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Acta Metallurgica Sinica(English Letters) 2021年第2期34卷 205-216页

作者： Jun-xiu Chen Xiang-Ying zhu Li-Li Tan Ke Yang Xu-ping Su Key Laboratory of Materials Surface Science and Technology of Jiangsu Province Changzhou UniversityChangzhou 213164China Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering Changzhou UniversityChangzhou 213164China National Experimental Teaching Demonstration Center of Materials Science and Engineering Changzhou UniversityChangzhou 213164China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

Effects of equal channel angular pressing(ECAP)extrusion on the microstructure,mechanical properties and biodegradability of Mg–2Zn–xGd–0.5Zr(x=0,0.5,1,2 wt%)alloys were studied in this *** analysis,tensile test at ambient temperature,immersion test and electrochemical test in Hank’s solution were carried *** results showed that Gd could further enhance the grain refinement during the ECAP *** Gd addition and ECAP extrusion could improve the mechanical properties of the alloys,and the extrusion played the dominant *** addition of Gd(0.5–1 wt%)could obviously enhance the corrosion resistance of the *** some extent,ECAP extrusion improved the corrosion resistance of the alloys due to the change of second phases distribution and the refinement of *** increase in extrusion pass was detrimental to the improvement of the corrosion resistance as a result of increment of the grain boundaries.

关键词： Mg alloys Gd addition ECAP extrusion pass Mechanical property Biodegradable behavior

荧光染色法在实验性异种角膜移植术后免疫诊断中的应用

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国际眼科杂志 2013年第11期13卷 2182-2184页

作者：刘先宁武鹏安吴洁程燕潘士印肖湘华艾婷婷安娜王伟朱秀萍中国陕西省西安市第一医院陕西省眼科研究所 710002 中国陕西省西安市第一医院病理科 710002 西安市眼科医院 710002

目的:采用单克隆抗体间接免疫荧光法测定异种角膜移植术后不同时间点角膜组织中CD4,CD8T淋巴细胞的变化。方法:取正常兔角膜、腋窝淋巴结组织;鸵鸟-兔异种角膜移植术后1,2wk角膜组织,经甲醛固定,常规石蜡包埋切片脱蜡复水,胃酶消化法进... 详细信息

目的:采用单克隆抗体间接免疫荧光法测定异种角膜移植术后不同时间点角膜组织中CD4,CD8T淋巴细胞的变化。方法:取正常兔角膜、腋窝淋巴结组织;鸵鸟-兔异种角膜移植术后1,2wk角膜组织,经甲醛固定,常规石蜡包埋切片脱蜡复水,胃酶消化法进行抗原修复,用鼠抗兔CD4,CD8单克隆抗体及荧光标记的羊抗鼠IgG进行免疫组化测定,荧光显微镜下观察角膜组织中CD4+,CD8+T淋巴细胞的表达。结果:鸵鸟-兔异种角膜移植后1wk角膜组织中CD4+,CD8+T淋巴细胞的表达为阴性,2wk时T淋巴细胞CD4呈强阳性表达,CD8呈阴性表达。结论:采用间接免疫荧光法测定动物异种角膜移植术后不同时间点局部角膜组织中CD4+,CD8+T淋巴细胞的表达,为异种角膜移植排斥反应机制研究及术后药物筛选奠定实验基础。

关键词：异种角膜移植排斥反应石蜡包埋组织间接免疫荧光染色 CIM CD8T淋巴细胞

A 2-D NUMERICAL IRREGULAR WAVE TANK AND ITS VERIFICATION

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Journal of Hydrodynamics 2005年第2期17卷 222-227页

作者： LIBen-xia YUXi-ping YUYu-xiu DepartmentofHydrauhcEngineering TsinghuaUniversityBeijing100084China StateKeyLaboratoryofCoastalandOffshoreEngineering DalianUniversityofTechnologyDalian116024China

A two-dimensional numerical irregular wave tank based on the potential wave theory was developed. A source term was used inside the domain to generate waves, and outgoing waves were dissipated by sponge layers and transmitted by radiation boundary. The σ-coordinate transformation was introduced to map the time-dependent irregular physical domain to a fixed regular computational domain, and thus the free surface and bottom boundary conditions could be implemented precisely. The model was verified by simulating the nonlinear regular and irregular wave propagation on constant-depth water, as well as regular waves reflected from a vertical wall, and satisfactory agreement between numerical results and analytical solutions was obtained. The present numerical model is proved to be an effective tool for a long-duration simulation of coastal wave dynamics where the wave reflection is significant.

