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Tungsten 2024年第2期6卷 422-427页

作者： xiu-Li Wang Yong-Zhen chen Zhi-Han Chang Yu-Chun Lin Jing-Yi Ma College of Chemistry and Materials Engineering Bohai UniversityJinzhou 121013China Professional Technology Innovation Center of Liaoning Province for Conversion Materials of Solar Cell Jinzhou 121013China

By employing a new semi-rigid pyrazole-amide-derived bis(pyridyl)ligand[N,N'-bis(4-picolylamine)-1-hydropyrazole(4-dpap)],a new homopolymolybdate-based two-dimensional(2D)plate-like complex[Co(4-dpap)(H_(2)O)(β-Mo_(8)O_(2)6)1/2](1)has been prepared under solvothermal condition and structurally ***β-Mo_(8)anions are fi xed between the 2D metal–organic networks[Co(4-dpap)(H_(2)O)]n 2n+via hydrogen-bonding *** 1 possesses satisfactory specifi c capacitance of 1512.4 F·g^(−1)(current density:1 A·g^(−1))and good cycling stability(90.8%after 1000 cycles).Moreover,1 represents a promising amperometric sensor for measurement of Cr(Ⅵ)with low detection limit(0.042μmol·L^(−1))and high *** insertion ofβ-Mo_(8)anions between the unique 2D metal−organic networks improves the active area of polyoxometalates,which further promotes electrochemical performance.

关键词： Homopolymolybdate Metal–organic network Pyrazole-amide-derived bis(pyridyl)ligand Supercapacitor Electrochemical sensor

Optimal Location and Sizing ofMulti-Resource Distributed Generator Based onMulti-Objective Artificial Bee Colony Algorithm

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Energy Engineering 2024年第2期121卷 499-521页

作者： Qiangfei Cao huilai Wang Zijia hui Lingyun chen Economic and Technological Research Institute State Grid Shanxi Electric Power Co.Ltd.Xi’an710075China Central Southern China Electric Power Design Institute Co. Ltd.China Power Engineering Consulting GroupWuhan430074China

Distribution generation(DG)technology based on a variety of renewable energy technologies has developed rapidly.A large number of multi-type DG are connected to the distribution network(DN),resulting in a decline in the stability of DN *** is urgent to find a method that can effectively connect multi-energy DG to ***(PV),wind power generation(WPG),fuel cell(FC),and micro gas turbine(MGT)are considered in this paper.A multi-objective optimization model was established based on the life cycle cost(LCC)of DG,voltage quality,voltage fluctuation,system network loss,power deviation of the tie-line,DG pollution emission index,and meteorological index weight of ***-objective artificial bee colony algorithm(MOABC)was used to determine the optimal location and capacity of the four kinds of DG access DN,and compared with the other three heuristic *** tests based on IEEE 33 test node and IEEE 69 test node show that in IEEE 33 test node,the total voltage deviation,voltage fluctuation,and system network loss of DN decreased by 49.67%,7.47%and 48.12%,respectively,compared with that without DG *** the IEEE 69 test node,the total voltage deviation,voltage fluctuation and system network loss of DN in the MOABC configuration scheme decreased by 54.98%,35.93%and 75.17%,respectively,compared with that without DG configuration,indicating that MOABC can reasonably plan the capacity and location of *** the maximum trade-off between DG economy and DN operation stability.

关键词： Distributed generation distribution network life cycle cost multi-objective artificial bee colony algorithm voltage stability

γδT cells:Major advances in basic and clinical research in tumor immunotherapy

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Chinese Medical Journal 2024年第1期137卷 21-33页

作者： Yueqi Zhao Peng Dong Wei He Jianmin Zhang hui chen Department of Immunology CAMS Key Laboratory for T Cell and ImmunotherapyState Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijing 100005China Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy ChangzhouJiangsu 213000China Haihe Laboratory of Cell Ecosystem Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China

γδT cells are a kind of innate immune T *** have not attracted sufficient attention because they account for only a small proportion of all immune cells,and many basic factors related to these cells remain ***,in recent years,with the rapid development of tumor immunotherapy,γδT cells have attracted increasing attention because of their ability to exert cytotoxic effects on most tumor cells without major histocompatibility complex(MHC)*** increasing number of basic studies have focused on the development,antigen recognition,activation,and antitumor immune response ofγδT ***,γδT cell-based immunotherapeutic strategies are being developed,and the number of clinical trials investigating such strategies is *** review mainly summarizes the progress of basic research and the clinical application ofγδT cells in tumor immunotherapy to provide a theoretical basis for further the development ofγδT cell-based strategies in the future.

