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Effect of three-volt moxibustion with helium-neon laser irradiation on quality of care in patients with lumbar radiculopathy spondylosis

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World Journal of Clinical Cases 2024年第15期12卷 2522-2528页

作者： xiu-Kun ji jian Li Department of Traditional Chinese Medicine The Second Hospital of Heilongjiang ProvinceHarbin 150028Heilongjiang ProvinceChina Departments of Four Neurology The Second Hospital of Heilongjiang ProvinceHarbin 150028Heilongjiang ProvinceChina

BACKGROUND Lumbar radiculopathy spondylosis is a relatively common orthopedic disease with a high incidence *** most commonly occurs in the lumbar 4-5 and lumbar 5-sacral 1 vertebrae,which account for approximately 95%of *** mostly occurs in people aged 30-50 years old and greatly affects their quality of *** To determine the effect of triple-voltage acupuncture combined with helium-neon laser irradiation on the quality of care and improvement of symptoms in patients with lumbar radiculopathy *** In this study,we selected 120 patients with lumbar radiculopathy spondylosis who were treated at our hospital between June 2019 to June *** patients were divided into control and observation groups according to the random number table method,with 60 patients in each *** in the observation group were treated with three-volt moxibustion combined with helium-neon laser irradiation,and those in the control group were treated with lumbar *** 1 month of treatment,the lumbar pain scores,lumbar spine motor functions,clinical treatment effects,and nursing satisfaction of the two groups were *** The results showed that acupuncture combined with laser irradiation significantly improved the patients'clinical symptoms,i.e.,reduced their low back pain,significantly lower numerical rating scale pain scores in the observation group than in the control group,and better lumbar spine motility than in the control group,compared to lumbar *** addition,they were cared *** treatment effectiveness rate of the observation group was 95.5%,which was significantly higher than that of the control group(81.67%).Satisfaction with care was higher than 90 points in both groups,but the difference was not statistically *** Our study provides a clinical rationale for the future treatment of patients with lumbar spine ***,further extensive research is needed for validation.

关键词： Moxibustion Laser irradiation Clinical rationale Lumbar spine Three-volt moxibustion

Surgical approaches to correct corneal astigmatism at time of cataract surgery: a mini-review

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1370-1374页

作者： Xiao-Lei Yin Zhi-Yang ji xiu-Xin Li Xue-Mei Liang Shu-Xing ji Department of Ophthalmology the 305 Hospital of PLABeijing 100017China Department of Ophthalmology Daping HospitalArmy Medical UniversityChongqing 400042China Department of Medical Administration the 305 Hospital of PLABeijing 100017China

Among refractive errors,astigmatism is the most common optical aberration,where refraction changes in different meridians of the *** causes blurred vision at any distance and includes corneal,lenticular,and retinal *** surgery used to cause a progressive increase in the pre-exisiting corneal astigmatism because of creating a surgically induced astigmatism,for example,a large size surgery *** development of surgical techniques during last decades has made cataract surgery interchange to treat preoperative corneal astigmatism at time of ***,three surgical approaches can be *** placing a sutureless clear corneal incision on the steep meridian of the cornea,a preoperative corneal astigmatism less than 1.0 D can be *** or paired peripheral corneal relaxing incisions(PCRIs)provide 1.0-3.0 D corneal astigmatism *** are typically used for treating 1.0-1.5 D of regular corneal astigmatism,if more than 2.0 D,the risk of overcorrection and irregular astigmatism is *** toric intraocular lenses(IOLs)are unavailable in markets,PCRIs are still a reasonable option for patients with up to 3.0 D of pre-existing corneal *** IOLs implantation can correct 1.0-4.5 D of corneal *** IOLs are approved to correct a high degree of corneal astigmatism with cylinder power up to 12.0 *** approaches can be used alone or in combination.

