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中国药理学与毒理学杂志 2018年第4期32卷 317-318页

作者： Huan-li XU Ru YUAN Xiao LI Cong LI Gan QIAO xiu-kun lin Department of Pharmacology School of Basic Medical Sciences Capital Medical University Beijing 100069 China

OBJECTIVE Zn-doped CuO nanocomposites(nZn-CuO NPs) are novel nanoparticles synthesized by sonochemical *** study aimed to further investigate the antitumor effects and mechanism of nZn-CuO NPs,as well as the exact mechanism of reactive oxygen species(ROS) on nZn-CuO NPs-induced death using N-acetylcysteine(NAC).METHODS The antitumor effects of nZn-CuO NPs were evaluated by MTS assay and orthotopic transplantation tumor model in nude *** effects of nZn-CuO NPs with or without NAC on ROS production,DNA damage,apoptosis,mitochondrial damage,autophagy,lysosome impairment,and ER and Golgi stress were ***,western blot was used to detect apoptosis and autophagy related proteins,as well as NF-κB pathway related *** nZn-CuO NPs significantly inhibit tumor growth both in vitro and in ***-CuO NPs were able to cause cytotoxicity,ROS production,DAN damage mitochondrial damage,apoptosis,and autophagy,and NAC can attenuate *** studies showed that nZn-CuO NPs induced changes of apoptosis,autophagy and NF-κB pathway related proteins,and NAC can restore *** Overall,our data demonstrated that nZn-CuO NPs could inhibit tumor growth both in vitro and in vivo by ROS-dependent regulation of apoptosis and autophagy,which might be cross-linked by NF-κB pathways.

关键词：超声化学方法抗肿瘤临床分析治疗方法

Water-soluble extract of clove inhibits in vitro and in vivo growth of colon cancer by inducing autophagy

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中国药理学与毒理学杂志 2018年第4期32卷 291-292页

作者： Cong LI Huan-li XU Ye TIAN Gan QIAO Xiao LI Xiao-hui LIU xiu-kun lin Department of Pharmacology Capital Medical University Beijing China.

OBJECTIVE Cloves(Syzygium aromaticumL.) have been used as both a spice and a traditional Chinese medicinal herb for thousands of ***,relatively little is known about its potential anticancer activity and *** this study,we investigated the in vitro and in vivo *** effects and mechanisms of water extract of cloves(WEC) against colorectal *** MTS assay and Colony-formation assay were used to detect the anti-tumor activity of WEC on HT-29 *** in vivo anti-tumor effect of WEC was detected in a subcutaneous transplantation tumor model of human HT-29 *** was detected by flow cytometry and the expressions of autophagy related proteins(Beclin-1 and LC-3 a/b) were determined by western *** MTS result showed that WEC significantly inhibited the viability of HT-29 cells,with the IC50 values of 150 μg·*** colonyformation assay showed that the WEC significantly suppressed colon cancer cells *** also exhibited significant antitumor activity in tumor bearing nude *** cytometry result showed that WEC significantly induced autophagy,and the averaged relative values of fluorescence intensity were206,251,341 and 356 in cells treated with 0,100,150 and 200 μg·mL-1 WEC for 48 *** blot result showed that WEC treatment significantly increased Beclin-1 expression and ratios of LC3-II/*** These result showed that WEC inhibited the growth of colon tumor both in vitro and in vivo,which might be related with autophagy induction,and WEC has potential to be developed as a novel anticancer agent for the treatment of colon cancer.

关键词：丁香中草药肿瘤治疗方法

Granulin A synergizes with cisplatin to inhibit the growth of human hepatocellular carcinoma

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中国药理学与毒理学杂志 2018年第4期32卷 299-300页

作者： Gan QIAO Huan-li XU Ye TIAN Cong LI Xiao LI Xiao-hui LIU xiu-kun lin Department of Pharmacology Capital Medical University Beijing China

OBJECTIVE Granulin A(GRN A),a cytokinesis protein,is derived from proteolysis of *** previous study in our laboratory has shown that GRN A is able to inhibit cancer cell growth *** study aimed to investigate the effect of combination of GRN A and cisplatin on in vitro and in vivo on the growth of hepatocellular *** The in vitro and in vivo antitumor effects of combination of GRN A and Cisplatin were evaluated with MTS assay and *** transplantation tumor ***-Talalay method was used to calculate the combination index(CI).Colony formation assay and flow cytometry were used to detect the effects of GRN A on *** expression of apoptosis-related proteins were detected by Western *** MTS assay showed that GRN A significantly inhibit hepatocellular carcinoma cells growth with the IC50 of 5.6 μmol·L^(-1),and GRN A combined with cisplatin synergistically inhibit hepatocellular carcinoma proliferation,with the CI<*** colony-formation assay showed that GRN A significantly enhanced the inhibitory effects of cisplatin on cellular anchorage-independent *** cytometry showed that GRN A combined with cisplatin synergistically induced apoptosis,with the apoptotic rates of 5.87%,32.74%,35.67% and 67.15% in control,GRN A,Cisplatin,and combination of GRN A and Cisplatin groups,*** blot confirmed that the two drugs synergistically changed the expressions of proteins related to *** vivo experiment indicated that combination of GRN A and cisplatin significantly suppressed tumor growth compared with single drug treatment *** The combination of GRN A and cisplatin resulted in synergistic antitumor effects against hepatocellular carcinoma both in vitro and in vivo.