关键词： Gamma-delta T-cells T cell receptor CD1a Tumor immunotherapy Receptors,chimeric antigen Vδ1 cells αβT cells

Self-actuating protection mechanisms for safer lithium-ion batteries

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Journal of Energy Chemistry 2024年第7期94卷 181-198页

作者： Yang Luo Chunchun Sang Kehan Le Hao chen hui Li Xinping Ai Hubei Key Lab of Electrochemical Power Sources College of Chemistry&Molecular ScienceWuhan UniversityWuhan 430072HubeiChina state Key Laboratory of New Textile Materials&Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200HubeiChina

Safety issue is still a problem nowadays for the large-scale application of lithium-ion batteries(LIBs)in electric vehicles and energy storage *** unsafe behaviors of LIBs arise from the thermal run-away,which is intrinsically triggered by the overcharging and *** improve the safety of LIBs,various protection strategies based on self-actuating reaction control mechanisms(SRCMs)have been proposed,including redox shuttle,polymerizable monomer additive,potential-sensitive separator,thermal shutdown separator,positive-temperature-coefficient electrode,thermally polymerizable addi-tive,and reversible thermal phase transition *** build-in protection mechanisms,these meth-ods can sensitively detect either the temperature change inside battery or the potential change of the electrode,and spontaneously shut down the electrode reaction at risky conditions,thus preventing the battery from going into thermal *** their advantages in enhancing the intrinsic safety of LIBs,this paper overviews the research progresses of SRCMs after a brief introduction of thermal runaway mechanism and limitations of conventional thermal runaway mitigating *** importantly,the current states and issues,key challenges,and future developing trends of SRCTs are also discussed and outlined from the viewpoint of practical application,aiming at providing insights and guidance for developing more effective SRCMs for LIBs.

关键词： Li-ion battery Safety Thermal runaway Thermal protection Overcharge protection

Novel Hf_(x)Ta_(1−x)C solid solution nanowire toughened HfC coating:An effective strategy for synchronous enhanced mechanical and anti-ablation performance

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Journal of Advanced Ceramics 2024年第5期13卷 590-601页

作者： hui chen Yulei Zhang Yanqin Fu Wenhan Gai Junhao Zhao Haohui Zhang Shaanxi Key Laboratory of Fiber Reinforced Light Composite Materials Northwestern Polytechnical UniversityXi’an 710072China Henan Key Laboratory of High Performance Carbon Fiber Reinforced Composites Institute of Carbon Matrix CompositesHenan Academy of SciencesZhengzhou 450046China

Ultra-high-temperature ceramic nanowires have shown increasing potential for use as thermal structural ***,novel single-crystal Hf_(0.5)Ta_(0.5)C solid solution nanowires were synthesized and incorporated with a HfC coating to construct a robust structure with Hf_(0.5)Ta_(0.5)C solid solution nanowires uniformly distributed and interconnected within the *** novel Hf_(0.5)Ta_(0.5)C solid solution nanowires could effectively hinder crack propagation through crack tip pinning and crack *** mechanism substantially enhanced the elastic modulus and fracture toughness of the HfC coating by 53.29%and 59.67%,*** toughened HfC coating displayed superior fracture toughness and good interfacial binding strength with the substrate to resist severe oxidation and ***,the high thermal conductivity of the toughened HfC coating promoted heat ***,in comparison to the pure HfC coating,the toughened HfC coating displayed smaller mass and linear ablation rates of−0.35 mg·s^(−1)and−0.46μm·s^(−1),which decreased by 39.66%and 36.98%,*** work not only simultaneously enhances the mechanical properties and ablation resistance of HfC-coated carbon/carbon(C/C)composites but also provides novel prospects for advanced ultrahigh-temperature ceramic nanowires under extreme conditions.

