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Autocrine IL-8 Contributes to Propionibacterium Acnes-induced Proliferation and Differentiation of HaCaT Cells via AKT/FOXO1/Autophagy

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Current Medical Science 2024年第5期44卷 1058-1065页

作者： xiu-qin yu Jin-zhu MAO Shu-yun YANG Lu WANG Chang-zhi YANG Lei HUANG Qi-hong QIAN Ting-ting ZHU Department of Dermatology the First Affiliated Hospital of Soochow UniversitySuzhou215006China Department of Dermatology Baoshan People’s Hospital of Yunnan ProvinceBaoshan678000China

Objective Proprionibacterium acnes(***)-induced inflammatory responses,proliferation and differentiation of keratinocytes contribute to the progression of acne vulgaris(AV).*** was found to enhance the production of interleukin-8(IL-8)by *** study aimed to investigate the role of IL-8 in ***-induced proliferation and differentiation of keratinocytes and the underlying *** The ***-stimulated HaCaT cell(a human keratinocyte cell line)model was *** blotting and immunofluorescence were performed to detect the expression of the IL-8 receptors C-X-C motif chemokine receptor 1(CXCR1)and C-X-C motif chemokine receptor 2(CXCR2)on HaCaT *** counting kit-8(CCK-8)assay,5-ethynyl-20-deoxyuridine(EdU)assay and Western blotting were performed to examine the effects of IL-8/CXCR2 axis on the proliferation and differentiation of HaCaT cells treated with ***,the IL-8 neutralizing antibody,the CXCR2 antagonist(SB225002),or the CXCR1/CXCR2 antagonist(G31P).Western blotting,nuclear and cytoplasmic separation,CCK-8 assay,and EdU assay were employed to determine the downstream pathway of CXCR2 after ***-stimulated HaCaT cells were treated with the CXCR2 antagonist,the protein kinase B(AKT)antagonist(AZD5363),or the constitutively active forkhead box O1(FOXO1)***,autophagy markers were measured in HaCaT cells following the transfection of the FOXO1 mutant or treatment with the autophagy inhibitor 3-methyladenine(3-MA).Results The expression levels of CXCR1 and CXCR2 were significantly increased on the membrane of HaCaT cells following *** *** IL-8/CXCR2 axis predominantly promoted the proliferation and differentiation of ***-induced HaCaT cells by activating AKT/FOXO1/autophagy *** brief,IL-8 bound to its receptor CXCR2 on the membrane of keratinocytes to activate the AKT/FOXO1 ***,phosphorylated FOXO1 facilitated autophagy to promote the proliferation and diffe

关键词： acne vulgaris Proprionibacterium acnes keratinocyte interleukin-8 C-X-C motif chemokine receptor 2 protein kinase B forkhead box O1 autophagy

Influence of Ammoniacal Copper Quaternary treatments on mechanical properties of blue-stained Lodgepole Pine wood

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Journal of Forestry Research 2007年第3期18卷 213-216页

作者： JIANG Jing-hui REN Hai-qing LU Jian-xiong LUO xiu-qin WU yu-zhang Research Institute of Wood Industry Chinese Academy of Forestry Key Laboratory of Wood Science and Technology of State Forestry Administration Beijing 100091 China

Three concentrations （2.8%, 2.0%, 1.2%） of Ammoniacal Copper Quaternary （ACQ） was selected to treat Lodgepole pine wood for evaluating ACQ treatment on mechanical properties of blue-stained wood. The bending modules of elasticity （MOE）, modules of rupture （MOR）, toughness and shearing strength parallel to grain on tangential surface, are tested according to the criteria GB1927-1943-91. Non-treated sample were also tested according to the same procedure. The results showed that the three groups specimen impregnated by different concentrations of ACQ solution met the AWPA standard 2003 of America （UC4A 6.4g/cm^3）. There were significant difference of toughness between treated wood and non-treated wood （p=0.01）, but there were no statistically significant differences among three concentrations in terms of toughness, and toughness of treated wood was approximately 20% lower than non-treated. MOR, MOE as well as sheafing strength parallel to grain were found to be not significantly different between treated wood and non-treated one, and there were no statistically significant difference among three concentrations of ACQ too. Toughness, MOR, MOE and sheafing strength parallel to grain increased with decrease of concentration of ACQ, but they were hardly affected by ACQ preservatives.

