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Endoscopic retrograde cholangiopancreatography for diagnosing and treating pediatric biliary and pancreatic diseases

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World Journal of Gastrointestinal Surgery 2023年第10期15卷 2272-2279页

作者： xiu-min qin Fei-Hong Yu Chuan-Kai Lv Zhi-min Liu Jie Wu Department of Gastroenterology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Ultrasound Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Radiology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China

BACKGROUND This study evaluated the safety and effectiveness of endoscopic retrograde cholangiopancreatography(ERCP)in pediatric patients with biliary and pancreatic diseases.A retrospective analysis was conducted on 57 ERCP procedures performed in 41 children,primarily for treating pancreatic *** overall success rate was 91.2%,with no major complications ***-ERCP pancreatitis(PEP)occurred in 8.8%of ***-up examinations over one year showed no recurrence of biliary or pancreatic ***,endoscopic treatment led to a significant increase in body mass index(BMI).These findings demonstrate the valuable role of ERCP in managing such *** To evaluate the safety and efficacy of ERCP for the management of biliary and pancreatic diseases in pediatric *** We conducted a retrospective analysis of data from children aged 1-18 years who underwent ERCP for biliary and pancreatic diseases at Beijing Children’s Hospital between January 2021 and December *** collected data included procedure time,endoscopic treatment,success rate,and postoperative *** Forty-one children underwent 57 ERCP procedures,including 14 with biliary duct disease and 27 with pancreatic *** mean age of the patients was 7.48±3.48 *** duct-related treatments were performed 18 times,and pancreatic disease treatments were performed 39 *** was primarily used to treat pediatric pancreatic diseases[68.4%(39/57)of the procedures].The overall success rate was 91.2%(52/57 patients).PEP was noted in five patients(8.8%,5/57),and no instances of bleeding,perforation,or cholangitis were *** patients were followed up for over one year,and no recurrence of biliary or pancreatic diseases was ***,BMI significantly increased after endoscopic treatment compared to that before treatment(P=0.001).CONCLUSION The high success rate and lack of major complications support the valuable role of ERCP in the

关键词： Pediatric Endoscopic retrograde cholangiopancreatography Choledocholithiasis Chronic pancreatitis Pancreatic ducts Postoperative complications

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Clinicopathological parameters predicting recurrence of pT1N0 esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2018年第45期24卷 5154-5166页

作者： Li-Yan Xue xiu-min qin Yong Liu Jun Liang Hua Lin Xue-min Xue Shuang-Mei Zou Mo-Yan Zhang Bai-Hua Zhang Zhou-Guang Hui Zi-Tong Zhao Li-Qun Ren Yue-ming Zhang xiu-Yun Liu Yan-Ling Yuan Jian-ming Ying Shu-Geng Gao Yong-Mei Song Gui-Qi Wang Sanford M Dawsey Ning Lu Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Center for Cancer Precision Medicine Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Endoscopy National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Medical Record National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College The 2nd Department of Thoracic Surgery Hunan Cancer Hospital The Affiliated Cancer Hospital of Xiangya School of Medicine CSU State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Pathology Chengde Medical College Metabolic Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute

AIM To identify the clinicopathological characteristics of pT1 N0 esophageal squamous cell carcinoma(ESCC) that are associated with tumor recurrence. METHODS We reviewed 216 pT1 N0 thoracic ESCC cases who underwent esophagectomy and thoracoabdominal two-field lymphadenectomy without preoperative chemoradiotherapy. After excluding those cases with clinical follow-up recorded fewer than 3 mo and those who died within 3 mo of surgery, we included 199 cases in the current analysis. Overall survival and recurrencefree survival were assessed by the Kaplan-Meier method, and clinicopathological characteristics associated with any recurrence or distant recurrence were evaluated using univariate and multivariate Cox proportional hazards models. Early recurrence(≤ 24 mo) and correlated parameters were assessed using univariate and multivariate logistic regression *** Forty-seven(24%) patients had a recurrence at 3 to 178(median, 33) mo. The 5-year recurrence-free survival rate was 80.7%. None of 13 asymptomatic cases had a recurrence. Preoperative clinical symptoms, upper thoracic location, ulcerative or intraluminal mass macroscopic tumor type, tumor invasion depth level, basaloid histology, angiolymphatic invasion, tumor thickness, submucosal invasion thickness, diameter of the largest single tongue of invasion, and complete negative aberrant p53 expression were significantly related to tumor recurrence and/or recurrence-free survival. Upper thoracic tumor location, angiolymphatic invasion, and submucosal invasion thickness were independent predictors of tumor recurrence(Hazard ratios = 3.26, 3.42, and 2.06, P < 0.001, P < 0.001, and P = 0.002, respectively), and a nomogram for predicting recurrence-free survival with these three predictors was constructed. Upper thoracic tumor location and angiolymphatic invasion were independent predictors of distant recurrence. Upper thoracic tumor location, angiolymphatic invasion, submucosal invasion thickness, and diameter o