关键词：细胞因子蛋白蛋白水解治疗方法临床分析

Selenium deficiency exacerbates ROS/ER stress mediated pyroptosis and ferroptosis induced by bisphenol A in chickens thymus

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Journal of Environmental Sciences 2025年第2期148卷 13-26页

作者： kun Wang Xu Shi Hongjin lin Tong Xu Shiwen Xu College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment Harbin 150030China

Bisphenol A(BPA)is an industrial pollutant that can cause immune *** acts as an antioxidant,as selenium deficiency often accompanies oxidative stress,resulting in organ *** study is the first to demonstrate that BPA and/or selenium deficiency induce pyroptosis and ferroptosis-mediated thymic injury in chicken and chicken lymphoma cell(MDCC-MSB-1)via oxidative stress-induced endoplasmic reticulum(ER)*** established a broiler chicken model of BPA and/or selenium deficiency exposure and collected thymus samples as research subjects after 42 *** results demonstrated that BPA or selenium deficiency led to a decrease in antioxidant enzyme activities(T-AOC,CAT,and GSH-Px),accumulation of peroxides(H2O2 and MDA),significant upregulation of ER stress-relatedmarkers(GRP78,IER 1,PERK,EIF-2α,ATF4,and CHOP),a significant increase in iron ion levels,significant upregulation of pyroptosis-related gene(NLRP3,ASC,Caspase1,GSDMD,IL-18 and IL-1β),significantly increase ferroptosis-related genes(TFRC,COX2)and downregulate GPX4,HO-1,FTH,*** vitro experiments conducted in MDCC-MSB-1 cells confirmed the results,demonstrating that the addition of antioxidant(NAC),ER stress inhibitor(TUDCA)and pyroptosis inhibitor(Vx765)alleviated oxidative stress,endoplasmic reticulum stress,pyroptosis,and ***,this study concludes that the combined effects of oxidative stress and ER stress mediate pyroptosis and ferroptosis in chicken thymus induced by BPA exposure and selenium deficiency.

关键词： Bisphenol A Selenium deficiency ROS/ER stress Pyroptosis Ferroptosis Thymic injury

Highly Oxidized Molecules Make a Significant Contribution to Enhanced Aromatic-Derived Secondary Organic Aerosol under a Humid Environment

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ADVANCES IN ATMOSPHERIC SCIENCES 2025年第4期42卷 641-652页

作者： Yang, Zhaomin Li, kun Du, lin Shandong Univ Environm Res Inst Qingdao 266237 Peoples R China

Enhanced mass concentrations of aromatic-derived secondary organic aerosol (SOA) are frequently observed during humid-haze events. However, the influencing mechanism of relative humidity (RH) in aromatic-derived SOA formation remains incompletely understood. Here, the RH dependence of SOA formation in the presence of NOx was explored by a series of chamber experiments for toluene (TOL) and 1,3,5-trimethylbenzene (TMB) photooxidation. The yield of TOL SOA and TMB SOA increased by 221% and 52% with increasing RH from similar to 8% to similar to 70%, respectively. Analytical results from a high-resolution mass spectrometer showed that SOA constituents with high oxygen content (O/C > 0.6) were more abundant in SOA formed in the similar to 70% RH experiment. The elevated yields and O/C of SOA could be attributed to the promoted formation and particle-phase diffusivity of highly oxidized molecules. In addition, in comparison with TMB, TOL could produce more unsaturated aldehydes, which are oxidized into carboxylic acids with high O/C, leading to a more sensitive response of TOL SOA formation to the change in RH. Our work provides mechanistic insights into RH roles in aromatic SOA formation and is helpful for a better understanding of humid-haze events.