关键词： Lodgepole pine wood Blue-treated wood Non-treated wood Toughness Modules of rupture Modules of elasticity Sheafing strength parallel to grain

Downstaging followed by resection plays a role in improving prognosis of unresectable hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2004年第4期3卷 495-498页

作者： Zhao-You Tang,Xin-Da Zhou, Zeng-Chen Ma, Zhi-Quan Wu, Jia Fan, Lun-xiu qin and Yao yu Shanghai, China Liver Cancer Institute & Zhongshan Hospital, Fudan University, Shanghai 200032 , China Liver Cancer Institute of Fudan University 136 Yi Xue Yuan Road Zhongshan Hospital Shanghai 200032 China. zytang@***

BACKGROUND: Curable outcome of unresectable hepato- cellular carcinoma ( HCC) was seldom encountered in the past. This study was designed to assess the role of down- staging followed by resection ( downstaging-resection) in the improvement of prognosis of unresectable HCC. METHODS: During the period of 1958-2003 , a total of 1085 patients were verified surgically to be unresectable. Of these patients, 139 received downstaging-resection, with a rate of 84.2% for coexisting cirrhosis and a median tumor diame- ter of 11.1 cm. Resection of the right lobe, hepatic hilum and bilateral cancer accounted for 97. 8% of the patients. Downstaging including hepatic artery ligation ( HAL) + he- patic artery chemo-infusion ( HAI ) was performed in 65.5% of the patients, HAL + HAI + radiotherapy/radioim- munotherapy in 29. 5%, and HAL or HAI alone in 5.0%. Retrospective analysis was made of the survival of patients with unresectable HCC, downstaging-resection rate and treatment pattern. RESULTS: In the 139 patients with downstaging-resection, the median interval between the first and second operation was 7.2 months and the 5-year survival rate calculated from the first operation was 48. 7%. In the 1085 patients with un- resectable HCC, their 5-year survival was 0% in the period of 1958-1973, 11.5% in the period of 1974-1988 and 19.3% in the period of 1989-2003. These figures were correlated with the increasing downstaging-resection rate from 0%, 9.0% to 15.6%, and the increasing percentage of triple or double combination treatment from 32.2%, 60.4% to 69.7%. The 5-year survival in triple treatment group was 24. 9%, double treatment 15.2%, and single treatment only 10.9%, which was also correlated with the downstaging-re- section rate of 34.6%, 16.2% and 1.8% respectively. CONCLUSIONS: Downstaging-resection plays a role in improving prognosis of unresectable HCC. Triple and double treatments provide a higher downstaging-resection rate and may result in better prognosis.

关键词： hepatocellular carcinoma downstaging cytoreduction resection multimodality treatment

Magnetron sputtered nickel oxide with suppressed interfacial defect states for efficient inverted perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 348-355页

作者： Guoqiang Ma qin Tan Zhaoning Li Jingwei xiu Jiafeng Wang Tianle Cheng Dong He Qiang Sun Xuhang Ma Francesco Lamberti Zhubing He Department of Materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research Facilities Southern University of Science and Technology Department of Chemical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （NiOx） based perovskite solar cells often suffer from severe interfacial reactions between the NiOxand adjacent perovskite layers due to surface defect states,which inherently impair device performance in a long-term view,even with surface molecule *** this study,we developed high-quality magnetron-sputtered NiOxthin films through detailed process optimization,and compared systematically sputtered and spin-coated NiOxthin film surfaces from materials to *** sputtered NiOxfilms exhibit improved crystallinity,smoother surfaces,and significantly reduced Ni3+or Ni vacancies compared to their spin-coated ***,the interface between the perovskite and sputtered NiOxfilm shows a substantially reduced density of defect *** solar cells （PSCs） fabricated with our optimally sputtered NiOxfilms achieved a high power conversion efficiency （PCE） of up to 19.93%and demonstrated enhanced stability,maintaining 86.2% efficiency during 500 h of maximum power point tracking under one standard sun ***,with the surface modification using (4-(2,7-dibromo-9,9-dimethylacridin-10（9H）-yl)butyl)p hosphonic acid （DMAcPA）,the device PCE was further promoted to 23.07%,which is the highest value reported for sputtered NiOxbased PSCs so far.