关键词： Esophageal squamous cell carcinoma Tumor recurrence Lymph node negative esophageal cancer Recurrence-free survival Clinicopathological parameters

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-min qin Zhongliang Li Wen‑Xia Su Jia‑min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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Magnetron sputtered nickel oxide with suppressed interfacial defect states for efficient inverted perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 348-355页

作者： Guoqiang Ma qin Tan Zhaoning Li Jingwei xiu Jiafeng Wang Tianle Cheng Dong He Qiang Sun Xuhang Ma Francesco Lamberti Zhubing He Department of Materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research Facilities Southern University of Science and Technology Department of Chemical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （NiOx） based perovskite solar cells often suffer from severe interfacial reactions between the NiOxand adjacent perovskite layers due to surface defect states,which inherently impair device performance in a long-term view,even with surface molecule *** this study,we developed high-quality magnetron-sputtered NiOxthin films through detailed process optimization,and compared systematically sputtered and spin-coated NiOxthin film surfaces from materials to *** sputtered NiOxfilms exhibit improved crystallinity,smoother surfaces,and significantly reduced Ni3+or Ni vacancies compared to their spin-coated ***,the interface between the perovskite and sputtered NiOxfilm shows a substantially reduced density of defect *** solar cells （PSCs） fabricated with our optimally sputtered NiOxfilms achieved a high power conversion efficiency （PCE） of up to 19.93%and demonstrated enhanced stability,maintaining 86.2% efficiency during 500 h of maximum power point tracking under one standard sun ***,with the surface modification using (4-(2,7-dibromo-9,9-dimethylacridin-10（9H）-yl)butyl)p hosphonic acid （DMAcPA）,the device PCE was further promoted to 23.07%,which is the highest value reported for sputtered NiOxbased PSCs so far.

关键词： Perovskite

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一种醇类水分蒸发抑制剂的开发及在多浪水库的应用

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节水灌溉 2017年第5期 25-28页

作者：吕喜风张娜李秀敏秦少伟李旭塔里木大学现代农业工程重点实验室新疆阿拉尔843300 塔里木大学生命科学学院新疆阿拉尔843300 塔里木大学南疆化工重点实验室新疆阿拉尔843300 塔里木大学信息工程学院新疆阿拉尔843300

为保障新疆农业用水,减少干旱地区水资源的无效蒸发,开发了一种水分蒸发抑制剂。利用十六醇和正丙醇为基材,探讨了组分比例、超声波强度、时间等因素对抑制效果的影响,确立了水分蒸发抑制剂的制备方案。具体方案为十六醇∶正丙醇∶AEO... 详细信息

为保障新疆农业用水,减少干旱地区水资源的无效蒸发,开发了一种水分蒸发抑制剂。利用十六醇和正丙醇为基材,探讨了组分比例、超声波强度、时间等因素对抑制效果的影响,确立了水分蒸发抑制剂的制备方案。具体方案为十六醇∶正丙醇∶AEO总量∶水∶石油醚为0.35∶1∶0.33∶12∶15,超声波处理仪以20%工作强度工作20min。抑制剂用于多浪水库后形成的单分子膜在72 h内使用性能良好。推广使用抑制剂对于减少干旱地区水资源损失具有重大意义,可带来巨大的经济效益和社会效益。

