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Downregulation of survivin by RNAi inhibits growth of human gastric carcinoma cells

World Journal of Gastroenterology 2007年第8期13卷 1170-1174页

作者： Guo-Ying Miao Qi-Ming lu xiu-Lan zhang Department of Digestion The People's Hospital of Gansu Province Lanzhou 730000 Gansu Province China

AIM: To investigate the inhibitory effect of a specific small survivin interfering RNA (siRNA) on cell proliferation and the expression of survivin in human gastric carcinoma cell line SGC-7901. METHODS: To knockdown survivin expression, a small interfering RNA targeting against survivin was synthesized and transfected into SGC-7901 cells with lipofectamineTM2000. The downregulation of survivin expression at both mRNA and protein levels were detected by reverse transcription-polymerase chain reaction (RT-PCR) and Western blot analysis. Cell proliferation inhibition rates were determined by methyl thiazolyl tetrazolium (MTT) assay. The effect of survivin siRNA on cell cycle distribution and cell apoptosis was determined by flow cytometry (FCM). RESULTS: RNA interference could efficiently suppress the survivin expression in SGC-7901 cells. At 48 h after transfection, the expression inhibition rate was 44.52% at mRNA level detected by RT-PCR and 40.17% at protein level by Western blot analysis. Downregulation of survivin resulted in significant inhibition of tumor cell growth in vitro. The cell proliferation inhibition rates at 24, 48 and 72 h after survivin siRNA and non-siliencing siRNA transfection, were 34.06%, 47.61% and 40.36%, respectively. The apoptosis rate was 3.56% and the number of cells was increased in G0/G1 phase from 38.2% to 88.6%, and decreased in S and G2/M phase at 48 h after transfection. CONCluSION: Downregulation of survivin results in significant inhibition of tumor growth in vitro. The inhibition of survivin expression can induce apoptosis of SGC-7901 cells. The use of survivin siRNA deserves further investigation as a novel approach to cancer therapy.

关键词： Gastric carcinoma Survivin RNA interference Apoptosis Gene expression

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Ab initio Predictions of Structural and Thermodynamic Properties of Zr2AIC Under High Pressure and High Temperature

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Chinese Journal of Chemical Physics 2015年第3期28卷 263-268,I0001页

作者： Fen luo Zhi-cheng Guo xiu-lu zhang Chang-ying Yuan Ling-cang Cai Laboratory for Extreme Conditions Matter Properties Southwest University of Science and Technol- ogy Mianyang 521900 China National Key Laboratory for Shock Wave and Detonation Physics Research Institute of Fluid Physics Chinese Academy of Engineering Physics Mianyang 521900 China

The structural and thermodynamic properties of Zr2A1C at high pressure and high temper- ature are investigated by first principles density functional theory method. The calculated lattice parameters of Zr2A1C are in good agreement with the available theoretical data. The pressure dependences of the elastic constants, bulk modulus, shear modulus, Young＇s mod- ulus, and Vickers hardness of Zr2A1C are successfully obtained. The elastic anisotropy is examined through the computation of the direction dependence of Young＇s modulus. By using the quasiharmonic Debye model, the thermodynamic properties including the Debye temperature, heat capacity, volume thermal expansion coefficient, and Griineisen parameter at high pressure and temperature are predicted for the first time.

关键词： Elastic property Thermodynamic property Density functional theory

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Molecular Dynamics Simulations of the Elastic Anisotropy of Pd at Extreme Conditions

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Communications in Theoretical Physics 2018年第6期69卷 735-740页

作者： xiu-lu zhang Yun-Xia Han Hong Jia Nuo Qu Zhong-Li Liu Laboratory for Extreme Conditions Matter Properties Southwest University of Science and Technology621010 Mianyang China College of Physics and Electric Information Luoyang Normal University Luoyang 471022 China

It is very interesting to discover the elastic properties of engineering material palladium, especially its elastic anisotropy along Hugoniot states. We here investigate the evolution of its high pressure and temperature(PT) elastic ansotropy along Hugoniot using molecular dynamics simulations based on accurate classical interatomic potential. In order to testify the validity of the interatomic potential of Pd in describing the high PT elastic properties, we calculate its isothermal and adiabatic elastic moduli using molecular dynamics method. The obtained data are in good agreement with experimental data. From the isothermal elastic constants, we deduce the Hugoniot acoustic velocities and find that the resulting data are in good agreement with experimental acoustic velocity data. Based on the reliable elastic constants, we further investigate the spacial elastic ansotropy along Hugoniot PT states. It is found that the spacial elastic anisotropy of Pd increases along Hugoniot states.

关键词： elastic anisotropy Hugoniot states extreme conditions

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Separating trash and solid materials from the wastewater ammonia stripping tower UASB biological oxidation pond processes for the treatment of the swine factory＇s wastewater

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Journal of Environmental Science and Engineering 2009年第3期3卷 12-16页

作者： lu xiu-guo zhang Pan RAO Ting LIU Yan School of Civil Engineering and Architecture East China Jiaotong University Nanchang Jiangxi 330013 China

By making the use of the processes which includes separating trash and solid materials from the wastewater-ammonia stripping tower-UASB-biological oxidation pond, we have treated the wastewater which comes from the swine factory. The treated wastewater can meet the primary standard of The People＇s Republic of China based on sewage discharge standards and the wastewater treatment project design contract （GBl8596-2001）, and the effluent will be used as irrigation-water. We introduce this project including the quality of influent and effluent and the flow scheme, the statement of every part, the investment and the effect, etc. The operation indicated that this process has many merits such as the stability in operation-effect and the convenience in management. So it will provide some help for the similar wastewater treatment.

