1%、4.6%;(2)胃癌组MUC1AA基因型携带频率显著高于正常对照组(P=0.03),携带MUC1AA基因型个体胃癌的发病风险增高到1.92倍;(3)以MUC1AG+GG基因型并血清幽门螺杆菌(***)IgG抗体阴性的个体为对照,AG+GG基因型并***抗体阳性个体、AA基因型并***抗体阴性个体、AA基因型并***抗体阳性个体胃癌患病风险增高,但3组各组间差异均无统计学意义(P>0.05)。说明MUC1基因568位点A/G多态与胃癌的遗传易感性相关;MUC1A/G基因多态性和***感染在胃癌发生发展过程未见交互作用。

关键词：基因多态性粘蛋白MUC1 胃癌幽门螺杆菌

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Lower Hybrid Current Drive Effects on HT-7 Superconducting Tokamak

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Chinese Physics Letters 1998年第6期15卷 435-437页

作者： KUANG Guang-li xu Wei-hua ZHANG Xiang-qin SHAN Jia-fang LIU yue-xiu LIU Deng-cheng ZHENG Guang-hua LIU Fu-kun LIN Jian-an WU Jun-shuan JIN qian-chun DING Bo-jiang YANG Chun-sheng ZHOU yuan-wei SHANG Lian-quan xu Han-dong FAN Heng-yu FANG yu-de XIE Ji-kang WAN yuan-xi Institute of Plasma Physics Chinese Academy of SciencesHefei 230031

Lower hybrid current drive(LHCD)experiments have been done on the superconducting Tokamak HT-7 by using a new developed long pulse megawatt lower hybrid wave *** LHCD efficiency of 0.5×10^(19)A·m^(-2)/W in a pulse length of several hundreds of milliseconds has been *** boronization of the tokamak vacuum vessel,considerable improvements of plasma energy confinement and particle confinement during LHCD phase have been achieved by adjusting wave *** energy transfer from the lower hybrid wave to plasma bulk electrons has been demonstrated experimentally.A computer simulation of the LHCD experiments by using a ray tracing code combined with a two dimensional Fokker-Planck code is in good accordance with experimental measurements and suggests an important role of plasma current profile.

关键词： wave hundreds energy

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The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-yun Zhao Shao-Lin Xiong Xiang-Yang wen Xin-Qiao Li Ce Cai Shuo Xiao Qi Luo wen-Xi Peng dong-Ya Guo Zheng-hua An Ke gong Jin-yuan Liao Yan-Qiu Zhang yue huang Lu Li Xing wen Fei Zhang Jing Duan Chen-Wei Wang dong-Li Shi Peng Zhang Qi-Bin Yi Chao-Yang Li Yan-Bing xu Xiao-hua Liang Ya-Qing Liu Da-Li Zhang Xi-Lei Sun Fan Zhang Gang Chen huan-yu Wang Sheng Yang Xiao-Jing Liu Min Gao Mao-Shun Li Jin-Zhou Wang Xing Zhou Yi Zhao Wang-Chen xue Chao Zheng Jia-Cong Liu Xing-Bo Han Jin-Ling Qi Jia huang Ke-Ke Zhang Can Chen Xiong-Tao Yang dong-Jie Hou yu-Sa Wang Rui Qiao Xiang Ma Xiao-Bo Li Ping Wang Xin-Ying Song Li-Ming Song Shi-Jie Zheng Bing Li Hong-Mei Zhang yue Zhu Wei Chen Jian-Jian He Zhen Zhang Jin Hou Hong-Jun Wang Yan-Chao Hao Xiang-yu Wang Zong-yuan Yang Zhi-Long wen Zhi Chang yuan-yuan Du Rui Gao Xiao-Fei Lan Yan-Guo Li Gang Li xu-Fang Li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui Wang Hui-Zhen Wang yu-Peng xu Jia-Wei Yang xue-Juan Yang Shuang-nan Zhang Chao-yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-Wei Liu Yi-Peng Jing Gang Wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai yue Wu Yan Cai Shu-yun Cao Zi-huang Cao Jeffrey L.Carlin Hai-yuan Chen Jian-Jun Chen Kun-Xin Chen Li Chen xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao dong Bing Du dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao xue-Fei gong Bo-Zhong Gu Yan-Xin Guo Zhan-wen Han Bo-Liang He Jin-Liang Hou Yong-Hui Hou wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-wen Hu Zhi-Ying Huo Lei Jia Fang-hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong xu Kong Ya-Juan Lei Ai-hua Li Chang-hua Li Guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-nan Li Yan Li Yin-Bi Li Ye-Ping Li yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu wen-Zhi Lu yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-nan Wang You Wang yue-Fei Wang You-Fen Wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu xue-Bing Wu yu-Zhong Wu Xiao-Zheng Xing Ling-Zhe xu Xin-Qi xu Yan xu Tai-Sheng Yan De-hua Yang Hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong yu Hui yuan Hai-Bo yuan Hai-Long yuan Wei-Min yuan Chao Zhai En-Peng Zhang hua-Wei Zhang Jian-nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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Searching for ^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao Zhang Jun-Zheng Wang Li-Tao Yang qian yue Ke-Jun Kang yuan-Jing Li Hai-Peng An C.Greeshma Jian-Ping Chang yun-huan Chen Jian-Ping Cheng wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng Hui gong Qiu-Ju Guo xu-yuan Guo Li He Sheng-Ming He Jin-Wei Hu Han-Xiong huang Tu-Chen huang Hai-Tao Jia Xi Jiang S.Karmakar Hao-Bin Li Jian-Min Li Jin Li qian-yun Li Ren-Ming-Jie Li xue-qian Li yu-Lan Li Yi-Fan Liang Bin Liao Fong-Kay Lin Shin-Ted Lin Jia-xuan Liu Shu-Kui Liu Yan-dong Liu yu Liu yuan-yuan Liu Zhong-Zhi Liu Hao Ma yu-Cai Mao Qi-yuan Nie Jin-hua Ning Hui Pan Ning-Chun Qi Jie Ren Xi-Chao Ruan Ze She Manoj Kumar Singh Tian-Xi Sun Chang-Jian Tang Wei-You Tang Yang Tian Guang-Fu Wang Li Wang Qing Wang yu-Feng Wang yun-Xiang Wang Henry-Tsz-King Wong Shi-Yong Wu yu-Cheng Wu Hao-Yang Xing Rui xu Yin xu Tao xue yu-Lu Yan nan Yi Chun-xu yu Hai-Jun yu Jian-Feng yue Ming Zeng Zhi Zeng Feng-Shou Zhang Lei Zhang Zhen-hua Zhang Zhen-yu Zhang Kang-Kang Zhao Ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the China Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of ^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

