检索结果-南通市图书馆

A new lavandulyl flavonoid from Sorphora flavescens Ait

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2008年第12期19卷 1453-1455页

作者： Dan Liu Rong lan xiu lan xin Xiao Jie Wang Dong Hai Su Guo Wei Yang School of Science Dalian Nationalities University Dalian 116600 China Beijing Vocational College of Electronic Science and Technology Beijing 100029 China

A new lavandulyl flavonoid was isolated from the rhizome of Sorphora flavescens. The structure of new compound was elucidated on the basis of spectral methods including 2D NMR. And it showed potent cytotoxic activity ... 详细信息

关键词： Sorphora flavescens Ait Flavonoid Lavandulyl flavanone Cytotoxicity

A new ent-labdane diterpenoid lactone from Andrographis paniculata

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2010年第5期21卷 587-589页

作者： Xiao Chi Ma Zhan Ping Gou Chang Yuan Wang Ji Hong Yao xiu lan xin Yuan Lin Ke xin Liu School of Pharmacy Dalian Medical UniversityDalian 116044China School of Pharmacology Guangdong Medical CollegeDongguan 523808China Biotechnology Application Center Beijing Vocational College of Electronic Science and TechnologyBeijing 100029China

A new ent-labdane diterpenoid lactone was isolated from Andrographis *** structure was identified on the basis of spectral data including 2D NMR.

关键词： Andrographis paniculata Ent-labdane diterpenoid Lactone

Effect of resveratrol in gestational diabetes mellitus and its complications

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2023年第6期14卷 808-819页

作者： Hui-Zhong Ma Yuan Chen Hao-Hao Guo Jing Wang xiu-lan xin Yan-Cheng Li Yu-Feng Liu School of Pharmaceutical Sciences Liaoning UniversityShenyang 110036Liaoning ProvinceChina College of Bioengineering Beijing PolytechnicBeijing 100176China Department of Epidemiology University of FloridaGainesvilleFL 32608United States School of Pharmaceutical Sciences Natural Products Pharmaceutical Engineering Technology Research Center of Liaoning ProvinceLiaoning UniversityShenyang 110036Liaoning ProvinceChina

The incidence rate of diabetes in pregnancy is about 20%,and diabetes in pregnancy will have a long-term impact on the metabolic health of mothers and their *** may have elevated blood glucose,which may lead to blood pressure disease,kidney disease,decreased resistance and secondary infection during *** offspring may suffer from abnormal embryonic development,intrauterine growth restriction,obesity,autism,and other adverse ***(RSV)is a natural polyphenol compound,which is found in more than 70 plant species and their products,such as Polygonum cuspidatum,seeds of grapes,peanuts,blueberries,bilberries,and *** studies have shown that RSV has a potential beneficial effect on complex pregnancy,including improving the indicators of diabetes and pregnancy diabetes *** article has reviewed the molecular targets and signaling pathways of RSV,including AMP-activated protein kinase,mitogen-activated protein kinases,silent information regulator sirtuin 1,miR-23a-3p,reactive oxygen species,potassium channels and CX3C chemokine ligand 1,and the effect of RSV on gestational diabetes mellitus(GDM)and its *** improves the indicators of GDM by improving glucose metabolism and insulin tolerance,regulating blood lipids and plasma adipokines,and modulating embryonic oxidative stress and ***,RSV can ameliorate the GDM complications by reducing oxidative stress,reducing the effects on placentation,reducing the adverse effects on embryonic development,reducing offspring's healthy risk,and so ***,this review is of great significance for providing more options and possibilities for further research on medication of gestational diabetes.

关键词： Gestational diabetes mellitus Complication Resveratrol Polyphenol Pathway

Cloning and Overexpression of CYP6F1,a Cytochrome P450 Gene,from Deltamethrin-resistant Culex pipiens pallens

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Biochimica et Biophysica Sinica 2005年第5期37卷 317-326页

作者： Mao-Qing GONG Yan GU Xiao-Bang HU Yan SUN Lei MA xiu-lan LI Li-xin SUN Jing SUN Jin QIAN Chang-Liang ZHU Department of Pathogenic Biology, Nanjing Medical University: Key Laboratory of Modern Pathogenic Biology of Jiangsu Province, Nanjing 210029, China DepartmentofPathogenicBiology NanjingMedicalUniversityKeyLaboratoryofModernPathogenicBiologyofJiangsuProvin