关键词： Nickle oxide Magnetron sputter Defect Stability Perovskite solar cell

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不同发包模式对油库改造项目过程管理的影响

化工管理 2020年第25期 181-182页

作者：秦秀豫中海油广东销售有限公司广东广州510240

油库改造项目是涉及多专业、多工种、具有危险性的工程项目,根据工作内容划分不同的采办包进行发包,不同的发包模式会对项目过程管理产生较大的影响。本文通过不同发包模式下L油库改造项目和N油库改造项目的过程管理对比,得出项目管理... 详细信息

油库改造项目是涉及多专业、多工种、具有危险性的工程项目,根据工作内容划分不同的采办包进行发包,不同的发包模式会对项目过程管理产生较大的影响。本文通过不同发包模式下L油库改造项目和N油库改造项目的过程管理对比,得出项目管理应根据项目工作内容合理划分采办包进行发包,合理的发包模式有助于管理目标实现,而项目管理目标实现的情况会对项目管理人员的心理健康产生影响。

关键词：发包模式过程管理心理健康

单中心重型血友病A患者FⅧ基因突变类型与FⅧ抑制物产生的相关性分析

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中国实验血液学杂志 2022年第5期30卷 1536-1540页

作者：朱履锴张夏林刘秀娥秦秀玉王刚杨林花山西医科大学血液病学研究所山西医科大学第二医院血液科(山西医科大学第二临床医学院)山西太原030001

目的:探讨重型血友病A(Hemophilia A,HA)患者的凝血因子Ⅷ(FactorⅧ,FⅧ)抑制物的产生与FⅧ基因突变之间的关系。方法:回顾2009年1月至2020年9月172例重型HA患者的病历资料,收集FⅧ基因突变类型与FⅧ抑制物产生情况,分为高风险突变组(包... 详细信息

目的:探讨重型血友病A(Hemophilia A,HA)患者的凝血因子Ⅷ(FactorⅧ,FⅧ)抑制物的产生与FⅧ基因突变之间的关系。方法:回顾2009年1月至2020年9月172例重型HA患者的病历资料,收集FⅧ基因突变类型与FⅧ抑制物产生情况,分为高风险突变组(包括1倒位、大片段缺失、无义突变)、低风险突变组(包括错义突变、小缺失/插入、剪接位点突变)和22倒位组。分析重型HA患者FⅧ基因型与FⅧ抑制物产生的关联性。结果:172例重型HA患者中,21例患者产生了FⅧ抑制物,高风险组FⅧ抑制物10例,发生率为32%(大片段缺失75%,1倒位43%,无义突变20%),低风险组FⅧ抑制物2例,发生率为5%(错义突变6%,小缺失/插入5%,剪接位点突变0%),22倒位组FⅧ抑制物9例,发生率为9%。与22倒位组相比,高风险组具有更高的FⅧ抑制物发生风险(OR=4.7,95%CI:1.7-13.0),低风险组与22倒位FⅧ抑制物发生风险无明显差异(OR=0.5,95%CI:0.1-2.3)。与低风险组相比,高风险组具有更高的FⅧ抑制物发生风险(OR=9.8,95%CI:2.0-48.7)。结论:FⅧ基因发生1倒位、大片段缺失、无义突变是重型HA患者FⅧ抑制物产生的危险因素。

关键词：血友病A 因子Ⅷ FⅧ抑制物 FⅧ基因突变

乳腺癌根治术患者围手术期健康教育路径表实施效果评价

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内蒙古民族大学学报（自然科学版） 2017年第2期32卷 170-172页

作者：金秀琴杨雨民内蒙古民族大学附属医院内蒙古通辽028000

目的:探讨健康教育路径对乳腺癌根治术患者康复的影响.方法:将126例行乳腺癌根治术患者随机分成观察组和对照组各63例.对照组采用传统的健康教育方法对患者进行健康教育,观察组采用健康教育路径表对患者实施健康教育,观察两组病人疾病... 详细信息