关键词： Hf_(x)Ta_(1−x)C solid solution nanowires HfC coating carbon/carbon(C/C)composites mechanical performance ablationresistance

Three-dimensional morphological and fluorescent imaging of zebrafish with a continuous-rotational light-sheet microscope

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 59-66页

作者： Dongmin Zhang Guang Yang Yao Tan Chong chen Jie Zhang hui Li School of Biomedical Engineering(Suzhou)Division of Life Sciences and Medicine University of Science and Technology of China Hefei 230041 P.R.China Suzhou Institute of Biomedical Engineering and Technology Chinese A cademy of Sciences Suzhou Jiangsu 215163P.R.China

Light-sheet fluorescence microscopy(LSFM)has been widely used to image the three-dimensional(3D)structures and functions of various millimeter-size bio-specimen such as ***,the sample adsorption and scattering cause shading of the light-sheet illumination,preventing the even 3D image of thick ***,we report a continuous-rotational light-sheet microscope(CR-LSM)that enables simultaneous 3D bright-field and fluorescence *** a high-accuracy rotational stage,CR-LSM records the outline projections and the fluorescent images of the sample at multiple rotation ***,3D morphology and fluorescent structure were reconstructed with a developed *** CR-LSM,zebrafish’s whole-fish contour and blood vessel structures were obtained simultaneously.

关键词： Light-sheet microscope zebrafish blood vessels morphology

Circulating proteomic biomarkers for diagnosing sporadic amyotrophic lateral sclerosis:a cross-sectional study

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Neural Regeneration Research 2024年第8期19卷 1842-1848页

作者： Lu He Qinming Zhou Chaoyang xiu Yaping Shao Dingding Shen Huanyu Meng Weidong Le Sheng chen Department of Neurology and Institute of Neurology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Hospital of Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina Center for Translational Research on Neurological Diseases the First Affiliated HospitalDalian Medical UniversityDalianLiaoning ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Institute of Neurology Sichuan Academy of Medical Sciences-Sichuan Provincial HospitalChengduSichuan ProvinceChina Department of Neurology Xinrui HospitalWuxiJiangsu ProvinceChina

Biomarke rs are required for the early detection,prognosis prediction,and monitoring of amyotrophic lateral sclerosis,a progressive *** is an unbiased and quantitative method that can be used to detect neurochemical signatures to aid in the identification of candidate biomarke *** this study,we used a label-free quantitative proteomics approach to screen for substantially differentially regulated proteins in ten patients with sporadic amyotrophic lateral scle rosis compared with five healthy *** bstantial upregulation of serum proteins related to multiple functional clusters was observed in patients with spo radic amyotrophic lateral *** biomarke rs were selected based on functionality and expression *** validate the proteomics profiles,blood samples from an additional cohort comprising 100 patients with sporadic amyotrophic lateral sclerosis and 100 healthy controls were subjected to enzyme-linked immunosorbent *** substantially upregulated serum proteins in patients with spora dic amyotrophic lateral sclerosis were selected,of which the cathelicidin-related antimicrobial peptide demonstrated the best discriminative ability between patients with sporadic amyotrophic lateral sclerosis and healthy controls(area under the curve[AUC]=0.713,P<0.0001).To further enhance diagnostic accuracy,a multi-protein combined discriminant algorithm was developed incorporating five proteins(hemoglobin beta,cathelicidin-related antimicrobial peptide,talin-1,zyxin,and translationally-controlled tumor protein).The algo rithm achieved an AUC of 0.811 and a P-value of<0.0001,resulting in 79%sensitivity and 71%specificity for the diagnosis of sporadic amyotrophic lateral scle ***,the ability of candidate biomarkers to discriminate between early-stage amyotrophic lateral sclerosis patients and controls,as well as patients with different disease severities,was examined.A two-protein panel comprising talin-1 and transl

关键词： amyotrophic lateral sclerosis cathelicidin-related antimicrobial peptide hemoglobin label-free quantitative proteomics multi-protein combined diagnostic panel serum biomarkers talin-1 translationally-controlled tumor protein zyxin

Ability of Helicobacter pylori to internalize into Candida

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World Journal of Gastroenterology 2024年第16期30卷 2281-2284页