关键词： irregular waves numerical wave tank source wave-generating method σ-coordinate transformation potential wave theory

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干燥保存角膜在感染性角膜溃疡治疗中的应用

国际眼科杂志 2008年第1期8卷 199-200页

作者：杨问学吴洁朱秀萍马挺银勇刘先宁西安市第一医院眼科西安市眼科医院及陕西省眼科研究所中国陕西省西安市710002

目的:评价应用干燥保存角膜片对554例严重感染性角膜溃疡行治疗性角膜移植手术的效果。方法:选自我院角膜病组1976-08/2000-12期间应用干燥保存角膜片对严重感染性角膜溃疡行治疗性角膜移植手术共计554例,本组病例统计分类为真菌性(238... 详细信息

目的:评价应用干燥保存角膜片对554例严重感染性角膜溃疡行治疗性角膜移植手术的效果。方法:选自我院角膜病组1976-08/2000-12期间应用干燥保存角膜片对严重感染性角膜溃疡行治疗性角膜移植手术共计554例,本组病例统计分类为真菌性(238例)、单疱病毒性(170例)、细菌性(70例)及混合感染性(76例角膜溃疡4种,分析临床应用效果。结果:本组手术治疗严重感染性角膜溃疡平均有效率88.8%,其中真菌性角膜溃疡81.5%,单疱病毒性角膜溃疡98.2%,细菌性角膜溃疡97.1%,混合感染性角膜溃疡82.9%。结论:无水氯化钙-硅胶干燥长期保存的角膜片为临床随时提供角膜材料,是一项简单易行、便于推广应用的方法;在临床治疗过程中尽快、尽早查明感染病原体,可避免盲目性;对严重感染性角膜溃疡,治疗性角膜移植可直接清除病灶、较快地控制炎症、缩短治疗过程,达到保存眼球及恢复部分有用视力,为下一步光学性角膜移植创造条件。

关键词：感染性角膜溃疡治疗性角膜移植干燥脱水法保存角膜片

以干燥脱水法保存的异种角膜基质为载体构建人工生物角膜上皮组织

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国际眼科杂志 2008年第11期8卷 2214-2216页

作者：刘先宁朱秀萍银勇吴洁杨华张长宁陕西省眼科研究所中国陕西省西安市710002 中国陕西省西安市眼科医院 710002

目的:观察以干燥脱水法保存的鸵鸟角膜基质为载体构建人工生物角膜上皮组织的生物学特性。方法:采用组织块培养法获得新西兰大白兔角膜缘干细胞,经胰蛋白酶消化法获得细胞,种植于干燥脱水法保存的鸵鸟角膜板层基质上,采用气液界面培养... 详细信息

目的:观察以干燥脱水法保存的鸵鸟角膜基质为载体构建人工生物角膜上皮组织的生物学特性。方法:采用组织块培养法获得新西兰大白兔角膜缘干细胞,经胰蛋白酶消化法获得细胞,种植于干燥脱水法保存的鸵鸟角膜板层基质上,采用气液界面培养法进行培养,通过倒置显微镜、透射电子显微镜、荧光显微镜观察其形态学、生长特点,超微结构及免疫学特征。结果:在干燥脱水法保存的鸵鸟角膜基质上种植兔角膜缘干细胞,接种72h后,细胞形成单层,移置气液交界面后继续培养7～10d,逐渐形成复层。经光镜、透射电镜、及免疫学检测显示其具有角膜上皮组织的生物学特性。结论:兔角膜缘干细胞能够在干燥脱水法保存的鸵鸟角膜基质载体上生长,并可形成复层,基本具有正常角膜上皮细胞的形态、超微结构和生物学特性。