关键词： separating trash and solid materials from wastewater ammonia stripping UASB biological oxidation pond the swine factory's wastewater

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From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua lu Jun Shen Xin zhang Lingcong Chao Liang Chen Ding zhang Tao Wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

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不同表面积硅胶上保留值变化规律

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化学学报 1981年第5期39卷 411-420页

作者：李秀珍卢佩章中国科学院大连化学物理研究所

采用简单的液体模型,得到了容量因子k′与溶质溶剂的分子参数之间的理论关系。从这个理论方程可知不同表面积硅胶上的两种线性关系,即:不同溶质在不同表面积硅胶上k′值对数之间线性关系及溶质k′值的对数和表面积的对数之间线性关系。... 详细信息

采用简单的液体模型,得到了容量因子k′与溶质溶剂的分子参数之间的理论关系。从这个理论方程可知不同表面积硅胶上的两种线性关系,即:不同溶质在不同表面积硅胶上k′值对数之间线性关系及溶质k′值的对数和表面积的对数之间线性关系。我们用不同表面积YWG-5微粒硅胶,用自制的高压液相色谱仪,以庚烷做冲洗剂,测定了芳烃卤代物、芳香醚、芳香酯等溶质的k′值。实验得到的线性关系与理论预测是一致的。

关键词：表面积保留值硅胶变化规律

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Controllable synthesis of biomimetic wood stem nanoporous high entropy oxides catalysts for oxygen evolution reaction

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Nano Research 2025年第1期18卷 107-117页

作者： Wei Wang Weiqi Wang Huihui Wang Xing lu Jinwen zhang Yunzhuo lu School of Materials Science and Engineering Dalian Jiaotong UniversityDalian 116028China School of Intelligence and Electronic Engineering Dalian Neusoft University of InformationDalian 116023China Guangdong Key Laboratory of Materials and Equipment in Harsh Marine Environment Guangzhou Maritime UniversityGuangzhou 510725China

Bubbles generated during the oxygen evolution reaction(OER)in water splitting readily adhere to the electrode surface,thereby impeding contact between the electrolyte and the active sites,thereby increasing the ***,it is imperative to elucidate the bubble release behavior and engineer electrodes that facilitate faster bubble *** this study,inspired by the wood stem of the Norway spruce,we synthesized a gradient nanoporous high-entropy oxide(GNP-HEO)electrode with a controllable pore *** GNP-HEO,featuring a well-controlled gradient in pore size,is achieved through a straightforward strategy combining selective laser melting with selective phase *** unique gradient nanoporous structure not only facilitates bubble release but also diminishes the bubble shielding effect in OER,thereby enhancing electrocatalytic *** affect interaction of Al,Co,Cr,Fe,and Ni,coupled with the gradient nanoporous structure,yields exceptional OER performance,evidenced by an overpotential of 250 mV at a current density of 50 mA/cm^(2) and a Tafel slope of 38.0 mV/dec in 1 M *** functional theory calculations confirm that the GNPHEO adheres to the adsorbate evolution mechanism reaction pathway and exhibits significant *** work highlights a promising approach for the design and synthesis of high-performance OER electrocatalysts.

关键词： oxygen evolution reaction high-entropy oxides selective phase dis-solution selective laser melting gradient nanoporous

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A quantum-search-based multi-classifier for image recognition

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 21-31页

作者： lu Liu Xingyu Wu lufan zhang Chuan Wang School of Artificial Intelligence Beijing Normal University Applied Optics Beijing Area Major Laboratory Beijing Normal University

The multi-class classification of images is a pivotal challenge within the realm of image processing. As the volume of visual data continues to expand, there is a burgeoning interest in harnessing the unique capabilities of quantum computation to augment the efficiency of classification tasks. However, many existing methods for training quantum image multi-classifiers parallel classical machine learning techniques, where the requisite circuit measurements increase linearly with the volume of training data. This work introduces a novel approach for training a quantum image multi-classifier based on the quantum search algorithm. We have meticulously conducted rigorous experiments on a handwritten digit dataset, a classic benchmark in the field. The results have been meticulously compared with previous works, and the comparative analysis not only validates the efficiency of our proposed approach, requiring only O(N/b) measurements during training, but also highlights a significant quadratic speedup of the algorithm.

关键词： quantum computation image recognition quantum search algorithm

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Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang zhang Danyang Wu Linke Cai Youluan lu Fanpeng Cheng Lijuan Shi Qun Yi Yao Liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction

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天津大港小学消能部件面外承载力探讨应用

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工程抗震与加固改造 2017年第4期39卷 47-54页

作者：周汉杰陆秀丽张涛耿耀明同济大学建筑设计研究院(集团)有限公司上海200092

目前消能减震技术的研究及工程应用都比较关注于消能器的力学性能,提供的附加阻尼比以及减震效果等方面,对于消能部件在罕遇地震作用下是否能够保证消能器能正常发挥效果等研究探讨相对缺乏,尤其是消能部件面外承载力的问题。本文以某... 详细信息

目前消能减震技术的研究及工程应用都比较关注于消能器的力学性能,提供的附加阻尼比以及减震效果等方面,对于消能部件在罕遇地震作用下是否能够保证消能器能正常发挥效果等研究探讨相对缺乏,尤其是消能部件面外承载力的问题。本文以某工程采用消能减震技术为例,介绍实际工程中如何考虑消能部件面外承载力的问题,以保证消能器在罕遇地震作用下能够发挥应有的消能减震效果。

关键词：消能部件消能子结构面外承载力消能减震

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