关键词： secondary organic aerosol aromatic hydrocarbons highly oxidized molecules relative humidity

New poly-types of LPSO structures in a non-equilibrium Mg_(97)Zn_(1)Y_(1.6)Ca_(0.4)alloy

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China Foundry 2025年第1期22卷 83-89页

作者： Qian-qian Jin Zi-hui Tang Wen-long Xiao xiu-yu Qu Xu-hao Han lin Mei Xiao-hong Shao xiu-liang Ma School of Biological and Chemical Engineering Guangxi University of Science and TechnologyLiuzhou 545006GuangxiChina Center for the Structure of Advanced Matter School of Electronic EngineeringGuangxi University of Science and TechnologyLiuzhou 545006GuangxiChina Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Bay Area Center for Electron Microscopy Songshan Lake Materials LaboratoryDongguan 523808GuangdongChina

In this study,a comprehensive analysis of microstructural features,morphology,crystal structures,and interface structures of long-period stacking ordered(LPSO)structures in a non-equilibrium Mg_(97)Zn_(1)Y_(16)Ca_(0.4)alloy cast in a steel mold was carried *** addition of Ca element plays an important role in the refinement of LPSO *** result reveals new poly-types including 20H F2F2F4,60R(F2F3F3)_(3),and 66H F2F3F3F2(F6)_(4)featuring a 6-Mg structure,alongside the prevalent 18R and 14H LPSO *** incoherent interface between 20H and the Mg matrix is split into two dislocation arrays,leading to the formation of a segment of 60R_(1).Moreover,the superstructure 116L,designated as(F2)_(18)F4,is formed through the ordered distribution of F4 stacking faults in 18R.

关键词： LPSO structures crystal structure Mg alloys heterogeneous interface

Roles of serum uric acid on the association between arsenic exposure and incident metabolic syndrome in an older Chinese population

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Journal of Environmental Sciences 2025年第1期147卷 332-341页

作者： Haiyan Jiang Simei Zhang Yaoyao lin lin Meng Jiayi Li Wenqing Wang Kaixuan Yang Mingjuan Jin Jianbing Wang Mengling Tang kun Chen Department of Public Health Fourth Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Department of Public Health Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Department of Public Health National Clinical Research Center for Child Health of Children’s HospitalZhejiang University School of MedicineHangzhou 310058China

Growing evidences showed that heavy metals exposure may be associated with metabolic ***,themechanism underlying arsenic(As)exposure and metabolic syndrome(MetS)risk has not been fully *** we aimed to prospectively investigate the role of serum uric acid(SUA)on the association between blood As exposure and incident MetS.A sample of 1045 older participants in a community in China was *** determined As at baseline and SUA concentration at follow-up in the Yiwu Elderly *** events were defined according to the criteria of the International Diabetes Federation(IDF).Generalized linear model with log-binominal regression model was applied to estimate the association of As with incident *** investigate the role of SUA in the association between As andMetS,amediation analysiswas *** the fully adjusted log-binominal model,per interquartile range increment of As,the risk of MetS increased *** with the lowest quartile of As,the adjusted relative risk(RR)of MetS in the highest quartile was 1.42(95%confidence interval,CI:1.03,2.00).Additionally,blood As was positively associated with SUA,while SUA had significant association with MetS *** mediation analysis demonstrated that the association of As and MetS risk was mediated by SUA,with the proportion of 15.7%.Our study found higher As was remarkably associated with the elevated risk of MetS in the Chinese older adults *** analysis indicated that SUA might be a mediator in the association between As exposure and MetS.

关键词： Arsenic(As)exposure Metabolic syndrome(MetS) Serum uric acid(SUA) Cohort study Mediation effect Older adults

Highly Oxidized Molecules Make a Significant Contribution to Enhanced Aromatic-Derived Secondary Organic Aerosol under a Humid Environment

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Advances in Atmospheric Sciences 2025年第04期 641-652页

作者： Zhaomin YANG kun LI lin DU Environment Research Institute Shandong University

Enhanced mass concentrations of aromatic-derived secondary organic aerosol(SOA) are frequently observed during humid-haze events. However, the influencing mechanism of relative humidity(RH) in aromatic-derived SOA formation remains incompletely understood. Here, the RH dependence of SOA formation in the presence of NOx was explored by a series of chamber experiments for toluene(TOL) and 1,3,5-trimethylbenzene(TMB) photooxidation. The yield of TOL SOA and TMB SOA increased by 221% and 52% with increasing RH from ～8% to ～70%, respectively. Analytical results from a high-resolution mass spectrometer showed that SOA constituents with high oxygen content(O/C > 0.6) were more abundant in SOA formed in the ～70% RH experiment. The elevated yields and O/C of SOA could be attributed to the promoted formation and particle-phase diffusivity of highly oxidized molecules. In addition, in comparison with TMB,TOL could produce more unsaturated aldehydes, which are oxidized into carboxylic acids with high O/C, leading to a more sensitive response of TOL SOA formation to the change in RH. Our work provides mechanistic insights into RH roles in aromatic SOA formation and is helpful for a better understanding of humid-haze events.