关键词： cornea astigmatism cataract surgery peripheral corneal relaxing incisions toric intraocular lens

Nd:YAG water mist laser treatment for giant gestational gingival tumor: A case report

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World Journal of Clinical Cases 2024年第11期12卷 1974-1979页

作者： Hong-Yu Chen Jun-ji Xu xiu-Lin Chang Pei Wu Department of Stomatology Women and Children's Hospital Affiliated to Ningbo UniversityNingbo 315012Zhejiang ProvinceChina

BACKGROUND This case of gestational gingival tumor is huge and extremely rare in clinical *** the growth location of this gingival tumor is in the upper anterior tooth area,it seriously affects the pregnant woman's speech and food,causing great pain to the *** use of Nd:YGA water mist laser to remove the gingival tumor resulted in minimal intraoperative bleeding,minimal adverse reactions,and good postoperative healing,which is worthy of clinical promotion and *** SUMMARY The patient,a pregnant woman,reported a large lump in her mouth on the first day of postpartum *** on medical history and clinical examination,the diagnosis was diagnosed as gestational gingival *** pathological biopsy also confirmed this *** use of Nd:YAG water mist laser to remove the tumor resulted in minimal intraoperative bleeding,clear surgical field of view,short surgical time,and good postoperative *** In comparison to traditional surgery,Nd:YAG water mist laser surgery is minimally invasive,minimizes cell damage,reduces bleeding,ensures a clear field of vision,and virtually eliminates postoperative edema,carbonization,and the risk of cross *** has unique advantages in oral soft tissue surgery for pregnant ***,the clinical application of Nd:YAG water mist laser for the treatment of gestational gingival tumors is an ideal choice.

关键词： Gestational gingival tumor Nd:YAG water mist laser Granulomatous gingival tumor Minimally invasive dentistry Pregnancy related diseases Oral soft tissue surgery Case report

Multiple Normalized Solutions for Nonlinear Biharmonic Schr?dinger Equations in ■with L-Subcritical Growth

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Acta Mathematicae Applicatae Sinica 2024年

作者： Jun WANG Li WANG ji-xiu WANG Department of Mathematics Sun Yat-sen University College of Science East China Jiaotong University School of Mathematics and Statistics Hubei University of Arts and Science

In this article, we consider the existence of normalized solutions for the following nonlinear biharmonic Schr?dinger equations:■where c, ε > 0, N ≥ 5, λ ∈ R is a Lagrange multiplier and is unknown, h ∈ C（■N, [0, ∞）), f : R → R is continuous function satisfying L2-subcritical growth. When ε is small enough, we get multiple normalized solutions. Moreover, we also obtain orbital stability of the solutions.

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Information Protocol Equilibrium in n-insider Perfect Competition with a Random Deadline

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Acta Mathematicae Applicatae Sinica 2024年

作者： Qi-hong NIE ji-xiu QIU ji-ze LI Yong-hui ZHOU School of Big Data and Computer Sciences Guizhou Normal University School of Mathematical Sciences Guizhou Normal University

This paper studies a model of n insiders with perfect information trading on a risky asset with value normally distributed and disclosed at a random deadline. We propose a concept of information protocol equilibrium under semi-strong efficient pricing, consisting of an n-profile of insider trading strategies with terminal residual information protocols, and find that if a common protocol on terminal residual information before trading is obeyed by all insiders, then, in the market with more than two insiders there exists a uique equilibrium only when it requires to release common partial information eventually, or it does not exist if it requires to release all or not any; but in the market with a single insider, the insider may release all private information eventually to make a maximal profit. Thereby, the existence and uniqueness of information protocol equilibrium among n insiders are deduced. Finally, numerical results illustrate some market characteristics of equilibria with different information protocols required before trading.

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Emerging role of exosomes in ulcerative colitis: Targeting NOD-like receptor family pyrin domain containing 3 inflammasome

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World Journal of Gastroenterology 2024年第6期30卷 527-541页

作者： Xin Li Li-jiang ji Kai-Di Feng Hua Huang Mei-Rou Liang Shi-jin Cheng xiu-Dong Meng School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550025Guizhou ProvinceChina Department of Anorectal Surgery Changshu Hospital Affiliated to Nanjing University of Chinese MedicineChangshu 215500Jiangsu ProvinceChina College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Ulcerative colitis(UC)is a chronic recurrent inflammatory bowel *** ongoing advances in our understanding of UC,its pathogenesis is yet unelu-cidated,underscoring the urgent need for novel treatment strategies for patients with *** are nanoscale membrane particles that mediate intercellular communication by carrying various bioactive molecules,such as proteins,RNAs,DNA,and *** NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome is a cytosolic tripartite protein complex whose activation induces the maturation and secretion of proinflammatory cytokines interleukin-1β(IL-1β)and IL-18,triggering the inflammatory response to a pathogenic agent or *** evidence suggests that exosomes are new modulators of the NLRP3 inflammasome,with vital roles in the pathological process of ***,recent evidence is reviewed on the role of exosomes and NLRP3 inflammasome in ***,the dual role of exosomes on NLRP3 inflammasome and the effect of NLRP3 inflammasome on exosome secretion are ***,an outlook on the directions of exosome-NLRP3 inflammasome crosstalk research in the context of UC is proposed and areas of further research on this topic are high-lighted.