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Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-Sheng Zhao dong Li Shao-Lin Xiong Yan-Qiu Zhang Yang Su Wei Chen Yi Zhao Xiao-Bo Li Jia-Cong Liu wen-Xi Peng Rui Qiao Xin-Qiao Li Xiang-Yang wen Li-Ming Song Shi-Jie Zheng Xin-Ying Song Xiao-yun Zhao yue huang Shuang-nan Zhang Shuo Xiao Ce Cai Zheng-hua An Can Chen Gang Chen Wei Chen Yan-Qi Du Min Gao Ke gong dong-Ya Guo Zhi-Wei Guo Jian-Jian He Bin Li Chao Li Chao-Yang Li Gang Li Jian-Hui Li Lu Li Qing-Xin Li Yan-Guo Li Jing Liang Xiao-hua Liang Jin-yuan Liao Xiao-Jing Liu Ya-Qing Liu Qi Luo Xiang Ma Bin Meng Ge Ou dong-Li Shi Jing-Yan Shi gong-Xing Sun Xi-Lei Sun You-Li Tuo Chen-Wei Wang Hui Wang Jin Wang Jin-Zhou Wang Ping Wang wen-Shuai Wang Hong Wu Sheng-Lun Xie Yan-Bing xu yu-Peng xu Wang-Chen xue Sheng Yang Min Yao Jian-Ying Ye Qi-Bin Yi Chao-yue Zhang Da-Li Zhang Fan Zhang Fei Zhang Hong-Mei Zhang Kai Zhang Peng Zhang Xiao-Lu Zhang Zhen Zhang Guo-Ying Zhao Shi-Yi Zhao Chao Zheng Xing Zhou yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