目的:探讨健康教育路径对乳腺癌根治术患者康复的影响.方法:将126例行乳腺癌根治术患者随机分成观察组和对照组各63例.对照组采用传统的健康教育方法对患者进行健康教育,观察组采用健康教育路径表对患者实施健康教育,观察两组病人疾病健康知识掌握、术后并发症发生情况、患侧肢体功能恢复状况.结果:观察两组病人疾病健康知识掌握情况及患侧肢体功能恢复情况均明显优于对照组,术后并发症发生率明显降低,差别有显著意义(P<0.05).结论:应用健康教育路径表可以保证健康教育实施的有效性,提高患者对疾病相关知识的认识和掌握,促使采用健康行为,有效地促进康复.

关键词：乳腺癌根治术健康教育路径并发症康复

重型血友病A患者凝血因子Ⅷ基因内含子22倒位检测

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中华血液学杂志 2013年第11期34卷 918-921页

作者：郭志萍陈剑芳秦秀玉张耀方杨林花山西医科大学第二医院血液科太原030001

目的检测重型血友病A（HA）患者凝血因子Ⅷ（FⅧ）基因内含子22倒位（INV22）的发生频率，探讨部分重型HA患者的发病机制，并对患者家系女性成员进行携带者诊断。方法126例重型HA患者均为男性，中位年龄14岁（4个月～63岁）。应用一期... 详细信息

目的检测重型血友病A（HA）患者凝血因子Ⅷ（FⅧ）基因内含子22倒位（INV22）的发生频率，探讨部分重型HA患者的发病机制，并对患者家系女性成员进行携带者诊断。方法126例重型HA患者均为男性，中位年龄14岁（4个月～63岁）。应用一期法检测凝血因子Ⅷ活性（FⅧ：C）；采用长距离PCR（LD—PCR）结合脉冲场凝胶电泳（PFGE）进行FⅧ基因1NV22检测，并对其中3例1NV22阳性患者进行家系调查。结果126例重型HA患者中检mINV22阳性患者52例（41．3％）。3个INV22阳性家系中疑为携带者的11例女性成员中检m携带者4例，其中3例为患者母亲，1例为患者胞姐。其中1个家系无家族史，该家系8名女性成员中除患者的姨表妹未检测外，其余7名成员检测结果显示患者母亲为INV22携带者，其外祖母及2个姨母、2个同胞姐妹及1个姨表姐均为非携带者。结论LD—PCR结合PFGE检测FⅧ基因INV22可用于部分重型HA患者和携带者基因诊断。

关键词：血友病A 内含子聚合酶链反应电泳,凝胶,脉冲场

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特非那定对成人哮喘者呼气流速的作用

中国新药与临床杂志 1998年第4期17卷 220-222页

作者：石昭泉叶曜芩修清玉罗文侗陈艺坛上海长征医院

目的：研究特非那定对成人哮喘的作用。方法：采用随机、单盲、交叉对照法，以呼气峰流速仪监测２０例稳定期或轻度发作期成年哮喘病人口服特非那定（６０ｍｇ，ｂｉｄ×２ｗｋ）时的呼气峰流速（ＰＥＦ）及其变异率（ＰＥＦＲＶ）。结... 详细信息

目的：研究特非那定对成人哮喘的作用。方法：采用随机、单盲、交叉对照法，以呼气峰流速仪监测２０例稳定期或轻度发作期成年哮喘病人口服特非那定（６０ｍｇ，ｂｉｄ×２ｗｋ）时的呼气峰流速（ＰＥＦ）及其变异率（ＰＥＦＲＶ）。结果：口服特非那定时ＰＥＦＲＶ和ＰＥＦ分别为１３％±ｓ１０％和２９２±８９Ｌ／ｍｉｎ，不用特非那定时分别为１９％±７％和２８１±１０４Ｌ／ｍｉｎ。胸闷、气急、咳嗽、咯痰及喘鸣有效率分别为７９％，８２％，８４％，５０％和３８％。对过敏性鼻炎症状（鼻痒、流涕。

关键词：哮喘呼气流速特非那定