关键词：水分蒸发抑制剂多浪水库水资源保护

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毛竹PheTCP19b基因可变剪接体对芽发育的影响

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农业生物技术学报 2025年第1期33卷 43-54页

作者：郝琴申孜闫小玲周敏舒郭小勤浙江农林大学竹子研究院/省部共建亚热带森林培育国家重点实验室

可变剪接(alternative splicing, AS)是一种转录后的修饰过程，在生物体各种生理过程中发挥重要作用。TCP是一种植物特有的转录因子，参与植物多种生长发育调控过程。为深入探究毛竹(Phyllostachys edulis) TCP19b基因可变剪接体的表达... 详细信息

可变剪接(alternative splicing, AS)是一种转录后的修饰过程，在生物体各种生理过程中发挥重要作用。TCP是一种植物特有的转录因子，参与植物多种生长发育调控过程。为深入探究毛竹(Phyllostachys edulis) TCP19b基因可变剪接体的表达特性及生物学功能，本研究采用RT-PCR技术克隆了毛竹TCP19b基因全长CDS，采用qRT-PCR技术和GUS组织染色分析了可变剪接体的表达量及表达部位，通过亚细胞定位及遗传转化分析了可变剪接体编码蛋白的定位及生物学功能。结果显示，毛竹PheTCP19b基因发生了可变剪接，产生了2种可变剪接体PheTCP19bα和PheTCP19bβ，分别编码346和382个氨基酸，2种可变剪接体都包含保守的bHLH结构域。PheTCP19b与水稻(Oryza sativa) OsTCP19亲缘关系最近。2个可变剪接体的组织特异性表达模式存在一定差异，PheTCP19bα的组织特异性强，而PheTCP19bβ表现出组成型表达特性，油菜素内酯(brassinolide, BR)可诱导2个可变剪接体的表达。2个可变剪接体蛋白均富集在细胞核。PheTCP19bα和PheTCP19bβ均可以将拟南芥(Arabidopsis thaliana) brc1突变体多分枝表型回补到野生型表型。本研究为进一步探讨PheTCP19b基因不同剪接体在芽发育过程中的分子机制提供了基础资料。

关键词：毛竹 TCP转录因子可变剪接(AS) 芽发育油菜素内酯(BR)

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Strategies for improving the efflcacy of immunotherapy in hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 420-429页

作者： Ying Zhu Lun-xiu qin Department of General Surgery Huashan HospitalCancer Metastasis InstituteFudan UniversityShanghai 200040China Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China

Primary liver cancer,mainly hepatocellular carcinoma(HCC),is the sixth most diagnosed cancer and third leading cause of cancer-related death ***,immunotherapies such as immune checkpoint inhibitors(ICIs)have made great progress in the systemic treatment of ***,anti-PD-1 therapy with pembrolizumab or nivolumab as a single agent did not meet their predefined end points of overall survival in the KEYNOTE-240 and Check Mate 459 *** is urgent to understand the immunological rationale and explore novel ways to improve the efflcacy of *** combination of ICIs with other therapies,such as tyrosine kinase inhibitors(TKIs),monoclonal antibodies,or local therapy,has been demonstrated to improve overall response rate and *** addition,modulating tumor microenvironment is a potential way to overcome the primary and secondary resistance to *** this review,we summarized the latest findings in the immune microenvironment,the mechanisms of their synergistic effects when combined with anti-VEGF agents or TKIs,as well as other kinds of immune treatment.

关键词： Hepatocellular carcinoma Tumor microenvironment Immune checkpoint inhibitors Interferon-α Programmed death receptor 1

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Immunotherapy for hepatobiliary malignancies:Progress and prospective

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 409-412页

作者： Lun-xiu qin Department of General Surgery Huashan HospitalFudan UniversityShanghai 200040China

Hepatobiliary malignancies include hepatocellular carcinoma(HCC)and biliary tract cancers(BTCs).They are characterized by high heterozygosity,rapid progression,and difflcult to treat[1,2].Recent rapid progress in targeted therapeutic agents has brought new hope for those with advanced HCC[3-5].But there are problems such as lower response rate,or drug resistance(primary or acquired),as well as poor tolerance due to their side-effects,which make this treatment alone still face great challenges.