关键词：兔角膜缘干燥脱水法保存鸵鸟角膜基质干细胞细胞培养人工生物角膜上皮组织

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近视回归镜控制青少年近视发展的临床观察

国际眼科杂志 2008年第7期8卷 1481-1482页

作者：杨问学张学辉李军唐颖常庆朱秀萍中国陕西省西安市眼科医院 710002 陕西省眼科研究所中国陕西省西安市710002

目的：临床观察近视回归镜对青少年近视发展的防治作用。方法：随机选取52例在我院视光中心就诊的年龄在9～18岁近视患者配戴近视回归镜作为治疗组,观察裸眼视力变化,屈光度变化,眼轴长度及角膜曲率变化情况.并与52例年龄及屈光度相似... 详细信息

目的：临床观察近视回归镜对青少年近视发展的防治作用。方法：随机选取52例在我院视光中心就诊的年龄在9～18岁近视患者配戴近视回归镜作为治疗组,观察裸眼视力变化,屈光度变化,眼轴长度及角膜曲率变化情况.并与52例年龄及屈光度相似的近视患者配戴框架眼镜作为对照组,观察时间12mo。结果：治疗组屈光度增加〈0.50D者38例（76眼）有效率73.1%,对照组屈光度增加〈0.50D者18例（36眼）有效率34.6%,两组间有显著差异（P〈0.01）;治疗组裸眼视力下降〈2行者39例（78眼）有效率73.6%,对照组裸眼视力下降〈2行者10例（20眼）有效率19.2%,两组间差异有显著性（P〈0.05）;眼轴长度及角膜曲率值变化治疗组与对照组之间无明显差别。结论：近视回归镜对青少年近视发展有延缓作用。

关键词：近视近视回归镜临床研究治疗方法

Strategies for improving the efflcacy of immunotherapy in hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 420-429页

作者： Ying zhu Lun-xiu Qin Department of General Surgery Huashan HospitalCancer Metastasis InstituteFudan UniversityShanghai 200040China Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China

Primary liver cancer,mainly hepatocellular carcinoma(HCC),is the sixth most diagnosed cancer and third leading cause of cancer-related death ***,immunotherapies such as immune checkpoint inhibitors(ICIs)have made great progress in the systemic treatment of ***,anti-PD-1 therapy with pembrolizumab or nivolumab as a single agent did not meet their predefined end points of overall survival in the KEYNOTE-240 and Check Mate 459 *** is urgent to understand the immunological rationale and explore novel ways to improve the efflcacy of *** combination of ICIs with other therapies,such as tyrosine kinase inhibitors(TKIs),monoclonal antibodies,or local therapy,has been demonstrated to improve overall response rate and *** addition,modulating tumor microenvironment is a potential way to overcome the primary and secondary resistance to *** this review,we summarized the latest findings in the immune microenvironment,the mechanisms of their synergistic effects when combined with anti-VEGF agents or TKIs,as well as other kinds of immune treatment.

关键词： Hepatocellular carcinoma Tumor microenvironment Immune checkpoint inhibitors Interferon-α Programmed death receptor 1

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转移性细菌性眼内炎22例临床报告(英文)

国际眼科杂志 2005年第3期5卷 433-435页

作者：张红兵赵燕麟张军军朱秀萍王彤中国陕西省西安市眼科医院 710002 四川大学华西眼科中心中国四川省成都市610041

目的:探讨转移性细菌性眼内炎的临床特点。方法:回顾性分析了我科近年诊治的22例转移性细菌性眼内炎的临床特点。结果:出现眼部症状前有身体其它部位感染者17例(77%);早期眼部检查2例虹膜面有脓性结节,3例视网膜可见黄白色脓性栓塞灶(23... 详细信息

目的:探讨转移性细菌性眼内炎的临床特点。方法:回顾性分析了我科近年诊治的22例转移性细菌性眼内炎的临床特点。结果:出现眼部症状前有身体其它部位感染者17例(77%);早期眼部检查2例虹膜面有脓性结节,3例视网膜可见黄白色脓性栓塞灶(23%);全部病例早期血液化验示白细胞总数和中性分叶核细胞数明显升高,淋巴细胞计数明显降低;细菌培养阳性率为36%。结论:转移性细菌性眼内炎患者发病前常有身体其它部位感染史,早期临床表现和实验室检查有一定的特异性,细菌培养是确定诊断的可靠方法,但是培养技术有待进一步提高。