CYP6F1(GenBank/EMBL accession ***662654),a novel gene with a complete encodingsequence in the cytochrome P450 family 6,was cloned and sequenced from deltamethrin-resistant 4thinstar larvae of Culex pipiens *** cDNA sequence of CYP6F1 has an open reading frame of 1527bp,which encodes a putative protein of 508 amino acid *** deduced amino acid sequence ofCYP6F1 indicated that the encoded P450 has conserved domains of a putative membrane-anchoring signal,putative reductase-binding sites,a typical heme-binding site,an ETLR motif and substrate recognition ***-quantitative RT-PCR analysis indicated that the CYP6F1 gene was expressed to a greater extent in thedeltamethrin-resistant strain than in the susceptible strain of *** *** expression levels ofthe CYP6F1 gene in the deltamethrin-resistant 1 st,2nd,3rd,4th instar larvae and adult female mosquitoesdiffered,with highest expression levels in the 4th instar *** addition,the CYP6F1 gene was stablyexpressed in mosquito C6/36 cells,and the expected 61.2 kDa band was identified by Western *** transfected with CYP6F1 had an increased resistance to deltamethrin as compared with control *** results indicate that CYP6F1 is expressed at higher levels in the deltamethrin-resistant strain,and mayconfer some insecticide resistance in *** pallens.

关键词： Culex pipiens pallens insecticide resistance cytochrome P450 RT-PCR

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng lan Zheng Wu Wen-Jia Chen xin-Ning Yu Hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

Experimental Study of Isopropanol Dehydrogenation over Amorphous Alloy Raney Nickel Catalysts

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2013年第6期22卷 613-618页

作者： xin Fang XU Min LI Xun-Feng HUAI xiu-lan Institute of Engineering Thermophysics Chinese Academy of Sciences University of Chinese Academy of Sciences

The dehydrogenation reaction of isopropanol occurring at low temperature is of great industrial importance. It is a key procedure in isopropanol/acetone/hydrogen chemical heat pump system. An experimental investigation was performed to study the behavior of the liquid phase dehydrogenation of isopropanol over amorphous alloy Raney nickel catalysts. Un-promoted and promoted catalysts were used and their performances were compared under various catalyst amounts, acetone content in the reactant and reaction temperature ranging from 348 K to 355 *** is found that there exists an optimum catalyst concentration which is about 0.34 g in 300 ml isopropanol. The temperature has evident effect on the reaction. The presence of activities of Fe-promoted catalyst decrease slightly compared to the un-promoted catalyst when the temperature are 348 K and 351 K. Besides, the reaction rate decreases almost linearly with the increase of acetone volume fraction in the reactant.

关键词： Chemical heat pump Liquid-phase dehydrogenation Isopropanol

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin Yang Yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Simulation of Gas Exothermic Chemical Reaction in Porous Media Reactor with Lattice Boltzmann Method

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2013年第1期22卷 42-47页

作者： xin Fang Li Xun-Feng Xu Min Huai xiu-lan Cai Jun Guo Zhi-Xiong Institute of Engineering Thermophysics Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences Department of Mechanical and Aerospace Engineering Rutgers the State University of New Jersey

Exothermic reactor is the main part in a chemical heat pump. It involves complex multi-component exothermal chemical reaction in catalyst-filled porous media. The lattice Boltzmann method (LBM) is developed to simulate the characteristics of fluid flow, heat and mass transfer coupling chemical reaction in the exothermic reactor of the isopropanol/acetone/hydrogen chemical heat pump system. Fractal theory is used to structure a porous medium model in the reactor. The simulation results show that LBM is suitable for the simulation and the conversion has an optimal value with different inlet velocities.

关键词： Chemical heat pump Hydrogenation reaction LBM.

Isolation and Structure Elucidation of an Antifungal Antibiotics A73 Produced by a Soil Fungus Strain No.131

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 1999年第1期15卷 85-88页

作者： YANG Jun QI xiu-lan SHAO Gang YAO xin-sheng Susumu Kitanaka Department of Natural Products Chemistry Department of Microbiology Shenyang Pharmaceutical UniversityShenyang110015 Department of Pharmacognosy College of PharmacyNihon UniversityJapan Chiba274

ＩｎｔｒｏｄｕｃｔｉｏｎＭｏｒｐｈｏｌｏｇｉｃａｌｄｅｆｏｒｍａｔｉｏｎｏｆｍｙｃｅｌｉａｏｒｃｏｎｉｄｉａｏｆｍｉｃｒｏｏｒｇａｎｉｓｍｓ，ｓｕｃｈａｓｃｕｒｌｉｎｇ，ｓｗｅｌｉｎｇ，ｈｙｐｅｒ－ｄｉｖｅｒｇｅｎｃ... 详细信息

ＩｎｔｒｏｄｕｃｔｉｏｎＭｏｒｐｈｏｌｏｇｉｃａｌｄｅｆｏｒｍａｔｉｏｎｏｆｍｙｃｅｌｉａｏｒｃｏｎｉｄｉａｏｆｍｉｃｒｏｏｒｇａｎｉｓｍｓ，ｓｕｃｈａｓｃｕｒｌｉｎｇ，ｓｗｅｌｉｎｇ，ｈｙｐｅｒ－ｄｉｖｅｒｇｅｎｃｙ，ｂｅａｄｆｏｒｍａｔｉｏｎ，ａ...

关键词： Antifungal antibiotics Isolation Structure elucidation A73