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Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin Liu yue huang Guang-Cheng Xiao Qing-Cui Bu Jin-Lu Qu Shu Zhang Shuang-nan Zhang Shu-Mei Jia Fang-Jun Lu Xiang Ma Lian Tao Wei Zhang Li Chen Li-Ming Song Ti-Pei Li yu-Peng xu xue-Lei Cao Yong Chen Cong-Zhan Liu Ce Cai Zhi Chang Gang Chen Tian-Xiang Chen Yi-Bao Chen yu-Peng Chen Wei Cui Wei-Wei Cui Jing-Kang Deng Yong-Wei dong yuan-yuan Du Min-xue Fu Guan-hua Gao He Gao Min Gao Ming-yu Ge yu-dong Gu Ju Guan Cheng-Cheng Guo Da-Wei Han Jia Huo Lu-hua Jiang Wei-Chun Jiang Jing Jin Yong-Jie Jin Ling-Da Kong Bing Li Cheng-Kui Li Gang Li Mao-Shun Li Wei Li Xian Li Xiao-Bo Li xu-Fang Li Yang-Guo Li Zheng-Wei Li Xiao-hua Liang Jing-yuan Liao Bai-Sheng Liu Guo-Qing Liu Hong-Wei Liu Xiao-Jing Liu Yi-Nong Liu Bo Lu xue-Feng Lu Qi Luo Tao Luo Bin Meng Yi nang Jian-Yin Nie Ge Ou Na Sai Ren-Cheng Shang Xin-Ying Song Liang Sun Ying Tan You-Li Tuo Chen Wang Guo-Feng Wang Juan Wang Ling-Jun Wang weng-Shuai Wang yu-Sa Wang Xiang-Yang wen Bai-Yang Wu Bo-Bing Wu Mei Wu Shuo Xiao Shao-Lin Xiong He xu Jia-Wei Yang Sheng Yang Yan-Ji Yang Yi-Jung Yang Qi-Bin Yi qian-Qing Yin yuan You Ai-Mei Zhang Cheng-Mo Zhang Fan Zhang Hong-Mei Zhang Juan Zhang Tong Zhang Wan-Chang Zhang wen-Zhao Zhang Yi Zhang Yi-Fei Zhang Yong-Jie Zhang yuan-Hang Zhang yue Zhang Zhao Zhang Zhi Zhang Zi-Liang Zhang Hai-Sheng Zhao Xiao-Fan Zhao Shi-Jie Zheng Yao-Guang Zheng Deng-Ke Zhou Jian-Feng Zhou yu-xuan Zhu Ren-Lin Zhuang yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

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异基因造血干细胞移植术治疗骨髓增生异常综合征患者临床疗效的分析

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中国实验血液学杂志 2021年第1期29卷 172-180页

作者：王清云董玉君王倩刘微孙玉华尹玥梁赜隐许蔚林李渊北京大学第一医院血液内科 100034

目的:分析异基因造血干细胞移植术(allo-HSCT)治疗骨髓增生异常综合征(MDS)患者的临床疗效,并探讨移植后复发的治疗新策略。方法:选取并回顾性分析2013年4月至2019年11月于北京大学第一医院行allo-HSCT的MDS患者共72例,总结移植疗效,并... 详细信息

目的:分析异基因造血干细胞移植术(allo-HSCT)治疗骨髓增生异常综合征(MDS)患者的临床疗效,并探讨移植后复发的治疗新策略。方法:选取并回顾性分析2013年4月至2019年11月于北京大学第一医院行allo-HSCT的MDS患者共72例,总结移植疗效,并对影响患者生存及复发的危险因素进行探讨。结果:72例患者中,中位随访时间37(12~111)个月,57例(79.2%)患者存活,15例(20.8%)死亡。5年总生存(OS)率、无病生存(DFS)率分别为76.6%和62.3%。IPSS-R预后危险分层、TP53突变、慢性移植物抗宿主病(cGVHD)为影响患者移植后OS的危险因素,IPSS-R预后危险分层、TP53突变、Ⅲ-Ⅳ度急性移植物抗宿主病(aGVHD)为影响患者移植后DFS的危险因素。移植后,19例(26.4%)患者发生aGVHD,5例(6.9%)患者发生Ⅲ-Ⅳ度aGVHD,25例(34.7%)患者发生cGVHD,4例(5.6%)发生广泛型cGVHD。17例(23.3%)患者在移植后出现复发,5年的累积复发率为27.5%,IPSS-R预后危险分层、TP53突变、cGVHD为影响患者复发的危险因素。复发后中位生存时间为9个月。复发后有7例患者获得无病生存,10例死亡,接受甲基化药物(HMA)联合G-CSF动员的供者淋巴细胞输注(DLI)维持治疗患者的3年OS率显著高于未接受维持治疗的患者(80.0%vs 10.0%,P=0.002)。结论:allo-HSCT是治疗中高危MDS患者的有效方法,但移植后复发仍为影响患者生存的主要因素。多次HMA联合DLI的维持治疗可能提高移植后复发患者的长期生存。

关键词：骨髓增生异常综合征异基因造血干细胞移植生存复发去甲基化药物

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