关键词：转移性细菌性眼内炎细菌培养眼部症状

“One stone, two birds”: Salt template enabling porosity engineering and single metal atom coordinating toward high-performance zinc-ion capacitors

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Journal of Energy Chemistry 2025年第1期 637-645页

作者： Chunliu zhu Huanyu Liang ping Li Chenglong Qiu Jingyi Wu Jingwei Chen Weiqian Tian Yue zhu Zhi Li Huanlei Wang School of Materials Science and Engineering Ocean University of China Department of Chemical and Materials Engineering University of Alberta

Zinc-ion hybrid capacitors （ZIHCs） have received increasing attention as energy storage devices owing to their low cost,high safety,and environmental ***,their progress has been hampered by low energy and power density,as well as unsatisfactory long-cycle stability,mainly due to the lack of suitable electrode *** this context,we have developed manganese single atoms implanted in nitrogen-doped porous carbon nanosheets （MnSAs/NCNs） using a metal salt template method as cathodes for *** metal salt serves a dual purpose in the synthesis process:It facilitates the uniform dispersion of Mn atoms within the carbon matrix and acts as an activating agent to create the porous *** applied in ZIHCs,the MnSAs/NCNs electrode demonstrates exceptional performance,including a high capacity of 203 m Ah g-1,an energy density of 138 Wh kg-1at 68 W kg-1,and excellent cycle stability with 91%retention over 10,000 *** calculations indicate that the introduced Mn atoms modulate the local charge distribution of carbon materials,thereby improving the electrochemical *** work demonstrates the significant potential of carbon materials with metal atoms in zinc-ion hybrid capacitors,not only in enhancing electrochemical performance but also in providing new insights and methods for developing high-performance energy storage devices.

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Changes of spring wind erosion based on wind erosion climate factor in the black soil region of Northeast China

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Journal of Mountain Science 2023年第6期20卷 1712-1724页

作者： YAN ping JI Sheng-tai LI xiu-fen zhu Hai-xia WANG Liang-liang ZHAI Mo WANG ping ZHAO Hui-ying Heilongjiang Institute of Meteorological Sciences Harbin 150030China Innovation and Open Laboratory of Eco-meteorology in Northeast China China Meteorological AdministrationHarbin 150030China Heilongjiang Ecological Meteorological Center Harbin 150030China

The dry and windy climate and low ground cover in spring in the black soil region of Northeast China make the soil strongly affected by wind erosion,which seriously threatens the food security and ecological security of this *** this paper,based on the daily observation data of 124 meteorological stations in study area from 1961 to 2020,seasonal and monthly wind erosion climate factor(C)in spring(March to May)were calculated by using the method proposed by the Food and Agriculture Organization of the United Nations(FAO),the wind erosion characterization in spring were systematically analyzed based on C by various statistical analysis *** results showed that in the past 60 years,spring wind erosion climate factor(CSp)and monthly C of the whole region and each province(region)all showed highly significant decreasing trend,but they began to show rebounded trend in the middle or late *** of the study area showed a significant upward trend since 2008 with an increase of 4.59(10a)^(-1).The main contributors to this upward trend are the changes of C in March and in *** the four provinces(regions),CSp in Heilongjiang,Jilin,Liaoning and eastern Inner Mongolia all showed rebounded since 2008,2011,2008 and 2009,*** rebounded trend of CSp in eastern Inner Mongolia was the most obvious with a tendency rate of 11.27(10a)^(-1),and its mutation occurred after *** rebound trend of CSp in Heilongjiang Province takes the second place,with a trend rate of 4.72(10a)^(-1),but there’s no obvious time mutation *** spatial characteristics of CSpand monthly C are similar,showing decreasing characteristics centered on the typical black soil belt of Northeast *** with 1961-1990,in the period from 1991 to 2020,the proportion of high value areas(CSp>35,monthly C>10)has decreased to varying degrees,while the proportion of low value areas(CSp≤10,monthly C≤4)has *** trends of seasonal and monthly C in 82.2%~87.7%of the

关键词： Wind erosion climate erosivity Spatiotemporal 1characteristics Climate change Rebounded trend Typical black soil region Northeast China