关键词： Ulcerative colitis Exosomes Inflammasome Evidence Therapeutics

Coinfection with hepatic cystic and alveolar echinococcosis with abdominal wall abscess and sinus tract formation:A case report

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World Journal of Hepatology 2024年第2期16卷 279-285页

作者： Miao-Miao Wang xiu-Qing An jin-Ping Chai jin-Yu Yang ji-De A Xiang-Ren A School of Continuing Education Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Internal Medicine-Cardiovascular Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina Department of General Surgery Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina Department of Hepatic Hydatidosis Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina Department of Medical Laboratory Medicine Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina

BACKGROUND Hepatic cystic and alveolar echinococcosis coinfections,particularly with concurrent abscesses and sinus tract formation,are extremely *** article presents a case of a patient diagnosed with this unique presentation,discussing the typical imaging manifestations of both echinococcosis types and detailing the diagnosis and surgical treatment experience *** SUMMARY A 39-year-old Tibetan woman presented with concurrent hepatic cystic and alveolar echinococcosis,accompanied by abdominal wall abscesses and sinus tract *** conventional imaging examinations suggested only hepatic cystic echinococcosis,but intraoperative and postoperative pathological examination revealed the *** radical resection of the lesions,the patient’s condition improved,and she was discharged soon *** outpatient follow-ups confirmed no recurrence of the hydatid lesion and normal surgical wound *** mixed hepatic cystic and alveolar echinococcosis with abdominal wall abscesses and sinus tract formations are rare,the general treatment approach remains consistent with that of simpler infections of alveolar *** Lesions involving the abdominal wall and sinus tract formation,may require radical ***-term prognosis includes albendazole and follow-up examinations.

关键词： Cystic echinococcosis Alveolar echinococcosis Abdominal wall abscess Surgical treatment Sinus tract Case report

Discovery of a potential bladder cancer inhibitor CHNQD-01281 by regulating EGFR and promoting infiltration of cytotoxic T cells

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Marine Life Science & Technology 2024年第3期6卷 502-514页

作者： jian-Yu Liu Yao-Yao jiang Peng-jie Li Bo Yao Yi-jing Song ji-xiu Gao Gulab Said Yang Gao Jun-Yu Lai Chang-Lun Shao Key Laboratory of Marine Drugs the Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Department of Critical Care Medicine the Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Chemistry Women University SwabiSwabi 23430Pakistan Laoshan Laboratory Qingdao 266237China Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringHainan Normal UniversityHaikou 571158China

As one of the common malignancies that threaten human life,bladder cancer occurs frequently with a high mortality rate in the world,due to its invasion,recurrence and drug *** products from marine microorganisms are becoming the hotspots in discovery of new candidate drug entities,especially in the area of *** A(BFA)is a natural Arf-GEFs inhibitor,but due to the low aqueous solubility,strong toxicity,and poor bioavailability,it is urgent to conduct structural optimization ***,a new BFA pyridine acrylate derivative CHNQD-01281 with improved solubility was prepared and found to exert moderate to strong antiproliferative activity on a variety of human cancer cell *** was noteworthy that CHNQD-01281 was most sensitive to two bladder cancer cell lines T24 and J82(IC50=0.079 and 0.081μmol/L)with high selectivity index(SI=14.68 and 14.32),suggesting a superior safety to *** vivo studies revealed that CHNQD-01281 remarkably suppressed tumor growth in a T24 nude mice xenograft model(TGI=52.63%)and prolonged the survival time(ILS=68.16%)in an MB49 allogeneic mouse model via inducing infiltration of cytotoxic T *** mechanism exploration indicated that CHNQD-01281 regulated both EGFR/PI3K/AKT and EGFR/ERK pathways and mediated the chemotactic effect of chemokines on immune effector ***,CHNQD-01281 may serve as a potential therapeutic agent for bladder cancer through multiple mechanisms.

关键词： Bladder cancer Marine natural products Brefeldin A EGFR/PI3K/AKT EGFR/ERK T-cell infiltration

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： xiu-Yun Zhao De-En Xu Ming-Lei Wu ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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