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A comparative study on the formation of nitrogen-containing organic compounds in cloud droplets and aerosol particles

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Journal of Environmental Sciences 2025年第3期149卷 456-464页

作者： Guohua Zhang TaoWang Qinhao lin kun Liu Wei Sun Duohong Chen Lei Li Xinming Wang Xinhui Bi State Key Laboratory of Organic Geochemistry and Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization Guangzhou Institute of GeochemistryChinese Academy of Sciences(CAS)Guangzhou 510640China Guangdong-Hong Kong-Macao Joint Laboratory for Environmental Pollution and Control Guangzhou Institute of GeochemistryCASGuangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China School of Environmental Science and Engineering Institute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China State Environmental Protection Key Laboratory of Regional Air Quality Monitoring Guangdong Environmental Monitoring CenterGuangzhou 510308China Institute of Mass Spectrometer and Atmospheric Environment Jinan UniversityGuangzhou 510632China

Nitrogen-containing organic compounds(NOCs)may potentially contribute to aqueous secondary organic aerosols,yet the different formation of NOCs in aerosol particles and cloud droplets remains *** the in-situ measurements performed at a mountain site(1690 m a.s.l.)in southern China,we investigated the formation of NOCs in the cloud droplets and the cloud-free particles,based on their mixing state information of NOCscontaining particles by single particle mass *** relative abundance of NOCs in the cloud-free particles was significantly higher than those in cloud residual(cloud RES)*** were highly correlated with carbonyl compounds(including glyoxalate and methylglyoxal)in the cloud-free particles,however,limited correlation was observed for cloud RES *** of their mixing state and temporal variations highlights that NOCs was mainly formed from the carbonyl compounds and ammonium in the cloud-free particles,rather than in the cloud RES *** results support that the formation of NOCs from carbonyl compounds is facilitated in concentrated solutions in wet aerosols,rather than cloud *** addition,we have identified the transport of biomass burning particles that facilitate the formation of NOCs,and that the observed NOCs is most likely contributed to the light *** findings have implications for the evaluation of NOCs formation and their contribution to light absorption.

关键词： Nitrogen-containing organic compounds Individual particles Cloud Carbonyl compounds Mixing state

Rosaceae phylogenomic studies provide insights into the evolution of new genes

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Horticultural Plant Journal 2025年第1期11卷 389-405页

作者： Lan Jiang Xiaoxu Li kun Lyu Han Wang Zhiyuan Li Wang Qi lin Zhang Yunpeng Cao Anhui Province Key Laboratory of Non-coding RNA Basic and Clinical Transformation(Wannan Medical College) Central LaboratoryYijishan Hospital of Wannan Medical CollegeWuhuAnhui 241000China Beijing Life Science Academy Beijing 102209China CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhanHubei 430074China Center of Economic Botany Core Botanical GardensChinese Academy of SciencesWuhanHubei 430074China Key Laboratory for Tobacco Gene Resources Tobacco Research InstituteChinese Academy of Agricultural SciencesQingdaoShangdong 266000China school of Life Sciences Anhui Agricultural UniversityHefeiAnhui 230036China School of Basic Medical Sciences Hubei University of Chinese MedicineWuhanHubei 430065China

Rosa banksiae,known as Lady Banks'rose,is a perennial ornamental crop and a versatile herb in traditional Chinese *** the lack of genomic resources,we assembled a Hi Fi and Nanopore sequencing-derived 458.58 Mb gap-free telomere-to-telomere high-quality *** genome with a scaffold N50=63.90 *** genome of *** exhibited no lineage-specific whole-genome duplication compared with other *** phylogenomic analysis of 13 Rosaceae and Arabidopsis through a comparative genomics study showed that numerous gene families were lineage-specific both before and after the diversification of *** of these genes are candidates for new genes that have evolved from parental genes through fusion *** genes are divided into three types:Type-I and Type-II genes contain two parental genes that are generated by duplication,distributed in the same and different regions of the genome,respectively;and Type-III can only be detected in one parental ***,Type-I genes are found to have more relaxed selection pressure and lower Ks values than Type-II,indicating that these newly evolved Type-I genes may play important roles in driving phenotypic *** analysis exhibited that newly formed fusion genes can regulate the phenotype traits of plant growth and development,suggesting the functional significance of these *** study identifies new fusion genes that could be responsible for phenotype evolution and provides information on the evolutionary history of recently diverged species in the Rosa *** data represents the major progress in understanding the new fusion genes evolution pattern of Rosaceae and provides an invaluable resource for phylogenomic studies in plants.

关键词： Rosa banksiae Gap-free genome Rosaceae Phenotype Evolutionary patterns