作者： Zheng-Hong chen Jian-Chao Sun Ting-xiu Yang Gu-Zhen Cui Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou Guizhou Medical UniversityGuiyang 561113Guizhou ProvinceChina Key Laboratory of Endemic and Ethnic Diseases of Ministry of Education Guizhou Medical UniversityGuiyang 561113Guizhou ProvinceChina Joint Laboratory of Helicobacter Pylori and Intestinal Microecology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550009Guizhou ProvinceChina Department of Quality Control Guizhou Provincial Center for Clinical LaboratoryGuiyang 550002Guizhou ProvinceChina Department of Hospital Infection and Management Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina

The following are our views regarding the“letter to the editor”(Helicobacter is preserved in yeast vacuoles!Does Koch’s postulates confirm it?)by Alipour and Gaeini,and the response“letter to the editor”(Candida accommodates nonculturable Helicobacter pylori in its vacuole-Koch’s postulates aren’t applicable)by Siavoshi and *** and Gaeini rejected the methods,results,discussion,and conclusions summarized in a review article by Siavoshi and *** present article reviews and discusses evidence on the evolutionary adaptation of Helicobacter pylori(***)to thrive in Candida cell vacuoles and concludes that Candida could act as a Trojan horse,transporting potentially infectious *** into the stomach of humans.

关键词： Helicobacter pylori Candida yeast Intracellular presence Helicobacter pylori-specific gene Helicobacter pylori transmission

Injectable chitosan hydrogels loaded with antioxidant agent as first-aid dressings for second-degree burn wounds

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Science China(Technological Sciences) 2024年第3期67卷 891-901页

作者： REN hui ZHANG Zhen LU KaiLun SHEN YuanYuan HE ChaoLiang chen XueSi CAS Key Laboratoryof Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

Burn wounds are destructive skin traumas typically of irregular shape and large area. Prone to infection, they require frequent dressing replacement, and painless removal of dressings from burn wounds remains a major challenge. This study focuses on the dynamic characteristics and treatment difficulty of burn wounds. Hydrogel dressings based on glycol chitosan and propionaldehyde-or benzaldehyde-terminated 4-arm poly(ethylene glycol) were designed on the basis of Schiff base cross-linking networks. The hydrogels exhibited shape-adaptability, self-healing and fast-degradation properties, which makes these hydrogels suitable for burn wounds. Salvianolic acid B(SaB)-loaded hydrogel exhibited good antioxidant properties in vitro. In a rat model of deep second-degree burn wounds, the SaB-loaded hydrogel could quickly reduce wound temperature, regulate wound oxidant microenvironment, promote angiogenesis, and accelerate wound healing. Thus, the drug-loaded hydrogel shows significant potential as a first-aid dressing for treatment of burn wounds.

关键词： hydrogel dressing fast-degradation shape-adaptability stress relaxation burn wound treatment

Nd:YAG water mist laser treatment for giant gestational gingival tumor: A case report

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World Journal of Clinical Cases 2024年第11期12卷 1974-1979页

作者： Hong-Yu chen Jun-Ji Xu xiu-Lin Chang Pei Wu Department of Stomatology Women and Children's Hospital Affiliated to Ningbo UniversityNingbo 315012Zhejiang ProvinceChina

BACKGROUND This case of gestational gingival tumor is huge and extremely rare in clinical *** the growth location of this gingival tumor is in the upper anterior tooth area,it seriously affects the pregnant woman's speech and food,causing great pain to the *** use of Nd:YGA water mist laser to remove the gingival tumor resulted in minimal intraoperative bleeding,minimal adverse reactions,and good postoperative healing,which is worthy of clinical promotion and *** SUMMARY The patient,a pregnant woman,reported a large lump in her mouth on the first day of postpartum *** on medical history and clinical examination,the diagnosis was diagnosed as gestational gingival *** pathological biopsy also confirmed this *** use of Nd:YAG water mist laser to remove the tumor resulted in minimal intraoperative bleeding,clear surgical field of view,short surgical time,and good postoperative *** In comparison to traditional surgery,Nd:YAG water mist laser surgery is minimally invasive,minimizes cell damage,reduces bleeding,ensures a clear field of vision,and virtually eliminates postoperative edema,carbonization,and the risk of cross *** has unique advantages in oral soft tissue surgery for pregnant ***,the clinical application of Nd:YAG water mist laser for the treatment of gestational gingival tumors is an ideal choice.

关键词： Gestational gingival tumor Nd:YAG water mist laser Granulomatous gingival tumor Minimally invasive dentistry Pregnancy related diseases Oral soft tissue surgery Case report