关键词： biliary malignancies prospective

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中国儿童青少年遗尿症患病率及影响因素的Meta分析

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中国全科医学 2025年第6期28卷 763-770,776页

作者：刘芹程敏江凤琼李小玉川北医学院护理学院四川省南充市637000 电子科技大学医学院附属绵阳医院绵阳市中心医院四川省绵阳市621000

背景遗尿症是儿科常见疾病之一,近年来,遗尿症对儿童青少年身心健康造成了极大的威胁,严重影响患儿的生活质量,给社会和家庭带来严重的负担。目前,关于儿童青少年遗尿症的影响因素还存在争议,且国内外鲜见相关的系统评价。目的利用Meta... 详细信息

背景遗尿症是儿科常见疾病之一,近年来,遗尿症对儿童青少年身心健康造成了极大的威胁,严重影响患儿的生活质量,给社会和家庭带来严重的负担。目前,关于儿童青少年遗尿症的影响因素还存在争议,且国内外鲜见相关的系统评价。目的利用Meta分析探讨国内儿童青少年遗尿症的患病率和影响因素。方法计算机检索中国知网(CNKI)、万方数据知识服务平台(Wanfang Data)、维普网(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Embase、Web of Science、Cochrane Library数据库中的相关研究,检索时间从建库至2024年5月。由2名研究者独立筛选并交叉核对,横断面研究采用美国医疗保健研究与质量机构进行评估,采用Stata17.0软件进行Meta分析。结果共纳入27篇文献,包括243530例患儿。Meta分析结果显示,中国儿童青少年遗尿症患病率为6.1%(95%CI=5.1%~7.2%),其中,男性(OR=1.52,95%CI=1.41~1.64)、遗尿症家族史(OR=3.46,95%CI=2.01~5.93)、便秘(OR=2.32,95%CI=1.59~3.40)、尿路感染史(OR=2.33,95%CI=1.81~3.01)、睡眠障碍(OR=2.01,95%CI=1.10~3.67)、尿频(OR=1.90,95%CI=1.43~2.52)、尿急(OR=1.67,95%CI=1.31~2.12)、尿失禁(OR=4.85,95%CI=2.78~8.45)是儿童青少年遗尿症的危险因素(P<0.05);排尿训练(OR=0.11,95%CI=0.02~0.46)是儿童青少年遗尿症的保护因素(P<0.05)。结论中国儿童青少年遗尿症患病率较高,性别、遗尿症家族史、便秘、尿路感染史、排尿训练、睡眠障碍、尿频、尿急、尿失禁是儿童青少年遗尿症的主要影响因素。因此,未来应对儿童青少年遗尿症进行早期识别和干预,提高家长对遗尿症的重视,做好疾病宣教普及,减少遗尿症患病率,提高患儿及家庭生活质量。

关键词：遗尿遗尿症儿童青少年患病率影响因素 Meta分析

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Exogenous Nitric Oxide Involved in Subcellular Distribution and Chemical Forms of Cu^(2+) Under Copper Stress in Tomato Seedlings

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Journal of Integrative Agriculture 2013年第10期12卷 1783-1790页

作者： DONG Yu-xiu WANG xiu-feng CUI xiu-min Key Laboratory of Crop Biology Shandong Agricultural University College of Resources and Environment Shandong Agricultural University

Nitric oxide（NO）,a bioactive signaling molecule,serves as an antioxidant and anti-stress agent under abiotic stress.A hydroponics experiment was conducted to investigate the effects of sodium nitroprusside（SNP）,a NO donor,on tomato seedlings exposed to 50 μmol L-1CuCl *** results show that copper is primarily stored in the soluble cell sap fraction in the roots,especially after treatment with Cu＋SNP treatment,which accounted for 66.2% of the total copper *** copper concentration gradually decreased from the roots to the *** the leaves,exogenous NO induces the storage of excess copper in the cell *** stress decreases the proportion of copper integrated with pectates and proteins,but exogenous NO remarkably reverses this *** alleviating effect of NO is blocked by ***,exogenous NO is likely involved in the regulation of the subcellular copper concentrations and its chemical forms under copper *** exogenous NO inhibited the absorption and transport of excess copper to some extent,the copper accumulation in tomato seedlings significantly increased under copper *** use of exogenous NO to enhance copper tolerance in some plants is a promising method for copper remediation.

关键词： tomato seedlings nitric oxide copper stress subcellular distribution chemical form

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